David Pacheu-Grau

Affiliations

Departamento de Bioquímica, Biología Molecular y Celular, Universidad de Zaragoza. C/ Miguel Servet, 177, 50013 Zaragoza, Spain.
Instituto de Investigación Sanitaria (IIS) de Aragón, Av. San Juan Bosco, 13, 50009 Zaragoza, Spain.
Centro de Investigaciones Biomédicas en Red de Enfermedades Raras (CIBERER), Av. Monforte de Lemos, 3-5, 28029 Madrid, Spain.

ORCID: 0000-0003-2645-3983

Publications (18)

Molecular Insights into Mitochondrial Protein Translocation and Human Disease.

Genes

Avec: Eduardo Ruiz-Pesini , Julio Montoya , David Pacheu-Grau

Monitoring mitochondrial translation in living cells.

EMBO reports

Avec: Roya Yousefi , Eugenio F Fornasiero , Lukas Cyganek , Julio Montoya , Stefan Jakobs , Silvio O Rizzoli , Peter Rehling , David Pacheu-Grau

Toxic and nutritional factors trigger Leber hereditary optic neuropathy due to a mitochondrial tRNA mutation.

Clinical genetics

Avec: Ana Vela-Sebastián , Ester López-Gallardo , Sonia Emperador , Carmen Hernández-Ainsa , David Pacheu-Grau , Ignacio Blanco , Andrea Ros , Ester Pascual-Benito , Neus Rabaneda-Lombarte , Silvia Presas-Rodríguez , Pilar García-Robles , Julio Montoya , Eduardo Ruiz-Pesini

Identification and characterization of a new pathologic mutation in a large Leber hereditary optic neuropathy pedigree.

Orphanet journal of rare diseases

Avec: Sonia Emperador , Mouna Habbane , Ester López-Gallardo , Alejandro Del Rio , Laura Llobet , Javier Mateo , Ana María Sanz-López , María José Fernández-García , Hortensia Sánchez-Tocino , Sol Benbunan-Ferreiro , María Calabuig-Goena , Carlos Narvaez-Palazón , Beatriz Fernández-Vega , Hector González-Iglesias , Roser Urreizti , Rafael Artuch , David Pacheu-Grau , Pilar Bayona-Bafaluy , Julio Montoya , Eduardo Ruiz-Pesini

Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.

Current biology : CB

Avec: Ridhima Gomkale , Luis Daniel Cruz-Zaragoza , Ida Suppanz , Bernard Guiard , Julio Montoya , Sylvie Callegari , David Pacheu-Grau , Bettina Warscheid , Peter Rehling

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria.

Journal of molecular biology

Avec: David Pacheu-Grau , Michał Wasilewski , Silke Oeljeklaus , Christine Silvia Gibhardt , Abhishek Aich , Margarita Chudenkova , Sven Dennerlein , Markus Deckers , Ivan Bogeski , Bettina Warscheid , Agnieszka Chacinska , Peter Rehling

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes.

Circulation research

Avec: Jonas Peper , Daniel Kownatzki-Danger , Gunnar Weninger , Fitzwilliam Seibertz , Julius Ryan D Pronto , Henry Sutanto , David Pacheu-Grau , Robin Hindmarsh , Sören Brandenburg , Tobias Kohl , Gerd Hasenfuss , Michael Gotthardt , Eva A Rog-Zielinska , Bernd Wollnik , Peter Rehling , Henning Urlaub , Jörg Wegener , Jordi Heijman , Niels Voigt , Lukas Cyganek , Christof Lenz , Stephan E Lehnart

Is population frequency a useful criterion to assign pathogenicity to newly described mitochondrial DNA variants?

Orphanet journal of rare diseases

Avec: M Pilar Bayona-Bafaluy , Ester López-Gallardo , Sonia Emperador , David Pacheu-Grau , Julio Montoya , Eduardo Ruiz-Pesini

Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents.

Cancers

Avec: Ileana Hernández-Reséndiz , David Pacheu-Grau , Araceli Sánchez , Luis A Pardo

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.

eLife

Avec: King Faisal Yambire , Christine Rostosky , Takashi Watanabe , David Pacheu-Grau , Sylvia Torres-Odio , Angela Sanchez-Guerrero , Ola Senderovich , Esther G Meyron-Holtz , Ira Milosevic , Jens Frahm , A Phillip West , Nuno Raimundo

Redox signals at the ER-mitochondria interface control melanoma progression.

The EMBO journal

Avec: Xin Zhang , Christine S Gibhardt , Thorsten Will , Hedwig Stanisz , Christina Körbel , Miso Mitkovski , Ioana Stejerean , Sabrina Cappello , David Pacheu-Grau , Jan Dudek , Nasser Tahbaz , Lucas Mina , Thomas Simmen , Matthias W Laschke , Michael D Menger , Michael P Schön , Volkhard Helms , Barbara A Niemeyer , Peter Rehling , Adina Vultur , Ivan Bogeski

Influence of Subcellular Localization and Functional State on Protein Turnover.

Cells

Avec: Roya Yousefi , Kristina Jevdokimenko , Verena Kluever , David Pacheu-Grau , Eugenio F Fornasiero

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex.

EMBO reports

Avec: Cong Wang , Ricarda Richter-Dennerlein , David Pacheu-Grau , Fan Liu , Ying Zhu , Sven Dennerlein , Peter Rehling

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation.

The EMBO journal

Avec: Till Stephan , Christian Brüser , Markus Deckers , Anna M Steyer , Francisco Balzarotti , Mariam Barbot , Tiana S Behr , Gudrun Heim , Wolfgang Hübner , Peter Ilgen , Felix Lange , David Pacheu-Grau , Jasmin K Pape , Stefan Stoldt , Thomas Huser , Stefan W Hell , Wiebke Möbius , Peter Rehling , Dietmar Riedel , Stefan Jakobs

Genetic aspects of the oxidative phosphorylation dysfunction in dilated cardiomyopathy.

Mutation research. Reviews in mutation research

Avec: M Pilar Bayona-Bafaluy , Eldris Iglesias , Ester López-Gallardo , Sonia Emperador , David Pacheu-Grau , Lorenzo Labarta , Julio Montoya , Eduardo Ruiz-Pesini

Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy.

Orphanet journal of rare diseases

Avec: Marie-Christine Reinert , David Pacheu-Grau , Claudia B Catarino , Thomas Klopstock , Andreas Ohlenbusch , Michael Schittkowski , Ekkehard Wilichowski , Peter Rehling , Knut Brockmann

Mitochondrial Genetic Background May Impact Statins Side Effects and Atherosclerosis Development in Familial Hypercholesterolemia.

International journal of molecular sciences

Avec: Eduardo Ruiz-Pesini , María Pilar Bayona-Bafaluy , Teresa Sanclemente , José Puzo , Julio Montoya , David Pacheu-Grau

ISR pathway contribution to tissue specificity of mitochondrial diseases.

Trends in endocrinology and metabolism: TEM

Avec: Ana Vela-Sebastián , Pilar Bayona-Bafaluy , David Pacheu-Grau

Réseau de co-auteurs

Julio Montoya 8 collaborations

Peter Rehling 8 collaborations

Eduardo Ruiz-Pesini 6 collaborations

Ester López-Gallardo 4 collaborations

Sonia Emperador 4 collaborations

Roya Yousefi 2 collaborations

Eugenio F Fornasiero 2 collaborations

Lukas Cyganek 2 collaborations

Stefan Jakobs 2 collaborations

Ana Vela-Sebastián 2 collaborations

Pilar Bayona-Bafaluy 2 collaborations

Bettina Warscheid 2 collaborations

Sven Dennerlein 2 collaborations

Markus Deckers 2 collaborations

Ivan Bogeski 2 collaborations

M Pilar Bayona-Bafaluy 2 collaborations

Silvio O Rizzoli 1 collaboration

Carmen Hernández-Ainsa 1 collaboration

Ignacio Blanco 1 collaboration

Andrea Ros 1 collaboration

Ester Pascual-Benito 1 collaboration

Neus Rabaneda-Lombarte 1 collaboration

Silvia Presas-Rodríguez 1 collaboration

Pilar García-Robles 1 collaboration

Mouna Habbane 1 collaboration

Alejandro Del Rio 1 collaboration

Laura Llobet 1 collaboration

Javier Mateo 1 collaboration

Ana María Sanz-López 1 collaboration

María José Fernández-García 1 collaboration

Hortensia Sánchez-Tocino 1 collaboration

Sol Benbunan-Ferreiro 1 collaboration

María Calabuig-Goena 1 collaboration

Carlos Narvaez-Palazón 1 collaboration

Beatriz Fernández-Vega 1 collaboration

Hector González-Iglesias 1 collaboration

Roser Urreizti 1 collaboration

Rafael Artuch 1 collaboration

Ridhima Gomkale 1 collaboration

Luis Daniel Cruz-Zaragoza 1 collaboration

Ida Suppanz 1 collaboration

Bernard Guiard 1 collaboration

Sylvie Callegari 1 collaboration

Michał Wasilewski 1 collaboration

Silke Oeljeklaus 1 collaboration

Christine Silvia Gibhardt 1 collaboration

Abhishek Aich 1 collaboration

Margarita Chudenkova 1 collaboration

Agnieszka Chacinska 1 collaboration

Jonas Peper 1 collaboration

Daniel Kownatzki-Danger 1 collaboration

Gunnar Weninger 1 collaboration

Fitzwilliam Seibertz 1 collaboration

Julius Ryan D Pronto 1 collaboration

Henry Sutanto 1 collaboration

Robin Hindmarsh 1 collaboration

Sören Brandenburg 1 collaboration

Tobias Kohl 1 collaboration

Gerd Hasenfuss 1 collaboration

Michael Gotthardt 1 collaboration

Eva A Rog-Zielinska 1 collaboration

Bernd Wollnik 1 collaboration

Henning Urlaub 1 collaboration

Jörg Wegener 1 collaboration

Jordi Heijman 1 collaboration

Niels Voigt 1 collaboration

Christof Lenz 1 collaboration

Stephan E Lehnart 1 collaboration

Ileana Hernández-Reséndiz 1 collaboration

Araceli Sánchez 1 collaboration

Luis A Pardo 1 collaboration

King Faisal Yambire 1 collaboration

Christine Rostosky 1 collaboration

Takashi Watanabe 1 collaboration

Sylvia Torres-Odio 1 collaboration

Angela Sanchez-Guerrero 1 collaboration

Ola Senderovich 1 collaboration

Esther G Meyron-Holtz 1 collaboration

Ira Milosevic 1 collaboration

Jens Frahm 1 collaboration

A Phillip West 1 collaboration

Nuno Raimundo 1 collaboration

Xin Zhang 1 collaboration

Christine S Gibhardt 1 collaboration

Thorsten Will 1 collaboration

Hedwig Stanisz 1 collaboration

Christina Körbel 1 collaboration

Miso Mitkovski 1 collaboration

Ioana Stejerean 1 collaboration

Sabrina Cappello 1 collaboration

Jan Dudek 1 collaboration

Nasser Tahbaz 1 collaboration

Lucas Mina 1 collaboration

Thomas Simmen 1 collaboration

Matthias W Laschke 1 collaboration

Michael D Menger 1 collaboration

Michael P Schön 1 collaboration

Volkhard Helms 1 collaboration

Barbara A Niemeyer 1 collaboration

Adina Vultur 1 collaboration

Kristina Jevdokimenko 1 collaboration

Verena Kluever 1 collaboration

Cong Wang 1 collaboration

Ricarda Richter-Dennerlein 1 collaboration

Fan Liu 1 collaboration

Ying Zhu 1 collaboration

Till Stephan 1 collaboration

Christian Brüser 1 collaboration

Anna M Steyer 1 collaboration

Francisco Balzarotti 1 collaboration

Mariam Barbot 1 collaboration

Tiana S Behr 1 collaboration

Gudrun Heim 1 collaboration

Wolfgang Hübner 1 collaboration

Peter Ilgen 1 collaboration

Felix Lange 1 collaboration

Jasmin K Pape 1 collaboration

Stefan Stoldt 1 collaboration

Thomas Huser 1 collaboration

Stefan W Hell 1 collaboration

Wiebke Möbius 1 collaboration

Dietmar Riedel 1 collaboration

Eldris Iglesias 1 collaboration

Lorenzo Labarta 1 collaboration

Marie-Christine Reinert 1 collaboration

Claudia B Catarino 1 collaboration

Thomas Klopstock 1 collaboration

Andreas Ohlenbusch 1 collaboration

Michael Schittkowski 1 collaboration

Ekkehard Wilichowski 1 collaboration

Knut Brockmann 1 collaboration

María Pilar Bayona-Bafaluy 1 collaboration

Teresa Sanclemente 1 collaboration

José Puzo 1 collaboration