Alexandre Orthwein

Affiliations

Gerald Bronfman Department of Oncology, McGill University Montreal, Montreal, Quebec, Canada.
Cancer Research Axis, Lady Davis Institute, Jewish General Hospital, Quebec, Montreal, Canada.

Publications (20)

A decade of RAD51C and RAD51D germline variants in cancer.

Human mutation

Avec: Jacopo Boni , Aida Idani , Carla Roca , Lidia Feliubadaló , Eva Tomiak , Evan Weber , William D Foulkes , Alexandre Orthwein , Zaki El Haffaf , Conxi Lazaro , Barbara Rivera

B cell-specific knockout of AID protects against atherosclerosis.

Scientific reports

Avec: Talin Ebrahimian , France Dierick , Vincent Ta , Maria Kotsiopriftis , Jonathan O'Connor Miranda , Koren K Mann , Alexandre Orthwein , Stephanie Lehoux

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma.

Blood advances

Avec: Steven Findlay , Remya Nair , Ronald A Merrill , Zafir Kaiser , Alexandre Cajelot , Zahra Aryanpour , John Heath , Catherine St-Louis , David Papadopoli , Ivan Topisirovic , Julie St-Pierre , Michael Sebag , Aparna H Kesarwala , Laura Hulea , Eric B Taylor , Mala Shanmugam , Alexandre Orthwein

A Functional Assay to Assess Toxicity During Murine B Cell Development In Vitro.

Current protocols in toxicology

Avec: Cynthia Guilbert , Hsiang Chou , Alicia M Bolt , Ting Hua Wu , Vincent Mingyi Luo , Alexandre Orthwein , Koren K Mann

POGZ promotes homology-directed DNA repair in an HP1-dependent manner.

EMBO reports

Avec: John Heath , Estelle Simo Cheyou , Steven Findlay , Vincent M Luo , Edgar Pinedo Carpio , Jeesan Lee , Billel Djerir , Xiaoru Chen , Théo Morin , Benjamin Lebeau , Martin Karam , Halil Bagci , Damien Grapton , Josie Ursini-Siegel , Jean-Francois Côté , Michael Witcher , Stéphane Richard , Alexandre Maréchal , Alexandre Orthwein

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.

Blood advances

Avec: Maja Jankovic , William Wl Poon , Cristobal Gonzales-Losada , Gabriela Galicia Vazquez , Bahram Sharif-Askari , Yi Ding , Constance Craplet-Desombre , Alexandru Ilie , Jiantao Shi , Yongie Wang , Ashok Kumar Jayavelu , Alexandre Orthwein , Francois Emile Mercier

Common clonal origin of chronic myelomonocytic leukemia and B-cell acute lymphoblastic leukemia in a patient with a germline

Cold Spring Harbor molecular case studies

Avec: Alexandre Bazinet , John Heath , Anne-Sophie Chong , Estelle R Simo-Cheyou , Samantha Worme , Barbara Rivera Polo , William D Foulkes , Stephen Caplan , Nathalie A Johnson , Alexandre Orthwein , François E Mercier

Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes.

Genome research

Avec: Dana Sherill-Rofe , Dolev Rahat , Steven Findlay , Anna Mellul , Irene Guberman , Maya Braun , Idit Bloch , Alon Lalezari , Arash Samiei , Ruslan Sadreyev , Michal Goldberg , Alexandre Orthwein , Aviad Zick , Yuval Tabach

Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance.

Autophagy

Avec: Michael S Dahabieh , Fan Huang , Christophe Goncalves , Raúl Ernesto Flores González , Sathyen Prabhu , Alicia Bolt , Erminia Di Pietro , Elie Khoury , John Heath , Zi Yi Xu , Joelle Rémy-Sarrazin , Koren K Mann , Alexandre Orthwein , François-Michel Boisvert , Nancy Braverman , Wilson H Miller , Sonia V Del Rincón

Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families.

NPJ breast cancer

Avec: Thibaut S Matis , Nadia Zayed , Bouchra Labraki , Manon de Ladurantaye , Théophane A Matis , José Camacho Valenzuela , Nancy Hamel , Adrienne Atayan , Barbara Rivera , Yuval Tabach , Patricia N Tonin , Alexandre Orthwein , Anne-Marie Mes-Masson , Zaki El Haffaf , William D Foulkes , Paz Polak

The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.

Molecular and cellular biology

Avec: Vincent M Luo , Connie Shen , Samantha Worme , Aanya Bhagrath , Estelle Simo-Cheyou , Steven Findlay , Steven Hébert , William Wai Lam Poon , Zahra Aryanpour , Thomas Zhang , René P Zahedi , Jonathan Boulais , Zachary S Buchwald , Christoph H Borchers , Jean-Francois Côté , Claudia L Kleinman , Judith N Mandl , Alexandre Orthwein

FHL2 Is Essential for Spleen T Cell-Dependent B Cell Activation and Antibody Response.

ImmunoHorizons

Avec: Talin Ebrahimian , France Dierick , David Simon , Maryam Heidari , Alexandre Orthwein , Koren K Mann , Stephanie Lehoux

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax.

Journal of experimental & clinical cancer research : CR

Avec: Katie Fooks , Gabriela Galicia-Vazquez , Victor Gife , Alejandro Schcolnik-Cabrera , Zaynab Nouhi , William W L Poon , Vincent Luo , Ryan N Rys , Raquel Aloyz , Alexandre Orthwein , Nathalie A Johnson , Laura Hulea , Francois E Mercier

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.

Science advances

Avec: Edgar Pinedo-Carpio , Julien Dessapt , Adèle Beneyton , Lauralicia Sacre , Marie-Anne Bérubé , Romain Villot , Elise G Lavoie , Yan Coulombe , Andréanne Blondeau , Jonathan Boulais , Abba Malina , Vincent M Luo , Anna-Maria Lazaratos , Jean-François Côté , Frédérick A Mallette , Alba Guarné , Jean-Yves Masson , Amélie Fradet-Turcotte , Alexandre Orthwein

Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair.

NAR cancer

Avec: Dana Sherill-Rofe , Oded Raban , Steven Findlay , Dolev Rahat , Irene Unterman , Arash Samiei , Amber Yasmeen , Zafir Kaiser , Hellen Kuasne , Morag Park , William D Foulkes , Idit Bloch , Aviad Zick , Walter H Gotlieb , Yuval Tabach , Alexandre Orthwein

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies.

Blood advances

Avec: Francois E Mercier , Jiantao Shi , David B Sykes , Toshihiko Oki , Maja Jankovic , Cheuk Him Man , Youmna S Kfoury , Elizabeth Miller , Shutao He , Alexander Zhu , Radovan Vasic , John Doench , Alexandre Orthwein , Franziska Michor , David T Scadden

Systematic proximal mapping of the classical RAD51 paralogs unravel functionally and clinically relevant interactors for genome stability.

PLoS genetics

Avec: Estelle Simo Cheyou , Jacopo Boni , Jonathan Boulais , Edgar Pinedo-Carpio , Abba Malina , Dana Sherill-Rofe , Vincent M Luo , Christophe Goncalves , Halil Bagci , Alexandra Maters , Raquel Cuella-Martin , Yuval Tabach , Sonia Del Rincon , Jean-Francois Côté , Barbara Rivera , Alexandre Orthwein

Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.

Research square

Avec: Zachary Buchwald , Yang Shen , Erin Connolly , Meili Aiello , Chengjing Zhou , Prasanthi Chappa , Haorui Song , Patan Tippitak , Tarralyn Clark , Maria Cardenas , Nataliya Prokhnevska , Annapaola Mariniello , Meghana Pagadala , Vishal Dhere , Sarwish Rafiq , Aparna Kesarwala , Alexandre Orthwein , Susan Thomas , Mohammad Khan , J Brandon Dixon , Gregory B Lesinski , Michael Lowe , Haydn Kissick , David Yu , Chrystal Paulos , Nicole Schmitt

An E3 Ubiquitin Ligase Localization Screen Uncovers DTX2 as a Novel ADP-Ribosylation-Dependent Regulator of DNA Double-Strand Break Repair.

The Journal of biological chemistry

Avec: Billel Djerir , Isabelle Marois , Jean-Christophe Dubois , Steven Findlay , Théo Morin , Issam Senoussi , Laurent Cappadocia , Alexandre Orthwein , Alexandre Maréchal

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple Negative Breast Cancer by Attenuating TGFβ Signaling.

Cancer research

Avec: John Heath , Caitlynn Mirabelli , Matthew G Annis , Valerie Sabourin , Steven Hébert , Steven Findlay , HaEun Kim , Michael Witcher , Claudia L Kleinman , Peter M Siegel , Alexandre Orthwein , Josie Ursini-Siegel

Réseau de co-auteurs

Steven Findlay 7 collaborations

John Heath 5 collaborations

William D Foulkes 4 collaborations

Koren K Mann 4 collaborations

Vincent M Luo 4 collaborations

Yuval Tabach 4 collaborations

Barbara Rivera 3 collaborations

Jean-Francois Côté 3 collaborations

Dana Sherill-Rofe 3 collaborations

Jonathan Boulais 3 collaborations

Jacopo Boni 2 collaborations

Zaki El Haffaf 2 collaborations

Talin Ebrahimian 2 collaborations

France Dierick 2 collaborations

Stephanie Lehoux 2 collaborations

Zafir Kaiser 2 collaborations

Zahra Aryanpour 2 collaborations

Laura Hulea 2 collaborations

Estelle Simo Cheyou 2 collaborations

Billel Djerir 2 collaborations

Théo Morin 2 collaborations

Halil Bagci 2 collaborations

Josie Ursini-Siegel 2 collaborations

Michael Witcher 2 collaborations

Alexandre Maréchal 2 collaborations

Maja Jankovic 2 collaborations

Jiantao Shi 2 collaborations

Samantha Worme 2 collaborations

Nathalie A Johnson 2 collaborations

Dolev Rahat 2 collaborations

Idit Bloch 2 collaborations

Arash Samiei 2 collaborations

Aviad Zick 2 collaborations

Christophe Goncalves 2 collaborations

Steven Hébert 2 collaborations

Claudia L Kleinman 2 collaborations

Francois E Mercier 2 collaborations

Edgar Pinedo-Carpio 2 collaborations

Abba Malina 2 collaborations

Aida Idani 1 collaboration

Carla Roca 1 collaboration

Lidia Feliubadaló 1 collaboration

Eva Tomiak 1 collaboration

Evan Weber 1 collaboration

Conxi Lazaro 1 collaboration

Vincent Ta 1 collaboration

Maria Kotsiopriftis 1 collaboration

Jonathan O'Connor Miranda 1 collaboration

Remya Nair 1 collaboration

Ronald A Merrill 1 collaboration

Alexandre Cajelot 1 collaboration

Catherine St-Louis 1 collaboration

David Papadopoli 1 collaboration

Ivan Topisirovic 1 collaboration

Julie St-Pierre 1 collaboration

Michael Sebag 1 collaboration

Aparna H Kesarwala 1 collaboration

Eric B Taylor 1 collaboration

Mala Shanmugam 1 collaboration

Cynthia Guilbert 1 collaboration

Hsiang Chou 1 collaboration

Alicia M Bolt 1 collaboration

Ting Hua Wu 1 collaboration

Vincent Mingyi Luo 1 collaboration

Edgar Pinedo Carpio 1 collaboration

Jeesan Lee 1 collaboration

Xiaoru Chen 1 collaboration

Benjamin Lebeau 1 collaboration

Martin Karam 1 collaboration

Damien Grapton 1 collaboration

Stéphane Richard 1 collaboration

William Wl Poon 1 collaboration

Cristobal Gonzales-Losada 1 collaboration

Gabriela Galicia Vazquez 1 collaboration

Bahram Sharif-Askari 1 collaboration

Yi Ding 1 collaboration

Constance Craplet-Desombre 1 collaboration

Alexandru Ilie 1 collaboration

Yongie Wang 1 collaboration

Ashok Kumar Jayavelu 1 collaboration

Francois Emile Mercier 1 collaboration

Alexandre Bazinet 1 collaboration

Anne-Sophie Chong 1 collaboration

Estelle R Simo-Cheyou 1 collaboration

Barbara Rivera Polo 1 collaboration

Stephen Caplan 1 collaboration

François E Mercier 1 collaboration

Anna Mellul 1 collaboration

Irene Guberman 1 collaboration

Maya Braun 1 collaboration

Alon Lalezari 1 collaboration

Ruslan Sadreyev 1 collaboration

Michal Goldberg 1 collaboration

Michael S Dahabieh 1 collaboration

Fan Huang 1 collaboration

Raúl Ernesto Flores González 1 collaboration

Sathyen Prabhu 1 collaboration

Alicia Bolt 1 collaboration

Erminia Di Pietro 1 collaboration

Elie Khoury 1 collaboration

Zi Yi Xu 1 collaboration

Joelle Rémy-Sarrazin 1 collaboration

François-Michel Boisvert 1 collaboration

Nancy Braverman 1 collaboration

Wilson H Miller 1 collaboration

Sonia V Del Rincón 1 collaboration

Thibaut S Matis 1 collaboration

Nadia Zayed 1 collaboration

Bouchra Labraki 1 collaboration

Manon de Ladurantaye 1 collaboration

Théophane A Matis 1 collaboration

José Camacho Valenzuela 1 collaboration

Nancy Hamel 1 collaboration

Adrienne Atayan 1 collaboration

Patricia N Tonin 1 collaboration

Anne-Marie Mes-Masson 1 collaboration

Paz Polak 1 collaboration

Connie Shen 1 collaboration

Aanya Bhagrath 1 collaboration

Estelle Simo-Cheyou 1 collaboration

William Wai Lam Poon 1 collaboration

Thomas Zhang 1 collaboration

René P Zahedi 1 collaboration

Zachary S Buchwald 1 collaboration

Christoph H Borchers 1 collaboration

Judith N Mandl 1 collaboration

David Simon 1 collaboration

Maryam Heidari 1 collaboration

Katie Fooks 1 collaboration

Gabriela Galicia-Vazquez 1 collaboration

Victor Gife 1 collaboration

Alejandro Schcolnik-Cabrera 1 collaboration

Zaynab Nouhi 1 collaboration

William W L Poon 1 collaboration

Vincent Luo 1 collaboration

Ryan N Rys 1 collaboration

Raquel Aloyz 1 collaboration

Julien Dessapt 1 collaboration

Adèle Beneyton 1 collaboration

Lauralicia Sacre 1 collaboration

Marie-Anne Bérubé 1 collaboration

Romain Villot 1 collaboration

Elise G Lavoie 1 collaboration

Yan Coulombe 1 collaboration

Andréanne Blondeau 1 collaboration

Anna-Maria Lazaratos 1 collaboration

Jean-François Côté 1 collaboration

Frédérick A Mallette 1 collaboration

Alba Guarné 1 collaboration

Jean-Yves Masson 1 collaboration

Amélie Fradet-Turcotte 1 collaboration

Oded Raban 1 collaboration

Irene Unterman 1 collaboration

Amber Yasmeen 1 collaboration

Hellen Kuasne 1 collaboration

Morag Park 1 collaboration

Walter H Gotlieb 1 collaboration

David B Sykes 1 collaboration

Toshihiko Oki 1 collaboration

Cheuk Him Man 1 collaboration

Youmna S Kfoury 1 collaboration

Elizabeth Miller 1 collaboration

Shutao He 1 collaboration

Alexander Zhu 1 collaboration

Radovan Vasic 1 collaboration

John Doench 1 collaboration

Franziska Michor 1 collaboration

David T Scadden 1 collaboration

Alexandra Maters 1 collaboration

Raquel Cuella-Martin 1 collaboration

Sonia Del Rincon 1 collaboration

Zachary Buchwald 1 collaboration

Yang Shen 1 collaboration

Erin Connolly 1 collaboration

Meili Aiello 1 collaboration

Chengjing Zhou 1 collaboration

Prasanthi Chappa 1 collaboration

Haorui Song 1 collaboration

Patan Tippitak 1 collaboration

Tarralyn Clark 1 collaboration

Maria Cardenas 1 collaboration

Nataliya Prokhnevska 1 collaboration

Annapaola Mariniello 1 collaboration

Meghana Pagadala 1 collaboration

Vishal Dhere 1 collaboration

Sarwish Rafiq 1 collaboration

Aparna Kesarwala 1 collaboration

Susan Thomas 1 collaboration

Mohammad Khan 1 collaboration

J Brandon Dixon 1 collaboration

Gregory B Lesinski 1 collaboration

Michael Lowe 1 collaboration

Haydn Kissick 1 collaboration

David Yu 1 collaboration

Chrystal Paulos 1 collaboration

Nicole Schmitt 1 collaboration

Isabelle Marois 1 collaboration

Jean-Christophe Dubois 1 collaboration

Issam Senoussi 1 collaboration

Laurent Cappadocia 1 collaboration

Caitlynn Mirabelli 1 collaboration

Matthew G Annis 1 collaboration

Valerie Sabourin 1 collaboration

HaEun Kim 1 collaboration

Peter M Siegel 1 collaboration