Tomas Mustelin

Affiliations

Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.

Publications (28)

Distal lung epithelial progenitor cell function declines with age.

Scientific reports

Avec: Julie K Watson , Philip Sanders , Rebecca Dunmore , Guglielmo Rosignoli , Yvon Julé , Emma L Rawlins , Richard May , Deborah Clarke , Donna K Finch

Autoantibodies Against Unmodified and Citrullinated Human Endogenous Retrovirus K Envelope Protein in Patients With Rheumatoid Arthritis.

The Journal of rheumatology

Avec: Xiaoxing Wang , Amanda Hefton , Kathryn Ni , Kennedy C Ukadike , Michael A Bowen , Mary Eckert , Anne Stevens , Christian Lood ,

Expression of L1 retrotransposons in granulocytes from patients with active systemic lupus erythematosus.

Mobile DNA

Avec: Kennedy C Ukadike , Rayan Najjar , Kathryn Ni , Amanda Laine , Xiaoxing Wang , Alison Bays , Martin S Taylor , John LaCava ,

Expression of Envelope Protein Encoded by Endogenous Retrovirus K102 in Rheumatoid Arthritis Neutrophils.

Microorganisms

Avec: Amanda Laine , Xiaoxing Wang , Kathryn Ni , Sarah E B Smith , Rayan Najjar , Leanne S Whitmore , Michael Yacoub , Alison Bays , Michael Gale ,

Keratinocytes present Staphylococcus aureus enterotoxins and promote malignant and non-malignant T cell proliferation in cutaneous T cell lymphoma.

The Journal of investigative dermatology

Avec: Ziao Zeng , Chella Krishna Vadivel , Maria Gluud , Martin R J Namini , Lang Yan , Sana Ahmad , Morten Bagge Hansen , Jonathan Coquet , Sergei B Koralov , Charlotte Menne Bonefeld , Anders Woetmann , Carsten Geisler , Emmanuella Guenova , Maria R Kamstrup , Thomas Litman , Lise-Mette R Gjerdrum , Terkild B Buus , Niels Ødum

Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus.

Journal of clinical medicine

Avec: Kennedy C Ukadike ,

Role of Neutrophils in Systemic Vasculitides.

Frontiers in immunology

Avec: Despina Michailidou , Christian Lood

The Contribution of PTPN22 to Rheumatic Disease.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Nunzio Bottini , Stephanie M Stanford

Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy.

Frontiers in immunology

Avec: Despina Michailidou , Daniella Muallem Schwartz , Grant C Hughes

Distinct Transcript-Level Expression Profiles and Unique Alternative Splicing in Inflammatory Myopathies.

ACR open rheumatology

Avec: Rayan Najjar , Hugh Alessi , Iago Pinal-Fernandez , Andrew L Mammen ,

Argonaute, Vault, and Ribosomal Proteins Targeted by Autoantibodies in Systemic Lupus Erythematosus.

The Journal of rheumatology

Avec: Fatemeh Moadab , Xiaoxing Wang , Rayan Najjar , Kennedy C Ukadike , Shaohui Hu , Tyler Hulett , Anders A Bengtsson , Christian Lood ,

Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus.

Frontiers in immunology

Avec: Christian Lood , Natalia V Giltiay

Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma.

Blood

Avec: Lise M Lindahl , Andreas Willerslev-Olsen , Lise M R Gjerdrum , Pia R Nielsen , Edda Blümel , Anne H Rittig , Pamela Celis , Bjorn Herpers , Jürgen C Becker , Birgitte Stausbøl-Grøn , Mariusz A Wasik , Maria Gluud , Simon Fredholm , Terkild B Buus , Claus Johansen , Claudia Nastasi , Lukas Peiffer , Linda Kubat , Michael Bzorek , Jens O Eriksen , Thorbjørn Krejsgaard , Charlotte M Bonefeld , Carsten Geisler , Erik Langhoff , Michael Givskov , Anders Woetmann , Mogens Kilian , Thomas Litman , Lars Iversen , Niels Odum

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.

Scientific reports

Avec: Elizabeth England , D Gareth Rees , Ian Christopher Scott , Sara Carmen , Denice T Y Chan , Catherine E Chaillan Huntington , Kirsty F Houslay , Teodor Erngren , Mark Penney , Jayesh B Majithiya , Laura Rapley , Dorothy A Sims , Claire Hollins , Elizabeth C Hinchy , Martin D Strain , Benjamin P Kemp , Dominic J Corkill , Richard D May , Katherine A Vousden , Robin J Butler , Tristan J Vaughan , David C Lowe , Caroline Colley , E Suzanne Cohen

Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker.

Cancer discovery

Avec: Martin S Taylor , Connie Wu , Peter C Fridy , Stephanie J Zhang , Yasmeen Senussi , Justina C Wolters , Tatiana Cajuso , Wen-Chih Cheng , John D Heaps , Bryant D Miller , Kei Mori , Limor Cohen , Hua Jiang , Kelly R Molloy , Brian T Chait , Michael G Goggins , Irun Bhan , Joseph W Franses , Xiaoyu Yang , Mary-Ellen Taplin , Xinan Wang , David C Christiani , Bruce E Johnson , Matthew Meyerson , Ravindra Uppaluri , Ann Marie Egloff , Elyssa N Denault , Laura M Spring , Tian-Li Wang , Ie-Ming Shih , Jennifer E Fairman , Euihye Jung , Kshitij S Arora , Osman H Yilmaz , Sonia Cohen , Tatyana Sharova , Gary Chi , Bryanna L Norden , Yuhui Song , Linda T Nieman , Leontios Pappas , Aparna R Parikh , Matthew R Strickland , Ryan B Corcoran , George Eng , Ömer H Yilmaz , Ursula A Matulonis , Andrew T Chan , Steven J Skates , Bo R Rueda , Ronny Drapkin , Samuel J Klempner , Vikram Deshpande , David T Ting , Michael P Rout , John LaCava , David R Walt , Kathleen H Burns

Autoantibodies are associated with disease progression in idiopathic pulmonary fibrosis.

The European respiratory journal

Avec: Katerina Koether , Valérie Besnard , Hilary Sandig , Alan Carruthers , Elena Miranda , Sabine Grootenboer-Mignot , Camille Taillé , Sylvie Chevret , Dominique Valeyre , Hilario Nunes , Dominique Israel-Biet , Wei Keat Lim , Vincent Cottin , Dominic Corkill , Claire Dobson , Maria Groves , Franco Ferraro , Edouard Guenzi , Ling Huang , Michal Sulikowski , Arnaud Mailleux , Lynne Anne Murray , Thomas Mustelin , Ian Strickland , Matthew A Sleeman , Bruno Crestani

Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes.

Mobile DNA

Avec: Fatemeh Moadab , Sepideh Sohrabi , Xiaoxing Wang , Rayan Najjar , Justina C Wolters , Hua Jiang , Wenyan Miao , Donna Romero , Dennis M Zaller , Megan Tran , Alison Bays , Martin S Taylor , Rosana Kapeller , John LaCava ,

High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus.

Arthritis & rheumatology (Hoboken, N.J.)

Avec: Victoria Carter , John LaCava , Martin S Taylor , Shu Ying Liang , Cecilia Mustelin , Kennedy C Ukadike , Anders Bengtsson , Christian Lood ,

Autoantibodies against the envelope proteins of endogenous retroviruses K102 and K108 in patients with systemic lupus erythematosus correlate with active disease.

Clinical and experimental rheumatology

Avec: Anastasia I Khadjinova , Xiaoxing Wang , Amanda Laine , Kennedy Ukadike , Mary Eckert , Anne Stevens , Anders A Bengtsson , Christian Lood ,

How Retroviruses and Retrotransposons in Our Genome May Contribute to Autoimmunity in Rheumatological Conditions.

Frontiers in immunology

Avec: Kennedy C Ukadike

Large overlap in neutrophil transcriptome between lupus and COVID-19 with limited lupus-specific gene expression.

Lupus science & medicine

Avec: Rayan Najjar , Noga Rogel , Jose Mario Bello Pineda , Xiaoxing Wang , Megan Tran , Alison Bays ,

Prediction of alternative pre-mRNA splicing outcomes.

Scientific reports

Avec: Rayan Najjar ,

Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis.

Scientific reports

Avec: Fatemeh Moadab , Xiaoxing Wang , Ethan Le , Tal Gazitt , Rayan Najjar , J Lee Nelson , Vijay Joshua , Vivianne Malmström , Keith Elkon , Caroline Grönwall ,

Autoantibodies against citrullinated serum albumin in patients with rheumatoid arthritis.

Journal of translational autoimmunity

Avec: Amanda Hefton , Shu Ying Liang , Kathryn Ni , Victoria Carter , Kennedy Ukadike , Christian Lood ,

Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Sladjana Skopelja-Gardner , Joyce Tai , Xizhang Sun , Lena Tanaka , James A Kuchenbecker , Jessica M Snyder , Paul Kubes , Keith B Elkon

IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus.

Arthritis research & therapy

Avec: Kennedy C Ukadike , Kathryn Ni , Xiaoxing Wang , Martin S Taylor , John LaCava , Lauren M Pachman , Mary Eckert , Anne Stevens , Christian Lood ,

Neutrophil activation in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis and large-vessel vasculitis.

Arthritis research & therapy

Avec: Despina Michailidou , Bhargavi Duvvuri , Runa Kuley , David Cuthbertson , Peter C Grayson , Nader A Khalidi , Curry L Koening , Carol A Langford , Carol A McAlear , Larry W Moreland , Christian Pagnoux , Philip Seo , Ulrich Specks , Antoine G Sreih , Kenneth J Warrington , Paul A Monach , Peter A Merkel , Christian Lood

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.

bioRxiv : the preprint server for biology

Avec: Martin S Taylor , Wu Connie , Peter C Fridy , Stephanie J Zhang , Yasmeen Senussi , Justina C Wolters , Wen-Chih Cheng , John Heaps , Bryant D Miller , Kei Mori , Limor Cohen , Hua Jiang , Kelly R Molloy , Bryanna L Norden , Brian T Chait , Michael Goggins , Irun Bhan , Joseph W Franses , Xiaoyu Yang , Mary-Ellen Taplin , Xinan Wang , David C Christiani , Bruce E Johnson , Matthew Meyerson , Ravindra Uppaluri , Ann Marie Egloff , Elyssa N Denault , Laura M Spring , Tian-Li Wang , Ie-Ming Shih , Euihye Jung , Kshitij S Arora , Lawrence R Zukerberg , Osman H Yilmaz , Gary Chi , Ursula A Matulonis , Yuhui Song , Linda Nieman , Aparna R Parikh , Matthew Strickland , Ryan B Corcoran , George Eng , Ã-Mer H Yilmaz , Steven J Skates , Bo R Rueda , Ronny Drapkin , Samuel J Klempner , Vikram Deshpande , David T Ting , Michael P Rout , John LaCava , David R Walt , Kathleen H Burns

Réseau de co-auteurs

Xiaoxing Wang 9 collaborations

Christian Lood 9 collaborations

Rayan Najjar 8 collaborations

Kennedy C Ukadike 7 collaborations

Martin S Taylor 6 collaborations

John LaCava 6 collaborations

Kathryn Ni 5 collaborations

Alison Bays 4 collaborations

Mary Eckert 3 collaborations

Anne Stevens 3 collaborations

Amanda Laine 3 collaborations

Despina Michailidou 3 collaborations

Fatemeh Moadab 3 collaborations

Justina C Wolters 3 collaborations

Hua Jiang 3 collaborations

Amanda Hefton 2 collaborations

Maria Gluud 2 collaborations

Anders Woetmann 2 collaborations

Carsten Geisler 2 collaborations

Thomas Litman 2 collaborations

Terkild B Buus 2 collaborations

Anders A Bengtsson 2 collaborations

Peter C Fridy 2 collaborations

Stephanie J Zhang 2 collaborations

Yasmeen Senussi 2 collaborations

Wen-Chih Cheng 2 collaborations

Bryant D Miller 2 collaborations

Kei Mori 2 collaborations

Limor Cohen 2 collaborations

Kelly R Molloy 2 collaborations

Brian T Chait 2 collaborations

Irun Bhan 2 collaborations

Joseph W Franses 2 collaborations

Xiaoyu Yang 2 collaborations

Mary-Ellen Taplin 2 collaborations

Xinan Wang 2 collaborations

David C Christiani 2 collaborations

Bruce E Johnson 2 collaborations

Matthew Meyerson 2 collaborations

Ravindra Uppaluri 2 collaborations

Ann Marie Egloff 2 collaborations

Elyssa N Denault 2 collaborations

Laura M Spring 2 collaborations

Tian-Li Wang 2 collaborations

Ie-Ming Shih 2 collaborations

Euihye Jung 2 collaborations

Kshitij S Arora 2 collaborations

Osman H Yilmaz 2 collaborations

Gary Chi 2 collaborations

Bryanna L Norden 2 collaborations

Yuhui Song 2 collaborations

Aparna R Parikh 2 collaborations

Ryan B Corcoran 2 collaborations

George Eng 2 collaborations

Ursula A Matulonis 2 collaborations

Steven J Skates 2 collaborations

Bo R Rueda 2 collaborations

Ronny Drapkin 2 collaborations

Samuel J Klempner 2 collaborations

Vikram Deshpande 2 collaborations

David T Ting 2 collaborations

Michael P Rout 2 collaborations

David R Walt 2 collaborations

Kathleen H Burns 2 collaborations

Megan Tran 2 collaborations

Victoria Carter 2 collaborations

Shu Ying Liang 2 collaborations

Kennedy Ukadike 2 collaborations

Julie K Watson 1 collaboration

Philip Sanders 1 collaboration

Rebecca Dunmore 1 collaboration

Guglielmo Rosignoli 1 collaboration

Yvon Julé 1 collaboration

Emma L Rawlins 1 collaboration

Richard May 1 collaboration

Deborah Clarke 1 collaboration

Donna K Finch 1 collaboration

Michael A Bowen 1 collaboration

Sarah E B Smith 1 collaboration

Leanne S Whitmore 1 collaboration

Michael Yacoub 1 collaboration

Michael Gale 1 collaboration

Ziao Zeng 1 collaboration

Chella Krishna Vadivel 1 collaboration

Martin R J Namini 1 collaboration

Lang Yan 1 collaboration

Sana Ahmad 1 collaboration

Morten Bagge Hansen 1 collaboration

Jonathan Coquet 1 collaboration

Sergei B Koralov 1 collaboration

Charlotte Menne Bonefeld 1 collaboration

Emmanuella Guenova 1 collaboration

Maria R Kamstrup 1 collaboration

Lise-Mette R Gjerdrum 1 collaboration

Niels Ødum 1 collaboration

Nunzio Bottini 1 collaboration

Stephanie M Stanford 1 collaboration

Daniella Muallem Schwartz 1 collaboration

Grant C Hughes 1 collaboration

Hugh Alessi 1 collaboration

Iago Pinal-Fernandez 1 collaboration

Andrew L Mammen 1 collaboration

Shaohui Hu 1 collaboration

Tyler Hulett 1 collaboration

Natalia V Giltiay 1 collaboration

Lise M Lindahl 1 collaboration

Andreas Willerslev-Olsen 1 collaboration

Lise M R Gjerdrum 1 collaboration

Pia R Nielsen 1 collaboration

Edda Blümel 1 collaboration

Anne H Rittig 1 collaboration

Pamela Celis 1 collaboration

Bjorn Herpers 1 collaboration

Jürgen C Becker 1 collaboration

Birgitte Stausbøl-Grøn 1 collaboration

Mariusz A Wasik 1 collaboration

Simon Fredholm 1 collaboration

Claus Johansen 1 collaboration

Claudia Nastasi 1 collaboration

Lukas Peiffer 1 collaboration

Linda Kubat 1 collaboration

Michael Bzorek 1 collaboration

Jens O Eriksen 1 collaboration

Thorbjørn Krejsgaard 1 collaboration

Charlotte M Bonefeld 1 collaboration

Erik Langhoff 1 collaboration

Michael Givskov 1 collaboration

Mogens Kilian 1 collaboration

Lars Iversen 1 collaboration

Niels Odum 1 collaboration

Elizabeth England 1 collaboration

D Gareth Rees 1 collaboration

Ian Christopher Scott 1 collaboration

Sara Carmen 1 collaboration

Denice T Y Chan 1 collaboration

Catherine E Chaillan Huntington 1 collaboration

Kirsty F Houslay 1 collaboration

Teodor Erngren 1 collaboration

Mark Penney 1 collaboration

Jayesh B Majithiya 1 collaboration

Laura Rapley 1 collaboration

Dorothy A Sims 1 collaboration

Claire Hollins 1 collaboration

Elizabeth C Hinchy 1 collaboration

Martin D Strain 1 collaboration

Benjamin P Kemp 1 collaboration

Dominic J Corkill 1 collaboration

Richard D May 1 collaboration

Katherine A Vousden 1 collaboration

Robin J Butler 1 collaboration

Tristan J Vaughan 1 collaboration

David C Lowe 1 collaboration

Caroline Colley 1 collaboration

E Suzanne Cohen 1 collaboration

Connie Wu 1 collaboration

Tatiana Cajuso 1 collaboration

John D Heaps 1 collaboration

Michael G Goggins 1 collaboration

Jennifer E Fairman 1 collaboration

Sonia Cohen 1 collaboration

Tatyana Sharova 1 collaboration

Linda T Nieman 1 collaboration

Leontios Pappas 1 collaboration

Matthew R Strickland 1 collaboration

Ömer H Yilmaz 1 collaboration

Andrew T Chan 1 collaboration

Katerina Koether 1 collaboration

Valérie Besnard 1 collaboration

Hilary Sandig 1 collaboration

Alan Carruthers 1 collaboration

Elena Miranda 1 collaboration

Sabine Grootenboer-Mignot 1 collaboration

Camille Taillé 1 collaboration

Sylvie Chevret 1 collaboration

Dominique Valeyre 1 collaboration

Hilario Nunes 1 collaboration

Dominique Israel-Biet 1 collaboration

Wei Keat Lim 1 collaboration

Vincent Cottin 1 collaboration

Dominic Corkill 1 collaboration

Claire Dobson 1 collaboration

Maria Groves 1 collaboration

Franco Ferraro 1 collaboration

Edouard Guenzi 1 collaboration

Ling Huang 1 collaboration

Michal Sulikowski 1 collaboration

Arnaud Mailleux 1 collaboration

Lynne Anne Murray 1 collaboration

Thomas Mustelin 1 collaboration

Ian Strickland 1 collaboration

Matthew A Sleeman 1 collaboration

Bruno Crestani 1 collaboration

Sepideh Sohrabi 1 collaboration

Wenyan Miao 1 collaboration

Donna Romero 1 collaboration

Dennis M Zaller 1 collaboration

Rosana Kapeller 1 collaboration

Cecilia Mustelin 1 collaboration

Anders Bengtsson 1 collaboration

Anastasia I Khadjinova 1 collaboration

Noga Rogel 1 collaboration

Jose Mario Bello Pineda 1 collaboration

Ethan Le 1 collaboration

Tal Gazitt 1 collaboration

J Lee Nelson 1 collaboration

Vijay Joshua 1 collaboration

Vivianne Malmström 1 collaboration

Keith Elkon 1 collaboration

Caroline Grönwall 1 collaboration

Sladjana Skopelja-Gardner 1 collaboration

Joyce Tai 1 collaboration

Xizhang Sun 1 collaboration

Lena Tanaka 1 collaboration

James A Kuchenbecker 1 collaboration

Jessica M Snyder 1 collaboration

Paul Kubes 1 collaboration

Keith B Elkon 1 collaboration

Lauren M Pachman 1 collaboration

Bhargavi Duvvuri 1 collaboration

Runa Kuley 1 collaboration

David Cuthbertson 1 collaboration

Peter C Grayson 1 collaboration

Nader A Khalidi 1 collaboration

Curry L Koening 1 collaboration

Carol A Langford 1 collaboration

Carol A McAlear 1 collaboration

Larry W Moreland 1 collaboration

Christian Pagnoux 1 collaboration

Philip Seo 1 collaboration

Ulrich Specks 1 collaboration

Antoine G Sreih 1 collaboration

Kenneth J Warrington 1 collaboration

Paul A Monach 1 collaboration

Peter A Merkel 1 collaboration

Wu Connie 1 collaboration

John Heaps 1 collaboration

Michael Goggins 1 collaboration

Lawrence R Zukerberg 1 collaboration

Linda Nieman 1 collaboration

Matthew Strickland 1 collaboration

Ã-Mer H Yilmaz 1 collaboration