Esther C W Breij

Affiliations

Genmab, Utrecht, The Netherlands.

Publications (14)

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation.

Oncoimmunology

Avec: Alexander Muik , Isil Altintas , Friederike Gieseke , Kristina B Schoedel , Saskia M Burm , Aras Toker , Theodora W Salcedo , Dennis Verzijl , David Eisel , Christian Grunwitz , Lena M Kranz , Mathias Vormehr , David P E Satijn , Mustafa Diken , Sebastian Kreiter , Kate Sasser , Tahamtan Ahmadi , Özlem Türeci , Esther C W Breij , Maria Jure-Kunkel , Ugur Sahin

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.

Haematologica

Avec: Simone C Oostindie , Hilma J van der Horst , Margaret A Lindorfer , Erika M Cook , Jillian C Tupitza , Clive S Zent , Richard Burack , Karl R VanDerMeid , Kristin Strumane , Martine E D Chamuleau , Tuna Mutis , Rob N de Jong , Janine Schuurman , Esther C W Breij , Frank J Beurskens , Paul W H I Parren , Ronald P Taylor

Antibodies as drugs-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Avec: Jennifer Cable , Erica Ollmann Saphire , Adrian C Hayday , Timothy D Wiltshire , Jarrod J Mousa , David P Humphreys , Esther C W Breij , Pierre Bruhns , Matteo Broketa , Genta Furuya , Blake M Hauser , Matthieu Mahévas , Andrea Carfi , Tineke Cantaert , Peter D Kwong , Prabhanshu Tripathi , Jonathan H Davis , Neil Brewis , Bruce A Keyt , Felix L Fennemann , Vincent Dussupt , Arvind Sivasubramanian , Philip M Kim , Reda Rawi , Eve Richardson , Daniel Leventhal , Rachael M Wolters , Cecile A W Geuijen , Matthew A Sleeman , Niccolo Pengo , Francesca Rose Donnellan

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.

Cancer discovery

Avec: Alexander Muik , Elena Garralda , Isil Altintas , Friederike Gieseke , Ravit Geva , Eytan Ben-Ami , Corinne Maurice-Dror , Emiliano Calvo , Patricia M LoRusso , Guzman Alonso , Maria E Rodriguez-Ruiz , Kristina B Schoedel , Jordan M Blum , Bianca Sänger , Theodora W Salcedo , Saskia M Burm , Eliana Stanganello , Dennis Verzijl , Fulvia Vascotto , Angelica Sette , Juliane Quinkhardt , Theo S Plantinga , Aras Toker , Edward N van den Brink , Mark Fereshteh , Mustafa Diken , David Satijn , Sebastian Kreiter , Esther C W Breij , Gaurav Bajaj , Eleni Lagkadinou , Kate Sasser , Özlem Türeci , Ulf Forssmann , Tahamtan Ahmadi , Uğur Şahin , Maria Jure-Kunkel , Ignacio Melero

Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism.

Molecular cancer therapeutics

Avec: Marije B Overdijk , Kristin Strumane , Frank J Beurskens , Antonio Ortiz Buijsse , Claudine Vermot-Desroches , Boris S Vuillermoz , Thessa Kroes , Bart de Jong , Naomi Hoevenaars , Richard G Hibbert , Andreas Lingnau , Ulf Forssmann , Janine Schuurman , Paul W H I Parren , Rob N de Jong , Esther C W Breij

Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma.

Blood advances

Avec: Hilma J van der Horst , Anne T Gelderloos , Martine E D Chamuleau , Esther C W Breij , Sonja Zweegman , Inger S Nijhof , Marije B Overdijk , Tuna Mutis

Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment.

Blood cancer journal

Avec: Hilma J van der Horst , A Vera de Jonge , Ida H Hiemstra , Anne T Gelderloos , Daniella R A I Berry , Nathalie J Hijmering , Hendrik F van Essen , Daphne de Jong , Martine E D Chamuleau , Sonja Zweegman , Esther C W Breij , Margaretha G M Roemer , Tuna Mutis

Cytotoxicity of the CD3×CD20 bispecific antibody epcoritamab in CLL is increased by concurrent BTK or BCL-2 targeting.

Blood advances

Avec: Maissa Mhibik , Erika M Gaglione , David Eik , John Herrick , Janet Le , Inhye E Ahn , Christopher Chiu , Monica Wielgos-Bonvallet , Ida H Hiemstra , Esther C W Breij , Jenny Chen , Edward B Reilly , Pearlie K Epling-Burnette , Edith Szafer-Glusman , Clare Sun , Adrian Wiestner

DuoHexaBody-CD37

Blood cancer journal

Avec: Simone C Oostindie , Hilma J van der Horst , Laurens P Kil , Kristin Strumane , Marije B Overdijk , Edward N van den Brink , Jeroen H N van den Brakel , Hendrik J Rademaker , Berris van Kessel , Juliette van den Noort , Martine E D Chamuleau , Tuna Mutis , Margaret A Lindorfer , Ronald P Taylor , Janine Schuurman , Paul W H I Parren , Frank J Beurskens , Esther C W Breij

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.

EBioMedicine

Avec: Patrick J Engelberts , Ida H Hiemstra , Bart de Jong , Danita H Schuurhuis , Joyce Meesters , Irati Beltran Hernandez , Simone C Oostindie , Joost Neijssen , Edward N van den Brink , G Jean Horbach , Sandra Verploegen , Aran F Labrijn , Theodora Salcedo , Janine Schuurman , Paul W H I Parren , Esther C W Breij

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity.

Journal for immunotherapy of cancer

Avec: Alexander Muik , Homer C Adams 3rd , Friederike Gieseke , Isil Altintas , Kristina B Schoedel , Jordan M Blum , Bianca Sänger , Saskia M Burm , Eliana Stanganello , Dennis Verzijl , Vanessa M Spires , Fulvia Vascotto , Aras Toker , Juliane Quinkhardt , Mark Fereshteh , Mustafa Diken , David P E Satijn , Sebastian Kreiter , Tahamtan Ahmadi , Esther C W Breij , Özlem Türeci , Kate Sasser , Ugur Sahin , Maria Jure-Kunkel

Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity.

EBioMedicine

Avec: Ida H Hiemstra , Kim C M Santegoets , Maarten L Janmaat , Bart E C G De Goeij , Wessel Ten Hagen , Sanne van Dooremalen , Peter Boross , Jeroen van den Brakel , Sieto Bosgra , Grietje Andringa , Berris van Kessel-Welmers , Dennis Verzijl , Richard G Hibbert , Kristine A Frerichs , Tuna Mutis , Niels W C J van de Donk , Tahamtan Ahmadi , David Satijn , A Kate Sasser , Esther C W Breij

An antibody-drug conjugate directed to tissue factor shows preclinical anti-tumor activity in head and neck cancer as a single agent and in combination with chemoradiotherapy.

Molecular cancer therapeutics

Avec: Jantine E Bakema , Marijke Stigter-van Walsum , Jeffrey R Harris , Sonja H Ganzevles , Anantharaman Muthuswamy , Mischa Houtkamp , Theo S Plantinga , Elisabeth Bloemena , Ruud H Brakenhoff , Esther C W Breij , Rieneke van de Ven

Systematic study of tissue factor expression in solid tumors.

Cancer reports (Hoboken, N.J.)

Avec: Johann S de Bono , Jeffrey R Harris , Saskia M Burm , Adriaan Vanderstichele , Mischa A Houtkamp , Saida Aarass , Ruth Riisnaes , Ines Figueiredo , Daniel Nava Rodrigues , Rossitza Christova , Siel Olbrecht , Hans W M Niessen , Sigrid R Ruuls , Danita H Schuurhuis , Jeroen J Lammerts van Bueren , Esther C W Breij , Ignace Vergote

Réseau de co-auteurs

Tuna Mutis 5 collaborations

Saskia M Burm 4 collaborations

Dennis Verzijl 4 collaborations

Tahamtan Ahmadi 4 collaborations

Hilma J van der Horst 4 collaborations

Martine E D Chamuleau 4 collaborations

Janine Schuurman 4 collaborations

Paul W H I Parren 4 collaborations

Ida H Hiemstra 4 collaborations

Alexander Muik 3 collaborations

Isil Altintas 3 collaborations

Friederike Gieseke 3 collaborations

Kristina B Schoedel 3 collaborations

Aras Toker 3 collaborations

Mustafa Diken 3 collaborations

Sebastian Kreiter 3 collaborations

Kate Sasser 3 collaborations

Özlem Türeci 3 collaborations

Maria Jure-Kunkel 3 collaborations

Simone C Oostindie 3 collaborations

Kristin Strumane 3 collaborations

Frank J Beurskens 3 collaborations

Edward N van den Brink 3 collaborations

Marije B Overdijk 3 collaborations

Theodora W Salcedo 2 collaborations

David P E Satijn 2 collaborations

Ugur Sahin 2 collaborations

Margaret A Lindorfer 2 collaborations

Rob N de Jong 2 collaborations

Ronald P Taylor 2 collaborations

Jordan M Blum 2 collaborations

Bianca Sänger 2 collaborations

Eliana Stanganello 2 collaborations

Fulvia Vascotto 2 collaborations

Juliane Quinkhardt 2 collaborations

Theo S Plantinga 2 collaborations

Mark Fereshteh 2 collaborations

David Satijn 2 collaborations

Ulf Forssmann 2 collaborations

Bart de Jong 2 collaborations

Richard G Hibbert 2 collaborations

Anne T Gelderloos 2 collaborations

Sonja Zweegman 2 collaborations

Danita H Schuurhuis 2 collaborations

Jeffrey R Harris 2 collaborations

David Eisel 1 collaboration

Christian Grunwitz 1 collaboration

Lena M Kranz 1 collaboration

Mathias Vormehr 1 collaboration

Erika M Cook 1 collaboration

Jillian C Tupitza 1 collaboration

Clive S Zent 1 collaboration

Richard Burack 1 collaboration

Karl R VanDerMeid 1 collaboration

Jennifer Cable 1 collaboration

Erica Ollmann Saphire 1 collaboration

Adrian C Hayday 1 collaboration

Timothy D Wiltshire 1 collaboration

Jarrod J Mousa 1 collaboration

David P Humphreys 1 collaboration

Pierre Bruhns 1 collaboration

Matteo Broketa 1 collaboration

Genta Furuya 1 collaboration

Blake M Hauser 1 collaboration

Matthieu Mahévas 1 collaboration

Andrea Carfi 1 collaboration

Tineke Cantaert 1 collaboration

Peter D Kwong 1 collaboration

Prabhanshu Tripathi 1 collaboration

Jonathan H Davis 1 collaboration

Neil Brewis 1 collaboration

Bruce A Keyt 1 collaboration

Felix L Fennemann 1 collaboration

Vincent Dussupt 1 collaboration

Arvind Sivasubramanian 1 collaboration

Philip M Kim 1 collaboration

Reda Rawi 1 collaboration

Eve Richardson 1 collaboration

Daniel Leventhal 1 collaboration

Rachael M Wolters 1 collaboration

Cecile A W Geuijen 1 collaboration

Matthew A Sleeman 1 collaboration

Niccolo Pengo 1 collaboration

Francesca Rose Donnellan 1 collaboration

Elena Garralda 1 collaboration

Ravit Geva 1 collaboration

Eytan Ben-Ami 1 collaboration

Corinne Maurice-Dror 1 collaboration

Emiliano Calvo 1 collaboration

Patricia M LoRusso 1 collaboration

Guzman Alonso 1 collaboration

Maria E Rodriguez-Ruiz 1 collaboration

Angelica Sette 1 collaboration

Gaurav Bajaj 1 collaboration

Eleni Lagkadinou 1 collaboration

Uğur Şahin 1 collaboration

Ignacio Melero 1 collaboration

Antonio Ortiz Buijsse 1 collaboration

Claudine Vermot-Desroches 1 collaboration

Boris S Vuillermoz 1 collaboration

Thessa Kroes 1 collaboration

Naomi Hoevenaars 1 collaboration

Andreas Lingnau 1 collaboration

Inger S Nijhof 1 collaboration

A Vera de Jonge 1 collaboration

Daniella R A I Berry 1 collaboration

Nathalie J Hijmering 1 collaboration

Hendrik F van Essen 1 collaboration

Daphne de Jong 1 collaboration

Margaretha G M Roemer 1 collaboration

Maissa Mhibik 1 collaboration

Erika M Gaglione 1 collaboration

David Eik 1 collaboration

John Herrick 1 collaboration

Janet Le 1 collaboration

Inhye E Ahn 1 collaboration

Christopher Chiu 1 collaboration

Monica Wielgos-Bonvallet 1 collaboration

Jenny Chen 1 collaboration

Edward B Reilly 1 collaboration

Pearlie K Epling-Burnette 1 collaboration

Edith Szafer-Glusman 1 collaboration

Clare Sun 1 collaboration

Adrian Wiestner 1 collaboration

Laurens P Kil 1 collaboration

Jeroen H N van den Brakel 1 collaboration

Hendrik J Rademaker 1 collaboration

Berris van Kessel 1 collaboration

Juliette van den Noort 1 collaboration

Patrick J Engelberts 1 collaboration

Joyce Meesters 1 collaboration

Irati Beltran Hernandez 1 collaboration

Joost Neijssen 1 collaboration

G Jean Horbach 1 collaboration

Sandra Verploegen 1 collaboration

Aran F Labrijn 1 collaboration

Theodora Salcedo 1 collaboration

Homer C Adams 3rd 1 collaboration

Vanessa M Spires 1 collaboration

Kim C M Santegoets 1 collaboration

Maarten L Janmaat 1 collaboration

Bart E C G De Goeij 1 collaboration

Wessel Ten Hagen 1 collaboration

Sanne van Dooremalen 1 collaboration

Peter Boross 1 collaboration

Jeroen van den Brakel 1 collaboration

Sieto Bosgra 1 collaboration

Grietje Andringa 1 collaboration

Berris van Kessel-Welmers 1 collaboration

Kristine A Frerichs 1 collaboration

Niels W C J van de Donk 1 collaboration

A Kate Sasser 1 collaboration

Jantine E Bakema 1 collaboration

Marijke Stigter-van Walsum 1 collaboration

Sonja H Ganzevles 1 collaboration

Anantharaman Muthuswamy 1 collaboration

Mischa Houtkamp 1 collaboration

Elisabeth Bloemena 1 collaboration

Ruud H Brakenhoff 1 collaboration

Rieneke van de Ven 1 collaboration

Johann S de Bono 1 collaboration

Adriaan Vanderstichele 1 collaboration

Mischa A Houtkamp 1 collaboration

Saida Aarass 1 collaboration

Ruth Riisnaes 1 collaboration

Ines Figueiredo 1 collaboration

Daniel Nava Rodrigues 1 collaboration

Rossitza Christova 1 collaboration

Siel Olbrecht 1 collaboration

Hans W M Niessen 1 collaboration

Sigrid R Ruuls 1 collaboration

Jeroen J Lammerts van Bueren 1 collaboration

Ignace Vergote 1 collaboration