Daniel Lucena-Agell

Affiliations

7Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

Publications (24)

Cancer cell international

Avec: Bryce Keenan , Rocio K Finol-Urdaneta , Ashleigh Hope , John B Bremner , Maria Kavallaris , Daniel Lucena-Agell , María Ángela Oliva , Jose Fernando Díaz , Kara L Vine

Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide.

Organic letters

Avec: Christian P Bold , Cindy Klaus , Bernhard Pfeiffer , Jasmine Schürmann , Rafael Lombardi , Daniel Lucena-Agell , J Fernando Díaz , Karl-Heinz Altmann

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Zlata Boiarska , Helena Pérez-Peña , Anne-Catherine Abel , Paola Marzullo , Beatriz Álvarez-Bernad , Francesca Bonato , Benedetta Santini , Dragos Horvath , Daniel Lucena-Agell , Francesca Vasile , Maurizio Sironi , J Fernando Díaz , Andrea E Prota , Stefano Pieraccini , Daniele Passarella

Synthesis of Morpholine-Based Analogues of (-)-Zampanolide and Their Biological Activity.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Christian Paul Bold , Melanie Gut , Jasmine Schürmann , Daniel Lucena-Agell , Jürg Gertsch , José Fernando Díaz , Karl-Heinz Altmann

Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia.

iScience

Avec: Nathália Moreno Cury , Tobias Mühlethaler , Angelo Brunelli Albertoni Laranjeira , Rafael Renatino Canevarolo , Priscila Pini Zenatti , Daniel Lucena-Agell , Isabel Barasoain , Chunhua Song , Dongxiao Sun , Sinisa Dovat , Rosendo Augusto Yunes , Andrea Enrico Prota , Michel Olivier Steinmetz , José Fernando Díaz , José Andrés Yunes

Design, synthesis and structure-activity relationship (SAR) studies of an unusual class of non-cationic fatty amine-tripeptide conjugates as novel synthetic antimicrobial agents.

Frontiers in pharmacology

Avec: Noelia Hernández-Ortiz , Pedro A Sánchez-Murcia , Celia Gil-Campillo , Mirian Domenech , Daniel Lucena-Agell , Rafael Hortigüela , Sonsoles Velázquez , María José Camarasa , Noemí Bustamante , Sonia de Castro , Margarita Menéndez

Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide.

Journal of medicinal chemistry

Avec: Toms Kalnins , Viktorija Vitkovska , Mihail Kazak , Diana Zelencova-Gopejenko , Melita Ozola , Nauris Narvaiss , Marina Makrecka-Kuka , Ilona Domračeva , Artis Kinens , Baiba Gukalova , Nele Konrad , Riina Aav , Francesca Bonato , Daniel Lucena-Agell , J Fernando Díaz , Edgars Liepinsh , Edgars Suna

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells.

Cancers

Avec: Lauralie Peronne , Eric Denarier , Ankit Rai , Renaud Prudent , Audrey Vernet , Peggy Suzanne , Sacnicté Ramirez-Rios , Sophie Michallet , Mélanie Guidetti , Julien Vollaire , Daniel Lucena-Agell , Anne-Sophie Ribba , Véronique Josserand , Jean-Luc Coll , Patrick Dallemagne , J Fernando Díaz , María Ángela Oliva , Karin Sadoul , Anna Akhmanova , Annie Andrieux , Laurence Lafanechère

Design, Synthesis, and in vitro Evaluation of Tubulin-Targeting Dibenzothiazines with Antiproliferative Activity as a Novel Heterocycle Building Block.

ChemMedChem

Avec: Walter D Guerra , Daniel Lucena-Agell , Rafael Hortigüela , Roberto A Rossi , J Fernando Díaz , José M Padrón , Silvia M Barolo

Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function.

International journal of molecular sciences

Avec: María Ángela Oliva , Carlota Tosat-Bitrián , Lucía Barrado-Gil , Francesca Bonato , Inmaculada Galindo , Urtzi Garaigorta , Beatriz Álvarez-Bernad , Rebeca París-Ogáyar , Daniel Lucena-Agell , Juan Francisco Giménez-Abián , Isabel García-Dorival , Jesús Urquiza , Pablo Gastaminza , José Fernando Díaz , Valle Palomo , Covadonga Alonso

Synthesis and Biological Evaluation of C(13)/C(13')-Bis(desmethyl)disorazole Z.

Angewandte Chemie (International ed. in English)

Avec: Christian Paul Bold , Daniel Lucena-Agell , María Ángela Oliva , José Fernando Díaz , Karl-Heinz Altmann

Chemical modulation of microtubule structure through the laulimalide/peloruside site.

Structure (London, England : 1993)

Avec: Juan Estévez-Gallego , Beatriz Álvarez-Bernad , Benet Pera , Christoph Wullschleger , Olivier Raes , Dirk Menche , Juan Carlos Martínez , Daniel Lucena-Agell , Andrea E Prota , Francesca Bonato , Katja Bargsten , Jelle Cornelus , Juan Francisco Giménez-Abián , Peter Northcote , Michel O Steinmetz , Shinji Kamimura , Karl-Heinz Altmann , Ian Paterson , Federico Gago , Johan Van der Eycken , J Fernando Díaz , María Ángela Oliva

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.

European journal of medicinal chemistry

Avec: Margherita Brindisi , Cristina Ulivieri , Gloria Alfano , Sandra Gemma , Francisco de Asís Balaguer , Tuhina Khan , Alessandro Grillo , Giulia Chemi , Grégory Menchon , Andrea E Prota , Natacha Olieric , Daniel Lucena-Agell , Isabel Barasoain , J Fernando Diaz , Angela Nebbioso , Mariarosaria Conte , Ludovica Lopresti , Stefania Magnano , Rebecca Amet , Paula Kinsella , Daniela M Zisterer , Ola Ibrahim , Jeff O'Sullivan , Lucia Morbidelli , Roberta Spaccapelo , Cosima Baldari , Stefania Butini , Ettore Novellino , Giuseppe Campiani , Lucia Altucci , Michel O Steinmetz , Simone Brogi

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Susan Matthew , Qi-Yin Chen , Ranjala Ratnayake , Charles S Fermaintt , Daniel Lucena-Agell , Francesca Bonato , Andrea E Prota , Seok Ting Lim , Xiaomeng Wang , J Fernando Díaz , April L Risinger , Valerie J Paul , Maria Ángela Oliva , Hendrik Luesch

PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin.

Journal of medicinal chemistry

Avec: Daniel Lucena-Agell , María José Guillén , Ruth Matesanz , Beatriz Álvarez-Bernad , Rafael Hortigüela , Pablo Avilés , Marta Martínez-Díez , Gema Santamaría-Núñez , Julia Contreras , Iván Plaza-Menacho , Juan F Giménez-Abián , María A Oliva , Carmen Cuevas , J Fernando Díaz

Structural insight into the stabilization of microtubules by taxanes.

eLife

Avec: Andrea E Prota , Daniel Lucena-Agell , Yuntao Ma , Juan Estevez-Gallego , Shuo Li , Katja Bargsten , Fernando Josa-Prado , Karl-Heinz Altmann , Natacha Gaillard , Shinji Kamimura , Tobias Mühlethaler , Federico Gago , Maria A Oliva , Michel O Steinmetz , Wei-Shuo Fang , J Fernando Díaz

Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(-)-Zampanolide Analogs.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Tobias M Brütsch , Etienne Cotter , Daniel Lucena-Agell , Mariano Redondo-Horcajo , Carolina Davies , Bernhard Pfeiffer , Sandro Pagani , Simone Berardozzi , J Fernando Díaz , John H Miller , Karl-Heinz Altmann

Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging.

Nature communications

Avec: Harrisson D A Santos , Irene Zabala Gutiérrez , Yingli Shen , José Lifante , Erving Ximendes , Marco Laurenti , Diego Méndez-González , Sonia Melle , Oscar G Calderón , Enrique López Cabarcos , Nuria Fernández , Irene Chaves-Coira , Daniel Lucena-Agell , Luis Monge , Mark D Mackenzie , José Marqués-Hueso , Callum M S Jones , Carlos Jacinto , Blanca Del Rosal , Ajoy K Kar , Jorge Rubio-Retama , Daniel Jaque

Structural model for differential cap maturation at growing microtubule ends.

eLife

Avec: Juan Estévez-Gallego , Fernando Josa-Prado , Siou Ku , Ruben M Buey , Francisco A Balaguer , Andrea E Prota , Daniel Lucena-Agell , Christina Kamma-Lorger , Toshiki Yagi , Hiroyuki Iwamoto , Laurence Duchesne , Isabel Barasoain , Michel O Steinmetz , Denis Chrétien , Shinji Kamimura , J Fernando Díaz , Maria A Oliva

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Paola Marzullo , Zlata Boiarska , Helena Pérez-Peña , Anne-Catherine Abel , Beatriz Álvarez-Bernad , Daniel Lucena-Agell , Francesca Vasile , Maurizio Sironi , Karl-Heinz Altmann , Andrea E Prota , J Fernando Díaz , Stefano Pieraccini , Daniele Passarella

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy.

European journal of medicinal chemistry

Avec: Giuseppe Campiani , Tuhina Khan , Cristina Ulivieri , Leopoldo Staiano , Chiara Papulino , Stefania Magnano , Seema Nathwani , Anna Ramunno , Daniel Lucena-Agell , Nicola Relitti , Stefano Federico , Luca Pozzetti , Gabriele Carullo , Alice Casagni , Simone Brogi , Francesca Vanni , Paola Galatello , Magda Ghanim , Niamh McCabe , Stefania Lamponi , Massimo Valoti , Ola Ibrahim , Jeffrey O'Sullivan , Richard Turkington , Vincent P Kelly , Ruben VanWemmel , J Fernando Díaz , Sandra Gemma , Daniela Zisterer , Lucia Altucci , Antonella De Matteis , Stefania Butini , Rosaria Benedetti

Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library.

Bioorganic chemistry

Avec: Faezeh Nemati , Iris Bischoff-Kont , Peyman Salehi , Samad Nejad-Ebrahimi , Maryam Mohebbi , Morteza Bararjanian , Nasim Hadian , Zahra Hassanpour , Yvonne Jung , Sofie Schaerlaekens , Daniel Lucena-Agell , María A Oliva , Robert Fürst , Hamid R Nasiri

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.

European journal of medicinal chemistry

Avec: Yuntao Ma , Fernando Josa-Prado , Jacob Nathaniel Essif , Shuqi Liu , Shuo Li , Daniel Lucena-Agell , Peter Yw Chan , Kenneth Goossens , Rafael Hortigüela , Ruth Matesanz , Yingjie Wang , Federico Gago , Hongbo Wang , April Risinger , J Fernando Diaz , Wei-Shuo Fang

Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics.

Chemistry (Weinheim an der Bergstrasse, Germany)

Réseau de co-auteurs

J Fernando Díaz 14 collaborations

Andrea E Prota 8 collaborations

Karl-Heinz Altmann 7 collaborations

Beatriz Álvarez-Bernad 6 collaborations

Francesca Bonato 6 collaborations

María Ángela Oliva 5 collaborations

José Fernando Díaz 4 collaborations

Rafael Hortigüela 4 collaborations

Michel O Steinmetz 4 collaborations

Zlata Boiarska 3 collaborations

Helena Pérez-Peña 3 collaborations

Anne-Catherine Abel 3 collaborations

Paola Marzullo 3 collaborations

Francesca Vasile 3 collaborations

Maurizio Sironi 3 collaborations

Stefano Pieraccini 3 collaborations

Daniele Passarella 3 collaborations

Isabel Barasoain 3 collaborations

Shinji Kamimura 3 collaborations

Federico Gago 3 collaborations

Fernando Josa-Prado 3 collaborations

Bernhard Pfeiffer 2 collaborations

Jasmine Schürmann 2 collaborations

Benedetta Santini 2 collaborations

Dragos Horvath 2 collaborations

Christian Paul Bold 2 collaborations

Tobias Mühlethaler 2 collaborations

Juan Francisco Giménez-Abián 2 collaborations

Juan Estévez-Gallego 2 collaborations

Katja Bargsten 2 collaborations

Cristina Ulivieri 2 collaborations

Sandra Gemma 2 collaborations

Tuhina Khan 2 collaborations

J Fernando Diaz 2 collaborations

Stefania Magnano 2 collaborations

Ola Ibrahim 2 collaborations

Stefania Butini 2 collaborations

Giuseppe Campiani 2 collaborations

Lucia Altucci 2 collaborations

Simone Brogi 2 collaborations

Ruth Matesanz 2 collaborations

María A Oliva 2 collaborations

Yuntao Ma 2 collaborations

Shuo Li 2 collaborations

Maria A Oliva 2 collaborations

Wei-Shuo Fang 2 collaborations

Bryce Keenan 1 collaboration

Rocio K Finol-Urdaneta 1 collaboration

Ashleigh Hope 1 collaboration

John B Bremner 1 collaboration

Maria Kavallaris 1 collaboration

Jose Fernando Díaz 1 collaboration

Kara L Vine 1 collaboration

Christian P Bold 1 collaboration

Cindy Klaus 1 collaboration

Rafael Lombardi 1 collaboration

Melanie Gut 1 collaboration

Jürg Gertsch 1 collaboration

Nathália Moreno Cury 1 collaboration

Angelo Brunelli Albertoni Laranjeira 1 collaboration

Rafael Renatino Canevarolo 1 collaboration

Priscila Pini Zenatti 1 collaboration

Chunhua Song 1 collaboration

Dongxiao Sun 1 collaboration

Sinisa Dovat 1 collaboration

Rosendo Augusto Yunes 1 collaboration

Andrea Enrico Prota 1 collaboration

Michel Olivier Steinmetz 1 collaboration

José Andrés Yunes 1 collaboration

Noelia Hernández-Ortiz 1 collaboration

Pedro A Sánchez-Murcia 1 collaboration

Celia Gil-Campillo 1 collaboration

Mirian Domenech 1 collaboration

Sonsoles Velázquez 1 collaboration

María José Camarasa 1 collaboration

Noemí Bustamante 1 collaboration

Sonia de Castro 1 collaboration

Margarita Menéndez 1 collaboration

Toms Kalnins 1 collaboration

Viktorija Vitkovska 1 collaboration

Mihail Kazak 1 collaboration

Diana Zelencova-Gopejenko 1 collaboration

Melita Ozola 1 collaboration

Nauris Narvaiss 1 collaboration

Marina Makrecka-Kuka 1 collaboration

Ilona Domračeva 1 collaboration

Artis Kinens 1 collaboration

Baiba Gukalova 1 collaboration

Nele Konrad 1 collaboration

Riina Aav 1 collaboration

Edgars Liepinsh 1 collaboration

Edgars Suna 1 collaboration

Lauralie Peronne 1 collaboration

Eric Denarier 1 collaboration

Ankit Rai 1 collaboration

Renaud Prudent 1 collaboration

Audrey Vernet 1 collaboration

Peggy Suzanne 1 collaboration

Sacnicté Ramirez-Rios 1 collaboration

Sophie Michallet 1 collaboration

Mélanie Guidetti 1 collaboration

Julien Vollaire 1 collaboration

Anne-Sophie Ribba 1 collaboration

Véronique Josserand 1 collaboration

Jean-Luc Coll 1 collaboration

Patrick Dallemagne 1 collaboration

Karin Sadoul 1 collaboration

Anna Akhmanova 1 collaboration

Annie Andrieux 1 collaboration

Laurence Lafanechère 1 collaboration

Walter D Guerra 1 collaboration

Roberto A Rossi 1 collaboration

José M Padrón 1 collaboration

Silvia M Barolo 1 collaboration

Carlota Tosat-Bitrián 1 collaboration

Lucía Barrado-Gil 1 collaboration

Inmaculada Galindo 1 collaboration

Urtzi Garaigorta 1 collaboration

Rebeca París-Ogáyar 1 collaboration

Isabel García-Dorival 1 collaboration

Jesús Urquiza 1 collaboration

Pablo Gastaminza 1 collaboration

Valle Palomo 1 collaboration

Covadonga Alonso 1 collaboration

Benet Pera 1 collaboration

Christoph Wullschleger 1 collaboration

Olivier Raes 1 collaboration

Dirk Menche 1 collaboration

Juan Carlos Martínez 1 collaboration

Jelle Cornelus 1 collaboration

Peter Northcote 1 collaboration

Ian Paterson 1 collaboration

Johan Van der Eycken 1 collaboration

Margherita Brindisi 1 collaboration

Gloria Alfano 1 collaboration

Francisco de Asís Balaguer 1 collaboration

Alessandro Grillo 1 collaboration

Giulia Chemi 1 collaboration

Grégory Menchon 1 collaboration

Natacha Olieric 1 collaboration

Angela Nebbioso 1 collaboration

Mariarosaria Conte 1 collaboration

Ludovica Lopresti 1 collaboration

Rebecca Amet 1 collaboration

Paula Kinsella 1 collaboration

Daniela M Zisterer 1 collaboration

Jeff O'Sullivan 1 collaboration

Lucia Morbidelli 1 collaboration

Roberta Spaccapelo 1 collaboration

Cosima Baldari 1 collaboration

Ettore Novellino 1 collaboration

Susan Matthew 1 collaboration

Qi-Yin Chen 1 collaboration

Ranjala Ratnayake 1 collaboration

Charles S Fermaintt 1 collaboration

Seok Ting Lim 1 collaboration

Xiaomeng Wang 1 collaboration

April L Risinger 1 collaboration

Valerie J Paul 1 collaboration

Maria Ángela Oliva 1 collaboration

Hendrik Luesch 1 collaboration

María José Guillén 1 collaboration

Pablo Avilés 1 collaboration

Marta Martínez-Díez 1 collaboration

Gema Santamaría-Núñez 1 collaboration

Julia Contreras 1 collaboration

Iván Plaza-Menacho 1 collaboration

Juan F Giménez-Abián 1 collaboration

Carmen Cuevas 1 collaboration

Juan Estevez-Gallego 1 collaboration

Natacha Gaillard 1 collaboration

Tobias M Brütsch 1 collaboration

Etienne Cotter 1 collaboration

Mariano Redondo-Horcajo 1 collaboration

Carolina Davies 1 collaboration

Sandro Pagani 1 collaboration

Simone Berardozzi 1 collaboration

John H Miller 1 collaboration

Harrisson D A Santos 1 collaboration

Irene Zabala Gutiérrez 1 collaboration

Yingli Shen 1 collaboration

José Lifante 1 collaboration

Erving Ximendes 1 collaboration

Marco Laurenti 1 collaboration

Diego Méndez-González 1 collaboration

Sonia Melle 1 collaboration

Oscar G Calderón 1 collaboration

Enrique López Cabarcos 1 collaboration

Nuria Fernández 1 collaboration

Irene Chaves-Coira 1 collaboration

Luis Monge 1 collaboration

Mark D Mackenzie 1 collaboration

José Marqués-Hueso 1 collaboration

Callum M S Jones 1 collaboration

Carlos Jacinto 1 collaboration

Blanca Del Rosal 1 collaboration

Ajoy K Kar 1 collaboration

Jorge Rubio-Retama 1 collaboration

Daniel Jaque 1 collaboration

Siou Ku 1 collaboration

Ruben M Buey 1 collaboration

Francisco A Balaguer 1 collaboration

Christina Kamma-Lorger 1 collaboration

Toshiki Yagi 1 collaboration

Hiroyuki Iwamoto 1 collaboration

Laurence Duchesne 1 collaboration

Denis Chrétien 1 collaboration

Leopoldo Staiano 1 collaboration

Chiara Papulino 1 collaboration

Seema Nathwani 1 collaboration

Anna Ramunno 1 collaboration

Nicola Relitti 1 collaboration

Stefano Federico 1 collaboration

Luca Pozzetti 1 collaboration

Gabriele Carullo 1 collaboration

Alice Casagni 1 collaboration

Francesca Vanni 1 collaboration

Paola Galatello 1 collaboration

Magda Ghanim 1 collaboration

Niamh McCabe 1 collaboration

Stefania Lamponi 1 collaboration

Massimo Valoti 1 collaboration

Jeffrey O'Sullivan 1 collaboration

Richard Turkington 1 collaboration

Vincent P Kelly 1 collaboration

Ruben VanWemmel 1 collaboration

Daniela Zisterer 1 collaboration

Antonella De Matteis 1 collaboration

Rosaria Benedetti 1 collaboration

Faezeh Nemati 1 collaboration

Iris Bischoff-Kont 1 collaboration

Peyman Salehi 1 collaboration

Samad Nejad-Ebrahimi 1 collaboration

Maryam Mohebbi 1 collaboration

Morteza Bararjanian 1 collaboration

Nasim Hadian 1 collaboration

Zahra Hassanpour 1 collaboration

Yvonne Jung 1 collaboration

Sofie Schaerlaekens 1 collaboration

Robert Fürst 1 collaboration

Hamid R Nasiri 1 collaboration

Jacob Nathaniel Essif 1 collaboration

Shuqi Liu 1 collaboration

Peter Yw Chan 1 collaboration

Kenneth Goossens 1 collaboration

Yingjie Wang 1 collaboration

Hongbo Wang 1 collaboration

April Risinger 1 collaboration