Erhard Bieberich

Affiliations

Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA.
Veterans Affairs Medical Center, Lexington, KY, 40502, USA.

Publications (30)

Ceramide analog [

Scientific reports

Avec: Simone M Crivelli , Daan van Kruining , Qian Luo , Jo A A Stevens , Caterina Giovagnoni , Andreas Paulus , Matthias Bauwens , Dusan Berkes , Helga E de Vries , Monique T Mulder , Jochen Walter , Etienne Waelkens , Rita Derua , Johannes V Swinnen , Jonas Dehairs , Felix M Mottaghy , Mario Losen , Erhard Bieberich , Pilar Martinez-Martinez

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis.

The Journal of biological chemistry

Avec: Rose Nganga , Natalia Oleinik , Jisun Kim , Shanmugam Panneer Selvam , Ryan De Palma , Kristen A Johnson , Rasesh Y Parikh , Vamsi Gangaraju , Yuri Peterson , Mohammed Dany , Robert V Stahelin , Christina Voelkel-Johnson , Zdzislaw M Szulc , Erhard Bieberich , Besim Ogretmen

Extracellular vesicles in pharmacology: Novel approaches in diagnostics and therapy.

Pharmacological research

Avec: Zainuddin Quadri , Ahmed Elsherbini , Erhard Bieberich

Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles.

Journal of extracellular vesicles

Avec: Zainuddin Quadri , Ahmed Elsherbini , Simone M Crivelli , Salim S El-Amouri , Priyanka Tripathi , Zhihui Zhu , Xiaojia Ren , Liping Zhang , Stefka D Spassieva , Mariana Nikolova-Karakashian , Erhard Bieberich

Cross-Link/Proximity Ligation Assay for Visualization of Lipid and Protein Complexes in Lipid Rafts.

Methods in molecular biology (Clifton, N.J.)

Avec: Priyanka Tripathi , Zhihui Zhu , Haiyan Qin , Ahmed Elsherbini , Emily A Roush , Simone M Crivelli , Stefka D Spassieva , Erhard Bieberich

Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Kosuke Murakami , Victoria R Tenge , Umesh C Karandikar , Shih-Ching Lin , Sasirekha Ramani , Khalil Ettayebi , Sue E Crawford , Xi-Lei Zeng , Frederick H Neill , B Vijayalakshmi Ayyar , Kazuhiko Katayama , David Y Graham , Erhard Bieberich , Robert L Atmar , Mary K Estes

Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins.

Advances in neurobiology

Avec: Erhard Bieberich

Chronic nSMase inhibition suppresses neuronal exosome spreading and sex-specifically attenuates amyloid pathology in APP knock-in Alzheimer's disease mice.

Neurobiology of disease

Avec: Francesca E Mowry , Francisco Espejo-Porras , Shijie Jin , Zainuddin Quadri , Limin Wu , Marcela Bertolio , Rachel Jarvis , Caroline Reynolds , Rashed Alananzeh , Erhard Bieberich , Yongjie Yang

Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes.

Journal of lipid research

Avec: S El-Amouri , A Karakashian , E Bieberich , M Nikolova-Karakashian

Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle-aged mouse brains.

Genes, brain, and behavior

Avec: Zhihui Zhu , Timothy S McClintock , Erhard Bieberich

Extracellular Vesicles Containing Ceramide-Rich Platforms: "Mobile Raft" Isolation and Analysis.

Methods in molecular biology (Clifton, N.J.)

Avec: Ahmed Elsherbini , Haiyan Qin , Zhihui Zhu , Priyanka Tripathi , Guanghu Wang , Simone M Crivelli , Stefka D Spassieva , Erhard Bieberich

Ceramide regulates interaction of Hsd17b4 with Pex5 and function of peroxisomes.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Avec: Zhihui Zhu , Jianzhong Chen , Guanghu Wang , Ahmed Elsherbini , Liansheng Zhong , Xue Jiang , Haiyan Qin , Priyanka Tripathi , Wenbo Zhi , Stefka D Spassieva , Andrew J Morris , Erhard Bieberich

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Simone M Crivelli , Qian Luo , Daan van Kruining , Caterina Giovagnoni , Marina Mané-Damas , Sandra den Hoedt , Dusan Berkes , Helga E De Vries , Monique T Mulder , Jochen Walter , Etienne Waelkens , Rita Derua , Johannes V Swinnen , Jonas Dehairs , Erwin P M Wijnands , Erhard Bieberich , Mario Losen , Pilar Martinez-Martinez

Inhibition of acid sphingomyelinase reduces reactive astrocyte secretion of mitotoxic extracellular vesicles and improves Alzheimer's disease pathology in the 5xFAD mouse.

Acta neuropathologica communications

Avec: Simone M Crivelli , Zainuddin Quadri , Hemendra J Vekaria , Zhihui Zhu , Priyanka Tripathi , Ahmed Elsherbini , Liping Zhang , Patrick G Sullivan , Erhard Bieberich

The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Aβ clearance in 5XFAD mice.

EBioMedicine

Avec: Zhihui Zhu , Liping Zhang , Ahmed Elsherbini , Simone M Crivelli , Priyanka Tripathi , Carmen Harper , Zainuddin Quadri , Stefka D Spassieva , Erhard Bieberich

Sphingolipids in Alzheimer's disease, how can we target them?

Advanced drug delivery reviews

Avec: Simone M Crivelli , Caterina Giovagnoni , Lars Visseren , Anna-Lena Scheithauer , Nienke de Wit , Sandra den Hoedt , Mario Losen , Monique T Mulder , Jochen Walter , Helga E de Vries , Erhard Bieberich , Pilar Martinez-Martinez

Role of 1-Deoxysphingolipids in docetaxel neurotoxicity.

Journal of neurochemistry

Avec: Katrin A Becker , Anne-Kathrin Uerschels , Laura Goins , Suzanne Doolen , Kristen J McQuerry , Jacek Bielawski , Ulrich Sure , Erhard Bieberich , Bradley K Taylor , Erich Gulbins , Stefka D Spassieva

Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma.

The Journal of allergy and clinical immunology

Avec: Briana N James , Clement Oyeniran , Jamie L Sturgill , Jason Newton , Rebecca K Martin , Erhard Bieberich , Cynthia Weigel , Melissa A Maczis , Elisa N D Palladino , Joseph C Lownik , John B Trudeau , Joan M Cook-Mills , Sally Wenzel , Sheldon Milstien , Sarah Spiegel

Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts.

Molecular neurobiology

Avec: Zhihui Zhu , Zainuddin Quadri , Simone M Crivelli , Ahmed Elsherbini , Liping Zhang , Priyanka Tripathi , Haiyan Qin , Emily Roush , Stefka D Spassieva , Mariana Nikolova-Karakashian , Timothy S McClintock , Erhard Bieberich

Function of ceramide transfer protein for biogenesis and sphingolipid composition of extracellular vesicles.

Journal of extracellular vesicles

Avec: Simone M Crivelli , Caterina Giovagnoni , Zhihui Zhu , Priyanka Tripathi , Ahmed Elsherbini , Zainuddin Quadri , Jian Pu , Liping Zhang , Branislav Ferko , Dusan Berkes , Stefka D Spassieva , Pilar Martinez-Martinez , Erhard Bieberich

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Elisa N D Palladino , Tytus Bernas , Christopher D Green , Cynthia Weigel , Sandeep K Singh , Can E Senkal , Andrea Martello , John P Kennelly , Erhard Bieberich , Peter Tontonoz , David A Ford , Sheldon Milstien , Emily R Eden , Sarah Spiegel

Novel Isolation Method Reveals Sex-Specific Composition and Neurotoxicity of Small Extracellular Vesicles in a Mouse Model of Alzheimer's Disease.

Cells

Avec: Ahmed Elsherbini , Zhihui Zhu , Zainuddin Quadri , Simone M Crivelli , Xiaojia Ren , Hemendra J Vekaria , Priyanka Tripathi , Liping Zhang , Wenbo Zhi , Erhard Bieberich

Visualization of Ceramide-Associated Proteins in Ceramide-Rich Platforms Using a Cross-Linkable Ceramide Analog and Proximity Ligation Assays With Anti-ceramide Antibody.

Frontiers in cell and developmental biology

Avec: Xue Jiang , Zhihui Zhu , Haiyan Qin , Priyanka Tripathi , Liansheng Zhong , Ahmed Elsherbini , Sanjib Karki , Simone M Crivelli , Wenbo Zhi , Guanghu Wang , Stefanka D Spassieva , Erhard Bieberich

Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide.

Glia

Avec: Liansheng Zhong , Xue Jiang , Zhihui Zhu , Haiyan Qin , Michael B Dinkins , Ji-Na Kong , Silvia Leanhart , Rebecca Wang , Ahmed Elsherbini , Erhard Bieberich , Yujie Zhao , Guanghu Wang

Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity.

Acta neuropathologica communications

Avec: Ahmed Elsherbini , Alexander S Kirov , Michael B Dinkins , Guanghu Wang , Haiyan Qin , Zhihui Zhu , Priyanka Tripathi , Simone M Crivelli , Erhard Bieberich

Theranostic Applications of Nanomaterials in Alzheimer's Disease: A Multifunctional Approach.

Current pharmaceutical design

Avec: Priyanka Tripathi , Poonam Shukla , Erhard Bieberich

Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis.

Journal of lipid research

Avec: Priyanka Tripathi , Zhihui Zhu , Haiyan Qin , Ahmed Elsherbini , Simone M Crivelli , Emily Roush , Guanghu Wang , Stefka D Spassieva , Erhard Bieberich

CERT

Alzheimer's research & therapy

Avec: Simone M Crivelli , Qian Luo , Jo A A Stevens , Caterina Giovagnoni , Daan van Kruining , Gerard Bode , Sandra den Hoedt , Barbara Hobo , Anna-Lena Scheithauer , Jochen Walter , Monique T Mulder , Christopher Exley , Matthew Mold , Michelle M Mielke , Helga E De Vries , Kristiaan Wouters , Daniel L A van den Hove , Dusan Berkes , María Dolores Ledesma , Joost Verhaagen , Mario Losen , Erhard Bieberich , Pilar Martinez-Martinez

Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision.

JCI insight

Avec: Dominik Lewandowski , Andrzej T Foik , Roman Smidak , Elliot H Choi , Jianye Zhang , Thanh Hoang , Aleksander Tworak , Susie Suh , Henri Leinonen , Zhiqian Dong , Antonio Fm Pinto , Emily Tom , Jennings Luu , Joan Lee , Xiuli Ma , Erhard Bieberich , Seth Blackshaw , Alan Saghatelian , David C Lyon , Dorota Skowronska-Krawczyk , Marcin Tabaka , Krzysztof Palczewski

CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection.

Nature communications

Avec: B Vijayalakshmi Ayyar , Khalil Ettayebi , Wilhelm Salmen , Umesh C Karandikar , Frederick H Neill , Victoria R Tenge , Sue E Crawford , Erhard Bieberich , B V Venkataram Prasad , Robert L Atmar , Mary K Estes

Réseau de co-auteurs

Simone M Crivelli 15 collaborations

Ahmed Elsherbini 14 collaborations

Zhihui Zhu 14 collaborations

Priyanka Tripathi 13 collaborations

Stefka D Spassieva 9 collaborations

Zainuddin Quadri 8 collaborations

Haiyan Qin 8 collaborations

Liping Zhang 6 collaborations

Guanghu Wang 6 collaborations

Caterina Giovagnoni 5 collaborations

Pilar Martinez-Martinez 5 collaborations

Dusan Berkes 4 collaborations

Monique T Mulder 4 collaborations

Jochen Walter 4 collaborations

Mario Losen 4 collaborations

Daan van Kruining 3 collaborations

Qian Luo 3 collaborations

Liansheng Zhong 3 collaborations

Xue Jiang 3 collaborations

Wenbo Zhi 3 collaborations

Sandra den Hoedt 3 collaborations

Jo A A Stevens 2 collaborations

Helga E de Vries 2 collaborations

Etienne Waelkens 2 collaborations

Rita Derua 2 collaborations

Johannes V Swinnen 2 collaborations

Jonas Dehairs 2 collaborations

Xiaojia Ren 2 collaborations

Mariana Nikolova-Karakashian 2 collaborations

Victoria R Tenge 2 collaborations

Umesh C Karandikar 2 collaborations

Khalil Ettayebi 2 collaborations

Sue E Crawford 2 collaborations

Frederick H Neill 2 collaborations

B Vijayalakshmi Ayyar 2 collaborations

Robert L Atmar 2 collaborations

Mary K Estes 2 collaborations

Timothy S McClintock 2 collaborations

Helga E De Vries 2 collaborations

Hemendra J Vekaria 2 collaborations

Anna-Lena Scheithauer 2 collaborations

Cynthia Weigel 2 collaborations

Elisa N D Palladino 2 collaborations

Sheldon Milstien 2 collaborations

Sarah Spiegel 2 collaborations

Emily Roush 2 collaborations

Michael B Dinkins 2 collaborations

Andreas Paulus 1 collaboration

Matthias Bauwens 1 collaboration

Felix M Mottaghy 1 collaboration

Rose Nganga 1 collaboration

Natalia Oleinik 1 collaboration

Jisun Kim 1 collaboration

Shanmugam Panneer Selvam 1 collaboration

Ryan De Palma 1 collaboration

Kristen A Johnson 1 collaboration

Rasesh Y Parikh 1 collaboration

Vamsi Gangaraju 1 collaboration

Yuri Peterson 1 collaboration

Mohammed Dany 1 collaboration

Robert V Stahelin 1 collaboration

Christina Voelkel-Johnson 1 collaboration

Zdzislaw M Szulc 1 collaboration

Besim Ogretmen 1 collaboration

Salim S El-Amouri 1 collaboration

Emily A Roush 1 collaboration

Kosuke Murakami 1 collaboration

Shih-Ching Lin 1 collaboration

Sasirekha Ramani 1 collaboration

Xi-Lei Zeng 1 collaboration

Kazuhiko Katayama 1 collaboration

David Y Graham 1 collaboration

Francesca E Mowry 1 collaboration

Francisco Espejo-Porras 1 collaboration

Shijie Jin 1 collaboration

Limin Wu 1 collaboration

Marcela Bertolio 1 collaboration

Rachel Jarvis 1 collaboration

Caroline Reynolds 1 collaboration

Rashed Alananzeh 1 collaboration

Yongjie Yang 1 collaboration

S El-Amouri 1 collaboration

A Karakashian 1 collaboration

E Bieberich 1 collaboration

M Nikolova-Karakashian 1 collaboration

Jianzhong Chen 1 collaboration

Andrew J Morris 1 collaboration

Marina Mané-Damas 1 collaboration

Erwin P M Wijnands 1 collaboration

Patrick G Sullivan 1 collaboration

Carmen Harper 1 collaboration

Lars Visseren 1 collaboration

Nienke de Wit 1 collaboration

Katrin A Becker 1 collaboration

Anne-Kathrin Uerschels 1 collaboration

Laura Goins 1 collaboration

Suzanne Doolen 1 collaboration

Kristen J McQuerry 1 collaboration

Jacek Bielawski 1 collaboration

Ulrich Sure 1 collaboration

Bradley K Taylor 1 collaboration

Erich Gulbins 1 collaboration

Briana N James 1 collaboration

Clement Oyeniran 1 collaboration

Jamie L Sturgill 1 collaboration

Jason Newton 1 collaboration

Rebecca K Martin 1 collaboration

Melissa A Maczis 1 collaboration

Joseph C Lownik 1 collaboration

John B Trudeau 1 collaboration

Joan M Cook-Mills 1 collaboration

Sally Wenzel 1 collaboration

Jian Pu 1 collaboration

Branislav Ferko 1 collaboration

Tytus Bernas 1 collaboration

Christopher D Green 1 collaboration

Sandeep K Singh 1 collaboration

Can E Senkal 1 collaboration

Andrea Martello 1 collaboration

John P Kennelly 1 collaboration

Peter Tontonoz 1 collaboration

David A Ford 1 collaboration

Emily R Eden 1 collaboration

Sanjib Karki 1 collaboration

Stefanka D Spassieva 1 collaboration

Ji-Na Kong 1 collaboration

Silvia Leanhart 1 collaboration

Rebecca Wang 1 collaboration

Yujie Zhao 1 collaboration

Alexander S Kirov 1 collaboration

Poonam Shukla 1 collaboration

Gerard Bode 1 collaboration

Barbara Hobo 1 collaboration

Christopher Exley 1 collaboration

Matthew Mold 1 collaboration

Michelle M Mielke 1 collaboration

Kristiaan Wouters 1 collaboration

Daniel L A van den Hove 1 collaboration

María Dolores Ledesma 1 collaboration

Joost Verhaagen 1 collaboration

Dominik Lewandowski 1 collaboration

Andrzej T Foik 1 collaboration

Roman Smidak 1 collaboration

Elliot H Choi 1 collaboration

Jianye Zhang 1 collaboration

Thanh Hoang 1 collaboration

Aleksander Tworak 1 collaboration

Susie Suh 1 collaboration

Henri Leinonen 1 collaboration

Zhiqian Dong 1 collaboration

Antonio Fm Pinto 1 collaboration

Emily Tom 1 collaboration

Jennings Luu 1 collaboration

Joan Lee 1 collaboration

Xiuli Ma 1 collaboration

Seth Blackshaw 1 collaboration

Alan Saghatelian 1 collaboration

David C Lyon 1 collaboration

Dorota Skowronska-Krawczyk 1 collaboration

Marcin Tabaka 1 collaboration

Krzysztof Palczewski 1 collaboration

Wilhelm Salmen 1 collaboration

B V Venkataram Prasad 1 collaboration