Alma Seitova

Affiliations

Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.

Publications (16)

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex.

Nucleic acids research

Avec: Danton Ivanochko , Levon Halabelian , Elizabeth Henderson , Pavel Savitsky , Harshika Jain , Edyta Marcon , Shili Duan , Ashley Hutchinson , Alma Seitova , Dalia Barsyte-Lovejoy , Panagis Filippakopoulos , Jack Greenblatt , Evelyne Lima-Fernandes , Cheryl H Arrowsmith

Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern.

JCI insight

Avec: Courtney Voss , Sally Esmail , Xuguang Liu , Michael J Knauer , Suzanne Ackloo , Tomonori Kaneko , Lori Lowes , Peter Stogios , Almagul Seitova , Ashley Hutchinson , Farhad Yusifov , Tatiana Skarina , Elena Evdokimova , Peter Loppnau , Pegah Ghiabi , Taraneh Haijan , Shanshan Zhong , Husam Abdoh , Benjamin D Hedley , Vipin Bhayana , Claudio M Martin , Marat Slessarev , Benjamin Chin-Yee , Douglas D Fraser , Ian Chin-Yee , Shawn Sc Li

Production of Recombinant PRMT Proteins using the Baculovirus Expression Vector System.

Journal of visualized experiments : JoVE

Avec: Ashley Hutchinson , Almagul Seitova

Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.

Journal of medicinal chemistry

Avec: John A Gilleran , Kutub Ashraf , Melvin Delvillar , Tyler Eck , Raheel Fondekar , Edward B Miller , Ashley Hutchinson , Aiping Dong , Alma Seitova , Mariana Laureano De Souza , David Augeri , Levon Halabelian , John Siekierka , David P Rotella , John Gordon , Wayne E Childers , Mark C Grier , Bart L Staker , Jacques Y Roberge , Purnima Bhanot

Human Diacylglycerol Kinase ε N-Terminal Segment Regulates the Phosphatidylinositol Cycle, Controlling the Rate but Not the Acyl Chain Composition of Its Lipid Intermediates.

ACS chemical biology

Avec: José Carlos Bozelli , Jenny Yune , Sukhvershjit S Aulakh , Zihao Cao , Alexia Fernandes , Alma Seitova , Yufeng Tong , Shirley Schreier , Richard M Epand

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.

Structure (London, England : 1993)

Avec: Matthew G Alteen , Justin C Deme , Claudia P Alvarez , Peter Loppnau , Ashley Hutchinson , Alma Seitova , Renu Chandrasekaran , Eduardo Silva Ramos , Christopher Secker , Mona Alqazzaz , Erich E Wanker , Susan M Lea , Cheryl H Arrowsmith , Rachel J Harding

Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies.

Cell reports methods

Avec: Sally Esmail , Michael J Knauer , Husam Abdoh , Courtney Voss , Benjamin Chin-Yee , Peter Stogios , Almagul Seitova , Ashley Hutchinson , Farhad Yusifov , Tatiana Skarina , Elena Evdokimova , Suzanne Ackloo , Lori Lowes , Benjamin D Hedley , Vipin Bhayana , Ian Chin-Yee , Shawn S-C Li

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1.

Communications biology

Avec: Rachel J Harding , Justin C Deme , Johannes F Hevler , Sem Tamara , Alexander Lemak , Jeffrey P Cantle , Magdalena M Szewczyk , Nola Begeja , Siobhan Goss , Xiaobing Zuo , Peter Loppnau , Alma Seitova , Ashley Hutchinson , Lixin Fan , Ray Truant , Matthieu Schapira , Jeffrey B Carroll , Albert J R Heck , Susan M Lea , Cheryl H Arrowsmith

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.

Journal of medicinal chemistry

Avec: Shabbir Ahmad , Jin Xu , Jianwen A Feng , Ashley Hutchinson , Hong Zeng , Pegah Ghiabi , Aiping Dong , Paolo A Centrella , Matthew A Clark , Marie-Aude Guié , John P Guilinger , Anthony D Keefe , Ying Zhang , Thomas Cerruti , John W Cuozzo , Moritz von Rechenberg , Albina Bolotokova , Yanjun Li , Peter Loppnau , Alma Seitova , Yen-Yen Li , Vijayaratnam Santhakumar , Peter J Brown , Suzanne Ackloo , Levon Halabelian

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Majida El Bakkouri , Imène Kouidmi , Amy K Wernimont , Mehrnaz Amani , Ashley Hutchinson , Peter Loppnau , Jeong Joo Kim , Christian Flueck , John R Walker , Alma Seitova , Guillermo Senisterra , Yoshito Kakihara , Choel Kim , Michael J Blackman , Charles Calmettes , David A Baker , Raymond Hui

Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.

The Journal of biological chemistry

Avec: Rachel J Harding , Peter Loppnau , Suzanne Ackloo , Alexander Lemak , Ashley Hutchinson , Brittany Hunt , Alex S Holehouse , Jolene C Ho , Lixin Fan , Leticia Toledo-Sherman , Alma Seitova , Cheryl H Arrowsmith

Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation.

Nature chemical biology

Avec: Bryan J Fraser , Serap Beldar , Almagul Seitova , Ashley Hutchinson , Dhiraj Mannar , Yanjun Li , Daniel Kwon , Ruiyan Tan , Ryan P Wilson , Karoline Leopold , Sriram Subramaniam , Levon Halabelian , Cheryl H Arrowsmith , François Bénard

RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.

Nucleic acids research

Avec: Rehna Krishnan , Mariah Lapierre , Brandon Gautreau , Kevin C J Nixon , Samah El Ghamrasni , Parasvi S Patel , Jun Hao , V Talya Yerlici , Kiran Kumar Naidu Guturi , Jonathan St-Germain , Francesca Mateo , Amine Saad , Arash Algouneh , Rebecca Earnshaw , Duan Shili , Alma Seitova , Joshua Miller , Negin Khosraviani , Adam Penn , Brandon Ho , Otto Sanchez , M Prakash Hande , Jean-Yves Masson , Grant W Brown , Moulay Alaoui-Jamali , John J Reynolds , Cheryl Arrowsmith , Brian Raught , Miguel A Pujana , Karim Mekhail , Grant S Stewart , Anne Hakem , Razqallah Hakem

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses.

Biochimica et biophysica acta. General subjects

Avec: Fengling Li , Pegah Ghiabi , Taraneh Hajian , Martin Klima , Alice Shi Ming Li , Aliakbar Khalili Yazdi , Irene Chau , Peter Loppnau , Maria Kutera , Almagul Seitova , Albina Bolotokova , Ashley Hutchinson , Sumera Perveen , Evzen Boura , Masoud Vedadi

Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2.

Journal of chemical information and modeling

Avec: Merveille Eguida , Guillaume Bret , François Sindt , Fengling Li , Irene Chau , Suzanne Ackloo , Cheryl Arrowsmith , Albina Bolotokova , Pegah Ghiabi , Elisa Gibson , Levon Halabelian , Scott Houliston , Rachel J Harding , Ashley Hutchinson , Peter Loppnau , Sumera Perveen , Almagul Seitova , Hong Zeng , Matthieu Schapira , Didier Rognan

Probing the CRL4

PNAS nexus

Avec: Germanna Lima Righetto , Yanting Yin , David M Duda , Victoria Vu , Magdalena M Szewczyk , Hong Zeng , Yanjun Li , Peter Loppnau , Tony Mei , Yen-Yen Li , Alma Seitova , Aaron N Patrick , Jean-Francois Brazeau , Charu Chaudhry , Dalia Barsyte-Lovejoy , Vijayaratnam Santhakumar , Levon Halabelian

Réseau de co-auteurs

Ashley Hutchinson 13 collaborations

Peter Loppnau 9 collaborations

Levon Halabelian 6 collaborations

Almagul Seitova 6 collaborations

Cheryl H Arrowsmith 5 collaborations

Suzanne Ackloo 5 collaborations

Pegah Ghiabi 4 collaborations

Rachel J Harding 4 collaborations

Hong Zeng 3 collaborations

Albina Bolotokova 3 collaborations

Yanjun Li 3 collaborations

Dalia Barsyte-Lovejoy 2 collaborations

Courtney Voss 2 collaborations

Sally Esmail 2 collaborations

Michael J Knauer 2 collaborations

Lori Lowes 2 collaborations

Peter Stogios 2 collaborations

Farhad Yusifov 2 collaborations

Tatiana Skarina 2 collaborations

Elena Evdokimova 2 collaborations

Husam Abdoh 2 collaborations

Benjamin D Hedley 2 collaborations

Vipin Bhayana 2 collaborations

Benjamin Chin-Yee 2 collaborations

Ian Chin-Yee 2 collaborations

Aiping Dong 2 collaborations

Justin C Deme 2 collaborations

Susan M Lea 2 collaborations

Alexander Lemak 2 collaborations

Magdalena M Szewczyk 2 collaborations

Lixin Fan 2 collaborations

Matthieu Schapira 2 collaborations

Yen-Yen Li 2 collaborations

Vijayaratnam Santhakumar 2 collaborations

Cheryl Arrowsmith 2 collaborations

Fengling Li 2 collaborations

Irene Chau 2 collaborations

Sumera Perveen 2 collaborations

Danton Ivanochko 1 collaboration

Elizabeth Henderson 1 collaboration

Pavel Savitsky 1 collaboration

Harshika Jain 1 collaboration

Edyta Marcon 1 collaboration

Shili Duan 1 collaboration

Panagis Filippakopoulos 1 collaboration

Jack Greenblatt 1 collaboration

Evelyne Lima-Fernandes 1 collaboration

Xuguang Liu 1 collaboration

Tomonori Kaneko 1 collaboration

Taraneh Haijan 1 collaboration

Shanshan Zhong 1 collaboration

Claudio M Martin 1 collaboration

Marat Slessarev 1 collaboration

Douglas D Fraser 1 collaboration

Shawn Sc Li 1 collaboration

John A Gilleran 1 collaboration

Kutub Ashraf 1 collaboration

Melvin Delvillar 1 collaboration

Tyler Eck 1 collaboration

Raheel Fondekar 1 collaboration

Edward B Miller 1 collaboration

Mariana Laureano De Souza 1 collaboration

David Augeri 1 collaboration

John Siekierka 1 collaboration

David P Rotella 1 collaboration

John Gordon 1 collaboration

Wayne E Childers 1 collaboration

Mark C Grier 1 collaboration

Bart L Staker 1 collaboration

Jacques Y Roberge 1 collaboration

Purnima Bhanot 1 collaboration

José Carlos Bozelli 1 collaboration

Jenny Yune 1 collaboration

Sukhvershjit S Aulakh 1 collaboration

Zihao Cao 1 collaboration

Alexia Fernandes 1 collaboration

Yufeng Tong 1 collaboration

Shirley Schreier 1 collaboration

Richard M Epand 1 collaboration

Matthew G Alteen 1 collaboration

Claudia P Alvarez 1 collaboration

Renu Chandrasekaran 1 collaboration

Eduardo Silva Ramos 1 collaboration

Christopher Secker 1 collaboration

Mona Alqazzaz 1 collaboration

Erich E Wanker 1 collaboration

Shawn S-C Li 1 collaboration

Johannes F Hevler 1 collaboration

Sem Tamara 1 collaboration

Jeffrey P Cantle 1 collaboration

Nola Begeja 1 collaboration

Siobhan Goss 1 collaboration

Xiaobing Zuo 1 collaboration

Ray Truant 1 collaboration

Jeffrey B Carroll 1 collaboration

Albert J R Heck 1 collaboration

Shabbir Ahmad 1 collaboration

Jin Xu 1 collaboration

Jianwen A Feng 1 collaboration

Paolo A Centrella 1 collaboration

Matthew A Clark 1 collaboration

Marie-Aude Guié 1 collaboration

John P Guilinger 1 collaboration

Anthony D Keefe 1 collaboration

Ying Zhang 1 collaboration

Thomas Cerruti 1 collaboration

John W Cuozzo 1 collaboration

Moritz von Rechenberg 1 collaboration

Peter J Brown 1 collaboration

Majida El Bakkouri 1 collaboration

Imène Kouidmi 1 collaboration

Amy K Wernimont 1 collaboration

Mehrnaz Amani 1 collaboration

Jeong Joo Kim 1 collaboration

Christian Flueck 1 collaboration

John R Walker 1 collaboration

Guillermo Senisterra 1 collaboration

Yoshito Kakihara 1 collaboration

Choel Kim 1 collaboration

Michael J Blackman 1 collaboration

Charles Calmettes 1 collaboration

David A Baker 1 collaboration

Raymond Hui 1 collaboration

Brittany Hunt 1 collaboration

Alex S Holehouse 1 collaboration

Jolene C Ho 1 collaboration

Leticia Toledo-Sherman 1 collaboration

Bryan J Fraser 1 collaboration

Serap Beldar 1 collaboration

Dhiraj Mannar 1 collaboration

Daniel Kwon 1 collaboration

Ruiyan Tan 1 collaboration

Ryan P Wilson 1 collaboration

Karoline Leopold 1 collaboration

Sriram Subramaniam 1 collaboration

François Bénard 1 collaboration

Rehna Krishnan 1 collaboration

Mariah Lapierre 1 collaboration

Brandon Gautreau 1 collaboration

Kevin C J Nixon 1 collaboration

Samah El Ghamrasni 1 collaboration

Parasvi S Patel 1 collaboration

Jun Hao 1 collaboration

V Talya Yerlici 1 collaboration

Kiran Kumar Naidu Guturi 1 collaboration

Jonathan St-Germain 1 collaboration

Francesca Mateo 1 collaboration

Amine Saad 1 collaboration

Arash Algouneh 1 collaboration

Rebecca Earnshaw 1 collaboration

Duan Shili 1 collaboration

Joshua Miller 1 collaboration

Negin Khosraviani 1 collaboration

Adam Penn 1 collaboration

Brandon Ho 1 collaboration

Otto Sanchez 1 collaboration

M Prakash Hande 1 collaboration

Jean-Yves Masson 1 collaboration

Grant W Brown 1 collaboration

Moulay Alaoui-Jamali 1 collaboration

John J Reynolds 1 collaboration

Brian Raught 1 collaboration

Miguel A Pujana 1 collaboration

Karim Mekhail 1 collaboration

Grant S Stewart 1 collaboration

Anne Hakem 1 collaboration

Razqallah Hakem 1 collaboration

Taraneh Hajian 1 collaboration

Martin Klima 1 collaboration

Alice Shi Ming Li 1 collaboration

Aliakbar Khalili Yazdi 1 collaboration

Maria Kutera 1 collaboration

Evzen Boura 1 collaboration

Masoud Vedadi 1 collaboration

Merveille Eguida 1 collaboration

Guillaume Bret 1 collaboration

François Sindt 1 collaboration

Elisa Gibson 1 collaboration

Scott Houliston 1 collaboration

Didier Rognan 1 collaboration

Germanna Lima Righetto 1 collaboration

Yanting Yin 1 collaboration

David M Duda 1 collaboration

Victoria Vu 1 collaboration

Tony Mei 1 collaboration

Aaron N Patrick 1 collaboration

Jean-Francois Brazeau 1 collaboration

Charu Chaudhry 1 collaboration