Thomas R Cech

Affiliations

Department of Biochemistry, University of Colorado Boulder, Boulder, CO 80303, USA. thomas.cech@colorado.edu deborah.wuttke@colorado.edu.
BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.
Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO 80303, USA.

ORCID: 0000-0001-7338-3389

Publications (21)

The structure of human CST reveals a decameric assembly bound to telomeric DNA.

Science (New York, N.Y.)

Avec: Ci Ji Lim , Alexandra T Barbour , Arthur J Zaug , Karen J Goodrich , Allison E McKay , Deborah S Wuttke ,

CST does not evict elongating telomerase but prevents initiation by ssDNA binding.

Nucleic acids research

Avec: Arthur J Zaug , Ci Ji Lim , Conner L Olson , Maria T Carilli , Karen J Goodrich , Deborah S Wuttke ,

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.

Nature reviews. Molecular cell biology

Avec: Ci Ji Lim ,

Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Katerina Kraft , Kathryn E Yost , Sedona E Murphy , Andreas Magg , Yicheng Long , M Ryan Corces , Jeffrey M Granja , Lars Wittler , Stefan Mundlos , Alistair N Boettiger , Howard Y Chang

Multiple RNA- and DNA-binding proteins exhibit direct transfer of polynucleotides with implications for target-site search.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Wayne O Hemphill , Calvin K Voong , Regan Fenske , James A Goodrich ,

POT1 recruits and regulates CST-Polα/primase at human telomeres.

Cell

Avec: Sarah W Cai , Hiroyuki Takai , Arthur J Zaug , Teague C Dilgen , Thomas Walz , Titia de Lange

Reflections from Nobel laureates in chemistry.

Cell chemical biology

Avec: Emmanuelle Charpentier , Aaron Ciechanover , Robert J Lefkowitz , Kurt Wüthrich

Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Teisha J Rowland , Gabrijela Dumbović , Evan P Hass , John L Rinn ,

Regulation of histone methylation by automethylation of PRC2.

Genes & development

Avec: Xueyin Wang , Yicheng Long , Richard D Paucek , Anne R Gooding , Thomas Lee , Rachel M Burdorf ,

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.

Molecular cell

Avec: Daniel T Youmans , Anne R Gooding , Robin D Dowell ,

Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms.

bioRxiv : the preprint server for biology

Avec: Wayne O Hemphill , Halley R Steiner , Jackson R Kominsky , Deborah S Wuttke ,

Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis.

RNA (New York, N.Y.)

Avec: Kaitlin Johnson , Julia M Seidel ,

RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells.

Nature genetics

Avec: Yicheng Long , Taeyoung Hwang , Anne R Gooding , Karen J Goodrich , John L Rinn ,

Bending and looping of long DNA by Polycomb repressive complex 2 revealed by AFM imaging in liquid.

Nucleic acids research

Avec: Patrick R Heenan , Xueyin Wang , Anne R Gooding , Thomas T Perkins

Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.

Molecular cancer research : MCR

Avec: Josh Lewis Stern , Grace Hibshman , Kevin Hu , Sarah E Ferrara , James C Costello , William Kim , Pablo Tamayo , Franklin W Huang

Telomerase misbehaves after a breakup.

Science (New York, N.Y.)

Avec: Nausica Arnoult ,

DNMT1 inhibition by pUG-fold quadruplex RNA.

RNA (New York, N.Y.)

Avec: Linnea I Jansson-Fritzberg , Camila I Sousa , Michael J Smallegan , Jessica J Song , Anne R Gooding , Vignesh Kasinath , John L Rinn ,

Structural basis for inactivation of PRC2 by G-quadruplex RNA.

bioRxiv : the preprint server for biology

Avec: Jiarui Song , Anne R Gooding , Wayne O Hemphill , Vignesh Kasinath ,

PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner.

Molecular cell

Avec: Chen Davidovich , Richard G Jenner

Targeted mutagenesis in human iPSCs using CRISPR genome-editing tools.

Methods (San Diego, Calif.)

Avec: Yicheng Long ,

TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Neeraj Agarwal , Sebastien Rinaldetti , Bassem B Cheikh , Qiong Zhou , Evan P Hass , Robert T Jones , Molishree Joshi , Daniel V LaBarbera , Simon R V Knott , Dan Theodorescu

Réseau de co-auteurs

Anne R Gooding 6 collaborations

Yicheng Long 4 collaborations

Ci Ji Lim 3 collaborations

Arthur J Zaug 3 collaborations

Karen J Goodrich 3 collaborations

Deborah S Wuttke 3 collaborations

Wayne O Hemphill 3 collaborations

John L Rinn 3 collaborations

Evan P Hass 2 collaborations

Xueyin Wang 2 collaborations

Vignesh Kasinath 2 collaborations

Alexandra T Barbour 1 collaboration

Allison E McKay 1 collaboration

Conner L Olson 1 collaboration

Maria T Carilli 1 collaboration

Katerina Kraft 1 collaboration

Kathryn E Yost 1 collaboration

Sedona E Murphy 1 collaboration

Andreas Magg 1 collaboration

M Ryan Corces 1 collaboration

Jeffrey M Granja 1 collaboration

Lars Wittler 1 collaboration

Stefan Mundlos 1 collaboration

Alistair N Boettiger 1 collaboration

Howard Y Chang 1 collaboration

Calvin K Voong 1 collaboration

Regan Fenske 1 collaboration

James A Goodrich 1 collaboration

Sarah W Cai 1 collaboration

Hiroyuki Takai 1 collaboration

Teague C Dilgen 1 collaboration

Thomas Walz 1 collaboration

Titia de Lange 1 collaboration

Emmanuelle Charpentier 1 collaboration

Aaron Ciechanover 1 collaboration

Robert J Lefkowitz 1 collaboration

Kurt Wüthrich 1 collaboration

Teisha J Rowland 1 collaboration

Gabrijela Dumbović 1 collaboration

Richard D Paucek 1 collaboration

Thomas Lee 1 collaboration

Rachel M Burdorf 1 collaboration

Daniel T Youmans 1 collaboration

Robin D Dowell 1 collaboration

Halley R Steiner 1 collaboration

Jackson R Kominsky 1 collaboration

Kaitlin Johnson 1 collaboration

Julia M Seidel 1 collaboration

Taeyoung Hwang 1 collaboration

Patrick R Heenan 1 collaboration

Thomas T Perkins 1 collaboration

Josh Lewis Stern 1 collaboration

Grace Hibshman 1 collaboration

Kevin Hu 1 collaboration

Sarah E Ferrara 1 collaboration

James C Costello 1 collaboration

William Kim 1 collaboration

Pablo Tamayo 1 collaboration

Franklin W Huang 1 collaboration

Nausica Arnoult 1 collaboration

Linnea I Jansson-Fritzberg 1 collaboration

Camila I Sousa 1 collaboration

Michael J Smallegan 1 collaboration

Jessica J Song 1 collaboration

Jiarui Song 1 collaboration

Chen Davidovich 1 collaboration

Richard G Jenner 1 collaboration

Neeraj Agarwal 1 collaboration

Sebastien Rinaldetti 1 collaboration

Bassem B Cheikh 1 collaboration

Qiong Zhou 1 collaboration

Robert T Jones 1 collaboration

Molishree Joshi 1 collaboration

Daniel V LaBarbera 1 collaboration

Simon R V Knott 1 collaboration

Dan Theodorescu 1 collaboration