Yousef Abu-Amer

Affiliations

Department of Orthopaedic Surgery, Washington University, St. Louis, MO, USA.

Publications (32)

Anti-Interleukin-6 Therapy Decreases Hip Synovitis and Bone Resorption and Increases Bone Formation Following Ischemic Osteonecrosis of the Femoral Head.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Avec: Yinshi Ren , Zhuo Deng , Vishal Gokani , Michael Kutschke , Thomas Wesley Mitchell , Olumide Aruwajoye , Naga Suresh Adapala , Nobuhiro Kamiya , Harry Kw Kim

Targeting the NF-κB signaling pathway in chronic tendon disease.

Science translational medicine

Avec: Adam C Abraham , Shivam A Shah , Mikhail Golman , Lee Song , Xiaoning Li , Iden Kurtaliaj , Moeed Akbar , Neal L Millar , Leesa M Galatz , Stavros Thomopoulos

PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Avec: Chun Wang , Jianqiu Xiao , Kathrin Nowak , Kapila Gunasekera , Yael Alippe , Sheree Speckman , Tong Yang , Dustin Kress , Michael O Hottiger , Gabriel Mbalaviele

Isoflurane Conditioning Provides Protection against Subarachnoid Hemorrhage Induced Delayed Cerebral Ischemia through NF-kB Inhibition.

Biomedicines

Avec: Meizi Liu , Keshav Jayaraman , Jogender Mehla , Deepti Diwan , James W Nelson , Ahmed E Hussein , Ananth K Vellimana , Gregory J Zipfel , Umeshkumar Athiraman

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss.

eLife

Avec: Chun Wang , Khushpreet Kaur , Canxin Xu , Gabriel Mbalaviele

Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.

PLoS biology

Avec: Jianqiu Xiao , Chun Wang , Juo-Chin Yao , Yael Alippe , Tong Yang , Dustin Kress , Kai Sun , Kourtney L Kostecki , Joseph B Monahan , Deborah J Veis , Daniel C Link , Gabriel Mbalaviele

Inflammatory Responses Reprogram T

Scientific reports

Avec: Tim Hung-Po Chen , Manoj Arra , Gabriel Mbalaviele , Gaurav Swarnkar ,

Cross-talk of inflammation and chondrocyte intracellular metabolism in osteoarthritis.

Osteoarthritis and cartilage

Avec: M Arra , Y Abu-Amer

Mechanisms Underlying Bone Loss Associated with Gut Inflammation.

International journal of molecular sciences

Avec: Ke Ke , Manoj Arra ,

Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Avec: Hua Shen , Susumu Yoneda , Farshid Guilak , Richard H Gelberman

Targeting angiogenesis for fracture nonunion treatment in inflammatory disease.

Bone research

Avec: Cuicui Wang , Jun Ying , Xiaolei Nie , Tianhong Zhou , Ding Xiao , Gaurav Swarnkar , Jianjun Guan , Jie Shen

Glutamine metabolism modulates chondrocyte inflammatory response.

eLife

Avec: Manoj Arra , Gaurav Swarnkar , Naga Suresh Adapala , Syeda Kanwal Naqvi , Lei Cai , Muhammad Farooq Rai , Srikanth Singamaneni , Gabriel Mbalaviele , Robert Brophy ,

DNA methylation mediated Rbpjk suppression protects against fracture nonunion caused by systemic inflammation.

The Journal of clinical investigation

Avec: Ding Xiao , Liang Fang , Zhongting Liu , Yonghua He , Jun Ying , Haocheng Qin , Aiwu Lu , Meng Shi , Tiandao Li , Bo Zhang , Jianjun Guan , Cuicui Wang , Jie Shen

Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.

eLife

Avec: Naga Suresh Adapala , Gaurav Swarnkar , Manoj Arra , Jie Shen , Gabriel Mbalaviele , Ke Ke ,

Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway.

JCI insight

Avec: Jun Ying , Taotao Xu , Cuicui Wang , Hongting Jin , Peijian Tong , Jianjun Guan , Regis O'Keefe , Jie Shen

Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Yael Alippe , Dustin Kress , Biancamaria Ricci , Kai Sun , Tong Yang , Chun Wang , Jianqiu Xiao , Gabriel Mbalaviele

Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle-Based Small Interfering RNA.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Xin Duan , Lei Cai , Christine T N Pham , Hua Pan , Robert H Brophy , Samuel A Wickline , Muhammad Farooq Rai

Methods to Analyze the Roles of TAK1, TRAF6, and NEMO in the Regulation of NF-κB Signaling by RANK Stimulation During Osteoclastogenesis.

Methods in molecular biology (Clifton, N.J.)

Avec: Gaurav Swarnkar , Manoj Arra , Suresh Adapala ,

Compound loss of GSDMD and GSDME function is necessary to achieve maximal therapeutic effect in colitis.

Journal of translational autoimmunity

Avec: Jianqiu Xiao , Kai Sun , Chun Wang , Gabriel Mbalaviele

DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Gaurav Swarnkar , Nicholas P Semenkovich , Manoj Arra , Dorothy K Mims , Syeda Kanwal Naqvi , Timothy Peterson , Gabriel Mbalaviele , Chia-Lung Wu ,

IĸBζ is a central modulator of inflammatory arthritis pathogenesis.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Gaurav Swarnkar , Musarrat Naaz , Dorothy Mims , Prashant Gupta , Timothy Peterson , Matthew J Christopher , Srikanth Singamaneni , Gabriel Mbalaviele ,

Targeting vascular endothelial growth factor ameliorates PMMA-particles induced inflammatory osteolysis in murine calvaria.

Bone

Avec: Wahid Abu-Amer , Manoj Arra , John C F Clohisy , Gaurav Swarnkar

Attenuation of NF-κB in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Avec: Ke Ke , Tim Hung-Po Chen , Manoj Arra , Gabriel Mbalaviele , Gaurav Swarnkar ,

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.

Nature communications

Avec: Manoj Arra , Gaurav Swarnkar , Ke Ke , Jesse E Otero , Jun Ying , Xin Duan , Takashi Maruyama , Muhammad Farooq Rai , Regis J O'Keefe , Gabriel Mbalaviele , Jie Shen ,

Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes.

Arthritis research & therapy

Avec: Tong Yang , Kai Sun , Chun Wang , Gaurav Swarnkar , Songtao Quan , Dustin Kress , Jianqiu Xiao , Yael Alippe , Hongjun Zheng , Robert H Brophy , Dingjun Hao , Audrey McAlinden , Jie Shen , Gabriel Mbalaviele

NLRP3 inflammasome activation triggers gasdermin D-independent inflammation.

Science immunology

Avec: Chun Wang , Tong Yang , Jianqiu Xiao , Canxin Xu , Yael Alippe , Kai Sun , Thirumala-Devi Kanneganti , Joseph B Monahan , Judy Lieberman , Gabriel Mbalaviele

Enhanced Tendon-to-Bone Healing via IKKβ Inhibition in a Rat Rotator Cuff Model.

The American journal of sports medicine

Avec: Mikhail Golman , Xiaoning Li , Dimitrios Skouteris , Adam A Abraham , Lee Song , Stavros Thomopoulos

Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling.

eLife

Avec: Kai Sun , Chun Wang , Jianqiu Xiao , Michael D Brodt , Luorongxin Yuan , Tong Yang , Yael Alippe , Huimin Hu , Dingjun Hao , Matthew J Silva , Jie Shen , Gabriel Mbalaviele

IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology.

Bone research

Avec: Manoj Arra , Gaurav Swarnkar , Yael Alippe , Gabriel Mbalaviele ,

Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB.

eLife

Avec: Gretchen A Meyer , Stavros Thomopoulos , Karen C Shen

STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Susan MacLauchlan , Priyanka Kushwaha , Albert Tai , Sijia Chen , Catherine Manning , Gaurav Swarnkar , Katherine A Fitzgerald , Shruti Sharma , Ellen M Gravallese

Isoflurane Conditioning-Induced Delayed Cerebral Ischemia Protection in Subarachnoid Hemorrhage-Role of Inducible Nitric Oxide Synthase.

Journal of the American Heart Association

Avec: Meizi Liu , Keshav Jayaraman , Aaron J Norris , Ahmed Hussein , James W Nelson , Jogender Mehla , Deepti Diwan , Ananth Vellimana , Gregory J Zipfel , Umeshkumar Athiraman

Réseau de co-auteurs

Gabriel Mbalaviele 16 collaborations

Gaurav Swarnkar 13 collaborations

Manoj Arra 10 collaborations

Chun Wang 8 collaborations

Jianqiu Xiao 7 collaborations

Yael Alippe 7 collaborations

Jie Shen 7 collaborations

Tong Yang 6 collaborations

Kai Sun 6 collaborations

Dustin Kress 4 collaborations

Ke Ke 4 collaborations

Jun Ying 4 collaborations

Naga Suresh Adapala 3 collaborations

Stavros Thomopoulos 3 collaborations

Cuicui Wang 3 collaborations

Jianjun Guan 3 collaborations

Muhammad Farooq Rai 3 collaborations

Mikhail Golman 2 collaborations

Lee Song 2 collaborations

Xiaoning Li 2 collaborations

Meizi Liu 2 collaborations

Keshav Jayaraman 2 collaborations

Jogender Mehla 2 collaborations

Deepti Diwan 2 collaborations

James W Nelson 2 collaborations

Gregory J Zipfel 2 collaborations

Umeshkumar Athiraman 2 collaborations

Canxin Xu 2 collaborations

Joseph B Monahan 2 collaborations

Tim Hung-Po Chen 2 collaborations

Ding Xiao 2 collaborations

Syeda Kanwal Naqvi 2 collaborations

Lei Cai 2 collaborations

Srikanth Singamaneni 2 collaborations

Xin Duan 2 collaborations

Robert H Brophy 2 collaborations

Timothy Peterson 2 collaborations

Dingjun Hao 2 collaborations

Yinshi Ren 1 collaboration

Zhuo Deng 1 collaboration

Vishal Gokani 1 collaboration

Michael Kutschke 1 collaboration

Thomas Wesley Mitchell 1 collaboration

Olumide Aruwajoye 1 collaboration

Nobuhiro Kamiya 1 collaboration

Harry Kw Kim 1 collaboration

Adam C Abraham 1 collaboration

Shivam A Shah 1 collaboration

Iden Kurtaliaj 1 collaboration

Moeed Akbar 1 collaboration

Neal L Millar 1 collaboration

Leesa M Galatz 1 collaboration

Kathrin Nowak 1 collaboration

Kapila Gunasekera 1 collaboration

Sheree Speckman 1 collaboration

Michael O Hottiger 1 collaboration

Ahmed E Hussein 1 collaboration

Ananth K Vellimana 1 collaboration

Khushpreet Kaur 1 collaboration

Juo-Chin Yao 1 collaboration

Kourtney L Kostecki 1 collaboration

Deborah J Veis 1 collaboration

Daniel C Link 1 collaboration

M Arra 1 collaboration

Y Abu-Amer 1 collaboration

Hua Shen 1 collaboration

Susumu Yoneda 1 collaboration

Farshid Guilak 1 collaboration

Richard H Gelberman 1 collaboration

Xiaolei Nie 1 collaboration

Tianhong Zhou 1 collaboration

Robert Brophy 1 collaboration

Liang Fang 1 collaboration

Zhongting Liu 1 collaboration

Yonghua He 1 collaboration

Haocheng Qin 1 collaboration

Aiwu Lu 1 collaboration

Meng Shi 1 collaboration

Tiandao Li 1 collaboration

Bo Zhang 1 collaboration

Taotao Xu 1 collaboration

Hongting Jin 1 collaboration

Peijian Tong 1 collaboration

Regis O'Keefe 1 collaboration

Biancamaria Ricci 1 collaboration

Christine T N Pham 1 collaboration

Hua Pan 1 collaboration

Samuel A Wickline 1 collaboration

Suresh Adapala 1 collaboration

Nicholas P Semenkovich 1 collaboration

Dorothy K Mims 1 collaboration

Chia-Lung Wu 1 collaboration

Musarrat Naaz 1 collaboration

Dorothy Mims 1 collaboration

Prashant Gupta 1 collaboration

Matthew J Christopher 1 collaboration

Wahid Abu-Amer 1 collaboration

John C F Clohisy 1 collaboration

Jesse E Otero 1 collaboration

Takashi Maruyama 1 collaboration

Regis J O'Keefe 1 collaboration

Songtao Quan 1 collaboration

Hongjun Zheng 1 collaboration

Audrey McAlinden 1 collaboration

Thirumala-Devi Kanneganti 1 collaboration

Judy Lieberman 1 collaboration

Dimitrios Skouteris 1 collaboration

Adam A Abraham 1 collaboration

Michael D Brodt 1 collaboration

Luorongxin Yuan 1 collaboration

Huimin Hu 1 collaboration

Matthew J Silva 1 collaboration

Gretchen A Meyer 1 collaboration

Karen C Shen 1 collaboration

Susan MacLauchlan 1 collaboration

Priyanka Kushwaha 1 collaboration

Albert Tai 1 collaboration

Sijia Chen 1 collaboration

Catherine Manning 1 collaboration

Katherine A Fitzgerald 1 collaboration

Shruti Sharma 1 collaboration

Ellen M Gravallese 1 collaboration

Aaron J Norris 1 collaboration

Ahmed Hussein 1 collaboration

Ananth Vellimana 1 collaboration