Allan R Brasier

Affiliations

Institute for Clinical and Translational Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI 53705, USA. Electronic address: abrasier@wisc.edu.

Publications (51)

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling.

Drug discovery today

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling.

Journal of proteomics

Avec: Yingxin Zhao , Bing Tian , Hong Sun , Jing Zhang , Yueqing Zhang , Maxim Ivannikov , Massoud Motamedi , Zhiqing Liu , Jia Zhou , Lata Kaphalia , William J Calhoun , Rosario Maroto , Allan R Brasier

Enhancing reproducibility using interprofessional team best practices.

Journal of clinical and translational science

Avec: Betsy Rolland , Elizabeth S Burnside , Corrine I Voils , Manish N Shah , Allan R Brasier

Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research.

Journal of proteome research

Avec: Yanlong Zhu , Benjamin Wancewicz , Michael Schaid , Timothy N Tiambeng , Kent Wenger , Yutong Jin , Heino Heyman , Christopher J Thompson , Aiko Barsch , Elizabeth D Cox , Dawn B Davis , Allan R Brasier , Michelle E Kimple , Ying Ge

Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis.

Frontiers in pharmacology

Avec: Melissa Skibba , Adam Drelich , Michael Poellmann , Seungpyo Hong , Allan R Brasier

Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis.

Frontiers in molecular medicine

Avec: Ksenija Bernau , Melissa Skibba , Jonathan P Leet , Sierra Furey , Carson Gehl , Yi Li , Jia Zhou , Nathan Sandbo , Allan R Brasier

Respiratory Syncytial Virus Infection Induces Chromatin Remodeling to Activate Growth Factor and Extracellular Matrix Secretion Pathways.

Viruses

Avec: Xiaofang Xu , Dianhua Qiao , Morgan Mann , Roberto P Garofalo , Allan R Brasier

Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections.

The American journal of pathology

Avec: Yingxin Zhao , Rong Fang , Jing Zhang , Yueqing Zhang , Jeremy Bechelli , Claire Smalley , Gustavo Valbuena , David H Walker , José A Oteo , Allan R Brasier

Targeting inducible epigenetic reprogramming pathways in chronic airway remodeling.

Drugs in context

Avec: Allan R Brasier , Istvan Boldogh

Alternative mRNA Processing of Innate Response Pathways in Respiratory Syncytial Virus (RSV) Infection.

Viruses

Avec: Xiaofang Xu , Morgan Mann , Dianhua Qiao , Allan R Brasier

Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma.

Metabolites

Avec: Yanlong Zhu , Stephane Esnault , Ying Ge , Nizar N Jarjour , Allan R Brasier

The Hexosamine Biosynthetic Pathway Links Innate Inflammation With Epithelial-Mesenchymal Plasticity in Airway Remodeling.

Frontiers in pharmacology

Avec: Allan R Brasier , Dianhua Qiao , Yingxin Zhao

RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection.

Cells

Avec: Xiaofang Xu , Dianhua Qiao , Lang Pan , Istvan Boldogh , Yingxin Zhao , Allan R Brasier

Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing.

bioRxiv : the preprint server for biology

Avec: Morgan Mann , Yao Fu , Xiaofang Xu , David S Roberts , Yi Li , Jia Zhou , Ying Ge , Allan R Brasier

Temporal development of high-performance translational teams.

Journal of clinical and translational science

Avec: Allan R Brasier , Shannon L Casey , Felice Resnik , Betsy Rolland , Elizabeth S Burnside

Win-win interactions: Results and implications of a user needs assessment of clinical and translational scientists.

Journal of clinical and translational science

Avec: Shannon Casey , Amanda Siebert-Evenstone , Allan R Brasier

Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury.

Frontiers in immunology

Avec: Lang Pan , Spiros Vlahopoulos , Lloyd Tanner , Jesper Bergwik , Attila Bacsi , Zsolt Radak , Arne Egesten , Xueqing Ba , Allan R Brasier , Istvan Boldogh

Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma.

Advances in experimental medicine and biology

Avec: Allan R Brasier

NFkB/RelA Signaling in Secretoglobin Progenitors Mediates Plasticity and MMP-Induced Barrier Disruption In House Dust Mite-Induced Allergic Asthma.

American journal of physiology. Lung cellular and molecular physiology

Avec: Melissa E Skibba , Allan R Brasier

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.

Journal of medicinal chemistry

Avec: Zhiqing Liu , Haiying Chen , Pingyuan Wang , Yi Li , Eric A Wold , Paul G Leonard , Sarah Joseph , Allan R Brasier , Bing Tian , Jia Zhou

Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling.

American journal of respiratory cell and molecular biology

Avec: Bing Tian , Zhiqing Liu , Julia Litvinov , Rosario Maroto , Mohammad Jamaluddin , Erik Rytting , Igor Patrikeev , Lorenzo Ochoa , Gracie Vargas , Massoud Motamedi , Bill T Ameredes , Jia Zhou , Allan R Brasier

Crosstalk of the IκB Kinase with Spliced X-Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial-Mesenchymal Transition.

Journal of proteome research

Avec: Yingxin Zhao , Jing Zhang , Hong Sun , Allan R Brasier

Role of Secretoglobin

Respiratory research

Avec: Melissa E Skibba , Xiaofang Xu , Kurt Weiss , Jan Huisken , Allan R Brasier

Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.

Inflammatory bowel diseases

Avec: Yi Li , Jianping Chen , Andrew A Bolinger , Haiying Chen , Zhiqing Liu , Yingzi Cong , Allan R Brasier , Irina V Pinchuk , Bing Tian , Jia Zhou

Bromodomain Containing Protein 4 (BRD4) Regulates Expression of its Interacting Coactivators in the Innate Response to Respiratory Syncytial Virus.

Frontiers in molecular biosciences

Avec: Xiaofang Xu , Morgan Mann , Dianhua Qiao , Yi Li , Jia Zhou , Allan R Brasier

Individual and team competencies in translational teams.

Journal of clinical and translational science

Avec: Gaetano R Lotrecchiano , Deborah DiazGranados , Jennifer Sprecher , Wayne T McCormack , Damayanthi Ranwala , Kevin Wooten , Daniel Lackland , Heather Billings , Allan R Brasier

Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E

Metabolites

Avec: Michael D Schaid , Yanlong Zhu , Nicole E Richardson , Chinmai Patibandla , Irene M Ong , Rachel J Fenske , Joshua C Neuman , Erin Guthery , Austin Reuter , Harpreet K Sandhu , Miles H Fuller , Elizabeth D Cox , Dawn B Davis , Brian T Layden , Allan R Brasier , Dudley W Lamming , Ying Ge , Michelle E Kimple

Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response.

American journal of physiology. Lung cellular and molecular physiology

Avec: Dianhua Qiao , Melissa Skibba , Xiaofang Xu , Roberto P Garofalo , Yingxin Zhao , Allan R Brasier

A leadership model supporting maturation of high-performance translational teams.

Journal of clinical and translational science

Avec: Allan R Brasier , Shannon L Casey , Peggy Hatfield , Patrick W Kelly , Whitney A Sweeney , Marin Schweizer , Bo Liu , Elizabeth S Burnside

Developing a Translational Team Training Program using the Wisconsin Interventions in Team Science Framework.

Journal of clinical and translational science

Avec: Whitney A Sweeney , Patrick W Kelly , Allan R Brasier , Betsy Rolland

8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury.

Nucleic acids research

Avec: Lang Pan , Wenjing Hao , Yaoyao Xue , Ke Wang , Xu Zheng , Jixian Luo , Xueqing Ba , Yang Xiang , Xiaoqun Qin , Jesper Bergwik , Lloyd Tanner , Arne Egesten , Allan R Brasier , Istvan Boldogh

Special Issue "Next-Generation Technologies to Understand Mechanisms of Virus Infections".

Viruses

Avec: Allan R Brasier

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling.

The Journal of allergy and clinical immunology

Avec: Bing Tian , Koa Hosoki , Zhiqing Liu , Jun Yang , Yingxin Zhao , Hong Sun , Jia Zhou , Erik Rytting , Lata Kaphalia , William J Calhoun , Sanjiv Sur , Allan R Brasier

RSV Reprograms the CDK9•BRD4 Chromatin Remodeling Complex to Couple Innate Inflammation to Airway Remodeling.

Viruses

Avec: Allan R Brasier

Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation-Serial Fragmentation (PASEF) Mass Spectrometry.

Viruses

Avec: Morgan Mann , David S Roberts , Yanlong Zhu , Yi Li , Jia Zhou , Ying Ge , Allan R Brasier

Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry.

Journal of the American Chemical Society

Avec: David S Roberts , Morgan Mann , Jake A Melby , Eli J Larson , Yanlong Zhu , Allan R Brasier , Song Jin , Ying Ge

Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

Journal of medicinal chemistry

Avec: Zhiqing Liu , Yi Li , Haiying Chen , Hsien-Tsung Lai , Pingyuan Wang , Shwu-Yuan Wu , Eric A Wold , Paul G Leonard , Sarah Joseph , Haitao Hu , Cheng-Ming Chiang , Allan R Brasier , Bing Tian , Jia Zhou

Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry.

bioRxiv : the preprint server for biology

Avec: David S Roberts , Morgan Mann , Brad H Li , Donguk Kim , Allan R Brasier , Song Jin , Ying Ge

Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling.

Clinical proteomics

Avec: Yanlong Zhu , Stephane Esnault , Ying Ge , Nizar N Jarjour , Allan R Brasier

Competencies supporting high-performance translational teams: A review of the SciTS evidence base.

Journal of clinical and translational science

Avec: Allan R Brasier , Elizabeth S Burnside , Betsy Rolland

RSV replication modifies the XBP1s binding complex on the IRF1 upstream enhancer to potentiate the mucosal anti-viral response.

Frontiers in immunology

Avec: Dianhua Qiao , Xiaofang Xu , Yueqing Zhang , Jun Yang , Allan R Brasier

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing.

Frontiers in immunology

Avec: Morgan W Mann , Yao Fu , Robert L Gearhart , Xiaofang Xu , David S Roberts , Yi Li , Jia Zhou , Ying Ge , Allan R Brasier

Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation To Maintain Proteostasis and Extracellular Matrix Production.

Journal of proteome research

Avec: Jing Zhang , Mohammad Jamaluddin , Yueqing Zhang , Steven G Widen , Hong Sun , Allan R Brasier , Yingxin Zhao

Mechanisms how mucosal innate immunity affects progression of allergic airway disease.

Expert review of respiratory medicine

Avec: Allan R Brasier

Optical biosensing of markers of mucosal inflammation.

Nanomedicine : nanotechnology, biology, and medicine

Avec: Obdulia Covarrubias-Zambrano , Massoud Motamedi , Bill T Ameredes , Bing Tian , William J Calhoun , Yingxin Zhao , Allan R Brasier , Madumali Kalubowilage , Aruni P Malalasekera , Asanka S Yapa , Hongwang Wang , Christopher T Culbertson , Deryl L Troyer , Stefan H Bossmann

The SWI/SNF-Related, Matrix Associated, Actin-Dependent Regulator of Chromatin A4 Core Complex Represses Respiratory Syncytial Virus-Induced Syncytia Formation and Subepithelial Myofibroblast Transition.

Frontiers in immunology

Avec: Xiaofang Xu , Dianhua Qiao , Chenyang Dong , Morgan Mann , Roberto P Garofalo , Sunduz Keles , Allan R Brasier

Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry.

bioRxiv : the preprint server for biology

Avec: David S Roberts , Morgan W Mann , Jake A Melby , Eli J Larson , Yanlong Zhu , Allan R Brasier , Song Jin , Ying Ge

Operationalization, implementation, and evaluation of Collaboration Planning: A pilot interventional study of nascent translational teams.

Journal of clinical and translational science

Avec: Betsy Rolland , Linda Scholl , Sainath Suryanarayanan , Peggy Hatfield , Kate Judge , Christine Sorkness , Elizabeth Burnside , Allan R Brasier

Training needs of investigators and research team members to improve inclusivity in clinical and translational research participation.

Journal of clinical and translational science

Avec: Susan R Passmore , Dorothy Farrar Edwards , Christine A Sorkness , Sarah Esmond , Allan R Brasier

Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions.

Journal of innate immunity

Avec: Xu Zheng , Ke Wang , Lang Pan , Wenjing Hao , Yaoyao Xue , Attila Bacsi , Spiros A Vlahopoulos , Zsolt Radak , Tapas K Hazra , Allan R Brasier , Lloyd Tanner , Xueqing Ba , Istvan Boldogh

The IRE1α-XBP1s Arm of the Unfolded Protein Response Activates N-Glycosylation to Remodel the Subepithelial Basement Membrane in Paramyxovirus Infection.

International journal of molecular sciences

Avec: Yingxin Zhao , Dianhua Qiao , Melissa Skibba , Allan R Brasier

Réseau de co-auteurs

Jia Zhou 12 collaborations

Yingxin Zhao 10 collaborations

Ying Ge 10 collaborations

Xiaofang Xu 10 collaborations

Dianhua Qiao 9 collaborations

Yi Li 8 collaborations

Morgan Mann 8 collaborations

Bing Tian 7 collaborations

Yanlong Zhu 7 collaborations

Zhiqing Liu 6 collaborations

David S Roberts 6 collaborations

Betsy Rolland 5 collaborations

Istvan Boldogh 5 collaborations

Hong Sun 4 collaborations

Jing Zhang 4 collaborations

Yueqing Zhang 4 collaborations

Elizabeth S Burnside 4 collaborations

Melissa Skibba 4 collaborations

Lang Pan 4 collaborations

Massoud Motamedi 3 collaborations

William J Calhoun 3 collaborations

Roberto P Garofalo 3 collaborations

Lloyd Tanner 3 collaborations

Xueqing Ba 3 collaborations

Haiying Chen 3 collaborations

Song Jin 3 collaborations

Lata Kaphalia 2 collaborations

Rosario Maroto 2 collaborations

Elizabeth D Cox 2 collaborations

Dawn B Davis 2 collaborations

Michelle E Kimple 2 collaborations

Stephane Esnault 2 collaborations

Nizar N Jarjour 2 collaborations

Yao Fu 2 collaborations

Shannon L Casey 2 collaborations

Jesper Bergwik 2 collaborations

Attila Bacsi 2 collaborations

Zsolt Radak 2 collaborations

Arne Egesten 2 collaborations

Melissa E Skibba 2 collaborations

Pingyuan Wang 2 collaborations

Eric A Wold 2 collaborations

Paul G Leonard 2 collaborations

Sarah Joseph 2 collaborations

Mohammad Jamaluddin 2 collaborations

Erik Rytting 2 collaborations

Bill T Ameredes 2 collaborations

Peggy Hatfield 2 collaborations

Patrick W Kelly 2 collaborations

Whitney A Sweeney 2 collaborations

Wenjing Hao 2 collaborations

Yaoyao Xue 2 collaborations

Ke Wang 2 collaborations

Xu Zheng 2 collaborations

Jun Yang 2 collaborations

Jake A Melby 2 collaborations

Eli J Larson 2 collaborations

Morgan W Mann 2 collaborations

Maxim Ivannikov 1 collaboration

Corrine I Voils 1 collaboration

Manish N Shah 1 collaboration

Benjamin Wancewicz 1 collaboration

Michael Schaid 1 collaboration

Timothy N Tiambeng 1 collaboration

Kent Wenger 1 collaboration

Yutong Jin 1 collaboration

Heino Heyman 1 collaboration

Christopher J Thompson 1 collaboration

Aiko Barsch 1 collaboration

Adam Drelich 1 collaboration

Michael Poellmann 1 collaboration

Seungpyo Hong 1 collaboration

Ksenija Bernau 1 collaboration

Jonathan P Leet 1 collaboration

Sierra Furey 1 collaboration

Carson Gehl 1 collaboration

Nathan Sandbo 1 collaboration

Rong Fang 1 collaboration

Jeremy Bechelli 1 collaboration

Claire Smalley 1 collaboration

Gustavo Valbuena 1 collaboration

David H Walker 1 collaboration

José A Oteo 1 collaboration

Felice Resnik 1 collaboration

Shannon Casey 1 collaboration

Amanda Siebert-Evenstone 1 collaboration

Spiros Vlahopoulos 1 collaboration

Julia Litvinov 1 collaboration

Igor Patrikeev 1 collaboration

Lorenzo Ochoa 1 collaboration

Gracie Vargas 1 collaboration

Kurt Weiss 1 collaboration

Jan Huisken 1 collaboration

Jianping Chen 1 collaboration

Andrew A Bolinger 1 collaboration

Yingzi Cong 1 collaboration

Irina V Pinchuk 1 collaboration

Gaetano R Lotrecchiano 1 collaboration

Deborah DiazGranados 1 collaboration

Jennifer Sprecher 1 collaboration

Wayne T McCormack 1 collaboration

Damayanthi Ranwala 1 collaboration

Kevin Wooten 1 collaboration

Daniel Lackland 1 collaboration

Heather Billings 1 collaboration

Michael D Schaid 1 collaboration

Nicole E Richardson 1 collaboration

Chinmai Patibandla 1 collaboration

Irene M Ong 1 collaboration

Rachel J Fenske 1 collaboration

Joshua C Neuman 1 collaboration

Erin Guthery 1 collaboration

Austin Reuter 1 collaboration

Harpreet K Sandhu 1 collaboration

Miles H Fuller 1 collaboration

Brian T Layden 1 collaboration

Dudley W Lamming 1 collaboration

Marin Schweizer 1 collaboration

Bo Liu 1 collaboration

Jixian Luo 1 collaboration

Yang Xiang 1 collaboration

Xiaoqun Qin 1 collaboration

Koa Hosoki 1 collaboration

Sanjiv Sur 1 collaboration

Hsien-Tsung Lai 1 collaboration

Shwu-Yuan Wu 1 collaboration

Haitao Hu 1 collaboration

Cheng-Ming Chiang 1 collaboration

Brad H Li 1 collaboration

Donguk Kim 1 collaboration

Robert L Gearhart 1 collaboration

Steven G Widen 1 collaboration

Obdulia Covarrubias-Zambrano 1 collaboration

Madumali Kalubowilage 1 collaboration

Aruni P Malalasekera 1 collaboration

Asanka S Yapa 1 collaboration

Hongwang Wang 1 collaboration

Christopher T Culbertson 1 collaboration

Deryl L Troyer 1 collaboration

Stefan H Bossmann 1 collaboration

Chenyang Dong 1 collaboration

Sunduz Keles 1 collaboration

Linda Scholl 1 collaboration

Sainath Suryanarayanan 1 collaboration

Kate Judge 1 collaboration

Christine Sorkness 1 collaboration

Elizabeth Burnside 1 collaboration

Susan R Passmore 1 collaboration

Dorothy Farrar Edwards 1 collaboration

Christine A Sorkness 1 collaboration

Sarah Esmond 1 collaboration

Spiros A Vlahopoulos 1 collaboration

Tapas K Hazra 1 collaboration