Daniel W McVicar

Affiliations

Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Publications (22)

Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.

British journal of pharmacology

Avec: Debashree Basudhar , Gaurav Bharadwaj , Veena Somasundaram , Robert Y S Cheng , Lisa A Ridnour , Mayumi Fujita , Stephen J Lockett , Stephen K Anderson , Daniel W McVicar , David A Wink

Diversity and environmental adaptation of phagocytic cell metabolism.

Journal of leukocyte biology

Avec: Luke C Davies , Christopher M Rice , Daniel W McVicar , Jonathan M Weiss

Interferon-gamma is quintessential for NOS2 and COX2 expression in ER

Cell death & disease

Avec: Robert Y S Cheng , Lisa A Ridnour , Adelaide L Wink , Ana L Gonzalez , Elise L Femino , Helene Rittscher , Veena Somasundaram , William F Heinz , Leandro Coutinho , M Cristina Rangel , Elijah F Edmondson , Donna Butcher , Robert J Kinders , Xiaoxian Li , Stephen T C Wong , Daniel W McVicar , Stephen K Anderson , Milind Pore , Stephen M Hewitt , Timothy R Billiar , Sharon A Glynn , Jenny C Chang , Stephen J Lockett , Stefan Ambs , David A Wink

Frontiers in immunology

Avec: Marieli Gonzalez-Cotto , Liang Guo , Megan Karwan , Shurjo K Sen , Jennifer Barb , Carlos J Collado , Fathi Elloumi , Erika M Palmieri , Kimberly Boelte , Frank D Kolodgie , Aloke V Finn , Leslie G Biesecker , Daniel W McVicar

Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER

bioRxiv : the preprint server for biology

Avec: Robert Ys Cheng , Lisa A Ridnour , Adelaide L Wink , Ana L Gonzalez , Elise L Femino , Helene Rittscher , Veena Somasundarum , William F Heinz , Leandro Coutinho , M Cristina Rangel , Elijah F Edmondson , Donna Butcher , Robert J Kinders , Xiaoxian Li , Stephen T C Wong , Daniel W McVicar , Steven K Anderson , Milind Pore , Stephen M Hewitt , Timothy R Billiar , Sharon Glynn , Jenny C Chang , Stephen J Lockett , Stefan Ambs , David A Wink

IFN-γ and androgens disrupt mitochondrial function in murine myocytes.

The Journal of pathology

Avec: John M Fenimore , Danielle A Springer , Maria E Romero , Elijah F Edmondson , Dan W McVicar , Sudhirkumar Yanpallewar , Michael Sanford , Thea Spindel , Elizabeth Engle , Thomas J Meyer , Julio C Valencia , Howard A Young

IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium.

Frontiers in immunology

Avec: Caroline Andrews , Mairi H McLean , Julie A Hixon , Sergio M Pontejo , Tregei Starr , Courtney Malo , Margaret Cam , Lisa Ridnour , Heather Hickman , Olivia Steele-Mortimer , David A Wink , Howard A Young , Daniel W McVicar , Wenqing Li , Scott K Durum

Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming.

Nature communications

Avec: Erika M Palmieri , Ronald Holewinski , Christopher L McGinity , Ciro L Pierri , Nunziata Maio , Jonathan M Weiss , Vincenzo Tragni , Katrina M Miranda , Tracey A Rouault , Thorkell Andresson , David A Wink , Daniel W McVicar

Reactive Oxygen Species-Sensitive Biodegradable Mesoporous Silica Nanoparticles Harboring TheraVac Elicit Tumor-Specific Immunity for Colon Tumor Treatment.

ACS nano

Avec: Yue Huang , Saifun Nahar , Md Masud Alam , Shuo Hu , Daniel W McVicar , De Yang

Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Cancer research communications

Avec: Lisa A Ridnour , William F Heinz , Robert Ys Cheng , Adelaide L Wink , Noemi Kedei , Milind Pore , Fatima Imtiaz , Elise L Femino , Ana L Gonzalez , Leandro L Coutinho , Rebecca L Moffat , Donna Butcher , Elijah F Edmondson , Xiaoxian Li , Maria Cristina Rangel , Robert J Kinders , Jens Rittscher , Stanley Lipkowitz , Stephen T C Wong , Stephen K Anderson , Daniel W McVicar , Sharon A Glynn , Timothy R Billiar , Jenny C Chang , Stephen M Hewitt , Stefan Ambs , Stephen J Lockett , David A Wink

Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses.

eLife

Avec: Jessica F Walls , Jeff J Subleski , Erika M Palmieri , Marieli Gonzalez-Cotto , Clair M Gardiner , Daniel W McVicar , David K Finlay

Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level.

Redox biology

Avec: Veena Somasundaram , Anne C Gilmore , Debashree Basudhar , Erika Mariana Palmieri , David A Scheiblin , William F Heinz , Robert Y S Cheng , Lisa A Ridnour , Grégoire Altan-Bonnet , Stephen J Lockett , Daniel W McVicar , David A Wink

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism.

Antioxidants & redox signaling

Avec: Veena Somasundaram , Debashree Basudhar , Gaurav Bharadwaj , Jae Hong No , Lisa A Ridnour , Robert Y S Cheng , Mayumi Fujita , Douglas D Thomas , Stephen K Anderson , Daniel W McVicar , David A Wink

Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages.

Cancer research

Avec: Julio C Valencia , Rebecca A Erwin-Cohen , Paul E Clavijo , Clint Allen , Michael E Sanford , Chi-Ping Day , Megan M Hess , Morgan Johnson , Jie Yin , John M Fenimore , Ian A Bettencourt , Koichi Tsuneyama , Maria E Romero , Kimberly D Klarmann , Peng Jiang , Heekyong R Bae , Daniel W McVicar , Glenn Merlino , Elijah F Edmondson , Niroshana Anandasabapathy , Howard A Young

Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight.

Metabolites

Avec: Erika M Palmieri , Christopher McGinity , David A Wink , Daniel W McVicar

Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice.

Nature metabolism

Avec: Jonathan M Weiss , Erika M Palmieri , Marieli Gonzalez-Cotto , Ian A Bettencourt , Emily L Megill , Nathaniel W Snyder , Daniel W McVicar

Androgen receptor inhibition suppresses anti-tumor neutrophil response against bone metastatic prostate cancer via regulation of TβRI expression.

Cancer letters

Avec: Massar Alsamraae , Diane Costanzo-Garvey , Benjamin A Teply , Shawna Boyle , Gary Sommerville , Zachary T Herbert , Colm Morrissey , Alicia J Dafferner , Maher Y Abdalla , Rachel W Fallet , Tammy Kielian , Heather Jensen-Smith , Edson I deOliveira , Keqiang Chen , Ian A Bettencourt , Ji Ming Wang , Daniel W McVicar , Tyler Keeley , Fang Yu , Leah M Cook

A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.

Science signaling

Avec: Orna Ernst , Jing Sun , Bin Lin , Balaji Banoth , Michael G Dorrington , Jonathan Liang , Benjamin Schwarz , Kaitlin A Stromberg , Samuel Katz , Sharat J Vayttaden , Clinton J Bradfield , Nadia Slepushkina , Christopher M Rice , Eugen Buehler , Jaspal S Khillan , Daniel W McVicar , Catharine M Bosio , Clare E Bryant , Fayyaz S Sutterwala , Scott E Martin , Madhu Lal-Nag , Iain D C Fraser

Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma.

Frontiers in oncology

Avec: Jill W Ford , Marieli Gonzalez-Cotto , Alexander W MacFarlane , Suraj Peri , O M Zack Howard , Jeffrey J Subleski , Karen J Ruth , Mohammed Haseebuddin , Tahseen Al-Saleem , Youfeng Yang , Pat Rayman , Brian Rini , W Marston Linehan , James Finke , Jonathan M Weiss , Kerry S Campbell , Daniel W McVicar

NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER-Breast Cancer.

bioRxiv : the preprint server for biology

Avec: Lisa A Ridnour , William F Heinz , Robert Ys Cheng , Adelaide L Wink , Noemi Kedei , Milind Pore , Fatima Imtiaz , Elise L Femino , Ana L Gonzalez , Leandro Coutinho , Donna Butcher , Elijah F Edmondson , M Cristina Rangel , Robert J Kinders , Stanley Lipkowitz , Stephen Tc Wong , Stephen K Anderson , Danial W McVicar , Xiaoxian Li , Sharon A Glynn , Timothy R Billiar , Jenny C Chang , Stephen M Hewitt , Stefan Ambs , Stephen J Lockett , David A Wink

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors.

JCI insight

Avec: Lisa A Ridnour , Robert Ys Cheng , Noemi Kedei , Veena Somasundaram , Dibyangana D Bhattacharyya , Debashree Basudhar , Adelaide L Wink , Abigail J Walke , Caleb Kim , William F Heinz , Elijah F Edmondson , Donna O Butcher , Andrew C Warner , Tiffany H Dorsey , Milind Pore , Robert J Kinders , Stanley Lipkowitz , Richard J Bryant , Jens Rittscher , Stephen Tc Wong , Stephen M Hewitt , Jenny C Chang , Aliaa Shalaby , Grace M Callagy , Sharon A Glynn , Stefan Ambs , Stephen K Anderson , Daniel W McVicar , Stephen J Lockett , David A Wink

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.

Nature communications

Avec: Erika M Palmieri , Marieli Gonzalez-Cotto , Walter A Baseler , Luke C Davies , Bart Ghesquière , Nunziata Maio , Christopher M Rice , Tracey A Rouault , Teresa Cassel , Richard M Higashi , Andrew N Lane , Teresa W-M Fan , David A Wink , Daniel W McVicar

Réseau de co-auteurs

David A Wink 12 collaborations

Lisa A Ridnour 8 collaborations

Stephen J Lockett 7 collaborations

Elijah F Edmondson 7 collaborations

Stephen K Anderson 6 collaborations

William F Heinz 6 collaborations

Erika M Palmieri 6 collaborations

Veena Somasundaram 5 collaborations

Adelaide L Wink 5 collaborations

Robert J Kinders 5 collaborations

Milind Pore 5 collaborations

Stephen M Hewitt 5 collaborations

Jenny C Chang 5 collaborations

Stefan Ambs 5 collaborations

Marieli Gonzalez-Cotto 5 collaborations

Debashree Basudhar 4 collaborations

Robert Y S Cheng 4 collaborations

Jonathan M Weiss 4 collaborations

Ana L Gonzalez 4 collaborations

Elise L Femino 4 collaborations

Donna Butcher 4 collaborations

Xiaoxian Li 4 collaborations

Timothy R Billiar 4 collaborations

Sharon A Glynn 4 collaborations

Robert Ys Cheng 4 collaborations

Christopher M Rice 3 collaborations

Leandro Coutinho 3 collaborations

M Cristina Rangel 3 collaborations

Stephen T C Wong 3 collaborations

Howard A Young 3 collaborations

Noemi Kedei 3 collaborations

Stanley Lipkowitz 3 collaborations

Ian A Bettencourt 3 collaborations

Gaurav Bharadwaj 2 collaborations

Mayumi Fujita 2 collaborations

Luke C Davies 2 collaborations

Helene Rittscher 2 collaborations

John M Fenimore 2 collaborations

Maria E Romero 2 collaborations

Julio C Valencia 2 collaborations

Nunziata Maio 2 collaborations

Tracey A Rouault 2 collaborations

Fatima Imtiaz 2 collaborations

Jens Rittscher 2 collaborations

Stephen Tc Wong 2 collaborations

Liang Guo 1 collaboration

Megan Karwan 1 collaboration

Shurjo K Sen 1 collaboration

Jennifer Barb 1 collaboration

Carlos J Collado 1 collaboration

Fathi Elloumi 1 collaboration

Kimberly Boelte 1 collaboration

Frank D Kolodgie 1 collaboration

Aloke V Finn 1 collaboration

Leslie G Biesecker 1 collaboration

Veena Somasundarum 1 collaboration

Steven K Anderson 1 collaboration

Sharon Glynn 1 collaboration

Danielle A Springer 1 collaboration

Dan W McVicar 1 collaboration

Sudhirkumar Yanpallewar 1 collaboration

Michael Sanford 1 collaboration

Thea Spindel 1 collaboration

Elizabeth Engle 1 collaboration

Thomas J Meyer 1 collaboration

Caroline Andrews 1 collaboration

Mairi H McLean 1 collaboration

Julie A Hixon 1 collaboration

Sergio M Pontejo 1 collaboration

Tregei Starr 1 collaboration

Courtney Malo 1 collaboration

Margaret Cam 1 collaboration

Lisa Ridnour 1 collaboration

Heather Hickman 1 collaboration

Olivia Steele-Mortimer 1 collaboration

Wenqing Li 1 collaboration

Scott K Durum 1 collaboration

Ronald Holewinski 1 collaboration

Christopher L McGinity 1 collaboration

Ciro L Pierri 1 collaboration

Vincenzo Tragni 1 collaboration

Katrina M Miranda 1 collaboration

Thorkell Andresson 1 collaboration

Yue Huang 1 collaboration

Saifun Nahar 1 collaboration

Md Masud Alam 1 collaboration

Shuo Hu 1 collaboration

De Yang 1 collaboration

Leandro L Coutinho 1 collaboration

Rebecca L Moffat 1 collaboration

Maria Cristina Rangel 1 collaboration

Jessica F Walls 1 collaboration

Jeff J Subleski 1 collaboration

Clair M Gardiner 1 collaboration

David K Finlay 1 collaboration

Anne C Gilmore 1 collaboration

Erika Mariana Palmieri 1 collaboration

David A Scheiblin 1 collaboration

Grégoire Altan-Bonnet 1 collaboration

Jae Hong No 1 collaboration

Douglas D Thomas 1 collaboration

Rebecca A Erwin-Cohen 1 collaboration

Paul E Clavijo 1 collaboration

Clint Allen 1 collaboration

Michael E Sanford 1 collaboration

Chi-Ping Day 1 collaboration

Megan M Hess 1 collaboration

Morgan Johnson 1 collaboration

Jie Yin 1 collaboration

Koichi Tsuneyama 1 collaboration

Kimberly D Klarmann 1 collaboration

Peng Jiang 1 collaboration

Heekyong R Bae 1 collaboration

Glenn Merlino 1 collaboration

Niroshana Anandasabapathy 1 collaboration

Christopher McGinity 1 collaboration

Emily L Megill 1 collaboration

Nathaniel W Snyder 1 collaboration

Massar Alsamraae 1 collaboration

Diane Costanzo-Garvey 1 collaboration

Benjamin A Teply 1 collaboration

Shawna Boyle 1 collaboration

Gary Sommerville 1 collaboration

Zachary T Herbert 1 collaboration

Colm Morrissey 1 collaboration

Alicia J Dafferner 1 collaboration

Maher Y Abdalla 1 collaboration

Rachel W Fallet 1 collaboration

Tammy Kielian 1 collaboration

Heather Jensen-Smith 1 collaboration

Edson I deOliveira 1 collaboration

Keqiang Chen 1 collaboration

Ji Ming Wang 1 collaboration

Tyler Keeley 1 collaboration

Fang Yu 1 collaboration

Leah M Cook 1 collaboration

Orna Ernst 1 collaboration

Jing Sun 1 collaboration

Bin Lin 1 collaboration

Balaji Banoth 1 collaboration

Michael G Dorrington 1 collaboration

Jonathan Liang 1 collaboration

Benjamin Schwarz 1 collaboration

Kaitlin A Stromberg 1 collaboration

Samuel Katz 1 collaboration

Sharat J Vayttaden 1 collaboration

Clinton J Bradfield 1 collaboration

Nadia Slepushkina 1 collaboration

Eugen Buehler 1 collaboration

Jaspal S Khillan 1 collaboration

Catharine M Bosio 1 collaboration

Clare E Bryant 1 collaboration

Fayyaz S Sutterwala 1 collaboration

Scott E Martin 1 collaboration

Madhu Lal-Nag 1 collaboration

Iain D C Fraser 1 collaboration

Jill W Ford 1 collaboration

Alexander W MacFarlane 1 collaboration

Suraj Peri 1 collaboration

O M Zack Howard 1 collaboration

Jeffrey J Subleski 1 collaboration

Karen J Ruth 1 collaboration

Mohammed Haseebuddin 1 collaboration

Tahseen Al-Saleem 1 collaboration

Youfeng Yang 1 collaboration

Pat Rayman 1 collaboration

Brian Rini 1 collaboration

W Marston Linehan 1 collaboration

James Finke 1 collaboration

Kerry S Campbell 1 collaboration

Danial W McVicar 1 collaboration

Dibyangana D Bhattacharyya 1 collaboration

Abigail J Walke 1 collaboration

Caleb Kim 1 collaboration

Donna O Butcher 1 collaboration

Andrew C Warner 1 collaboration

Tiffany H Dorsey 1 collaboration

Richard J Bryant 1 collaboration

Aliaa Shalaby 1 collaboration

Grace M Callagy 1 collaboration

Walter A Baseler 1 collaboration

Bart Ghesquière 1 collaboration

Teresa Cassel 1 collaboration

Richard M Higashi 1 collaboration

Andrew N Lane 1 collaboration

Teresa W-M Fan 1 collaboration