Alexandre P A Theocharides

Affiliations

Department of Medical Oncology and Hematology, University Hospital and University of Zurich, Zurich, Switzerland.

Publications (15)

Delivery of oligonucleotides to bone marrow to modulate ferrochelatase splicing in a mouse model of erythropoietic protoporphyria.

Nucleic acids research

Avec: François Halloy , Pavithra S Iyer , Paulina Ćwiek , Alice Ghidini , Jasmin Barman-Aksözen , Nicole Wildner-Verhey van Wijk , Alexandre P A Theocharides , Elisabeth I Minder , Xiaoye Schneider-Yin , Daniel Schümperli , Jonathan Hall

Proteomic identification of proliferation and progression markers in human polycythemia vera stem and progenitor cells.

Blood advances

Avec: Ge Tan , Witold E Wolski , Sandra Kummer , Mara Hofstetter , Alexandre P A Theocharides , Markus G Manz , Ruedi Aebersold , Fabienne Meier-Abt

Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia.

Nature communications

Avec: Rebekka Wegmann , Ximena Bonilla , Ruben Casanova , Stéphane Chevrier , Ricardo Coelho , Cinzia Esposito , Joanna Ficek-Pascual , Sandra Goetze , Gabriele Gut , Francis Jacob , Andrea Jacobs , Jack Kuipers , Ulrike Lischetti , Julien Mena , Emanuela S Milani , Michael Prummer , Jacobo Sarabia Del Castillo , Franziska Singer , Sujana Sivapatham , Nora C Toussaint , Oliver Vilinovszki , Mattheus H E Wildschut , Tharshika Thavayogarajah , Disha Malani , Auteur inconnu , Rudolf Aebersold , Marina Bacac , Niko Beerenwinkel , Christian Beisel , Bernd Bodenmiller , Viola Heinzelmann-Schwarz , Viktor H Koelzer , Mitchell P Levesque , Holger Moch , Lucas Pelkmans , Gunnar Rätsch , Markus Tolnay , Andreas Wicki , Bernd Wollscheid , Markus G Manz , Berend Snijder , Alexandre P A Theocharides

Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice.

Blood advances

Avec: Veronika Lysenko , Nicole Wildner-Verhey van Wijk , Kathrin Zimmermann , Marie-Christine Weller , Marco Bühler , Mattheus H E Wildschut , Patrick Schürch , Christine Fritz , Ulrich Wagner , Laura Calabresi , Bethan Psaila , Richard A Flavell , Alessandro M Vannucchi , Adam J Mead , Peter J Wild , Stefan Dirnhofer , Markus G Manz , Alexandre P A Theocharides

Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis.

Nature communications

Avec: Mattheus H E Wildschut , Julien Mena , Cyril Dördelmann , Marc van Oostrum , Benjamin D Hale , Jens Settelmeier , Yasmin Festl , Veronika Lysenko , Patrick M Schürch , Alexander Ring , Yannik Severin , Michael S Bader , Patrick G A Pedrioli , Sandra Goetze , Audrey van Drogen , Stefan Balabanov , Radek C Skoda , Massimo Lopes , Bernd Wollscheid , Alexandre P A Theocharides , Berend Snijder

The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support.

Cancer cell

Avec: Anja Irmisch , Ximena Bonilla , Stéphane Chevrier , Kjong-Van Lehmann , Franziska Singer , Nora C Toussaint , Cinzia Esposito , Julien Mena , Emanuela S Milani , Ruben Casanova , Daniel J Stekhoven , Rebekka Wegmann , Francis Jacob , Bettina Sobottka , Sandra Goetze , Jack Kuipers , Jacobo Sarabia Del Castillo , Michael Prummer , Mustafa A Tuncel , Ulrike Menzel , Andrea Jacobs , Stefanie Engler , Sujana Sivapatham , Anja L Frei , Gabriele Gut , Joanna Ficek , Nicola Miglino , Auteur inconnu , Rudolf Aebersold , Marina Bacac , Niko Beerenwinkel , Christian Beisel , Bernd Bodenmiller , Reinhard Dummer , Viola Heinzelmann-Schwarz , Viktor H Koelzer , Markus G Manz , Holger Moch , Lucas Pelkmans , Berend Snijder , Alexandre P A Theocharides , Markus Tolnay , Andreas Wicki , Bernd Wollscheid , Gunnar Rätsch , Mitchell P Levesque

Calreticulin mutations affect its chaperone function and perturb the glycoproteome.

Cell reports

Avec: Patrick M Schürch , Liliana Malinovska , Mohammad Hleihil , Marco Losa , Mara C Hofstetter , Mattheus H E Wildschut , Veronika Lysenko , Asvin K K Lakkaraju , Christina A Maat , Dietmar Benke , Adriano Aguzzi , Bernd Wollscheid , Paola Picotti , Alexandre P A Theocharides

Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.

Cell chemical biology

Avec: François Halloy , Pavithra S Iyer , Alice Ghidini , Veronika Lysenko , Jasmin Barman-Aksözen , Chia-Pei Grubenmann , Jessica Jucker , Nicole Wildner-Verhey van Wijk , Marc-David Ruepp , Elisabeth I Minder , Anna-Elisabeth Minder , Xiaoye Schneider-Yin , Alexandre P A Theocharides , Daniel Schümperli , Jonathan Hall

Sensitive Quantitative Proteomics of Human Hematopoietic Stem and Progenitor Cells by Data-independent Acquisition Mass Spectrometry.

Molecular & cellular proteomics : MCP

Avec: Sabine Amon , Fabienne Meier-Abt , Ludovic C Gillet , Slavica Dimitrieva , Alexandre P A Theocharides , Markus G Manz , Ruedi Aebersold

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.

Cell reports

Avec: Eleanna Kara , Alessandro Crimi , Anne Wiedmer , Marc Emmenegger , Claudia Manzoni , Sara Bandres-Ciga , Karishma D'Sa , Regina H Reynolds , Juan A Botía , Marco Losa , Veronika Lysenko , Manfredi Carta , Daniel Heinzer , Merve Avar , Andra Chincisan , Cornelis Blauwendraat , Sonia García-Ruiz , Daniel Pease , Lorene Mottier , Alessandra Carrella , Dezirae Beck-Schneider , Andreia D Magalhães , Caroline Aemisegger , Alexandre P A Theocharides , Zhanyun Fan , Jordan D Marks , Sarah C Hopp , Andrey Y Abramov , Patrick A Lewis , Mina Ryten , John Hardy , Bradley T Hyman , Adriano Aguzzi

Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms.

Nature cancer

Avec: Elodie Grockowiak , Claudia Korn , Justyna Rak , Veronika Lysenko , Adrien Hallou , Francesca M Panvini , Matthew Williams , Claire Fielding , Zijian Fang , Eman Khatib-Massalha , Andrés García-García , Juan Li , Reema A Khorshed , Sara González-Antón , E Joanna Baxter , Anjali Kusumbe , Bridget S Wilkins , Anna Green , Benjamin D Simons , Claire N Harrison , Anthony R Green , Cristina Lo Celso , Alexandre P A Theocharides , Simón Méndez-Ferrer

PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapy.

Cell reports. Medicine

Avec: Bruktawit Maru , Alessandra Messikommer , Linhui Huang , Katja Seipel , Olivia Kovecses , Peter J M Valk , Alexandre P A Theocharides , Francois E Mercier , Thomas Pabst , Maureen McKeague , Nathan W Luedtke

Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma.

Blood advances

Avec: Anna Stelling , Cheuk-Ting Wu , Katrin Bertram , Hind Hashwah , Alexandre P A Theocharides , Markus G Manz , Alexandar Tzankov , Anne Müller

Production and Characterization of Peptide Antibodies to the C-Terminal of Frameshifted Calreticulin Associated with Myeloproliferative Diseases.

International journal of molecular sciences

Avec: Farah Perveen Mughal , Ann Christina Bergmann , Ha Uyen Buu Huynh , Sarah Hyllekvist Jørgensen , Inaam Mansha , Meliha Kesmez , Patrick Mark Schürch , Alexandre Pierre André Theocharides , Paul Robert Hansen , Tina Friis , Morten Orebo Holmström , Evaldas Ciplys , Rimantas Slibinskas , Peter Højrup , Gunnar Houen , Nicole Hartwig Trier

Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.

Leukemia

Avec: Veronika Lysenko , Patrick M Schürch , Selma Tuzlak , Nicole Wildner-Verhey van Wijk , Larisa V Kovtonyuk , Burkhard Becher , Markus G Manz , Stefanie Kreutmair , Alexandre P A Theocharides

Réseau de co-auteurs

Markus G Manz 7 collaborations

Veronika Lysenko 7 collaborations

Nicole Wildner-Verhey van Wijk 4 collaborations

Mattheus H E Wildschut 4 collaborations

Bernd Wollscheid 4 collaborations

Sandra Goetze 3 collaborations

Julien Mena 3 collaborations

Berend Snijder 3 collaborations

Patrick M Schürch 3 collaborations

François Halloy 2 collaborations

Pavithra S Iyer 2 collaborations

Alice Ghidini 2 collaborations

Jasmin Barman-Aksözen 2 collaborations

Elisabeth I Minder 2 collaborations

Xiaoye Schneider-Yin 2 collaborations

Daniel Schümperli 2 collaborations

Jonathan Hall 2 collaborations

Ruedi Aebersold 2 collaborations

Fabienne Meier-Abt 2 collaborations

Rebekka Wegmann 2 collaborations

Ximena Bonilla 2 collaborations

Ruben Casanova 2 collaborations

Stéphane Chevrier 2 collaborations

Cinzia Esposito 2 collaborations

Gabriele Gut 2 collaborations

Francis Jacob 2 collaborations

Andrea Jacobs 2 collaborations

Jack Kuipers 2 collaborations

Emanuela S Milani 2 collaborations

Michael Prummer 2 collaborations

Jacobo Sarabia Del Castillo 2 collaborations

Franziska Singer 2 collaborations

Sujana Sivapatham 2 collaborations

Nora C Toussaint 2 collaborations

None None 2 collaborations

Rudolf Aebersold 2 collaborations

Marina Bacac 2 collaborations

Niko Beerenwinkel 2 collaborations

Christian Beisel 2 collaborations

Bernd Bodenmiller 2 collaborations

Viola Heinzelmann-Schwarz 2 collaborations

Viktor H Koelzer 2 collaborations

Mitchell P Levesque 2 collaborations

Holger Moch 2 collaborations

Lucas Pelkmans 2 collaborations

Gunnar Rätsch 2 collaborations

Markus Tolnay 2 collaborations

Andreas Wicki 2 collaborations

Marco Losa 2 collaborations

Adriano Aguzzi 2 collaborations

Paulina Ćwiek 1 collaboration

Ge Tan 1 collaboration

Witold E Wolski 1 collaboration

Sandra Kummer 1 collaboration

Mara Hofstetter 1 collaboration

Ricardo Coelho 1 collaboration

Joanna Ficek-Pascual 1 collaboration

Ulrike Lischetti 1 collaboration

Oliver Vilinovszki 1 collaboration

Tharshika Thavayogarajah 1 collaboration

Disha Malani 1 collaboration

Kathrin Zimmermann 1 collaboration

Marie-Christine Weller 1 collaboration

Marco Bühler 1 collaboration

Patrick Schürch 1 collaboration

Christine Fritz 1 collaboration

Ulrich Wagner 1 collaboration

Laura Calabresi 1 collaboration

Bethan Psaila 1 collaboration

Richard A Flavell 1 collaboration

Alessandro M Vannucchi 1 collaboration

Adam J Mead 1 collaboration

Peter J Wild 1 collaboration

Stefan Dirnhofer 1 collaboration

Cyril Dördelmann 1 collaboration

Marc van Oostrum 1 collaboration

Benjamin D Hale 1 collaboration

Jens Settelmeier 1 collaboration

Yasmin Festl 1 collaboration

Alexander Ring 1 collaboration

Yannik Severin 1 collaboration

Michael S Bader 1 collaboration

Patrick G A Pedrioli 1 collaboration

Audrey van Drogen 1 collaboration

Stefan Balabanov 1 collaboration

Radek C Skoda 1 collaboration

Massimo Lopes 1 collaboration

Anja Irmisch 1 collaboration

Kjong-Van Lehmann 1 collaboration

Daniel J Stekhoven 1 collaboration

Bettina Sobottka 1 collaboration

Mustafa A Tuncel 1 collaboration

Ulrike Menzel 1 collaboration

Stefanie Engler 1 collaboration

Anja L Frei 1 collaboration

Joanna Ficek 1 collaboration

Nicola Miglino 1 collaboration

Reinhard Dummer 1 collaboration

Liliana Malinovska 1 collaboration

Mohammad Hleihil 1 collaboration

Mara C Hofstetter 1 collaboration

Asvin K K Lakkaraju 1 collaboration

Christina A Maat 1 collaboration

Dietmar Benke 1 collaboration

Paola Picotti 1 collaboration

Chia-Pei Grubenmann 1 collaboration

Jessica Jucker 1 collaboration

Marc-David Ruepp 1 collaboration

Anna-Elisabeth Minder 1 collaboration

Sabine Amon 1 collaboration

Ludovic C Gillet 1 collaboration

Slavica Dimitrieva 1 collaboration

Eleanna Kara 1 collaboration

Alessandro Crimi 1 collaboration

Anne Wiedmer 1 collaboration

Marc Emmenegger 1 collaboration

Claudia Manzoni 1 collaboration

Sara Bandres-Ciga 1 collaboration

Karishma D'Sa 1 collaboration

Regina H Reynolds 1 collaboration

Juan A Botía 1 collaboration

Manfredi Carta 1 collaboration

Daniel Heinzer 1 collaboration

Merve Avar 1 collaboration

Andra Chincisan 1 collaboration

Cornelis Blauwendraat 1 collaboration

Sonia García-Ruiz 1 collaboration

Daniel Pease 1 collaboration

Lorene Mottier 1 collaboration

Alessandra Carrella 1 collaboration

Dezirae Beck-Schneider 1 collaboration

Andreia D Magalhães 1 collaboration

Caroline Aemisegger 1 collaboration

Zhanyun Fan 1 collaboration

Jordan D Marks 1 collaboration

Sarah C Hopp 1 collaboration

Andrey Y Abramov 1 collaboration

Patrick A Lewis 1 collaboration

Mina Ryten 1 collaboration

John Hardy 1 collaboration

Bradley T Hyman 1 collaboration

Elodie Grockowiak 1 collaboration

Claudia Korn 1 collaboration

Justyna Rak 1 collaboration

Adrien Hallou 1 collaboration

Francesca M Panvini 1 collaboration

Matthew Williams 1 collaboration

Claire Fielding 1 collaboration

Zijian Fang 1 collaboration

Eman Khatib-Massalha 1 collaboration

Andrés García-García 1 collaboration

Juan Li 1 collaboration

Reema A Khorshed 1 collaboration

Sara González-Antón 1 collaboration

E Joanna Baxter 1 collaboration

Anjali Kusumbe 1 collaboration

Bridget S Wilkins 1 collaboration

Anna Green 1 collaboration

Benjamin D Simons 1 collaboration

Claire N Harrison 1 collaboration

Anthony R Green 1 collaboration

Cristina Lo Celso 1 collaboration

Simón Méndez-Ferrer 1 collaboration

Bruktawit Maru 1 collaboration

Alessandra Messikommer 1 collaboration

Linhui Huang 1 collaboration

Katja Seipel 1 collaboration

Olivia Kovecses 1 collaboration

Peter J M Valk 1 collaboration

Francois E Mercier 1 collaboration

Thomas Pabst 1 collaboration

Maureen McKeague 1 collaboration

Nathan W Luedtke 1 collaboration

Anna Stelling 1 collaboration

Cheuk-Ting Wu 1 collaboration

Katrin Bertram 1 collaboration

Hind Hashwah 1 collaboration

Alexandar Tzankov 1 collaboration

Anne Müller 1 collaboration

Farah Perveen Mughal 1 collaboration

Ann Christina Bergmann 1 collaboration

Ha Uyen Buu Huynh 1 collaboration

Sarah Hyllekvist Jørgensen 1 collaboration

Inaam Mansha 1 collaboration

Meliha Kesmez 1 collaboration

Patrick Mark Schürch 1 collaboration

Alexandre Pierre André Theocharides 1 collaboration

Paul Robert Hansen 1 collaboration

Tina Friis 1 collaboration

Morten Orebo Holmström 1 collaboration

Evaldas Ciplys 1 collaboration

Rimantas Slibinskas 1 collaboration

Peter Højrup 1 collaboration

Gunnar Houen 1 collaboration

Nicole Hartwig Trier 1 collaboration

Selma Tuzlak 1 collaboration

Larisa V Kovtonyuk 1 collaboration

Burkhard Becher 1 collaboration

Stefanie Kreutmair 1 collaboration