Claude M Wischik

Affiliations

Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZP, UK.
Genting TauRx Diagnostic Centre Sdn. Bhd., Aberdeen AB24 5RP, UK.
TauRx Therapeutics Ltd., Aberdeen AB24 5RP, UK.

Publications (38)

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer's Disease.

International journal of molecular sciences

Avec: Mohammad Arastoo , Richard Lofthouse , Lewis K Penny , Charles R Harrington , Andy Porter , Claude M Wischik , Soumya Palliyil

Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.

Cellular signalling

Avec: Karima Schwab , Zoi Chasapopoulou , Silke Frahm , Mandy Magbagbeolu , Anna Cranston , Charles R Harrington , Claude M Wischik , Franz Theuring , Gernot Riedel

Solubility of α-synuclein species in the L62 mouse model of synucleinopathy.

Scientific reports

Avec: Karima Schwab , Mandy Magbagbeolu , Franz Theuring , Charles R Harrington , Claude M Wischik , Gernot Riedel

Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model.

Current Alzheimer research

Avec: Gernot Riedel , Jochen Klein , Grazyna Niewiadomska , Constantin Kondak , Karima Schwab , Dilyara Lauer , Mandy Magbagbeolu , Marta Steczkowska , Maciej Zadrozny , Malgorzata Wydrych , Anna Cranston , Valeria Melis , Renato X Santos , Franz Theuring , Charles R Harrington , Claude M Wischik

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration.

Brain communications

Avec: Anna L Cranston , Adrianna Wysocka , Marta Steczkowska , Maciej Zadrożny , Ewelina Palasz , Charles R Harrington , Franz Theuring , Claude M Wischik , Gernot Riedel , Grazyna Niewiadomska

Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants.

International journal of molecular sciences

Avec: Mohammad Arastoo , Michael P Mazanetz , Sonya Miller , Helen Shiells , Claire Hull , Keith Robinson , John M D Storey , Charles R Harrington , Claude M Wischik

Assays for the Screening and Characterization of Tau Aggregation Inhibitors.

Methods in molecular biology (Clifton, N.J.)

Avec: David Horsley , Janet E Rickard , Thomas Vorley , Matilda F Leeper , Claude M Wischik , Charles R Harrington

Rescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine.

Cellular signalling

Avec: Anna L Cranston , Igor Kraev , Mike G Stewart , David Horsley , Lianne Robinson , Eline Dreesen , Paul Armstrong , Soumya Palliyil , Charles R Harrington , Claude M Wischik , Gernot Riedel

High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer's disease.

Alzheimer's research & therapy

Avec: Mohammad Arastoo , Lewis K Penny , Richard Lofthouse , Aya Abdallah , Anna Abrahamsson , Pietro Marini , Valeria Melis , Gernot Riedel , Charles R Harrington , Claude M Wischik , Andrew Porter , Soumya Palliyil

Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia.

The Journal of biological chemistry

Avec: Nora Lemke , Valeria Melis , Dilyara Lauer , Mandy Magbagbeolu , Boris Neumann , Charles R Harrington , Gernot Riedel , Claude M Wischik , Franz Theuring , Karima Schwab

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain.

FEBS letters

Avec: Youssra K Al-Hilaly , Bronwen E Foster , Luca Biasetti , Liisa Lutter , Saskia J Pollack , Janet E Rickard , John M D Storey , Charles R Harrington , Wei-Feng Xue , Claude M Wischik , Louise C Serpell

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.

Journal of Alzheimer's disease : JAD

Avec: Helen Shiells , Bjoern O Schelter , Peter Bentham , Thomas C Baddeley , Christopher M Rubino , Harish Ganesan , Jeffrey Hammel , Vesna Vuksanovic , Roger T Staff , Alison D Murray , Luc Bracoud , Damon J Wischik , Gernot Riedel , Serge Gauthier , Jianping Jia , Hans J Moebius , Jiri Hardlund , Christopher M Kipps , Karin Kook , John M D Storey , Charles R Harrington , Claude M Wischik

Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia.

Brain communications

Avec: Vesna Vuksanović , Roger T Staff , Suzannah Morson , Trevor Ahearn , Luc Bracoud , Alison D Murray , Peter Bentham , Christopher M Kipps , Charles R Harrington , Claude M Wischik

Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis.

Journal of molecular biology

Avec: Liisa Lutter , Youssra K Al-Hilaly , Christopher J Serpell , Mick F Tuite , Claude M Wischik , Louise C Serpell , Wei-Feng Xue

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease.

Translational neurodegeneration

Avec: Lewis K Penny , Richard Lofthouse , Mohammad Arastoo , Andy Porter , Soumya Palliyil , Charles R Harrington , Claude M Wischik

An Additive-Free Model for Tau Self-Assembly.

Methods in molecular biology (Clifton, N.J.)

Avec: Youssra K Al-Hilaly , Karen E Marshall , Liisa Lutter , Luca Biasetti , Kurtis Mengham , Charles R Harrington , Wei-Feng Xue , Claude M Wischik , Louise C Serpell

Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice.

International journal of molecular sciences

Avec: Constantin Kondak , Michael Leith , Thomas C Baddeley , Renato X Santos , Charles R Harrington , Claude M Wischik , Gernot Riedel , Jochen Klein

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.

Cells

Avec: Maciej Zadrozny , Patrycja Drapich , Anna Gasiorowska-Bien , Wiktor Niewiadomski , Charles R Harrington , Claude M Wischik , Gernot Riedel , Grazyna Niewiadomska

Paired Helical Filament-Forming Region of Tau (297-391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells.

Journal of molecular biology

Avec: Saskia J Pollack , Jasmine Trigg , Tahmida Khanom , Luca Biasetti , Karen E Marshall , Youssra K Al-Hilaly , Janet E Rickard , Charles R Harrington , Claude M Wischik , Louise C Serpell

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Avec: Bjoern O Schelter , Helen Shiells , Thomas C Baddeley , Christopher M Rubino , Harish Ganesan , Jeffrey Hammel , Vesna Vuksanovic , Roger T Staff , Alison D Murray , Luc Bracoud , Gernot Riedel , Serge Gauthier , Jianping Jia , Peter Bentham , Karin Kook , John M D Storey , Charles R Harrington , Claude M Wischik

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62).

ACS chemical neuroscience

Avec: Magdalena König , Beata Berlin , Karima Schwab , Silke Frahm , Franz Theuring , Claude M Wischik , Charles R Harrington , Gernot Riedel , Jochen Klein

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.

Frontiers in neurology

Avec: Sebastian S Oakley , Mahmoud B Maina , Karen E Marshall , Youssra K Al-Hilaly , Charlie R Harrington , Claude M Wischik , Louise C Serpell

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates.

Cells

Avec: Mahmoud B Maina , Youssra K Al-Hilaly , Gunasekhar Burra , Janet E Rickard , Charles R Harrington , Claude M Wischik , Louise C Serpell

Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier.

Journal of Alzheimer's disease : JAD

Avec: Peter Bentham , Roger T Staff , Bjoern O Schelter , Helen Shiells , Charles R Harrington , Claude M Wischik

Crossed cerebellar diaschisis in Alzheimer's disease.

Nuclear medicine communications

Avec: Shailendra Mohan Tripathi , Alison D Murray , Claude M Wischik , Bjoern Schelter

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis.

Cells

Avec: Alex Zabala-Findlay , Lewis K Penny , Richard A Lofthouse , Andrew J Porter , Soumya Palliyil , Charles R Harrington , Claude M Wischik , Mohammad Arastoo

LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy.

European journal of pharmacology

Avec: Karima Schwab , Silke Frahm , Mandy Magbagbeolu , David Horsley , Elizabeth A Goatman , Valeria Melis , Franz Theuring , Ahtsham Ishaq , John M D Storey , Charles R Harrington , Claude M Wischik , Gernot Riedel

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study.

Journal of Alzheimer's disease : JAD

Avec: Paola Flores-Rodríguez , Charles R Harrington , Claude M Wischik , Vanessa Ibarra-Bracamontes , Natanael Zarco , Araceli Navarrete , Alejandra Martínez-Maldonado , Parménides Guadarrama-Ortíz , Ignacio Villanueva-Fierro , Miguel Angel Ontiveros-Torres , George Perry , Alejandra D Alonso , Benjamin Floran-Garduño , José Segovia , José Luna-Muñoz

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer's Disease and Behavioral Variant Fronto-Temporal Dementia.

International journal of neural systems

Avec: Vesna Vuksanović , Roger T Staff , Trevor Ahearn , Alison D Murray , Claude M Wischik

Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Avec: Mario Hernandes-Alejandro , Sarita Montaño , Charles R Harrington , Claude M Wischik , Andrés Salas-Casas , Pedro Cortes-Reynosa , Eduardo Pérez Salazar , Javier Cazares-Apatiga , Ricardo Apatiga-Perez , Miguel Ángel Ontiveros Torres , George Perry , Mar Pacheco-Herrero , José Luna-Muñoz

Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.

Journal of neurochemistry

Avec: Constantin Kondak , Gernot Riedel , Charles R Harrington , Claude M Wischik , Jochen Klein

Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks.

Cells

Avec: Karima Schwab , Valeria Melis , Charles R Harrington , Claude M Wischik , Mandy Magbagbeolu , Franz Theuring , Gernot Riedel

HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.

Biomedicines

Avec: Renato X Santos , Valeria Melis , Elizabeth A Goatman , Michael Leith , Thomas C Baddeley , John M D Storey , Gernot Riedel , Claude M Wischik , Charles R Harrington

A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Avec: Anne Anschuetz , Karima Schwab , Charles R Harrington , Claude M Wischik , Gernot Riedel

Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors.

Brain research bulletin

Avec: Karima Schwab , Dilyara Lauer , Mandy Magbagbeolu , Franz Theuring , Anna Gasiorowska , Maciej Zadrozny , Charles R Harrington , Claude M Wischik , Grażyna Niewiadomska , Gernot Riedel

Oral Tau Aggregation Inhibitor for Alzheimer's Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate.

The journal of prevention of Alzheimer's disease

Avec: C M Wischik , P Bentham , S Gauthier , S Miller , K Kook , B O Schelter

Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro.

Journal of molecular biology

Avec: Mahmoud B Maina , Youssra K Al-Hilaly , Sebastian Oakley , Gunasekhar Burra , Tahmida Khanom , Luca Biasetti , Kurtis Mengham , Karen Marshall , Charles R Harrington , Claude M Wischik , Louise C Serpell

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391).

Frontiers in neuroscience

Avec: Youssra K Al-Hilaly , Connor Hurt , Janet E Rickard , Charles R Harrington , John M D Storey , Claude M Wischik , Louise C Serpell , Ansgar B Siemer

Réseau de co-auteurs

Charles R Harrington 33 collaborations

Gernot Riedel 18 collaborations

Karima Schwab 9 collaborations

Franz Theuring 9 collaborations

Youssra K Al-Hilaly 8 collaborations

Louise C Serpell 8 collaborations

Mandy Magbagbeolu 7 collaborations

John M D Storey 7 collaborations

Valeria Melis 6 collaborations

Mohammad Arastoo 5 collaborations

Soumya Palliyil 5 collaborations

Janet E Rickard 5 collaborations

Roger T Staff 5 collaborations

Alison D Murray 5 collaborations

Lewis K Penny 4 collaborations

Jochen Klein 4 collaborations

Helen Shiells 4 collaborations

Luca Biasetti 4 collaborations

Peter Bentham 4 collaborations

Thomas C Baddeley 4 collaborations

Richard Lofthouse 3 collaborations

Silke Frahm 3 collaborations

Grazyna Niewiadomska 3 collaborations

Constantin Kondak 3 collaborations

Dilyara Lauer 3 collaborations

Maciej Zadrozny 3 collaborations

Renato X Santos 3 collaborations

David Horsley 3 collaborations

Liisa Lutter 3 collaborations

Wei-Feng Xue 3 collaborations

Bjoern O Schelter 3 collaborations

Luc Bracoud 3 collaborations

Karen E Marshall 3 collaborations

Mahmoud B Maina 3 collaborations

Andy Porter 2 collaborations

Anna Cranston 2 collaborations

Marta Steczkowska 2 collaborations

Anna L Cranston 2 collaborations

Saskia J Pollack 2 collaborations

Christopher M Rubino 2 collaborations

Harish Ganesan 2 collaborations

Jeffrey Hammel 2 collaborations

Vesna Vuksanovic 2 collaborations

Serge Gauthier 2 collaborations

Jianping Jia 2 collaborations

Christopher M Kipps 2 collaborations

Karin Kook 2 collaborations

Vesna Vuksanović 2 collaborations

Trevor Ahearn 2 collaborations

Kurtis Mengham 2 collaborations

Michael Leith 2 collaborations

Tahmida Khanom 2 collaborations

Gunasekhar Burra 2 collaborations

Elizabeth A Goatman 2 collaborations

George Perry 2 collaborations

José Luna-Muñoz 2 collaborations

Zoi Chasapopoulou 1 collaboration

Malgorzata Wydrych 1 collaboration

Adrianna Wysocka 1 collaboration

Maciej Zadrożny 1 collaboration

Ewelina Palasz 1 collaboration

Michael P Mazanetz 1 collaboration

Sonya Miller 1 collaboration

Claire Hull 1 collaboration

Keith Robinson 1 collaboration

Thomas Vorley 1 collaboration

Matilda F Leeper 1 collaboration

Igor Kraev 1 collaboration

Mike G Stewart 1 collaboration

Lianne Robinson 1 collaboration

Eline Dreesen 1 collaboration

Paul Armstrong 1 collaboration

Aya Abdallah 1 collaboration

Anna Abrahamsson 1 collaboration

Pietro Marini 1 collaboration

Andrew Porter 1 collaboration

Nora Lemke 1 collaboration

Boris Neumann 1 collaboration

Bronwen E Foster 1 collaboration

Damon J Wischik 1 collaboration

Hans J Moebius 1 collaboration

Jiri Hardlund 1 collaboration

Suzannah Morson 1 collaboration

Christopher J Serpell 1 collaboration

Mick F Tuite 1 collaboration

Patrycja Drapich 1 collaboration

Anna Gasiorowska-Bien 1 collaboration

Wiktor Niewiadomski 1 collaboration

Jasmine Trigg 1 collaboration

Magdalena König 1 collaboration

Beata Berlin 1 collaboration

Sebastian S Oakley 1 collaboration

Charlie R Harrington 1 collaboration

Shailendra Mohan Tripathi 1 collaboration

Bjoern Schelter 1 collaboration

Alex Zabala-Findlay 1 collaboration

Richard A Lofthouse 1 collaboration

Andrew J Porter 1 collaboration

Ahtsham Ishaq 1 collaboration

Paola Flores-Rodríguez 1 collaboration

Vanessa Ibarra-Bracamontes 1 collaboration

Natanael Zarco 1 collaboration

Araceli Navarrete 1 collaboration

Alejandra Martínez-Maldonado 1 collaboration

Parménides Guadarrama-Ortíz 1 collaboration

Ignacio Villanueva-Fierro 1 collaboration

Miguel Angel Ontiveros-Torres 1 collaboration

Alejandra D Alonso 1 collaboration

Benjamin Floran-Garduño 1 collaboration

José Segovia 1 collaboration

Mario Hernandes-Alejandro 1 collaboration

Sarita Montaño 1 collaboration

Andrés Salas-Casas 1 collaboration

Pedro Cortes-Reynosa 1 collaboration

Eduardo Pérez Salazar 1 collaboration

Javier Cazares-Apatiga 1 collaboration

Ricardo Apatiga-Perez 1 collaboration

Miguel Ángel Ontiveros Torres 1 collaboration

Mar Pacheco-Herrero 1 collaboration

Anne Anschuetz 1 collaboration

Anna Gasiorowska 1 collaboration

Grażyna Niewiadomska 1 collaboration

C M Wischik 1 collaboration

P Bentham 1 collaboration

S Gauthier 1 collaboration

S Miller 1 collaboration

K Kook 1 collaboration

B O Schelter 1 collaboration

Sebastian Oakley 1 collaboration

Karen Marshall 1 collaboration

Connor Hurt 1 collaboration

Ansgar B Siemer 1 collaboration