Sergi Regot

Affiliations

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. mcovert@stanford.edu sregot@jhmi.edu.
Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

ORCID: 0000-0001-9786-3897

Publications (14)

NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop.

Science signaling

Avec: Mialy M DeFelice , Helen R Clark , Jacob J Hughey , Inbal Maayan , Takamasa Kudo , Miriam V Gutschow , Markus W Covert ,

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate.

Cell

Avec: Colin Chih-Chien Wu , Amy Peterson , Boris Zinshteyn , Rachel Green

CDK4/6 activity is required during G

Science (New York, N.Y.)

Avec: Connor McKenney , Yovel Lendner , Adler Guerrero Zuniga , Niladri Sinha , Benjamin Veresko , Timothy J Aikin ,

CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution.

Nature communications

Avec: Qinchuan Wang , Erick O Hernández-Ochoa , Meera C Viswanathan , Ian D Blum , Danh C Do , Jonathan M Granger , Kevin R Murphy , An-Chi Wei , Susan Aja , Naili Liu , Corina M Antonescu , Liliana D Florea , C Conover Talbot , David Mohr , Kathryn R Wagner , Richard M Lovering , Peisong Gao , Mario A Bianchet , Mark N Wu , Anthony Cammarato , Martin F Schneider , Gabriel S Bever , Mark E Anderson

Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate.

Cell systems

Avec: Amy F Peterson , Kayla Ingram , E J Huang , Jeeun Parksong , Connor McKenney , Gabriel S Bever ,

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation.

eLife

Avec: Hee Won Yang , Steven D Cappell , Ariel Jaimovich , Chad Liu , Mingyu Chung , Leighton H Daigh , Lindsey R Pack , Yilin Fan , Markus Covert , Tobias Meyer

Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo.

Developmental cell

Avec: Michael J Pokrass , Kathleen A Ryan , Tianchi Xin , Brittany Pielstick , Winston Timp , Valentina Greco ,

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.

Nature cell biology

Avec: Tianchi Xin , Sara Gallini , Haoyang Wei , David G Gonzalez , Catherine Matte-Martone , Hiroki Machida , Hironobu Fujiwara , H Amalia Pasolli , Kathleen C Suozzi , Lauren E Gonzalez , Valentina Greco

The ribotoxic stress response drives UV-mediated cell death.

Cell

Avec: Niladri K Sinha , Connor McKenney , Zhong Y Yeow , Jeffrey J Li , Ki Hong Nam , Tomer M Yaron-Barir , Jared L Johnson , Emily M Huntsman , Lewis C Cantley , Alban Ordureau , Rachel Green

3D time-lapse microscopy paired with endpoint lineage analysis in mouse blastocysts.

STAR protocols

Avec: Michael J Pokrass ,

Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level.

Nature communications

Avec: Helen R Clark , Connor McKenney , Nathan M Livingston , Ariel Gershman , Seema Sajjan , Isaac S Chan , Andrew J Ewald , Winston Timp , Bin Wu , Abhyudai Singh ,

MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression.

eLife

Avec: Timothy J Aikin , Amy F Peterson , Michael J Pokrass , Helen R Clark ,

Organ function is preserved despite reorganization of niche architecture in the hair follicle.

Cell stem cell

Avec: Haoyang Wei , Shuangshuang Du , Jeeun Parksong , H Amalia Pasolli , Catherine Matte-Martone , Lauren E Gonzalez , Tianchi Xin , Valentina Greco

Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication.

Developmental cell

Avec: Adler Guerrero Zuniga , Timothy J Aikin , Connor McKenney , Yovel Lendner , Alain Phung , Paul W Hook , Amy Meltzer , Winston Timp ,

Réseau de co-auteurs

Connor McKenney 5 collaborations

Helen R Clark 3 collaborations

Timothy J Aikin 3 collaborations

Michael J Pokrass 3 collaborations

Tianchi Xin 3 collaborations

Winston Timp 3 collaborations

Valentina Greco 3 collaborations

Rachel Green 2 collaborations

Yovel Lendner 2 collaborations

Adler Guerrero Zuniga 2 collaborations

Gabriel S Bever 2 collaborations

Amy F Peterson 2 collaborations

Jeeun Parksong 2 collaborations

Haoyang Wei 2 collaborations

Catherine Matte-Martone 2 collaborations

H Amalia Pasolli 2 collaborations

Lauren E Gonzalez 2 collaborations

Mialy M DeFelice 1 collaboration

Jacob J Hughey 1 collaboration

Inbal Maayan 1 collaboration

Takamasa Kudo 1 collaboration

Miriam V Gutschow 1 collaboration

Markus W Covert 1 collaboration

Colin Chih-Chien Wu 1 collaboration

Amy Peterson 1 collaboration

Boris Zinshteyn 1 collaboration

Niladri Sinha 1 collaboration

Benjamin Veresko 1 collaboration

Qinchuan Wang 1 collaboration

Erick O Hernández-Ochoa 1 collaboration

Meera C Viswanathan 1 collaboration

Ian D Blum 1 collaboration

Danh C Do 1 collaboration

Jonathan M Granger 1 collaboration

Kevin R Murphy 1 collaboration

An-Chi Wei 1 collaboration

Susan Aja 1 collaboration

Naili Liu 1 collaboration

Corina M Antonescu 1 collaboration

Liliana D Florea 1 collaboration

C Conover Talbot 1 collaboration

David Mohr 1 collaboration

Kathryn R Wagner 1 collaboration

Richard M Lovering 1 collaboration

Peisong Gao 1 collaboration

Mario A Bianchet 1 collaboration

Mark N Wu 1 collaboration

Anthony Cammarato 1 collaboration

Martin F Schneider 1 collaboration

Mark E Anderson 1 collaboration

Kayla Ingram 1 collaboration

E J Huang 1 collaboration

Hee Won Yang 1 collaboration

Steven D Cappell 1 collaboration

Ariel Jaimovich 1 collaboration

Chad Liu 1 collaboration

Mingyu Chung 1 collaboration

Leighton H Daigh 1 collaboration

Lindsey R Pack 1 collaboration

Yilin Fan 1 collaboration

Markus Covert 1 collaboration

Tobias Meyer 1 collaboration

Kathleen A Ryan 1 collaboration

Brittany Pielstick 1 collaboration

Sara Gallini 1 collaboration

David G Gonzalez 1 collaboration

Hiroki Machida 1 collaboration

Hironobu Fujiwara 1 collaboration

Kathleen C Suozzi 1 collaboration

Niladri K Sinha 1 collaboration

Zhong Y Yeow 1 collaboration

Jeffrey J Li 1 collaboration

Ki Hong Nam 1 collaboration

Tomer M Yaron-Barir 1 collaboration

Jared L Johnson 1 collaboration

Emily M Huntsman 1 collaboration

Lewis C Cantley 1 collaboration

Alban Ordureau 1 collaboration

Nathan M Livingston 1 collaboration

Ariel Gershman 1 collaboration

Seema Sajjan 1 collaboration

Isaac S Chan 1 collaboration

Andrew J Ewald 1 collaboration

Bin Wu 1 collaboration

Abhyudai Singh 1 collaboration

Shuangshuang Du 1 collaboration

Alain Phung 1 collaboration

Paul W Hook 1 collaboration

Amy Meltzer 1 collaboration