Douglas P Millay

Affiliations

Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Publications (31)

Myocyte-derived Myomaker expression is required for regenerative fusion but exacerbates membrane instability in dystrophic myofibers.

JCI insight

Avec: Michael J Petrany , Taejeong Song , Sakthivel Sadayappan , Douglas P Millay

Molecular regulation of myocyte fusion.

Current topics in developmental biology

Avec: Tanner J Wherley , Serena Thomas , Douglas P Millay , Timothy Saunders , Sudipto Roy

Proteasome inhibition preserves longitudinal growth of denervated muscle and prevents neonatal neuromuscular contractures.

JCI insight

Avec: Sia Nikolaou , Alyssa Aw Cramer , Liangjun Hu , Qingnian Goh , Douglas P Millay , Roger Cornwall

FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma.

Oncogene

Avec: David Milewski , Samriddhi Shukla , Berkley E Gryder , Arun Pradhan , Johnny Donovan , Parvathi Sudha , Sushmitha Vallabh , Athena Pyros , Yan Xu , Artem Barski , Sara Szabo , Brian Turpin , Joseph G Pressey , Douglas P Millay , Javed Khan , Vladimir V Kalinichenko , Tanya V Kalin

Regulation of the myoblast fusion reaction for muscle development, regeneration, and adaptations.

Experimental cell research

Avec: Douglas P Millay

Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery.

bioRxiv : the preprint server for biology

Avec: Sajedah M Hindi , Michael J Petrany , Elena Greenfeld , Leah C Focke , Alyssa A W Cramer , Michael A Whitt , Vikram Prasad , Jeffrey S Chamberlain , Benjamin Podbilewicz , Douglas P Millay

Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery.

Cell

Avec: Sajedah M Hindi , Michael J Petrany , Elena Greenfeld , Leah C Focke , Alyssa A W Cramer , Michael A Whitt , Ramzi J Khairallah , Christopher W Ward , Jeffrey S Chamberlain , Benjamin Podbilewicz , Vikram Prasad , Douglas P Millay

MEK1-ERK1/2 Signaling Regulates the Cardiomyocyte Non-sarcomeric Actin Cytoskeletal Network.

American journal of physiology. Heart and circulatory physiology

Avec: Kelly M Grimes , Marjorie Maillet , Casey O Swoboda , Stephanie L K Bowers , Doug P Millay , Jeffery D Molkentin

Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains.

Nature communications

Avec: Alyssa A W Cramer , Vikram Prasad , Einar Eftestøl , Taejeong Song , Kenth-Arne Hansson , Hannah F Dugdale , Sakthivel Sadayappan , Julien Ochala , Kristian Gundersen , Douglas P Millay

Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers.

Nature communications

Avec: Michael J Petrany , Casey O Swoboda , Chengyi Sun , Kashish Chetal , Xiaoting Chen , Matthew T Weirauch , Nathan Salomonis , Douglas P Millay

Cell Fusion: Merging Membranes and Making Muscle.

Trends in cell biology

Avec: Michael J Petrany , Douglas P Millay

DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies.

Human molecular genetics

Avec: Andrea L Reid , Yimin Wang , Adrienne Samani , Rylie M Hightower , Michael A Lopez , Shawn R Gilbert , Lara Ianov , David K Crossman , Louis J Dell'Italia , Douglas P Millay , Thomas van Groen , Ganesh V Halade , Matthew S Alexander

Comparing the epigenetic landscape in myonuclei purified with a PCM1 antibody from a fast/glycolytic and a slow/oxidative muscle.

PLoS genetics

Avec: Mads Bengtsen , Ivan Myhre Winje , Einar Eftestøl , Johannes Landskron , Chengyi Sun , Kamilla Nygård , Diana Domanska , Douglas P Millay , Leonardo A Meza-Zepeda , Kristian Gundersen

ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.

Developmental cell

Avec: Tamar Eigler , Giulia Zarfati , Emmanuel Amzallag , Sansrity Sinha , Nadav Segev , Yishaia Zabary , Assaf Zaritsky , Avraham Shakked , Kfir-Baruch Umansky , Eyal D Schejter , Douglas P Millay , Eldad Tzahor , Ori Avinoam

Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Dilani G Gamage , Kamran Melikov , Paola Munoz-Tello , Tanner J Wherley , Leah C Focke , Evgenia Leikina , Elliana Huffman , Jiajie Diao , Douglas J Kojetin , Vikram Prasad , Leonid V Chernomordik , Douglas P Millay

All for One and One for All: Regenerating Skeletal Muscle.

Cold Spring Harbor perspectives in biology

Avec: Sajedah M Hindi , Douglas P Millay

Lipid Mixing Assay for Murine Myoblast Fusion and Other Slow Cell-cell Fusion Processes.

Bio-protocol

Avec: Evgenia Leikina , Kamran Melikov , Anthony G Rabinovich , Douglas P Millay , Leonid V Chernomordik

Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation.

bioRxiv : the preprint server for biology

Avec: Ashok Daniel Prabakaran , Kevin McFarland , Karen Miz , Hima Bindu Durumutla , Kevin Piczer , Fadoua El Abdellaoui Soussi , Hannah Latimer , Cole Werbrich , N Scott Blair , Douglas P Millay , Brendan Prideaux , Brian N Finck , Mattia Quattrocelli

Localized Prox1 Regulates Aortic Valve Endothelial Cell Diversity and Extracellular Matrix Stratification in Mice.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Anna O'Donnell , Brittany A Gonzalez , Shreyasi Mukherjee , Ruby Wilson , Christina M Alfieri , Casey O Swoboda , Douglas P Millay , Aaron M Zorn , Katherine E Yutzey

Lineage tracing of newly accrued nuclei in skeletal myofibers uncovers distinct transcripts and interplay between nuclear populations.

bioRxiv : the preprint server for biology

Avec: Chengyi Sun , Casey O Swoboda , Michael J Petrany , Sreeja Parameswaran , Andrew VonHandorf , Matthew T Weirauch , Christoph Lepper , Douglas P Millay

C16ORF70/Mytho promotes healthy ageing in C. elegans and prevents cellular senescence in mammals.

The Journal of clinical investigation

Avec: Anais Franco-Romero , Valeria Morbidoni , Giulia Milan , Roberta Sartori , Jesper Wulff , Vanina Romanello , Andrea Armani , Leonardo Salviati , Maria Conte , Stefano Salvioli , Claudio Franceschi , Viviana Buonomo , Casey O Swoboda , Paolo Grumati , Luca Pannone , Simone Martinelli , Harold Bj Jefferies , Ivan Dikic , Jennifer van der Laan , Filipe Cabreiro , Douglas P Millay , Sharon A Tooze , Eva Trevisson , Marco Sandri

Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations.

Nature communications

Avec: Chengyi Sun , Casey O Swoboda , Fabian Montecino Morales , Cristofer Calvo , Michael J Petrany , Sreeja Parameswaran , Andrew VonHandorf , Matthew T Weirauch , Christoph Lepper , Douglas P Millay

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation.

Skeletal muscle

Avec: Taejeong Song , Palanikumar Manoharan , Douglas P Millay , Sheryl E Koch , Jack Rubinstein , Judith A Heiny , Sakthivel Sadayappan

Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle.

eLife

Avec: Qingnian Goh , Taejeong Song , Michael J Petrany , Alyssa Aw Cramer , Chengyi Sun , Sakthivel Sadayappan , Se-Jin Lee , Douglas P Millay

Fibroblast fusion to the muscle fiber regulates myotendinous junction formation.

Nature communications

Avec: Wesal Yaseen , Ortal Kraft-Sheleg , Shelly Zaffryar-Eilot , Shay Melamed , Chengyi Sun , Douglas P Millay , Peleg Hasson

Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm.

Nature communications

Avec: Gonen Golani , Evgenia Leikina , Kamran Melikov , Jarred M Whitlock , Dilani G Gamage , Gracia Luoma-Overstreet , Douglas P Millay , Michael M Kozlov , Leonid V Chernomordik

Myonuclear content regulates cell size with similar scaling properties in mice and humans.

Nature communications

Avec: Kenth-Arne Hansson , Einar Eftestøl , Jo C Bruusgaard , Inga Juvkam , Alyssa W Cramer , Anders Malthe-Sørenssen , Douglas P Millay , Kristian Gundersen

Skeletal muscle fibers count on nuclear numbers for growth.

Seminars in cell & developmental biology

Avec: Vikram Prasad , Douglas P Millay

TGFβ signaling curbs cell fusion and muscle regeneration.

Nature communications

Avec: Francesco Girardi , Anissa Taleb , Majid Ebrahimi , Asiman Datye , Dilani G Gamage , Cécile Peccate , Lorenzo Giordani , Douglas P Millay , Penney M Gilbert , Bruno Cadot , Fabien Le Grand

Expression of Myomaker and Myomerger in myofibers causes muscle pathology.

Skeletal muscle

Avec: Phillip C Witcher , Chengyi Sun , Douglas P Millay

Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model.

The Journal of clinical investigation

Avec: Ashok Daniel Prabakaran , Kevin McFarland , Karen Miz , Hima Bindu Durumutla , Kevin Piczer , Fadoua El Abdellaoui-Soussi , Hannah Latimer , Cole Werbrich , Hyun-Jy Chung , N Scott Blair , Douglas P Millay , Andrew J Morris , Brendan Prideaux , Brian N Finck , Mattia Quattrocelli

Réseau de co-auteurs

Michael J Petrany 8 collaborations

Chengyi Sun 7 collaborations

Casey O Swoboda 6 collaborations

Vikram Prasad 5 collaborations

Taejeong Song 4 collaborations

Sakthivel Sadayappan 4 collaborations

Sajedah M Hindi 3 collaborations

Leah C Focke 3 collaborations

Alyssa A W Cramer 3 collaborations

Einar Eftestøl 3 collaborations

Kristian Gundersen 3 collaborations

Matthew T Weirauch 3 collaborations

Dilani G Gamage 3 collaborations

Kamran Melikov 3 collaborations

Evgenia Leikina 3 collaborations

Leonid V Chernomordik 3 collaborations

Tanner J Wherley 2 collaborations

Alyssa Aw Cramer 2 collaborations

Qingnian Goh 2 collaborations

Elena Greenfeld 2 collaborations

Michael A Whitt 2 collaborations

Jeffrey S Chamberlain 2 collaborations

Benjamin Podbilewicz 2 collaborations

Kenth-Arne Hansson 2 collaborations

Ashok Daniel Prabakaran 2 collaborations

Kevin McFarland 2 collaborations

Karen Miz 2 collaborations

Hima Bindu Durumutla 2 collaborations

Kevin Piczer 2 collaborations

Hannah Latimer 2 collaborations

Cole Werbrich 2 collaborations

N Scott Blair 2 collaborations

Brendan Prideaux 2 collaborations

Brian N Finck 2 collaborations

Mattia Quattrocelli 2 collaborations

Sreeja Parameswaran 2 collaborations

Andrew VonHandorf 2 collaborations

Christoph Lepper 2 collaborations

Serena Thomas 1 collaboration

Timothy Saunders 1 collaboration

Sudipto Roy 1 collaboration

Sia Nikolaou 1 collaboration

Liangjun Hu 1 collaboration

Roger Cornwall 1 collaboration

David Milewski 1 collaboration

Samriddhi Shukla 1 collaboration

Berkley E Gryder 1 collaboration

Arun Pradhan 1 collaboration

Johnny Donovan 1 collaboration

Parvathi Sudha 1 collaboration

Sushmitha Vallabh 1 collaboration

Athena Pyros 1 collaboration

Yan Xu 1 collaboration

Artem Barski 1 collaboration

Sara Szabo 1 collaboration

Brian Turpin 1 collaboration

Joseph G Pressey 1 collaboration

Javed Khan 1 collaboration

Vladimir V Kalinichenko 1 collaboration

Tanya V Kalin 1 collaboration

Ramzi J Khairallah 1 collaboration

Christopher W Ward 1 collaboration

Kelly M Grimes 1 collaboration

Marjorie Maillet 1 collaboration

Stephanie L K Bowers 1 collaboration

Doug P Millay 1 collaboration

Jeffery D Molkentin 1 collaboration

Hannah F Dugdale 1 collaboration

Julien Ochala 1 collaboration

Kashish Chetal 1 collaboration

Xiaoting Chen 1 collaboration

Nathan Salomonis 1 collaboration

Andrea L Reid 1 collaboration

Yimin Wang 1 collaboration

Adrienne Samani 1 collaboration

Rylie M Hightower 1 collaboration

Michael A Lopez 1 collaboration

Shawn R Gilbert 1 collaboration

Lara Ianov 1 collaboration

David K Crossman 1 collaboration

Louis J Dell'Italia 1 collaboration

Thomas van Groen 1 collaboration

Ganesh V Halade 1 collaboration

Matthew S Alexander 1 collaboration

Mads Bengtsen 1 collaboration

Ivan Myhre Winje 1 collaboration

Johannes Landskron 1 collaboration

Kamilla Nygård 1 collaboration

Diana Domanska 1 collaboration

Leonardo A Meza-Zepeda 1 collaboration

Tamar Eigler 1 collaboration

Giulia Zarfati 1 collaboration

Emmanuel Amzallag 1 collaboration

Sansrity Sinha 1 collaboration

Nadav Segev 1 collaboration

Yishaia Zabary 1 collaboration

Assaf Zaritsky 1 collaboration

Avraham Shakked 1 collaboration

Kfir-Baruch Umansky 1 collaboration

Eyal D Schejter 1 collaboration

Eldad Tzahor 1 collaboration

Ori Avinoam 1 collaboration

Paola Munoz-Tello 1 collaboration

Elliana Huffman 1 collaboration

Jiajie Diao 1 collaboration

Douglas J Kojetin 1 collaboration

Anthony G Rabinovich 1 collaboration

Fadoua El Abdellaoui Soussi 1 collaboration

Anna O'Donnell 1 collaboration

Brittany A Gonzalez 1 collaboration

Shreyasi Mukherjee 1 collaboration

Ruby Wilson 1 collaboration

Christina M Alfieri 1 collaboration

Aaron M Zorn 1 collaboration

Katherine E Yutzey 1 collaboration

Anais Franco-Romero 1 collaboration

Valeria Morbidoni 1 collaboration

Giulia Milan 1 collaboration

Roberta Sartori 1 collaboration

Jesper Wulff 1 collaboration

Vanina Romanello 1 collaboration

Andrea Armani 1 collaboration

Leonardo Salviati 1 collaboration

Maria Conte 1 collaboration

Stefano Salvioli 1 collaboration

Claudio Franceschi 1 collaboration

Viviana Buonomo 1 collaboration

Paolo Grumati 1 collaboration

Luca Pannone 1 collaboration

Simone Martinelli 1 collaboration

Harold Bj Jefferies 1 collaboration

Ivan Dikic 1 collaboration

Jennifer van der Laan 1 collaboration

Filipe Cabreiro 1 collaboration

Sharon A Tooze 1 collaboration

Eva Trevisson 1 collaboration

Marco Sandri 1 collaboration

Fabian Montecino Morales 1 collaboration

Cristofer Calvo 1 collaboration

Palanikumar Manoharan 1 collaboration

Sheryl E Koch 1 collaboration

Jack Rubinstein 1 collaboration

Judith A Heiny 1 collaboration

Se-Jin Lee 1 collaboration

Wesal Yaseen 1 collaboration

Ortal Kraft-Sheleg 1 collaboration

Shelly Zaffryar-Eilot 1 collaboration

Shay Melamed 1 collaboration

Peleg Hasson 1 collaboration

Gonen Golani 1 collaboration

Jarred M Whitlock 1 collaboration

Gracia Luoma-Overstreet 1 collaboration

Michael M Kozlov 1 collaboration

Jo C Bruusgaard 1 collaboration

Inga Juvkam 1 collaboration

Alyssa W Cramer 1 collaboration

Anders Malthe-Sørenssen 1 collaboration

Francesco Girardi 1 collaboration

Anissa Taleb 1 collaboration

Majid Ebrahimi 1 collaboration

Asiman Datye 1 collaboration

Cécile Peccate 1 collaboration

Lorenzo Giordani 1 collaboration

Penney M Gilbert 1 collaboration

Bruno Cadot 1 collaboration

Fabien Le Grand 1 collaboration

Phillip C Witcher 1 collaboration

Fadoua El Abdellaoui-Soussi 1 collaboration

Hyun-Jy Chung 1 collaboration

Andrew J Morris 1 collaboration