Steven P Gelone

Affiliations

Nabriva Therapeutics US, Inc., King of Prussia, Pennsylvania, USA.

Publications (19)

A Multicenter Evaluation of the US Prevalence and Regional Variation in Macrolide-Resistant

Open forum infectious diseases

Avec: Vikas Gupta , Kalvin C Yu , Jennifer Schranz ,

Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.

Antimicrobial agents and chemotherapy

Avec: Rodrigo E Mendes , Susanne Paukner , Timothy B Doyle , Robert K Flamm , Helio S Sader

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Thomas M File , Lisa Goldberg , Anita Das , Carolyn Sweeney , John Saviski , Elyse Seltzer , Susanne Paukner , Wolfgang W Wicha , George H Talbot , Leanne B Gasink

7-Year (2015-21) longitudinal surveillance of lefamulin in vitro activity against bacterial pathogens collected worldwide from patients with respiratory tract infections including pneumonia and characterization of resistance mechanisms.

The Journal of antimicrobial chemotherapy

Avec: Susanne Paukner , Rodrigo E Mendes , S J Ryan Arends , Gisela Gassner , Helio S Sader

Pooled microbiological findings and efficacy outcomes by pathogen in adults with community-acquired bacterial pneumonia from the Lefamulin Evaluation Against Pneumonia (LEAP) 1 and LEAP 2 phase 3 trials of lefamulin versus moxifloxacin.

Journal of global antimicrobial resistance

Avec: Susanne Paukner , Lisa Goldberg , Elizabeth Alexander , Anita F Das , Stefanie Heinrich , Pritty Patel , Gregory J Moran , Christian Sandrock , Thomas M File , Jorge E Vidal , Ken B Waites , Jennifer Schranz

Pharmacokinetics and safety of lefamulin after single intravenous dose administration in subjects with impaired renal function and those requiring hemodialysis.

Pharmacotherapy

Avec: Wolfgang W Wicha , Thomas C Marbury , James A Dowell , Jared L Crandon , Cathie Leister , James Ermer ,

Pharmacokinetics and safety of lefamulin after single intravenous dose administration in subjects with impaired-hepatic function.

Pharmacotherapy

Avec: Wolfgang W Wicha , Thomas C Marbury , James A Dowell , Jared L Crandon , Cathie Leister , James Ermer ,

Improving Traditional Registrational Trial End Points: Development and Application of a Desirability of Outcome Ranking End Point for Complicated Urinary Tract Infection Clinical Trials.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Jessica Howard-Anderson , Toshimitsu Hamasaki , Weixiao Dai , Deborah Collyar , Daniel Rubin , Sumathi Nambiar , Tori Kinamon , Carol Hill , David Mariano , Takamichi Baba , Thomas L Holland , Sarah B Doernberg , Henry F Chambers , Vance G Fowler , Scott R Evans , Helen W Boucher

In Vivo Immune-Modulatory Activity of Lefamulin in an Influenza Virus A (H1N1) Infection Model in Mice.

International journal of molecular sciences

Avec: Susanne Paukner , Sandra Kimber , Charlotte Cumper , Tina Rea-Davies , Lorena Sueiro Ballesteros , Christopher Kirkham , Adam Hargreaves , Claire Richards , Wolfgang W Wicha

Antibacterial Activity of Lefamulin against Pathogens Most Commonly Causing Community-Acquired Bacterial Pneumonia: SENTRY Antimicrobial Surveillance Program (2015-2016).

Antimicrobial agents and chemotherapy

Avec: Susanne Paukner , S J Ryan Arends , Robert K Flamm , Helio S Sader

Pharmacokinetic/pharmacodynamic target attainment analyses to support intravenous and oral lefamulin dose selection for the treatment of patients with community-acquired bacterial pneumonia.

The Journal of antimicrobial chemotherapy

Avec: Sujata M Bhavnani , Li Zhang , Jeffrey P Hammel , Christopher M Rubino , Justin C Bader , Helio S Sader , Wolfgang W Wicha , Paul G Ambrose

Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse model.

PloS one

Avec: Michael Hafner , Susanne Paukner , Wolfgang W Wicha , Boška Hrvačić , Matea Cedilak , Ivan Faraho ,

Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating

Frontiers in pharmacology

Avec: Susanne Jacobsson , Daniel Golparian , Joakim Oxelbark , Wolfgang W Wicha , Renata Maria Augusto da Costa , Francois Franceschi , David Brown , Arnold Louie , George Drusano , Magnus Unemo

Safety and Pharmacokinetics Following Oral or Intravenous Lefamulin in Adults With Cystic Fibrosis.

Clinical therapeutics

Avec: Gregory S Sawicki , Wolfgang W Wicha , Tara S Hiley , Nicole C Close , Christine J Guico-Pabia

Pharmacokinetics and tolerability of lefamulin following intravenous and oral dosing.

The Journal of antimicrobial chemotherapy

Avec: Wolfgang W Wicha , William T Prince , Claudia Lell , Werner Heilmayer ,

Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial.

JAMA

Avec: Elizabeth Alexander , Lisa Goldberg , Anita F Das , Gregory J Moran , Christian Sandrock , Leanne B Gasink , Patricia Spera , Carolyn Sweeney , Susanne Paukner , Wolfgang W Wicha , Jennifer Schranz

A plain language summary of how lefamulin alone can be used to treat pneumonia caught outside of the hospital due to common bacterial causes, including drug-resistant bacteria.

Future microbiology

Avec: Susanne Paukner , Gregory J Moran , Christian Sandrock , Thomas M File , Jorge E Vidal , Ken B Waites , Kalvin Yu

Physiologically-based pharmacokinetic modeling of the drug-drug interaction between ivacaftor and lefamulin in cystic fibrosis patients.

CPT: pharmacometrics & systems pharmacology

Avec: Magali Amiel , Alice Ke , Hannah M Jones , Wolfgang Wicha

Tissue Distribution of [

Antimicrobial agents and chemotherapy

Avec: Wolfgang W Wicha , Claire Henson , Kathryn Webbley ,

Réseau de co-auteurs

Wolfgang W Wicha 11 collaborations

Susanne Paukner 9 collaborations

Helio S Sader 4 collaborations

Jennifer Schranz 3 collaborations

Thomas M File 3 collaborations

Lisa Goldberg 3 collaborations

Gregory J Moran 3 collaborations

Christian Sandrock 3 collaborations

Rodrigo E Mendes 2 collaborations

Robert K Flamm 2 collaborations

Carolyn Sweeney 2 collaborations

Leanne B Gasink 2 collaborations

S J Ryan Arends 2 collaborations

Elizabeth Alexander 2 collaborations

Anita F Das 2 collaborations

Jorge E Vidal 2 collaborations

Ken B Waites 2 collaborations

Thomas C Marbury 2 collaborations

James A Dowell 2 collaborations

Jared L Crandon 2 collaborations

Cathie Leister 2 collaborations

James Ermer 2 collaborations

Vikas Gupta 1 collaboration

Kalvin C Yu 1 collaboration

Timothy B Doyle 1 collaboration

Anita Das 1 collaboration

John Saviski 1 collaboration

Elyse Seltzer 1 collaboration

George H Talbot 1 collaboration

Gisela Gassner 1 collaboration

Stefanie Heinrich 1 collaboration

Pritty Patel 1 collaboration

Jessica Howard-Anderson 1 collaboration

Toshimitsu Hamasaki 1 collaboration

Weixiao Dai 1 collaboration

Deborah Collyar 1 collaboration

Daniel Rubin 1 collaboration

Sumathi Nambiar 1 collaboration

Tori Kinamon 1 collaboration

Carol Hill 1 collaboration

David Mariano 1 collaboration

Takamichi Baba 1 collaboration

Thomas L Holland 1 collaboration

Sarah B Doernberg 1 collaboration

Henry F Chambers 1 collaboration

Vance G Fowler 1 collaboration

Scott R Evans 1 collaboration

Helen W Boucher 1 collaboration

Sandra Kimber 1 collaboration

Charlotte Cumper 1 collaboration

Tina Rea-Davies 1 collaboration

Lorena Sueiro Ballesteros 1 collaboration

Christopher Kirkham 1 collaboration

Adam Hargreaves 1 collaboration

Claire Richards 1 collaboration

Sujata M Bhavnani 1 collaboration

Li Zhang 1 collaboration

Jeffrey P Hammel 1 collaboration

Christopher M Rubino 1 collaboration

Justin C Bader 1 collaboration

Paul G Ambrose 1 collaboration

Michael Hafner 1 collaboration

Boška Hrvačić 1 collaboration

Matea Cedilak 1 collaboration

Ivan Faraho 1 collaboration

Susanne Jacobsson 1 collaboration

Daniel Golparian 1 collaboration

Joakim Oxelbark 1 collaboration

Renata Maria Augusto da Costa 1 collaboration

Francois Franceschi 1 collaboration

David Brown 1 collaboration

Arnold Louie 1 collaboration

George Drusano 1 collaboration

Magnus Unemo 1 collaboration

Gregory S Sawicki 1 collaboration

Tara S Hiley 1 collaboration

Nicole C Close 1 collaboration

Christine J Guico-Pabia 1 collaboration

William T Prince 1 collaboration

Claudia Lell 1 collaboration

Werner Heilmayer 1 collaboration

Patricia Spera 1 collaboration

Kalvin Yu 1 collaboration

Magali Amiel 1 collaboration

Alice Ke 1 collaboration

Hannah M Jones 1 collaboration

Wolfgang Wicha 1 collaboration

Claire Henson 1 collaboration

Kathryn Webbley 1 collaboration