Duncan Sproul

Affiliations

MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XR, UK.

ORCID: http://orcid.org/0000-0001-6168-4563

Publications (20)

Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.

Nature communications

Avec: Yanni Zeng , Carmen Amador , Charley Xia , Riccardo Marioni , Duncan Sproul , Rosie M Walker , Stewart W Morris , Andrew Bretherick , Oriol Canela-Xandri , Thibaud S Boutin , David W Clark , Archie Campbell , Konrad Rawlik , Caroline Hayward , Reka Nagy , Albert Tenesa , David J Porteous , James F Wilson , Ian J Deary , Kathryn L Evans , Andrew M McIntosh , Pau Navarro , Chris S Haley

Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.

Nature genetics

Avec: Patricia Heyn , Clare V Logan , Adeline Fluteau , Rachel C Challis , Tatsiana Auchynnikava , Carol-Anne Martin , Joseph A Marsh , Francesca Taglini , Fiona Kilanowski , David A Parry , Valerie Cormier-Daire , Chin-To Fong , Kate Gibson , Vivian Hwa , Lourdes Ibáñez , Stephen P Robertson , Giorgia Sebastiani , Juri Rappsilber , Robin C Allshire , Martin A M Reijns , Andrew Dauber , Duncan Sproul , Andrew P Jackson

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.

Cell

Avec: Ester Gangoso , Benjamin Southgate , Leanne Bradley , Stefanie Rus , Felipe Galvez-Cancino , Niamh McGivern , Esra Güç , Chantriolnt-Andreas Kapourani , Adam Byron , Kirsty M Ferguson , Neza Alfazema , Gillian Morrison , Vivien Grant , Carla Blin , IengFong Sou , Maria Angeles Marques-Torrejon , Lucia Conde , Simona Parrinello , Javier Herrero , Stephan Beck , Sebastian Brandner , Paul M Brennan , Paul Bertone , Jeffrey W Pollard , Sergio A Quezada , Duncan Sproul , Margaret C Frame , Alan Serrels , Steven M Pollard

Cluster mean-field theory accurately predicts statistical properties of large-scale DNA methylation patterns.

Journal of the Royal Society, Interface

Avec: Lyndsay Kerr , Duncan Sproul , Ramon Grima

Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair.

Nature communications

Avec: Kitty Sherwood , Joseph C Ward , Ignacio Soriano , Lynn Martin , Archie Campbell , Raheleh Rahbari , Ioannis Kafetzopoulos , Duncan Sproul , Andrew Green , Julian R Sampson , Alan Donaldson , Kai-Ren Ong , Karl Heinimann , Maartje Nielsen , Huw Thomas , Andrew Latchford , Claire Palles , Ian Tomlinson

cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing.

Nature genetics

Avec: Carolina Uggenti , Alice Lepelley , Marine Depp , Andrew P Badrock , Mathieu P Rodero , Marie-Thérèse El-Daher , Gillian I Rice , Somdutta Dhir , Ann P Wheeler , Ashish Dhir , Waad Albawardi , Marie-Louise Frémond , Luis Seabra , Jennifer Doig , Natalie Blair , Maria José Martin-Niclos , Erika Della Mina , Alejandro Rubio-Roldán , Jose L García-Pérez , Duncan Sproul , Jan Rehwinkel , Jonny Hertzog , Anne Boland-Auge , Robert Olaso , Jean-François Deleuze , Julien Baruteau , Karine Brochard , Jonathan Buckley , Vanessa Cavallera , Cristina Cereda , Liesbeth M H De Waele , Angus Dobbie , Diane Doummar , Frances Elmslie , Margarete Koch-Hogrebe , Ram Kumar , Kate Lamb , John H Livingston , Anirban Majumdar , Charles Marques Lorenço , Simona Orcesi , Sylviane Peudenier , Kevin Rostasy , Caroline A Salmon , Christiaan Scott , Davide Tonduti , Guy Touati , Marialuisa Valente , Hélio van der Linden , Hilde Van Esch , Marie Vermelle , Kate Webb , Andrew P Jackson , Martin A M Reijns , Nick Gilbert , Yanick J Crow

Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes.

Nucleic acids research

Avec: Ruchi Shukla , Heidi K Mjoseng , John P Thomson , Simon Kling , Duncan Sproul , Donncha S Dunican , Bernard Ramsahoye , Tuempong Wongtawan , Fridolin Treindl , Markus F Templin , Ian R Adams , Sari Pennings , Richard R Meehan

Risk Factors Associated with Quadriceps Tendon Extensor Mechanism Disruption Following Total Knee Arthroplasty.

The Journal of arthroplasty

Avec: Shu Lin , David Sproul , Amil Agarwal , Andrew B Harris , Gregory J Golladay , Savyasachi C Thakkar

Using human disease mutations to understand de novo DNA methyltransferase function.

Biochemical Society transactions

Avec: Willow Rolls , Marcus D Wilson , Duncan Sproul

Parent of origin genetic effects on methylation in humans are common and influence complex trait variation.

Nature communications

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin that reflect nucleosome organisation.

PLoS genetics

Avec: Lyndsay Kerr , Ioannis Kafetzopoulos , Ramon Grima , Duncan Sproul

Graft failure within 2 years of isolated anterior cruciate ligament reconstruction is associated with increased risk of secondary meniscus tears.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

Avec: David Sproul , Amil Agarwal , Alisa Malyavko , Abhay Mathur , R Timothy Kreulen , Savyasachi C Thakkar , Matthew J Best

Early, low-dose hydrocortisone and near-term brain connectivity in extremely preterm infants.

Pediatric research

Avec: Sarah E Dubner , Lucy Rickerich , Lisa Bruckert , Rocío Velasco Poblaciones , Dawson Sproul , Melissa Scala , Heidi M Feldman , Katherine E Travis

Local CpG density affects the trajectory and variance of age-associated DNA methylation changes.

Genome biology

Avec: Jonathan Higham , Lyndsay Kerr , Qian Zhang , Rosie M Walker , Sarah E Harris , David M Howard , Emma L Hawkins , Anca-Larisa Sandu , J Douglas Steele , Gordon D Waiter , Alison D Murray , Kathryn L Evans , Andrew M McIntosh , Peter M Visscher , Ian J Deary , Simon R Cox , Duncan Sproul

An epigenetic predictor of death captures multi-modal measures of brain health.

Molecular psychiatry

Avec: Robert F Hillary , Anna J Stevenson , Simon R Cox , Daniel L McCartney , Sarah E Harris , Anne Seeboth , Jon Higham , Duncan Sproul , Adele M Taylor , Paul Redmond , Janie Corley , Alison Pattie , Maria Del C Valdés Hernández , Susana Muñoz-Maniega , Mark E Bastin , Joanna M Wardlaw , Steve Horvath , Craig W Ritchie , Tara L Spires-Jones , Andrew M McIntosh , Kathryn L Evans , Ian J Deary , Riccardo E Marioni

De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.

Nature communications

Avec: Roza H Ali Masalmeh , Francesca Taglini , Cristina Rubio-Ramon , Kamila I Musialik , Jonathan Higham , Hazel Davidson-Smith , Ioannis Kafetzopoulos , Kamila P Pawlicka , Hannah M Finan , Richard Clark , Jimi Wills , Andrew J Finch , Lee Murphy , Duncan Sproul

Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation.

Nature communications

Avec: Hemalvi Patani , Michael D Rushton , Jonathan Higham , Saul A Teijeiro , David Oxley , Pedro Cutillas , Duncan Sproul , Gabriella Ficz

Age-related clonal haemopoiesis is associated with increased epigenetic age.

Current biology : CB

Avec: Neil A Robertson , Robert F Hillary , Daniel L McCartney , Maria Terradas-Terradas , Jonathan Higham , Duncan Sproul , Ian J Deary , Kristina Kirschner , Riccardo E Marioni , Tamir Chandra

In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.

Cancer research

Avec: Nicholas T Younger , Mollie L Wilson , Anabel Martinez Lyons , Edward J Jarman , Alison M Meynert , Graeme R Grimes , Konstantinos Gournopanos , Scott H Waddell , Peter A Tennant , David H Wilson , Rachel V Guest , Stephen J Wigmore , Juan Carlos Acosta , Timothy J Kendall , Martin S Taylor , Duncan Sproul , Pleasantine Mill , Luke Boulter

DNMT3B PWWP mutations cause hypermethylation of heterochromatin.

EMBO reports

Avec: Francesca Taglini , Ioannis Kafetzopoulos , Willow Rolls , Kamila Irena Musialik , Heng Yang Lee , Yujie Zhang , Mattia Marenda , Lyndsay Kerr , Hannah Finan , Cristina Rubio-Ramon , Philippe Gautier , Hannah Wapenaar , Dhananjay Kumar , Hazel Davidson-Smith , Jimi Wills , Laura C Murphy , Ann Wheeler , Marcus D Wilson , Duncan Sproul

Réseau de co-auteurs

Ian J Deary 5 collaborations

Kathryn L Evans 4 collaborations

Andrew M McIntosh 4 collaborations

Lyndsay Kerr 4 collaborations

Ioannis Kafetzopoulos 4 collaborations

Jonathan Higham 4 collaborations

Rosie M Walker 3 collaborations

Archie Campbell 3 collaborations

Francesca Taglini 3 collaborations

Yanni Zeng 2 collaborations

Carmen Amador 2 collaborations

Charley Xia 2 collaborations

Riccardo Marioni 2 collaborations

Stewart W Morris 2 collaborations

Andrew Bretherick 2 collaborations

Oriol Canela-Xandri 2 collaborations

Thibaud S Boutin 2 collaborations

David W Clark 2 collaborations

Konrad Rawlik 2 collaborations

Caroline Hayward 2 collaborations

Reka Nagy 2 collaborations

Albert Tenesa 2 collaborations

David J Porteous 2 collaborations

James F Wilson 2 collaborations

Pau Navarro 2 collaborations

Chris S Haley 2 collaborations

Martin A M Reijns 2 collaborations

Andrew P Jackson 2 collaborations

Ramon Grima 2 collaborations

David Sproul 2 collaborations

Amil Agarwal 2 collaborations

Savyasachi C Thakkar 2 collaborations

Willow Rolls 2 collaborations

Marcus D Wilson 2 collaborations

Sarah E Harris 2 collaborations

Simon R Cox 2 collaborations

Robert F Hillary 2 collaborations

Daniel L McCartney 2 collaborations

Riccardo E Marioni 2 collaborations

Cristina Rubio-Ramon 2 collaborations

Hazel Davidson-Smith 2 collaborations

Jimi Wills 2 collaborations

Patricia Heyn 1 collaboration

Clare V Logan 1 collaboration

Adeline Fluteau 1 collaboration

Rachel C Challis 1 collaboration

Tatsiana Auchynnikava 1 collaboration

Carol-Anne Martin 1 collaboration

Joseph A Marsh 1 collaboration

Fiona Kilanowski 1 collaboration

David A Parry 1 collaboration

Valerie Cormier-Daire 1 collaboration

Chin-To Fong 1 collaboration

Kate Gibson 1 collaboration

Vivian Hwa 1 collaboration

Lourdes Ibáñez 1 collaboration

Stephen P Robertson 1 collaboration

Giorgia Sebastiani 1 collaboration

Juri Rappsilber 1 collaboration

Robin C Allshire 1 collaboration

Andrew Dauber 1 collaboration

Ester Gangoso 1 collaboration

Benjamin Southgate 1 collaboration

Leanne Bradley 1 collaboration

Stefanie Rus 1 collaboration

Felipe Galvez-Cancino 1 collaboration

Niamh McGivern 1 collaboration

Esra Güç 1 collaboration

Chantriolnt-Andreas Kapourani 1 collaboration

Adam Byron 1 collaboration

Kirsty M Ferguson 1 collaboration

Neza Alfazema 1 collaboration

Gillian Morrison 1 collaboration

Vivien Grant 1 collaboration

Carla Blin 1 collaboration

IengFong Sou 1 collaboration

Maria Angeles Marques-Torrejon 1 collaboration

Lucia Conde 1 collaboration

Simona Parrinello 1 collaboration

Javier Herrero 1 collaboration

Stephan Beck 1 collaboration

Sebastian Brandner 1 collaboration

Paul M Brennan 1 collaboration

Paul Bertone 1 collaboration

Jeffrey W Pollard 1 collaboration

Sergio A Quezada 1 collaboration

Margaret C Frame 1 collaboration

Alan Serrels 1 collaboration

Steven M Pollard 1 collaboration

Kitty Sherwood 1 collaboration

Joseph C Ward 1 collaboration

Ignacio Soriano 1 collaboration

Lynn Martin 1 collaboration

Raheleh Rahbari 1 collaboration

Andrew Green 1 collaboration

Julian R Sampson 1 collaboration

Alan Donaldson 1 collaboration

Kai-Ren Ong 1 collaboration

Karl Heinimann 1 collaboration

Maartje Nielsen 1 collaboration

Huw Thomas 1 collaboration

Andrew Latchford 1 collaboration

Claire Palles 1 collaboration

Ian Tomlinson 1 collaboration

Carolina Uggenti 1 collaboration

Alice Lepelley 1 collaboration

Marine Depp 1 collaboration

Andrew P Badrock 1 collaboration

Mathieu P Rodero 1 collaboration

Marie-Thérèse El-Daher 1 collaboration

Gillian I Rice 1 collaboration

Somdutta Dhir 1 collaboration

Ann P Wheeler 1 collaboration

Ashish Dhir 1 collaboration

Waad Albawardi 1 collaboration

Marie-Louise Frémond 1 collaboration

Luis Seabra 1 collaboration

Jennifer Doig 1 collaboration

Natalie Blair 1 collaboration

Maria José Martin-Niclos 1 collaboration

Erika Della Mina 1 collaboration

Alejandro Rubio-Roldán 1 collaboration

Jose L García-Pérez 1 collaboration

Jan Rehwinkel 1 collaboration

Jonny Hertzog 1 collaboration

Anne Boland-Auge 1 collaboration

Robert Olaso 1 collaboration

Jean-François Deleuze 1 collaboration

Julien Baruteau 1 collaboration

Karine Brochard 1 collaboration

Jonathan Buckley 1 collaboration

Vanessa Cavallera 1 collaboration

Cristina Cereda 1 collaboration

Liesbeth M H De Waele 1 collaboration

Angus Dobbie 1 collaboration

Diane Doummar 1 collaboration

Frances Elmslie 1 collaboration

Margarete Koch-Hogrebe 1 collaboration

Ram Kumar 1 collaboration

Kate Lamb 1 collaboration

John H Livingston 1 collaboration

Anirban Majumdar 1 collaboration

Charles Marques Lorenço 1 collaboration

Simona Orcesi 1 collaboration

Sylviane Peudenier 1 collaboration

Kevin Rostasy 1 collaboration

Caroline A Salmon 1 collaboration

Christiaan Scott 1 collaboration

Davide Tonduti 1 collaboration

Guy Touati 1 collaboration

Marialuisa Valente 1 collaboration

Hélio van der Linden 1 collaboration

Hilde Van Esch 1 collaboration

Marie Vermelle 1 collaboration

Kate Webb 1 collaboration

Nick Gilbert 1 collaboration

Yanick J Crow 1 collaboration

Ruchi Shukla 1 collaboration

Heidi K Mjoseng 1 collaboration

John P Thomson 1 collaboration

Simon Kling 1 collaboration

Donncha S Dunican 1 collaboration

Bernard Ramsahoye 1 collaboration

Tuempong Wongtawan 1 collaboration

Fridolin Treindl 1 collaboration

Markus F Templin 1 collaboration

Ian R Adams 1 collaboration

Sari Pennings 1 collaboration

Richard R Meehan 1 collaboration

Shu Lin 1 collaboration

Andrew B Harris 1 collaboration

Gregory J Golladay 1 collaboration

Alisa Malyavko 1 collaboration

Abhay Mathur 1 collaboration

R Timothy Kreulen 1 collaboration

Matthew J Best 1 collaboration

Sarah E Dubner 1 collaboration

Lucy Rickerich 1 collaboration

Lisa Bruckert 1 collaboration

Rocío Velasco Poblaciones 1 collaboration

Dawson Sproul 1 collaboration

Melissa Scala 1 collaboration

Heidi M Feldman 1 collaboration

Katherine E Travis 1 collaboration

Qian Zhang 1 collaboration

David M Howard 1 collaboration

Emma L Hawkins 1 collaboration

Anca-Larisa Sandu 1 collaboration

J Douglas Steele 1 collaboration

Gordon D Waiter 1 collaboration

Alison D Murray 1 collaboration

Peter M Visscher 1 collaboration

Anna J Stevenson 1 collaboration

Anne Seeboth 1 collaboration

Jon Higham 1 collaboration

Adele M Taylor 1 collaboration

Paul Redmond 1 collaboration

Janie Corley 1 collaboration

Alison Pattie 1 collaboration

Maria Del C Valdés Hernández 1 collaboration

Susana Muñoz-Maniega 1 collaboration

Mark E Bastin 1 collaboration

Joanna M Wardlaw 1 collaboration

Steve Horvath 1 collaboration

Craig W Ritchie 1 collaboration

Tara L Spires-Jones 1 collaboration

Roza H Ali Masalmeh 1 collaboration

Kamila I Musialik 1 collaboration

Kamila P Pawlicka 1 collaboration

Hannah M Finan 1 collaboration

Richard Clark 1 collaboration

Andrew J Finch 1 collaboration

Lee Murphy 1 collaboration

Hemalvi Patani 1 collaboration

Michael D Rushton 1 collaboration

Saul A Teijeiro 1 collaboration

David Oxley 1 collaboration

Pedro Cutillas 1 collaboration

Gabriella Ficz 1 collaboration

Neil A Robertson 1 collaboration

Maria Terradas-Terradas 1 collaboration

Kristina Kirschner 1 collaboration

Tamir Chandra 1 collaboration

Nicholas T Younger 1 collaboration

Mollie L Wilson 1 collaboration

Anabel Martinez Lyons 1 collaboration

Edward J Jarman 1 collaboration

Alison M Meynert 1 collaboration

Graeme R Grimes 1 collaboration

Konstantinos Gournopanos 1 collaboration

Scott H Waddell 1 collaboration

Peter A Tennant 1 collaboration

David H Wilson 1 collaboration

Rachel V Guest 1 collaboration

Stephen J Wigmore 1 collaboration

Juan Carlos Acosta 1 collaboration

Timothy J Kendall 1 collaboration

Martin S Taylor 1 collaboration

Pleasantine Mill 1 collaboration

Luke Boulter 1 collaboration

Kamila Irena Musialik 1 collaboration

Heng Yang Lee 1 collaboration

Yujie Zhang 1 collaboration

Mattia Marenda 1 collaboration

Hannah Finan 1 collaboration

Philippe Gautier 1 collaboration

Hannah Wapenaar 1 collaboration

Dhananjay Kumar 1 collaboration

Laura C Murphy 1 collaboration

Ann Wheeler 1 collaboration