Silke Leimkühler

Affiliations

Institute of Biochemistry and Biology, Department of Molecular Enzymology, University of Potsdam, Potsdam, Germany sleim@uni-potsdam.de.

ORCID: 0000-0003-3238-2122

Publications (40)

TusA Is a Versatile Protein That Links Translation Efficiency to Cell Division in Escherichia coli.

Journal of bacteriology

Avec: Tugba Yildiz ,

Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case.

Journal of medicinal chemistry

Avec: Cristiano Mota , Ana Diniz , Catarina Coelho , Teresa Santos-Silva , Mariam Esmaeeli , Eurico J Cabrita , Filipa Marcelo , Maria João Romão

Redox potentials elucidate the electron transfer pathway of NAD

Journal of inorganic biochemistry

Avec: Benjamin R Duffus , Marcel Gauglitz , Christian Teutloff ,

A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H.

Chemical communications (Cambridge, England)

Avec: Holly A Reeve , Jake Nicholson , Farieha Altaf , Thomas H Lonsdale , Janina Preissler , Lars Lauterbach , Oliver Lenz , Frank Hollmann , Caroline E Paul , Kylie A Vincent

The Mechanism of Metal-Containing Formate Dehydrogenases Revisited: The Formation of Bicarbonate as Product Intermediate Provides Evidence for an Oxygen Atom Transfer Mechanism.

Molecules (Basel, Switzerland)

Avec: Hemant Kumar , Maryam Khosraneh , Siva S M Bandaru , Carola Schulzke ,

Binding of IscU and TusA to different but competing sites of IscS influences the activity of IscS and directs sulfur to the respective biomolecular synthesis pathway.

Microbiology spectrum

Avec: Paolo Olivieri , Moritz Klabes , Jason C Crack , Angelika Lehmann , Sophie P Bennett , Nick E Le Brun ,

Shewanella decolorationis LDS1 Chromate Resistance.

Applied and environmental microbiology

Avec: Olivier N Lemaire , Flora A Honoré , Sébastien Tempel , Emma M Fortier , Vincent Méjean , Chantal Iobbi-Nivol

Iron-sulfur cluster carrier proteins involved in the assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I).

Molecular microbiology

Avec: Sabrina Burschel , Doris Kreuzer Decovic , Franziska Nuber , Marie Stiller , Maud Hofmann , Arkadiusz Zupok , Beata Siemiatkowska , Michal Gorka , Thorsten Friedrich

The biosynthesis of the molybdenum cofactors in Escherichia coli.

Environmental microbiology

Avec:

Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase.

Chemical reviews

Avec: Sven T Stripp , Benjamin R Duffus , Vincent Fourmond , Christophe Léger , Shun Hirota , Yilin Hu , Andrew Jasniewski , Hideaki Ogata , Markus W Ribbe

Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.

Angewandte Chemie (International ed. in English)

Avec: Arnar Sigurdsson , Berta M Martins , Simon A Düttmann , Martin Jasyk , Benjamin Dimos-Röhl , Felix Schöpf , Manuel Gemander , Caroline H Knittel , Romina Schnegotzki , Bianca Schmid , Simone Kosol , Lea Pommerening , María Gonzáles-Viegaz , Maria Seidel , Manuela Hügelland , Holger Dobbek , Andi Mainz , Roderich D Süssmuth

Cryo-EM structures reveal intricate Fe-S cluster arrangement and charging in Rhodobacter capsulatus formate dehydrogenase.

Nature communications

Avec: Christin Radon , Gerd Mittelstädt , Benjamin R Duffus , Jörg Bürger , Tobias Hartmann , Thorsten Mielke , Christian Teutloff , Petra Wendler

The regulation of Moco biosynthesis and molybdoenzyme gene expression by molybdenum and iron in bacteria.

Metallomics : integrated biometal science

Avec: Arkadiusz Zupok , Chantal Iobbi-Nivol , Vincent Méjean ,

Identification of YdhV as the First Molybdoenzyme Binding a Bis-Mo-MPT Cofactor in Escherichia coli.

Biochemistry

Avec: Stefan Reschke , Benjamin R Duffus , Peer Schrapers , Stefan Mebs , Christian Teutloff , Holger Dau , Michael Haumann ,

Involvement of aldehyde oxidase in the metabolism of aromatic and aliphatic aldehyde-odorants in the mouse olfactory epithelium.

Archives of biochemistry and biophysics

Avec: Naoki Takaoka , Seigo Sanoh , Shigeru Ohta , Mariam Esmaeeli , Mami Kurosaki , Mineko Terao , Enrico Garattini , Yaichiro Kotake

Electrochemical Trimethylamine

Biosensors

Avec: Armel F T Waffo , Biljana Mitrova , Kim Tiedemann , Chantal Iobbi-Nivol , Ulla Wollenberger

A-Type Carrier Proteins Are Involved in [4Fe-4S] Cluster Insertion into the Radical

Journal of bacteriology

Avec: Muhammad Abrar Hasnat , Arkadiusz Zupok , Justyna Jadwiga Olas , Bernd Mueller-Roeber ,

The Inactivation of Human Aldehyde Oxidase 1 by Hydrogen Peroxide and Superoxide.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Claudia Garrido ,

Nicotine inhalation and metabolism triggers AOX-mediated superoxide generation with oxidative lung injury.

The Journal of biological chemistry

Avec: Jay L Zweier , Tapan Kundu , Mahmoud Eid , Craig Hemann , Mohamed A El-Mahdy

Anion Binding and Oxidative Modification at the Molybdenum Cofactor of Formate Dehydrogenase from

Inorganic chemistry

Avec: Benjamin R Duffus , Peer Schrapers , Nils Schuth , Stefan Mebs , Holger Dau , Michael Haumann

The functional diversity of the prokaryotic sulfur carrier protein TusA.

Advances in microbial physiology

Avec: Tomohisa Sebastian Tanabe , Christiane Dahl

Iron-Dependent Regulation of Molybdenum Cofactor Biosynthesis Genes in Escherichia coli.

Journal of bacteriology

Avec: Arkadiusz Zupok , Michal Gorka , Beata Siemiatkowska , Aleksandra Skirycz ,

The Role of the Nucleotides in the Insertion of the bis-Molybdopterin Guanine Dinucleotide Cofactor into apo-Molybdoenzymes.

Molecules (Basel, Switzerland)

Avec: Kim Tiedemann , Chantal Iobbi-Nivol ,

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction.

Science advances

Avec: Kenji M Fujihara , Bonnie Z Zhang , Thomas D Jackson , Moses O Ogunkola , Brunda Nijagal , Julia V Milne , David A Sallman , Ching-Seng Ang , Iva Nikolic , Conor J Kearney , Simon J Hogg , Carlos S Cabalag , Vivien R Sutton , Sally Watt , Asuka T Fujihara , Joseph A Trapani , Kaylene J Simpson , Diana Stojanovski , Sue Haupt , Wayne A Phillips , Nicholas J Clemons

The [4Fe-4S]-Cluster of HydF is not Required for the Binding and Transfer of the Diiron Site of [FeFe]-Hydrogenases.

Chembiochem : a European journal of chemical biology

Avec: Rieke Haas , Vera Engelbrecht , Oliver Lampret , Shanika Yadav , Ulf-Peter Apfel , Thomas Happe

Metal-Containing Formate Dehydrogenases, a Personal View.

Molecules (Basel, Switzerland)

Avec:

TusA influences Fe-S cluster assembly and iron homeostasis in

Microbiology spectrum

Avec: Paolo Olivieri , Arkadiuz Zupok , Tugba Yildiz , Jonathan Oltmanns , Angelika Lehmann , Ewelina Sokolowska , Aleksandra Skirycz , Volker Schünemann ,

CyaY and TusA regulate ISC- and SUF-mediated l-cysteine desulfurase activity.

RSC chemical biology

Avec: Paolo Olivieri , Jason C Crack , Angelika Lehmann , Nick E Le Brun ,

Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes.

The Journal of biological chemistry

Avec: Mineko Terao , Enrico Garattini , Maria João Romão ,

Human aldehyde oxidase (hAOX1): structure determination of the Moco-free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms.

FEBS open bio

Avec: Cristiano Mota , Mariam Esmaeeli , Catarina Coelho , Teresa Santos-Silva , Martin Wolff , Alessandro Foti , Maria João Romão

Analysis of the Cellular Roles of MOCS3 Identifies a MOCS3-Independent Localization of NFS1 at the Tips of the Centrosome.

Biochemistry

Avec: Yannika Neukranz , Annika Kotter , Lena Beilschmidt , Zvonimir Marelja , Mark Helm , Ralph Gräf ,

The ABCB7-Like Transporter PexA in

Frontiers in microbiology

Avec: Simona Riedel , Beata Siemiatkowska , Mutsumi Watanabe , Christina S Müller , Volker Schünemann , Rainer Hoefgen ,

Reconstitution of Molybdoenzymes with Bis-Molybdopterin Guanine Dinucleotide Cofactors.

Methods in molecular biology (Clifton, N.J.)

Avec: Paul Kaufmann , Chantal Iobbi-Nivol ,

Infrared Spectroscopy Elucidates the Inhibitor Binding Sites in a Metal-Dependent Formate Dehydrogenase.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Konstantin Laun , Benjamin R Duffus , Stefan Wahlefeld , Sagie Katz , Dennis Belger , Peter Hildebrandt , Maria Andrea Mroginski , Ingo Zebger

Changing the Electron Acceptor Specificity of

International journal of molecular sciences

Avec: Hemant Kumar ,

Mechanistic insights into the ROS-mediated inactivation of human aldehyde oxidase.

FEBS letters

Avec: Mariam Esmaeeli , Manfred Nimtz , Lothar Jänsch , Lloyd W Ruddock ,

Iron limitation indirectly reduces the

Microbiology spectrum

Avec: Muhammad Abrar Hasnat , Arkadiusz Zupok , Michal Gorka , Chantal Iobbi-Nivol , Aleksandra Skirycz , Cécile Jourlin-Castelli , Frank Bier , Saloni Agarwal , Ehizode Irefo ,

The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells.

Biomolecules

Avec: Moses Olalekan Ogunkola , Gaelle Guiraudie-Capraz , Francois Feron ,

Inactivation of Human Aldehyde Oxidase by Small Sulfhydryl-Containing Reducing Agents.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Mariam Esmaeeli , Manfred Nimtz , Lothar Jänsch , Lloyd W Ruddock ,

Shared functions of FeS cluster assembly and Moco biosynthesis.

Biochimica et biophysica acta. Molecular cell research

Avec: Muhammad Abrar Hasnat ,

Réseau de co-auteurs

Benjamin R Duffus 6 collaborations

Chantal Iobbi-Nivol 6 collaborations

Mariam Esmaeeli 5 collaborations

Arkadiusz Zupok 5 collaborations

Maria João Romão 3 collaborations

Christian Teutloff 3 collaborations

Paolo Olivieri 3 collaborations

Angelika Lehmann 3 collaborations

Beata Siemiatkowska 3 collaborations

Michal Gorka 3 collaborations

Muhammad Abrar Hasnat 3 collaborations

Aleksandra Skirycz 3 collaborations

Tugba Yildiz 2 collaborations

Cristiano Mota 2 collaborations

Catarina Coelho 2 collaborations

Teresa Santos-Silva 2 collaborations

Hemant Kumar 2 collaborations

Jason C Crack 2 collaborations

Nick E Le Brun 2 collaborations

Vincent Méjean 2 collaborations

Peer Schrapers 2 collaborations

Stefan Mebs 2 collaborations

Holger Dau 2 collaborations

Michael Haumann 2 collaborations

Mineko Terao 2 collaborations

Enrico Garattini 2 collaborations

Kim Tiedemann 2 collaborations

Volker Schünemann 2 collaborations

Manfred Nimtz 2 collaborations

Lothar Jänsch 2 collaborations

Lloyd W Ruddock 2 collaborations

Ana Diniz 1 collaboration

Eurico J Cabrita 1 collaboration

Filipa Marcelo 1 collaboration

Marcel Gauglitz 1 collaboration

Holly A Reeve 1 collaboration

Jake Nicholson 1 collaboration

Farieha Altaf 1 collaboration

Thomas H Lonsdale 1 collaboration

Janina Preissler 1 collaboration

Lars Lauterbach 1 collaboration

Oliver Lenz 1 collaboration

Frank Hollmann 1 collaboration

Caroline E Paul 1 collaboration

Kylie A Vincent 1 collaboration

Maryam Khosraneh 1 collaboration

Siva S M Bandaru 1 collaboration

Carola Schulzke 1 collaboration

Moritz Klabes 1 collaboration

Sophie P Bennett 1 collaboration

Olivier N Lemaire 1 collaboration

Flora A Honoré 1 collaboration

Sébastien Tempel 1 collaboration

Emma M Fortier 1 collaboration

Sabrina Burschel 1 collaboration

Doris Kreuzer Decovic 1 collaboration

Franziska Nuber 1 collaboration

Marie Stiller 1 collaboration

Maud Hofmann 1 collaboration

Thorsten Friedrich 1 collaboration

Sven T Stripp 1 collaboration

Vincent Fourmond 1 collaboration

Christophe Léger 1 collaboration

Shun Hirota 1 collaboration

Yilin Hu 1 collaboration

Andrew Jasniewski 1 collaboration

Hideaki Ogata 1 collaboration

Markus W Ribbe 1 collaboration

Arnar Sigurdsson 1 collaboration

Berta M Martins 1 collaboration

Simon A Düttmann 1 collaboration

Martin Jasyk 1 collaboration

Benjamin Dimos-Röhl 1 collaboration

Felix Schöpf 1 collaboration

Manuel Gemander 1 collaboration

Caroline H Knittel 1 collaboration

Romina Schnegotzki 1 collaboration

Bianca Schmid 1 collaboration

Simone Kosol 1 collaboration

Lea Pommerening 1 collaboration

María Gonzáles-Viegaz 1 collaboration

Maria Seidel 1 collaboration

Manuela Hügelland 1 collaboration

Holger Dobbek 1 collaboration

Andi Mainz 1 collaboration

Roderich D Süssmuth 1 collaboration

Christin Radon 1 collaboration

Gerd Mittelstädt 1 collaboration

Jörg Bürger 1 collaboration

Tobias Hartmann 1 collaboration

Thorsten Mielke 1 collaboration

Petra Wendler 1 collaboration

Stefan Reschke 1 collaboration

Naoki Takaoka 1 collaboration

Seigo Sanoh 1 collaboration

Shigeru Ohta 1 collaboration

Mami Kurosaki 1 collaboration

Yaichiro Kotake 1 collaboration

Armel F T Waffo 1 collaboration

Biljana Mitrova 1 collaboration

Ulla Wollenberger 1 collaboration

Justyna Jadwiga Olas 1 collaboration

Bernd Mueller-Roeber 1 collaboration

Claudia Garrido 1 collaboration

Jay L Zweier 1 collaboration

Tapan Kundu 1 collaboration

Mahmoud Eid 1 collaboration

Craig Hemann 1 collaboration

Mohamed A El-Mahdy 1 collaboration

Nils Schuth 1 collaboration

Tomohisa Sebastian Tanabe 1 collaboration

Christiane Dahl 1 collaboration

Kenji M Fujihara 1 collaboration

Bonnie Z Zhang 1 collaboration

Thomas D Jackson 1 collaboration

Moses O Ogunkola 1 collaboration

Brunda Nijagal 1 collaboration

Julia V Milne 1 collaboration

David A Sallman 1 collaboration

Ching-Seng Ang 1 collaboration

Iva Nikolic 1 collaboration

Conor J Kearney 1 collaboration

Simon J Hogg 1 collaboration

Carlos S Cabalag 1 collaboration

Vivien R Sutton 1 collaboration

Sally Watt 1 collaboration

Asuka T Fujihara 1 collaboration

Joseph A Trapani 1 collaboration

Kaylene J Simpson 1 collaboration

Diana Stojanovski 1 collaboration

Sue Haupt 1 collaboration

Wayne A Phillips 1 collaboration

Nicholas J Clemons 1 collaboration

Rieke Haas 1 collaboration

Vera Engelbrecht 1 collaboration

Oliver Lampret 1 collaboration

Shanika Yadav 1 collaboration

Ulf-Peter Apfel 1 collaboration

Thomas Happe 1 collaboration

Arkadiuz Zupok 1 collaboration

Jonathan Oltmanns 1 collaboration

Ewelina Sokolowska 1 collaboration

Martin Wolff 1 collaboration

Alessandro Foti 1 collaboration

Yannika Neukranz 1 collaboration

Annika Kotter 1 collaboration

Lena Beilschmidt 1 collaboration

Zvonimir Marelja 1 collaboration

Mark Helm 1 collaboration

Ralph Gräf 1 collaboration

Simona Riedel 1 collaboration

Mutsumi Watanabe 1 collaboration

Christina S Müller 1 collaboration

Rainer Hoefgen 1 collaboration

Paul Kaufmann 1 collaboration

Konstantin Laun 1 collaboration

Stefan Wahlefeld 1 collaboration

Sagie Katz 1 collaboration

Dennis Belger 1 collaboration

Peter Hildebrandt 1 collaboration

Maria Andrea Mroginski 1 collaboration

Ingo Zebger 1 collaboration

Cécile Jourlin-Castelli 1 collaboration

Frank Bier 1 collaboration

Saloni Agarwal 1 collaboration

Ehizode Irefo 1 collaboration

Moses Olalekan Ogunkola 1 collaboration

Gaelle Guiraudie-Capraz 1 collaboration

Francois Feron 1 collaboration