Caroline Ospelt

Affiliations

Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland. Electronic address: caroline.ospelt@usz.ch.

Publications (25)

Individual functions of the histone acetyl transferases CBP and p300 in regulating the inflammatory response of synovial fibroblasts.

Journal of autoimmunity

Avec: Monika Krošel , Marcel Gabathuler , Malgorzata Maciukiewicz , Larissa Moser , Gideon Isaac Lee , Miriam Marks , Matija Tomšič , Oliver Distler , Caroline Ospelt , Kerstin Klein

Obesity Represents a Persisting Health Issue in Axial Spondyloarthritis, Particularly Affecting Socially Disadvantaged Patients.

The Journal of rheumatology

Avec: Raphael Micheroli , Sangeeta Bhatia , Enriqueta Vallejo-Yagüe , Andrea Michelle Burden , Burkhard Möller , Michael J Nissen , Diego Kyburz , Seraphina Kissling , Oliver Distler , Caroline Ospelt , Adrian Ciurea

Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts.

Cells

Avec: Monika Krošel , Larissa Moser , Miranda Houtman , Jasna Friščić , Matija Tomšič , Oliver Distler , Markus H Hoffmann , Caroline Ospelt , Kerstin Klein

The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis.

Nature communications

Avec: Muriel Elhai , Raphael Micheroli , Miranda Houtman , Masoumeh Mirrahimi , Larissa Moser , Chantal Pauli , Kristina Bürki , Andrea Laimbacher , Gabriela Kania , Kerstin Klein , Philipp Schätzle , Mojca Frank Bertoncelj , Sam G Edalat , Leandra Keusch , Alexandra Khmelevskaya , Melpomeni Toitou , Celina Geiss , Thomas Rauer , Maria Sakkou , George Kollias , Marietta Armaka , Oliver Distler , Caroline Ospelt

Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Jasna Friščić , Christiane Reinwald , Martin Böttcher , Miranda Houtman , Maximilien Euler , Xi Chen , Kellie I Walker , Philipp Kirchner , Honglin Zhu , Benjamin Wirth , Daniela Weidner , René Krüger , Vladimir Trajkovic , Arif B Ekici , Kerstin Klein , Dimitrios Mougiakakos , Caroline Ospelt , Georg Schett , Markus H Hoffmann

Explainable deep learning for disease activity prediction in chronic inflammatory joint diseases.

PLOS digital health

Avec: Cécile Trottet , Ahmed Allam , Aron N Horvath , Axel Finckh , Thomas Hügle , Sabine Adler , Diego Kyburz , Raphael Micheroli , Michael Krauthammer , Caroline Ospelt

Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts.

Annals of the rheumatic diseases

Avec: Meng Sun , Bence Rethi , Akilan Krishnamurthy , Vijay Joshua , Alexandra Circiumaru , Aase Haj Hensvold , Elena Ossipova , Caroline Grönwall , Yanying Liu , Marianne Engstrom , Sergiu Bogdan Catrina , Johanna Steen , Vivianne Malmstrom , Lars Klareskog , Camilla Svensson , Caroline Ospelt , Heidi Wähämaa , Anca Irinel Catrina

TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies.

Cardiovascular research

Avec: Alexander Akhmedov , Margot Crucet , Branko Simic , Simon Kraler , Nicole R Bonetti , Caroline Ospelt , Oliver Distler , Adrian Ciurea , Luca Liberale , Matti Jauhiainen , Jari Metso , Melroy Miranda , Rose Cydecian , Lena Schwarz , Vera Fehr , Rita Zilinyi , Mohammad Amrollahi-Sharifabadi , Lydia Ntari , Niki Karagianni , Frank Ruschitzka , Reijo Laaksonen , Paul M Vanhoutte , George Kollias , Giovanni G Camici , Thomas F Lüscher

Role of synovial fibroblast subsets across synovial pathotypes in rheumatoid arthritis: a deconvolution analysis.

RMD open

Avec: Raphael Micheroli , Muriel Elhai , Sam Edalat , Mojca Frank-Bertoncelj , Kristina Bürki , Adrian Ciurea , Lucy MacDonald , Mariola Kurowska-Stolarska , Myles J Lewis , Katriona Goldmann , Cankut Cubuk , Tadeja Kuret , Oliver Distler , Costantino Pitzalis , Caroline Ospelt

BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts.

Biomedicines

Avec: Tanja Seifritz , Matthias Brunner , Eva Camarillo Retamosa , Malgorzata Maciukiewicz , Monika Krošel , Larissa Moser , Thomas Züllig , Matija Tomšič , Oliver Distler , Caroline Ospelt , Kerstin Klein

A brief history of epigenetics.

Immunology letters

Avec: Caroline Ospelt

Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start.

Arthritis research & therapy

Avec: Adrian Ciurea , Oliver Distler , Kenneth Kwok , Hyejin Jo , Lisy Wang , Tim Killeen , Caroline Ospelt , Mojca Frank Bertoncelj

Molecular Characterization of Human Lymph Node Stromal Cells During the Earliest Phases of Rheumatoid Arthritis.

Frontiers in immunology

Avec: Emmanuel Karouzakis , Janine Hähnlein , Cristoforo Grasso , Johanna F Semmelink , Paul P Tak , Danielle M Gerlag , Steffen Gay , Caroline Ospelt , Lisa G M van Baarsen

Location, location, location: how the tissue microenvironment affects inflammation in RA.

Nature reviews. Rheumatology

Avec: Christopher D Buckley , Caroline Ospelt , Steffen Gay , Kim S Midwood

Site-specific assessment of spinal radiographic progression improves detection of TNF blocker-associated disease modification in axial spondyloarthritis: longitudinal observational data from the Swiss Clinical Quality Management Registry.

Arthritis research & therapy

Avec: Vjara Popova , Seraphina Kissling , Raphael Micheroli , René Bräm , Manouk de Hooge , Xenofon Baraliakos , Michael J Nissen , Burkhard Möller , Pascale Exer , Michael Andor , Oliver Distler , Almut Scherer , Caroline Ospelt , Adrian Ciurea

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

Scientific reports

Avec: Monika Krošel , Marcel Gabathuler , Larissa Moser , Malgorzata Maciukiewicz , Thomas Züllig , Tanja Seifritz , Matija Tomšič , Oliver Distler , Caroline Ospelt , Kerstin Klein

Molecular maps of synovial cells in inflammatory arthritis using an optimized synovial tissue dissociation protocol.

iScience

Avec: Sam G Edalat , Reto Gerber , Miranda Houtman , Janine Lückgen , Rui Lourenço Teixeira , Maria Del Pilar Palacios Cisneros , Tamara Pfanner , Tadeja Kuret , Nadja Ižanc , Raphael Micheroli , Joaquim Polido-Pereira , Fernando Saraiva , Swathi Lingam , Kristina Burki , Blaž Burja , Chantal Pauli , Žiga Rotar , Matija Tomšič , Saša Čučnik , João Eurico Fonseca , Oliver Distler , Ângelo Calado , Vasco C Romão , Caroline Ospelt , Snežna Sodin-Semrl , Mark D Robinson , Mojca Frank Bertoncelj

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.

Genome biology

Avec: Xiangyu Ge , Mojca Frank-Bertoncelj , Kerstin Klein , Amanda McGovern , Tadeja Kuret , Miranda Houtman , Blaž Burja , Raphael Micheroli , Chenfu Shi , Miriam Marks , Andrew Filer , Christopher D Buckley , Gisela Orozco , Oliver Distler , Andrew P Morris , Paul Martin , Stephen Eyre , Caroline Ospelt

Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells.

Nucleic acids research

Avec: Octavio Morante-Palacios , Laura Ciudad , Raphael Micheroli , Carlos de la Calle-Fabregat , Tianlu Li , Gisela Barbisan , Miranda Houtman , Sam G Edalat , Mojca Frank-Bertoncelj , Caroline Ospelt , Esteban Ballestar

Epigenetics, pregnancy and autoimmune rheumatic diseases.

Autoimmunity reviews

Avec: Greta Pacini , Sabrina Paolino , Laura Andreoli , Angela Tincani , Maria Gerosa , Roberto Caporali , Annamaria Iagnocco , Caroline Ospelt , Vanessa Smith , Maurizio Cutolo

Gender equity in academic rheumatology, current status and potential for improvement: a cross-sectional study to inform an EULAR task force.

RMD open

Avec: Pavel V Ovseiko , Laure Gossec , Laura Andreoli , Uta Kiltz , Leonieke van Mens , Neelam Hassan , Marike van der Leeden , Heidi J Siddle , Alessia Alunno , Iain B McInnes , Nemanja S Damjanov , Florence Apparailly , Caroline Ospelt , Irene E van der Horst-Bruinsma , Elena Nikiphorou , Katie L Druce , Zoltán Szekanecz , Alexandre Sepriano , Tadej Avcin , George Bertsias , Georg Schett , Anne-Maree Keenan , Linda H Pololi , Laura C Coates

IL-6 Signaling Attenuates TNF-α Production by Plasmacytoid Dendritic Cells in Rheumatoid Arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Garyfalia Papadaki , Panagiota Goutakoli , Ioanna Tiniakou , Joachim R Grün , Andreas Grützkau , Georgios A Pavlopoulos , Ioannis Iliopoulos , George Bertsias , Dimitrios Boumpas , Caroline Ospelt , Boris Reizis , Prodromos Sidiropoulos , Panayotis Verginis

Protein atlas of fibroblast specific protein 1 (FSP1)/S100A4.

Histology and histopathology

Avec: Bettina Marturet Fendt , Astrid Hirschmann , Malgorzata Bruns , Eva Camarillo-Retamosa , Caroline Ospelt , Alexander Vogetseder

Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2023.

Annals of the rheumatic diseases

Avec: Kevin L Winthrop , Philip Mease , Andreas Kerschbaumer , Reinhard E Voll , Ferdinand C Breedveld , Josef S Smolen , Jacques-Eric Gottenberg , Xenofon Baraliakos , Hans P Kiener , Daniel Aletaha , John D Isaacs , Maya H Buch , Mary K Crow , Jonathan Kay , Leslie Crofford , Ronald F van Vollenhoven , Caroline Ospelt , Stefan Siebert , Margreet Kloppenburg , Iain B McInnes , Tom Wj Huizinga , Ellen M Gravallese

Site of invasion revisited: epigenetic drivers of joint destruction in RA.

Annals of the rheumatic diseases

Avec: Caroline Ospelt

Réseau de co-auteurs

Oliver Distler 12 collaborations

Raphael Micheroli 8 collaborations

Kerstin Klein 7 collaborations

Miranda Houtman 6 collaborations

Larissa Moser 5 collaborations

Matija Tomšič 5 collaborations

Adrian Ciurea 5 collaborations

Monika Krošel 4 collaborations

Malgorzata Maciukiewicz 3 collaborations

Mojca Frank Bertoncelj 3 collaborations

Sam G Edalat 3 collaborations

Mojca Frank-Bertoncelj 3 collaborations

Tadeja Kuret 3 collaborations

Marcel Gabathuler 2 collaborations

Miriam Marks 2 collaborations

Burkhard Möller 2 collaborations

Michael J Nissen 2 collaborations

Diego Kyburz 2 collaborations

Seraphina Kissling 2 collaborations

Jasna Friščić 2 collaborations

Markus H Hoffmann 2 collaborations

Muriel Elhai 2 collaborations

Chantal Pauli 2 collaborations

Kristina Bürki 2 collaborations

George Kollias 2 collaborations

Georg Schett 2 collaborations

Tanja Seifritz 2 collaborations

Thomas Züllig 2 collaborations

Steffen Gay 2 collaborations

Christopher D Buckley 2 collaborations

Xenofon Baraliakos 2 collaborations

Blaž Burja 2 collaborations

Laura Andreoli 2 collaborations

Iain B McInnes 2 collaborations

George Bertsias 2 collaborations

Gideon Isaac Lee 1 collaboration

Sangeeta Bhatia 1 collaboration

Enriqueta Vallejo-Yagüe 1 collaboration

Andrea Michelle Burden 1 collaboration

Masoumeh Mirrahimi 1 collaboration

Andrea Laimbacher 1 collaboration

Gabriela Kania 1 collaboration

Philipp Schätzle 1 collaboration

Leandra Keusch 1 collaboration

Alexandra Khmelevskaya 1 collaboration

Melpomeni Toitou 1 collaboration

Celina Geiss 1 collaboration

Thomas Rauer 1 collaboration

Maria Sakkou 1 collaboration

Marietta Armaka 1 collaboration

Christiane Reinwald 1 collaboration

Martin Böttcher 1 collaboration

Maximilien Euler 1 collaboration

Xi Chen 1 collaboration

Kellie I Walker 1 collaboration

Philipp Kirchner 1 collaboration

Honglin Zhu 1 collaboration

Benjamin Wirth 1 collaboration

Daniela Weidner 1 collaboration

René Krüger 1 collaboration

Vladimir Trajkovic 1 collaboration

Arif B Ekici 1 collaboration

Dimitrios Mougiakakos 1 collaboration

Cécile Trottet 1 collaboration

Ahmed Allam 1 collaboration

Aron N Horvath 1 collaboration

Axel Finckh 1 collaboration

Thomas Hügle 1 collaboration

Sabine Adler 1 collaboration

Michael Krauthammer 1 collaboration

Meng Sun 1 collaboration

Bence Rethi 1 collaboration

Akilan Krishnamurthy 1 collaboration

Vijay Joshua 1 collaboration

Alexandra Circiumaru 1 collaboration

Aase Haj Hensvold 1 collaboration

Elena Ossipova 1 collaboration

Caroline Grönwall 1 collaboration

Yanying Liu 1 collaboration

Marianne Engstrom 1 collaboration

Sergiu Bogdan Catrina 1 collaboration

Johanna Steen 1 collaboration

Vivianne Malmstrom 1 collaboration

Lars Klareskog 1 collaboration

Camilla Svensson 1 collaboration

Heidi Wähämaa 1 collaboration

Anca Irinel Catrina 1 collaboration

Alexander Akhmedov 1 collaboration

Margot Crucet 1 collaboration

Branko Simic 1 collaboration

Simon Kraler 1 collaboration

Nicole R Bonetti 1 collaboration

Luca Liberale 1 collaboration

Matti Jauhiainen 1 collaboration

Jari Metso 1 collaboration

Melroy Miranda 1 collaboration

Rose Cydecian 1 collaboration

Lena Schwarz 1 collaboration

Vera Fehr 1 collaboration

Rita Zilinyi 1 collaboration

Mohammad Amrollahi-Sharifabadi 1 collaboration

Lydia Ntari 1 collaboration

Niki Karagianni 1 collaboration

Frank Ruschitzka 1 collaboration

Reijo Laaksonen 1 collaboration

Paul M Vanhoutte 1 collaboration

Giovanni G Camici 1 collaboration

Thomas F Lüscher 1 collaboration

Sam Edalat 1 collaboration

Lucy MacDonald 1 collaboration

Mariola Kurowska-Stolarska 1 collaboration

Myles J Lewis 1 collaboration

Katriona Goldmann 1 collaboration

Cankut Cubuk 1 collaboration

Costantino Pitzalis 1 collaboration

Matthias Brunner 1 collaboration

Eva Camarillo Retamosa 1 collaboration

Kenneth Kwok 1 collaboration

Hyejin Jo 1 collaboration

Lisy Wang 1 collaboration

Tim Killeen 1 collaboration

Emmanuel Karouzakis 1 collaboration

Janine Hähnlein 1 collaboration

Cristoforo Grasso 1 collaboration

Johanna F Semmelink 1 collaboration

Paul P Tak 1 collaboration

Danielle M Gerlag 1 collaboration

Lisa G M van Baarsen 1 collaboration

Kim S Midwood 1 collaboration

Vjara Popova 1 collaboration

René Bräm 1 collaboration

Manouk de Hooge 1 collaboration

Pascale Exer 1 collaboration

Michael Andor 1 collaboration

Almut Scherer 1 collaboration

Reto Gerber 1 collaboration

Janine Lückgen 1 collaboration

Rui Lourenço Teixeira 1 collaboration

Maria Del Pilar Palacios Cisneros 1 collaboration

Tamara Pfanner 1 collaboration

Nadja Ižanc 1 collaboration

Joaquim Polido-Pereira 1 collaboration

Fernando Saraiva 1 collaboration

Swathi Lingam 1 collaboration

Kristina Burki 1 collaboration

Žiga Rotar 1 collaboration

Saša Čučnik 1 collaboration

João Eurico Fonseca 1 collaboration

Ângelo Calado 1 collaboration

Vasco C Romão 1 collaboration

Snežna Sodin-Semrl 1 collaboration

Mark D Robinson 1 collaboration

Xiangyu Ge 1 collaboration

Amanda McGovern 1 collaboration

Chenfu Shi 1 collaboration

Andrew Filer 1 collaboration

Gisela Orozco 1 collaboration

Andrew P Morris 1 collaboration

Paul Martin 1 collaboration

Stephen Eyre 1 collaboration

Octavio Morante-Palacios 1 collaboration

Laura Ciudad 1 collaboration

Carlos de la Calle-Fabregat 1 collaboration

Tianlu Li 1 collaboration

Gisela Barbisan 1 collaboration

Esteban Ballestar 1 collaboration

Greta Pacini 1 collaboration

Sabrina Paolino 1 collaboration

Angela Tincani 1 collaboration

Maria Gerosa 1 collaboration

Roberto Caporali 1 collaboration

Annamaria Iagnocco 1 collaboration

Vanessa Smith 1 collaboration

Maurizio Cutolo 1 collaboration

Pavel V Ovseiko 1 collaboration

Laure Gossec 1 collaboration

Uta Kiltz 1 collaboration

Leonieke van Mens 1 collaboration

Neelam Hassan 1 collaboration

Marike van der Leeden 1 collaboration

Heidi J Siddle 1 collaboration

Alessia Alunno 1 collaboration

Nemanja S Damjanov 1 collaboration

Florence Apparailly 1 collaboration

Irene E van der Horst-Bruinsma 1 collaboration

Elena Nikiphorou 1 collaboration

Katie L Druce 1 collaboration

Zoltán Szekanecz 1 collaboration

Alexandre Sepriano 1 collaboration

Tadej Avcin 1 collaboration

Anne-Maree Keenan 1 collaboration

Linda H Pololi 1 collaboration

Laura C Coates 1 collaboration

Garyfalia Papadaki 1 collaboration

Panagiota Goutakoli 1 collaboration

Ioanna Tiniakou 1 collaboration

Joachim R Grün 1 collaboration

Andreas Grützkau 1 collaboration

Georgios A Pavlopoulos 1 collaboration

Ioannis Iliopoulos 1 collaboration

Dimitrios Boumpas 1 collaboration

Boris Reizis 1 collaboration

Prodromos Sidiropoulos 1 collaboration

Panayotis Verginis 1 collaboration

Bettina Marturet Fendt 1 collaboration

Astrid Hirschmann 1 collaboration

Malgorzata Bruns 1 collaboration

Eva Camarillo-Retamosa 1 collaboration

Alexander Vogetseder 1 collaboration

Kevin L Winthrop 1 collaboration

Philip Mease 1 collaboration

Andreas Kerschbaumer 1 collaboration

Reinhard E Voll 1 collaboration

Ferdinand C Breedveld 1 collaboration

Josef S Smolen 1 collaboration

Jacques-Eric Gottenberg 1 collaboration

Hans P Kiener 1 collaboration

Daniel Aletaha 1 collaboration

John D Isaacs 1 collaboration

Maya H Buch 1 collaboration

Mary K Crow 1 collaboration

Jonathan Kay 1 collaboration

Leslie Crofford 1 collaboration

Ronald F van Vollenhoven 1 collaboration

Stefan Siebert 1 collaboration

Margreet Kloppenburg 1 collaboration

Tom Wj Huizinga 1 collaboration

Ellen M Gravallese 1 collaboration