Elisabeth Mertsching

Affiliations

Immunology, Biogen, 225 Binney Street, Cambridge, MA 02142, USA.

Publications (4)

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model.

Bioorganic & medicinal chemistry letters

Avec: George H Vandeveer , Robert M Arduini , Darren P Baker , Kevin Barry , Tonika Bohnert , Jon K Bowden-Verhoek , Patrick Conlon , Patrick F Cullen , Bing Guan , Tracy J Jenkins , Shu-Yu Liao , Lin Lin , Yu-Ting Liu , Douglas Marcotte , Elisabeth Mertsching , Claire M Metrick , Ella Negrou , Noel Powell , Daniel Scott , Laura F Silvian , Brian T Hopkins

Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.

Cellular & molecular immunology

Avec: Ryan A Adams , Cátia Fernandes-Cerqueira , Antonella Notarnicola , Elisabeth Mertsching , Zhiwen Xu , Wing-Sze Lo , Kathleen Ogilvie , Kyle P Chiang , Jeanette Ampudia , Sanna Rosengren , Andrea Cubitt , David J King , John D Mendlein , Xiang-Lei Yang , Leslie A Nangle , Ingrid E Lundberg , Per-Johan Jakobsson , Paul Schimmel

Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.

Bioorganic & medicinal chemistry

Avec: Brian T Hopkins , Eris Bame , Noah Bell , Tonika Bohnert , Jon K Bowden-Verhoek , Minna Bui , Mark T Cancilla , Patrick Conlon , Patrick Cullen , Daniel A Erlanson , Junfa Fan , Tarra Fuchs-Knotts , Stig Hansen , Stacey Heumann , Tracy J Jenkins , Douglas Marcotte , Bob McDowell , Elisabeth Mertsching , Ella Negrou , Kevin L Otipoby , Urjana Poreci , Michael J Romanowski , Daniel Scott , Laura Silvian , Wenjin Yang , Min Zhong

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.

Bioorganic & medicinal chemistry

Avec: Brian T Hopkins , Eris Bame , Noah Bell , Tonika Bohnert , Jon K Bowden-Verhoek , Minna Bui , Mark T Cancilla , Patrick Conlon , Patrick Cullen , Daniel A Erlanson , Junfa Fan , Tarra Fuchs-Knotts , Stig Hansen , Stacey Heumann , Tracy J Jenkins , Chuck Gua , Ying Liu , YuTing Liu , Mukush Lulla , Douglas Marcotte , Isaac Marx , Bob McDowell , Elisabeth Mertsching , Ella Negrou , Michael J Romanowski , Daniel Scott , Laura Silvian , Wenjin Yang , Min Zhong

Réseau de co-auteurs

Tonika Bohnert 3 collaborations

Jon K Bowden-Verhoek 3 collaborations

Patrick Conlon 3 collaborations

Tracy J Jenkins 3 collaborations

Douglas Marcotte 3 collaborations

Ella Negrou 3 collaborations

Daniel Scott 3 collaborations

Brian T Hopkins 3 collaborations

Eris Bame 2 collaborations

Noah Bell 2 collaborations

Minna Bui 2 collaborations

Mark T Cancilla 2 collaborations

Patrick Cullen 2 collaborations

Daniel A Erlanson 2 collaborations

Junfa Fan 2 collaborations

Tarra Fuchs-Knotts 2 collaborations

Stig Hansen 2 collaborations

Stacey Heumann 2 collaborations

Bob McDowell 2 collaborations

Michael J Romanowski 2 collaborations

Laura Silvian 2 collaborations

Wenjin Yang 2 collaborations

Min Zhong 2 collaborations

George H Vandeveer 1 collaboration

Robert M Arduini 1 collaboration

Darren P Baker 1 collaboration

Kevin Barry 1 collaboration

Patrick F Cullen 1 collaboration

Bing Guan 1 collaboration

Shu-Yu Liao 1 collaboration

Lin Lin 1 collaboration

Yu-Ting Liu 1 collaboration

Claire M Metrick 1 collaboration

Noel Powell 1 collaboration

Laura F Silvian 1 collaboration

Ryan A Adams 1 collaboration

Cátia Fernandes-Cerqueira 1 collaboration

Antonella Notarnicola 1 collaboration

Zhiwen Xu 1 collaboration

Wing-Sze Lo 1 collaboration

Kathleen Ogilvie 1 collaboration

Kyle P Chiang 1 collaboration

Jeanette Ampudia 1 collaboration

Sanna Rosengren 1 collaboration

Andrea Cubitt 1 collaboration

David J King 1 collaboration

John D Mendlein 1 collaboration

Xiang-Lei Yang 1 collaboration

Leslie A Nangle 1 collaboration

Ingrid E Lundberg 1 collaboration

Per-Johan Jakobsson 1 collaboration

Paul Schimmel 1 collaboration

Kevin L Otipoby 1 collaboration

Urjana Poreci 1 collaboration

Chuck Gua 1 collaboration

Ying Liu 1 collaboration

YuTing Liu 1 collaboration

Mukush Lulla 1 collaboration

Isaac Marx 1 collaboration