Shoukat Dedhar

Affiliations

Genetics Unit, Integrative Oncology, BC Cancer, Vancouver, BC V5Z 1L3, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Publications (25)

Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors.

Cell stem cell

Avec: Katharina Rothe , Artem Babaian , Naoto Nakamichi , Min Chen , Shawn C Chafe , Akie Watanabe , Donna L Forrest , Dixie L Mager , Connie J Eaves , Xiaoyan Jiang

Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment.

Frontiers in cell and developmental biology

Avec: Geetha Venkateswaran ,

A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance.

Cell reports

Avec: Edward J Morris , Jordan A Gillespie , Christopher A Maxwell ,

New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis.

Cancers

Avec: Paul C McDonald ,

Co-vulnerabilities of inhibiting carbonic anhydrase IX in ferroptosis-mediated tumor cell death.

Frontiers in molecular biosciences

Avec: Paul C McDonald ,

PrP

Oncogene

Avec: Claire Lailler , Audrey Didelot , Simon Garinet , Hugo Berthou , Marine Sroussi , Aurélien de Reyniès , Séverine Martin-Lannerée , Elizabeth Fabre , Françoise Le Pimpec-Barthes , Alexandre Perrier , Virginie Poindessous , Audrey Mansuet-Lupo , Fatima Djouadi , Jean-Marie Launay , Pierre Laurent-Puig , Hélène Blons , Sophie Mouillet-Richard

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment.

Metabolites

Avec: Andrea Angeli , Fabrizio Carta , Alessio Nocentini , Jean-Yves Winum , Raivis Zalubovskis , Atilla Akdemir , Valentina Onnis , Wagdy M Eldehna , Clemente Capasso , Giuseppina De Simone , Simona Maria Monti , Simone Carradori , William A Donald , Claudiu T Supuran

Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism.

Heliyon

Avec: Jacqueline Tan , Murat Digicaylioglu , Stacy X J Wang , Jonathan Dresselhuis , Julia Mills

β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells.

Scientific reports

Avec: Rouhollah Mousavizadeh , Payman Hojabrpour , Felipe Eltit , Paul C McDonald , Robert G McCormack , Vincent Duronio , Seyed Mehdi Jafarnejad , Alex Scott

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking.

Molecular cancer research : MCR

Avec: Megan I Brasher , Shawn C Chafe , Paul C McDonald , Oksana Nemirovsky , Genya Gorshtein , Zachary J Gerbec , Wells S Brown , Olivia R Grafinger , Matthew Marchment , Esther Matus , Marc G Coppolino

Combination treatment with histone deacetylase and carbonic anhydrase 9 inhibitors shows therapeutic potential in experimental diffuse intrinsic pontine glioma.

Brain tumor pathology

Avec: Naohide Fujita , Andrew Bondoc , Sergio Simoes , Joji Ishida , Michael S Taccone , Amanda Luck , Dilakshan Srikanthan , Robert Siddaway , Adrian Levine , Nesrin Sabha , Stacey Krumholtz , Akihide Kondo , Hajime Arai , Christian Smith , Paul McDonald , Cynthia Hawkins , James Rutka

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts.

Cancers

Avec: Eva-Maria E Hedlund , Paul C McDonald , Oksana Nemirovsky , Shannon Awrey , Lasse D E Jensen ,

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Cancer immunology research

Avec: Shawn C Chafe , Paul C McDonald , Saeed Saberi , Oksana Nemirovsky , Geetha Venkateswaran , Samantha Burugu , Dongxia Gao , Alberto Delaidelli , Alastair H Kyle , Jennifer H E Baker , Jordan A Gillespie , Ali Bashashati , Andrew I Minchinton , Youwen Zhou , Sohrab P Shah ,

Guidelines and definitions for research on epithelial-mesenchymal transition.

Nature reviews. Molecular cell biology

Avec: Jing Yang , Parker Antin , Geert Berx , Cédric Blanpain , Thomas Brabletz , Marianne Bronner , Kyra Campbell , Amparo Cano , Jordi Casanova , Gerhard Christofori , Rik Derynck , Heide L Ford , Jonas Fuxe , Antonio García de Herreros , Gregory J Goodall , Anna-Katerina Hadjantonakis , Ruby Y J Huang , Chaya Kalcheim , Raghu Kalluri , Yibin Kang , Yeesim Khew-Goodall , Herbert Levine , Jinsong Liu , Gregory D Longmore , Sendurai A Mani , Joan Massagué , Roberto Mayor , David McClay , Keith E Mostov , Donald F Newgreen , M Angela Nieto , Alain Puisieux , Raymond Runyan , Pierre Savagner , Ben Stanger , Marc P Stemmler , Yoshiko Takahashi , Masatoshi Takeichi , Eric Theveneau , Jean Paul Thiery , Erik W Thompson , Robert A Weinberg , Elizabeth D Williams , Jianhua Xing , Binhua P Zhou , Guojun Sheng , Auteur inconnu

Evaluation of carbonic anhydrase IX as a potential therapeutic target in urothelial carcinoma.

Urologic oncology

Avec: Tilman Todenhöfer , Ewan A Gibb , Roland Seiler , Alireza Kamyabi , Jörg Hennenlotter , Paul McDonald , Igor Moskalev , Craig Stewart , Jian Gao , Ladan Fazli , Arnulf Stenzl , Htoo Zarni Oo , Peter C Black

A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells.

Molecular cancer therapeutics

Avec: Geetha Venkateswaran , Paul C McDonald , Shawn C Chafe , Wells S Brown , Zachary J Gerbec , Shannon J Awrey , Seth J Parker ,

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles.

Cancer & metabolism

Avec: Hassan A Ali , Joanna M Karasinska , James T Topham , Danisha Johal , Steve Kalloger , Andrew Metcalfe , Cassia S Warren , Anthony Miyagi , Lan V Tao , Maya Kevorkova , Shawn C Chafe , Paul C McDonald , Seth J Parker , Daniel J Renouf , David F Schaeffer

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors.

American journal of clinical oncology

Avec: Paul C McDonald , Stephen Chia , Philippe L Bedard , Quincy Chu , Michael Lyle , Liren Tang , Madhu Singh , Zaihui Zhang , Claudiu T Supuran , Daniel J Renouf ,

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.

Gastroenterology

Avec: Paul C McDonald , Shawn C Chafe , Wells S Brown , Saeed Saberi , Mridula Swayampakula , Geetha Venkateswaran , Oksana Nemirovsky , Jordan A Gillespie , Joanna M Karasinska , Steve E Kalloger , Claudiu T Supuran , David F Schaeffer , Ali Bashashati , Sohrab P Shah , James T Topham , Donald T Yapp , Jinyang Li , Daniel J Renouf , Ben Z Stanger ,

Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints.

Cancers

Avec: Shawn C Chafe , Nazia Riaz , Samantha Burugu , Dongxia Gao , Samuel C Y Leung , Anna F Lee , Cheng-Han Lee , Torsten O Nielsen

Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer.

Cell reports. Medicine

Avec: Wells S Brown , Paul C McDonald , Oksana Nemirovsky , Shannon Awrey , Shawn C Chafe , David F Schaeffer , Jinyang Li , Daniel J Renouf , Ben Z Stanger ,

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.

Science advances

Avec: Shawn C Chafe , Frederick S Vizeacoumar , Geetha Venkateswaran , Oksana Nemirovsky , Shannon Awrey , Wells S Brown , Paul C McDonald , Fabrizio Carta , Andrew Metcalfe , Joanna M Karasinska , Ling Huang , Senthil K Muthuswamy , David F Schaeffer , Daniel J Renouf , Claudiu T Supuran , Franco J Vizeacoumar ,

Prognostic value of the PrP

Oncoimmunology

Avec: Alexandre Ghazi , Delphine Le Corre , Camilla Pilati , Julien Taieb , Thomas Aparicio , Audrey Didelot , Claire Mulot , Karine Le Malicot , Fatima Djouadi , Aurélien de Reynies , Jean-Marie Launay , Pierre Laurent-Puig , Sophie Mouillet-Richard

Persister cell plasticity in tumour drug resistance.

Seminars in cell & developmental biology

Avec: Paul C McDonald ,

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside.

Cancers

Avec: Paul C McDonald , Shawn C Chafe , Claudiu T Supuran ,

Réseau de co-auteurs

Paul C McDonald 14 collaborations

Shawn C Chafe 10 collaborations

Oksana Nemirovsky 6 collaborations

Geetha Venkateswaran 5 collaborations

Claudiu T Supuran 5 collaborations

Wells S Brown 5 collaborations

Daniel J Renouf 5 collaborations

David F Schaeffer 4 collaborations

Jordan A Gillespie 3 collaborations

Shannon Awrey 3 collaborations

Joanna M Karasinska 3 collaborations

Audrey Didelot 2 collaborations

Fatima Djouadi 2 collaborations

Jean-Marie Launay 2 collaborations

Pierre Laurent-Puig 2 collaborations

Sophie Mouillet-Richard 2 collaborations

Fabrizio Carta 2 collaborations

Zachary J Gerbec 2 collaborations

Paul McDonald 2 collaborations

Saeed Saberi 2 collaborations

Samantha Burugu 2 collaborations

Dongxia Gao 2 collaborations

Ali Bashashati 2 collaborations

Sohrab P Shah 2 collaborations

Seth J Parker 2 collaborations

James T Topham 2 collaborations

Andrew Metcalfe 2 collaborations

Jinyang Li 2 collaborations

Ben Z Stanger 2 collaborations

Katharina Rothe 1 collaboration

Artem Babaian 1 collaboration

Naoto Nakamichi 1 collaboration

Min Chen 1 collaboration

Akie Watanabe 1 collaboration

Donna L Forrest 1 collaboration

Dixie L Mager 1 collaboration

Connie J Eaves 1 collaboration

Xiaoyan Jiang 1 collaboration

Edward J Morris 1 collaboration

Christopher A Maxwell 1 collaboration

Claire Lailler 1 collaboration

Simon Garinet 1 collaboration

Hugo Berthou 1 collaboration

Marine Sroussi 1 collaboration

Aurélien de Reyniès 1 collaboration

Séverine Martin-Lannerée 1 collaboration

Elizabeth Fabre 1 collaboration

Françoise Le Pimpec-Barthes 1 collaboration

Alexandre Perrier 1 collaboration

Virginie Poindessous 1 collaboration

Audrey Mansuet-Lupo 1 collaboration

Hélène Blons 1 collaboration

Andrea Angeli 1 collaboration

Alessio Nocentini 1 collaboration

Jean-Yves Winum 1 collaboration

Raivis Zalubovskis 1 collaboration

Atilla Akdemir 1 collaboration

Valentina Onnis 1 collaboration

Wagdy M Eldehna 1 collaboration

Clemente Capasso 1 collaboration

Giuseppina De Simone 1 collaboration

Simona Maria Monti 1 collaboration

Simone Carradori 1 collaboration

William A Donald 1 collaboration

Jacqueline Tan 1 collaboration

Murat Digicaylioglu 1 collaboration

Stacy X J Wang 1 collaboration

Jonathan Dresselhuis 1 collaboration

Julia Mills 1 collaboration

Rouhollah Mousavizadeh 1 collaboration

Payman Hojabrpour 1 collaboration

Felipe Eltit 1 collaboration

Robert G McCormack 1 collaboration

Vincent Duronio 1 collaboration

Seyed Mehdi Jafarnejad 1 collaboration

Alex Scott 1 collaboration

Megan I Brasher 1 collaboration

Genya Gorshtein 1 collaboration

Olivia R Grafinger 1 collaboration

Matthew Marchment 1 collaboration

Esther Matus 1 collaboration

Marc G Coppolino 1 collaboration

Naohide Fujita 1 collaboration

Andrew Bondoc 1 collaboration

Sergio Simoes 1 collaboration

Joji Ishida 1 collaboration

Michael S Taccone 1 collaboration

Amanda Luck 1 collaboration

Dilakshan Srikanthan 1 collaboration

Robert Siddaway 1 collaboration

Adrian Levine 1 collaboration

Nesrin Sabha 1 collaboration

Stacey Krumholtz 1 collaboration

Akihide Kondo 1 collaboration

Hajime Arai 1 collaboration

Christian Smith 1 collaboration

Cynthia Hawkins 1 collaboration

James Rutka 1 collaboration

Eva-Maria E Hedlund 1 collaboration

Lasse D E Jensen 1 collaboration

Alberto Delaidelli 1 collaboration

Alastair H Kyle 1 collaboration

Jennifer H E Baker 1 collaboration

Andrew I Minchinton 1 collaboration

Youwen Zhou 1 collaboration

Jing Yang 1 collaboration

Parker Antin 1 collaboration

Geert Berx 1 collaboration

Cédric Blanpain 1 collaboration

Thomas Brabletz 1 collaboration

Marianne Bronner 1 collaboration

Kyra Campbell 1 collaboration

Amparo Cano 1 collaboration

Jordi Casanova 1 collaboration

Gerhard Christofori 1 collaboration

Rik Derynck 1 collaboration

Heide L Ford 1 collaboration

Jonas Fuxe 1 collaboration

Antonio García de Herreros 1 collaboration

Gregory J Goodall 1 collaboration

Anna-Katerina Hadjantonakis 1 collaboration

Ruby Y J Huang 1 collaboration

Chaya Kalcheim 1 collaboration

Raghu Kalluri 1 collaboration

Yibin Kang 1 collaboration

Yeesim Khew-Goodall 1 collaboration

Herbert Levine 1 collaboration

Jinsong Liu 1 collaboration

Gregory D Longmore 1 collaboration

Sendurai A Mani 1 collaboration

Joan Massagué 1 collaboration

Roberto Mayor 1 collaboration

David McClay 1 collaboration

Keith E Mostov 1 collaboration

Donald F Newgreen 1 collaboration

M Angela Nieto 1 collaboration

Alain Puisieux 1 collaboration

Raymond Runyan 1 collaboration

Pierre Savagner 1 collaboration

Ben Stanger 1 collaboration

Marc P Stemmler 1 collaboration

Yoshiko Takahashi 1 collaboration

Masatoshi Takeichi 1 collaboration

Eric Theveneau 1 collaboration

Jean Paul Thiery 1 collaboration

Erik W Thompson 1 collaboration

Robert A Weinberg 1 collaboration

Elizabeth D Williams 1 collaboration

Jianhua Xing 1 collaboration

Binhua P Zhou 1 collaboration

Guojun Sheng 1 collaboration

None None 1 collaboration

Tilman Todenhöfer 1 collaboration

Ewan A Gibb 1 collaboration

Roland Seiler 1 collaboration

Alireza Kamyabi 1 collaboration

Jörg Hennenlotter 1 collaboration

Igor Moskalev 1 collaboration

Craig Stewart 1 collaboration

Jian Gao 1 collaboration

Ladan Fazli 1 collaboration

Arnulf Stenzl 1 collaboration

Htoo Zarni Oo 1 collaboration

Peter C Black 1 collaboration

Shannon J Awrey 1 collaboration

Hassan A Ali 1 collaboration

Danisha Johal 1 collaboration

Steve Kalloger 1 collaboration

Cassia S Warren 1 collaboration

Anthony Miyagi 1 collaboration

Lan V Tao 1 collaboration

Maya Kevorkova 1 collaboration

Stephen Chia 1 collaboration

Philippe L Bedard 1 collaboration

Quincy Chu 1 collaboration

Michael Lyle 1 collaboration

Liren Tang 1 collaboration

Madhu Singh 1 collaboration

Zaihui Zhang 1 collaboration

Mridula Swayampakula 1 collaboration

Steve E Kalloger 1 collaboration

Donald T Yapp 1 collaboration

Nazia Riaz 1 collaboration

Samuel C Y Leung 1 collaboration

Anna F Lee 1 collaboration

Cheng-Han Lee 1 collaboration

Torsten O Nielsen 1 collaboration

Frederick S Vizeacoumar 1 collaboration

Ling Huang 1 collaboration

Senthil K Muthuswamy 1 collaboration

Franco J Vizeacoumar 1 collaboration

Alexandre Ghazi 1 collaboration

Delphine Le Corre 1 collaboration

Camilla Pilati 1 collaboration

Julien Taieb 1 collaboration

Thomas Aparicio 1 collaboration

Claire Mulot 1 collaboration

Karine Le Malicot 1 collaboration

Aurélien de Reynies 1 collaboration