David Chiron

Affiliations

Centre de Recherches en Cancérologie et Immunologie Nantes-Angers, U1232 INSERM, Centre National de la Recherche Scientifique (CNRS) ERL6001, Université de Nantes, Nantes, France.

Publications (9)

Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma.

Oncogene

Avec: Gregory Lazarian , Chloe Friedrich , Anne Quinquenel , Julie Tran , Souhail Ouriemmi , Elisabetta Dondi , Antoine Martin , Imane Mihoub , David Chiron , Céline Bellanger , Carole Fleury , Pascal Gélébart , Emmet McCormack , Dominique Ledoux , Catherine Thieblemont , Jacek Marzec , John G Gribben , Florence Cymbalista , Nadine Varin-Blank , Laura Gardano , Fanny Baran-Marszak

Pannexin-1 limits the production of proinflammatory cytokines during necroptosis.

EMBO reports

Avec: Tiphaine Douanne , Gwennan André-Grégoire , Kilian Trillet , An Thys , Antonin Papin , Magalie Feyeux , Philippe Hulin , David Chiron , Julie Gavard , Nicolas Bidère

Ibrutinib, obinutuzumab, and venetoclax in relapsed and untreated patients with mantle cell lymphoma: a phase 1/2 trial.

Blood

Avec: Steven Le Gouill , Franck Morschhauser , David Chiron , Krimo Bouabdallah , Guillaume Cartron , Olivier Casasnovas , Caroline Bodet-Milin , Sylviane Ragot , Céline Bossard , Nathalie Nadal , Charles Herbaux , Benoit Tessoulin , Emmanuelle Tchernonog , Cédric Rossi , Rory McCulloch , Thomas Gastinne , Mary B Callanan , Simon Rule

The IL32/BAFF axis supports prosurvival dialogs in the lymphoma ecosystem and is disrupted by NIK inhibition.

Haematologica

Avec: Salomé Decombis , Antonin Papin , Céline Bellanger , Clara Sortais , Christelle Dousset , Yannick Le Bris , Thiphanie Riveron , Stéphanie Blandin , Philippe Hulin , Benoit Tessoulin , Mathieu Rouel , Steven Le Gouill , Agnès Moreau-Aubry , Catherine Pellat-Deceunynck , David Chiron

CSF1R and BTK inhibitions as novel strategies to disrupt the dialog between mantle cell lymphoma and macrophages.

Leukemia

Avec: Antonin Papin , Benoit Tessoulin , Céline Bellanger , Anne Moreau , Yannick Le Bris , Hervé Maisonneuve , Philippe Moreau , Cyrille Touzeau , Martine Amiot , Catherine Pellat-Deceunynck , Steven Le Gouill , David Chiron

Tumor Microenvironment and Immunotherapy-Based Approaches in Mantle Cell Lymphoma.

Cancers

Avec: Khalil Saleh , Morgane Cheminant , David Chiron , Barbara Burroni , Vincent Ribrag , Clémentine Sarkozy

Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion.

Experimental hematology & oncology

Avec: Diana Malarikova , Radek Jorda , Kristyna Kupcova , Jana Senavova , Alexandra Dolnikova , Eva Pokorna , Dmitry Kazantsev , Kristina Nozickova , Dana Sovilj , Celine Bellanger , David Chiron , Ladislav Andera , Vladimir Krystof , Miroslav Strnad , Karel Helman , Magdalena Klanova , Marek Trneny , Ondrej Havranek , Pavel Klener

Combined inhibition of CTPS1 and ATR is a metabolic vulnerability in p53-deficient myeloma cells.

HemaSphere

Avec: Romane Durand , Céline Bellanger , Géraldine Descamps , Christelle Dousset , Sophie Maïga , Jennifer Derrien , Laura Thirouard , Louise Bouard , Hélène Asnagli , Philip Beer , Andrew Parker , Patricia Gomez-Bougie , Marie-Claire Devilder , Philippe Moreau , Cyrille Touzeau , Agnès Moreau-Aubry , David Chiron , Catherine Pellat-Deceunynck

Oxaliplatin before autologous transplantation in combination with high-dose cytarabine and rituximab provides longer disease control than cisplatin or carboplatin in patients with mantle-cell lymphoma: results from the LyMA prospective trial.

Bone marrow transplantation

Avec: Benoit Tessoulin , David Chiron , Catherine Thieblemont , Lucie Oberic , Kamal Bouadballah , Emmanuel Gyan , Gandhi Damaj , Vincent Ribrag , Rémy Gressin , Pierre Feugier , Olivier Casasnovas , Hacène Zerazhi , François Lemonnier , Hervé Maisonneuve , Clementine Joubert , Eric Van Den Neste , Thierry Lamy , Hervé Tilly , Anne Moreau , Olivier Hermine , Steven Le Gouill

Réseau de co-auteurs

Céline Bellanger 4 collaborations

Steven Le Gouill 4 collaborations

Benoit Tessoulin 4 collaborations

Antonin Papin 3 collaborations

Catherine Pellat-Deceunynck 3 collaborations

Catherine Thieblemont 2 collaborations

Philippe Hulin 2 collaborations

Olivier Casasnovas 2 collaborations

Christelle Dousset 2 collaborations

Yannick Le Bris 2 collaborations

Agnès Moreau-Aubry 2 collaborations

Anne Moreau 2 collaborations

Hervé Maisonneuve 2 collaborations

Philippe Moreau 2 collaborations

Cyrille Touzeau 2 collaborations

Vincent Ribrag 2 collaborations

Gregory Lazarian 1 collaboration

Chloe Friedrich 1 collaboration

Anne Quinquenel 1 collaboration

Julie Tran 1 collaboration

Souhail Ouriemmi 1 collaboration

Elisabetta Dondi 1 collaboration

Antoine Martin 1 collaboration

Imane Mihoub 1 collaboration

Carole Fleury 1 collaboration

Pascal Gélébart 1 collaboration

Emmet McCormack 1 collaboration

Dominique Ledoux 1 collaboration

Jacek Marzec 1 collaboration

John G Gribben 1 collaboration

Florence Cymbalista 1 collaboration

Nadine Varin-Blank 1 collaboration

Laura Gardano 1 collaboration

Fanny Baran-Marszak 1 collaboration

Tiphaine Douanne 1 collaboration

Gwennan André-Grégoire 1 collaboration

Kilian Trillet 1 collaboration

An Thys 1 collaboration

Magalie Feyeux 1 collaboration

Julie Gavard 1 collaboration

Nicolas Bidère 1 collaboration

Franck Morschhauser 1 collaboration

Krimo Bouabdallah 1 collaboration

Guillaume Cartron 1 collaboration

Caroline Bodet-Milin 1 collaboration

Sylviane Ragot 1 collaboration

Céline Bossard 1 collaboration

Nathalie Nadal 1 collaboration

Charles Herbaux 1 collaboration

Emmanuelle Tchernonog 1 collaboration

Cédric Rossi 1 collaboration

Rory McCulloch 1 collaboration

Thomas Gastinne 1 collaboration

Mary B Callanan 1 collaboration

Simon Rule 1 collaboration

Salomé Decombis 1 collaboration

Clara Sortais 1 collaboration

Thiphanie Riveron 1 collaboration

Stéphanie Blandin 1 collaboration

Mathieu Rouel 1 collaboration

Martine Amiot 1 collaboration

Khalil Saleh 1 collaboration

Morgane Cheminant 1 collaboration

Barbara Burroni 1 collaboration

Clémentine Sarkozy 1 collaboration

Diana Malarikova 1 collaboration

Radek Jorda 1 collaboration

Kristyna Kupcova 1 collaboration

Jana Senavova 1 collaboration

Alexandra Dolnikova 1 collaboration

Eva Pokorna 1 collaboration

Dmitry Kazantsev 1 collaboration

Kristina Nozickova 1 collaboration

Dana Sovilj 1 collaboration

Celine Bellanger 1 collaboration

Ladislav Andera 1 collaboration

Vladimir Krystof 1 collaboration

Miroslav Strnad 1 collaboration

Karel Helman 1 collaboration

Magdalena Klanova 1 collaboration

Marek Trneny 1 collaboration

Ondrej Havranek 1 collaboration

Pavel Klener 1 collaboration

Romane Durand 1 collaboration

Géraldine Descamps 1 collaboration

Sophie Maïga 1 collaboration

Jennifer Derrien 1 collaboration

Laura Thirouard 1 collaboration

Louise Bouard 1 collaboration

Hélène Asnagli 1 collaboration

Philip Beer 1 collaboration

Andrew Parker 1 collaboration

Patricia Gomez-Bougie 1 collaboration

Marie-Claire Devilder 1 collaboration

Lucie Oberic 1 collaboration

Kamal Bouadballah 1 collaboration

Emmanuel Gyan 1 collaboration

Gandhi Damaj 1 collaboration

Rémy Gressin 1 collaboration

Pierre Feugier 1 collaboration

Hacène Zerazhi 1 collaboration

François Lemonnier 1 collaboration

Clementine Joubert 1 collaboration

Eric Van Den Neste 1 collaboration

Thierry Lamy 1 collaboration

Hervé Tilly 1 collaboration

Olivier Hermine 1 collaboration