Roland E Kontermann

Affiliations

Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569, Stuttgart, Germany.

Publications (37)

Influence of antigen density and immunosuppressive factors on tumor-targeted costimulation with antibody-fusion proteins and bispecific antibody-mediated T cell response.

Cancer immunology, immunotherapy : CII

Avec: Sabrina Sapski , Nadine Beha , Dafne Müller

A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3.

mAbs

Avec: Alexander Rau , Katharina Kocher , Mirjam Rommel , Lennart Kühl , Maximilian Albrecht , Hannes Gotthard , Nadine Aschmoneit , Bettina Noll , Monilola A Olayioye , Oliver Seifert

The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration.

Scientific reports

Avec: Natalia Ortí-Casañ , Ate S Boerema , Karina Köpke , Amber Ebskamp , Jan Keijser , Yuequ Zhang , Tingting Chen , Amalia M Dolga , Kerensa Broersen , Roman Fischer , Klaus Pfizenmaier , Ulrich L M Eisel

Exogenous activation of tumor necrosis factor receptor 2 promotes recovery from sensory and motor disease in a model of multiple sclerosis.

Brain, behavior, and immunity

Avec: Roman Fischer , Tanja Padutsch , Valerie Bracchi-Ricard , Kayla L Murphy , George F Martinez , Niky Delguercio , Nicholas Elmer , Maksim Sendetski , Ricarda Diem , Ulrich L M Eisel , Richard J Smeyne , Klaus Pfizenmaier , John R Bethea

Back-to-Germline (B2G) Procedure for Antibody Devolution.

Antibodies (Basel, Switzerland)

Avec: Anja Schrade , Alexander Bujotzek , Christian Spick , Martina Wagner , Johannes Goerl , Xenia Wezler , Guy Georges , Ulrich Brinkmann

Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes.

Pharmaceutics

Avec: Felista L Tansi , Ronny Rüger , Ansgar M Kollmeier , Markus Rabenhold , Frank Steiniger , Ulf K Teichgräber , Alfred Fahr , Ingrid Hilger

TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.

Cell death & disease

Avec: Franziska Wandrer , Stephanie Liebig , Silke Marhenke , Arndt Vogel , Katharina John , Michael P Manns , Andreas Teufel , Timo Itzel , Thomas Longerich , Olaf Maier , Roman Fischer , Klaus Pfizenmaier , Klaus Schulze-Osthoff , Heike Bantel

Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc).

Oncoimmunology

Avec: Nadine Aschmoneit , Katharina Kocher , Martin Siegemund , Martina S Lutz , Lennart Kühl , Oliver Seifert ,

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.

Nature immunology

Avec: Kai Ling Liang , Juliette Roels , Marieke Lavaert , Tom Putteman , Lena Boehme , Laurentijn Tilleman , Imke Velghe , Valentina Pegoretti , Inge Van de Walle , Stephanie Sontag , Jolien Vandewalle , Bart Vandekerckhove , Georges Leclercq , Pieter Van Vlierberghe , Claude Libert , Filip Van Nieuwerburgh , Roman Fischer , Klaus Pfizenmaier , Gina Doody , Martin Zenke , Tom Taghon

Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns.

Viruses

Avec: Leila Abassi , Federico Bertoglio , Željka Mačak Šafranko , Thomas Schirrmann , Marina Greweling-Pils , Oliver Seifert , Fawad Khan , Maeva Katzmarzyk , Henning Jacobsen , Natascha Gödecke , Philip Alexander Heine , André Frenzel , Helena Nowack , Stefan Dübel , Ivan-Christian Kurolt , Alemka Markotić , Maren Schubert , Michael Hust , Luka Čičin-Šain

Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc.

mAbs

Avec: Fabian Richter , Oliver Seifert , Andreas Herrmann , Klaus Pfizenmaier ,

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury.

CNS neuroscience & therapeutics

Avec: Marcus J Gerald , Valerie Bracchi-Ricard , Jerome Ricard , Roman Fischer , Bharadwaj Nandakumar , Gary H Blumenthal , Raushaun Williams , Klaus Pfizenmaier , Karen A Moxon , John R Bethea

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins.

mAbs

Avec: Christian Jost , Diana Darowski , John Challier , Vesna Pulko , Lydia J Hanisch , Wei Xu , Ekkehard Mössner , Alexander Bujotzek , Stefan Klostermann , Pablo Umana , Christian Klein

Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors.

Pharmaceutics

Avec: Felista L Tansi , Ronny Rüger , Claudia Böhm , Frank Steiniger , Martin Raasch , Alexander S Mosig , Ulf K Teichgräber , Alfred Fahr , Ingrid Hilger

OMTX705, a Novel FAP-Targeting ADC Demonstrates Activity in Chemotherapy and Pembrolizumab-Resistant Solid Tumor Models.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Myriam Fabre , Cristina Ferrer , Saioa Domínguez-Hormaetxe , Bruno Bockorny , Laura Murias , Oliver Seifert , Stephan A Eisler , Klaus Pfizenmaier , So Young Lee , María dM Vivanco , Pedro P López-Casas , Sofia Perea , Muhammad Abbas , Wolfgang Richter , Laureano Simon , Manuel Hidalgo

Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice.

Journal of neuroinflammation

Avec: Irini Papazian , Eleni Tsoukala , Athena Boutou , Maria Karamita , Konstantinos Kambas , Lida Iliopoulou , Roman Fischer , Maria C Denis , George Kollias , Hans Lassmann , Lesley Probert

Pharmacokinetic Engineering of OX40-Blocking Anticalin Proteins Using Monomeric Plasma Half-Life Extension Domains.

Frontiers in pharmacology

Avec: Martin Siegemund , Prajakta Oak , Eva-Maria Hansbauer , Andrea Allersdorfer , Karoline Utschick , Alexandra Winter , Christina Grasmüller , Gunther Galler , Jan-Peter Mayer , Benjamin Weiche , Josef Prassler , Christine Rothe

Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release.

Journal for immunotherapy of cancer

Avec: Nadine Aschmoneit , Lennart Kühl , Oliver Seifert ,

GlycoTAIL and FlexiTAIL as Half-Life Extension Modules for Recombinant Antibody Fragments.

Molecules (Basel, Switzerland)

Avec: Oliver Seifert ,

Tumor necrosis factor receptor 2 activation elicits sex-specific effects on cortical myelin proteins and functional recovery in a model of multiple sclerosis.

Brain research bulletin

Avec: Kayla L Nguyen , Ishaan J Bhatt , Shruti Gupta , Nazaf Showkat , Kathryn A Swanson , Roman Fischer , Klaus Pfizenmaier , Valerie Bracchi-Ricard , John R Bethea

Inhibition of Tumor Cell Growth and Cancer Stem Cell Expansion by a Bispecific Antibody Targeting EGFR and HER3.

Molecular cancer therapeutics

Avec: Alexander Rau , Wolfgang S Lieb , Oliver Seifert , Jonas Honer , Dennis Birnstock , Fabian Richter , Nadine Aschmoneit , Monilola A Olayioye ,

Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids.

Cell death and differentiation

Avec: Daniela Stöhr , Jens O Schmid , Tobias B Beigl , Alexandra Mack , Daniela S Maichl , Kai Cao , Beate Budai , Gavin Fullstone , Thomas E Mürdter , Stephen W G Tait , Cathrin Hagenlocher , Nadine Pollak , Peter Scheurich , Markus Rehm

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach.

Frontiers in cell and developmental biology

Avec: Roman Fischer , Klaus Pfizenmaier

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Roman Fischer , Maksim Sendetski , Tania Del Rivero , George F Martinez , Valerie Bracchi-Ricard , Kathryn A Swanson , Elizabeth K Pruzinsky , Niky Delguercio , Michael J Rosalino , Tanja Padutsch , Klaus Pfizenmaier , John R Bethea

Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules.

mAbs

Avec: Oliver Seifert , Alexander Rau , Nadine Beha , Fabian Richter ,

IL15-Based Trifunctional Antibody-Fusion Proteins with Costimulatory TNF-Superfamily Ligands in the Single-Chain Format for Cancer Immunotherapy.

Molecular cancer therapeutics

Avec: Nadine Beha , Markus Harder , Sarah Ring , Dafne Müller

Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity.

mAbs

Avec: Fabian Richter , Kirstin A Zettlitz , Oliver Seifert , Andreas Herrmann , Peter Scheurich , Klaus Pfizenmaier ,

Low-Level Endothelial TRAIL-Receptor Expression Obstructs the CNS-Delivery of Angiopep-2 Functionalised TRAIL-Receptor Agonists for the Treatment of Glioblastoma.

Molecules (Basel, Switzerland)

Avec: Nivetha Krishna Moorthy , Oliver Seifert , Stephan Eisler , Sara Weirich , Markus Rehm , Gavin Fullstone

A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells.

Scientific reports

Avec: Nadine Aschmoneit , Sophia Steinlein , Lennart Kühl , Oliver Seifert ,

Superior Treg-Expanding Properties of a Novel Dual-Acting Cytokine Fusion Protein.

Frontiers in pharmacology

Avec: Tanja Padutsch , Maksim Sendetski , Carina Huber , Nathalie Peters , Klaus Pfizenmaier , John R Bethea , Roman Fischer

The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation.

Frontiers in immunology

Avec: Fabian Richter , Sarah K Williams , Katharina John , Carina Huber , Camille Vaslin , Henri Zanker , Richard Fairless , Kira Pichi , Silke Marhenke , Arndt Vogel , Marie-Ann Dhaen , Stefanie Herrmann , Andreas Herrmann , Klaus Pfizenmaier , Heike Bantel , Ricarda Diem , Roman Fischer

Proteolysis-Targeting Chimeras Enhance T Cell Bispecific Antibody-Driven T Cell Activation and Effector Function through Increased MHC Class I Antigen Presentation in Cancer Cells.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Vittoria Massafra , Sofia Tundo , Aline Dietzig , Axel Ducret , Christian Jost , Christian Klein , Hendrik Knoetgen , Martin Steegmaier , Andrea Romagnani , Yvonne A Nagel

Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma.

Cell death & disease

Avec: Greta Del Mistro , Shamala Riemann , Sebastian Schindler , Stefan Beissert , Aurelien Ginolhac , Rashi Halder , Luana Presta , Lasse Sinkkonen , Thomas Sauter , Dagmar Kulms

Triple Targeting of HER Receptors Overcomes Heregulin-mediated Resistance to EGFR Blockade in Colorectal Cancer.

Molecular cancer therapeutics

Avec: Alexander Rau , Nicole Janssen , Lennart Kühl , Thomas Sell , Svetlana Kalmykova , Thomas E Mürdter , Marc-H Dahlke , Christine Sers , Markus Morkel , Matthias Schwab , Monilola A Olayioye

Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis.

Journal of neuroinflammation

Avec: Timon Fiedler , Richard Fairless , Kira Pichi , Roman Fischer , Fabian Richter , Klaus Pfizenmaier , Ricarda Diem , Sarah K Williams

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS.

Journal of neuroinflammation

Avec: Valentina Pegoretti , Jan Bauer , Roman Fischer , Iskra Paro , Wanda Douwenga , Klaus Pfizenmaier , Evelien Houben , Bieke Broux , Niels Hellings , Wia Baron , Jon D Laman , Ulrich L M Eisel

The present and future of bispecific antibodies for cancer therapy.

Nature reviews. Drug discovery

Avec: Christian Klein , Ulrich Brinkmann , Janice M Reichert ,

Réseau de co-auteurs

Klaus Pfizenmaier 15 collaborations

Roman Fischer 13 collaborations

Oliver Seifert 12 collaborations

Fabian Richter 6 collaborations

Lennart Kühl 5 collaborations

Nadine Aschmoneit 5 collaborations

John R Bethea 5 collaborations

Alexander Rau 4 collaborations

Valerie Bracchi-Ricard 4 collaborations

Nadine Beha 3 collaborations

Monilola A Olayioye 3 collaborations

Ulrich L M Eisel 3 collaborations

Tanja Padutsch 3 collaborations

Maksim Sendetski 3 collaborations

Ricarda Diem 3 collaborations

Andreas Herrmann 3 collaborations

Christian Klein 3 collaborations

Dafne Müller 2 collaborations

Katharina Kocher 2 collaborations

George F Martinez 2 collaborations

Niky Delguercio 2 collaborations

Alexander Bujotzek 2 collaborations

Ulrich Brinkmann 2 collaborations

Felista L Tansi 2 collaborations

Ronny Rüger 2 collaborations

Frank Steiniger 2 collaborations

Ulf K Teichgräber 2 collaborations

Alfred Fahr 2 collaborations

Ingrid Hilger 2 collaborations

Silke Marhenke 2 collaborations

Arndt Vogel 2 collaborations

Katharina John 2 collaborations

Heike Bantel 2 collaborations

Martin Siegemund 2 collaborations

Valentina Pegoretti 2 collaborations

Christian Jost 2 collaborations

Kathryn A Swanson 2 collaborations

Gavin Fullstone 2 collaborations

Thomas E Mürdter 2 collaborations

Peter Scheurich 2 collaborations

Markus Rehm 2 collaborations

Carina Huber 2 collaborations

Sarah K Williams 2 collaborations

Richard Fairless 2 collaborations

Kira Pichi 2 collaborations

Sabrina Sapski 1 collaboration

Mirjam Rommel 1 collaboration

Maximilian Albrecht 1 collaboration

Hannes Gotthard 1 collaboration

Bettina Noll 1 collaboration

Natalia Ortí-Casañ 1 collaboration

Ate S Boerema 1 collaboration

Karina Köpke 1 collaboration

Amber Ebskamp 1 collaboration

Jan Keijser 1 collaboration

Yuequ Zhang 1 collaboration

Tingting Chen 1 collaboration

Amalia M Dolga 1 collaboration

Kerensa Broersen 1 collaboration

Kayla L Murphy 1 collaboration

Nicholas Elmer 1 collaboration

Richard J Smeyne 1 collaboration

Anja Schrade 1 collaboration

Christian Spick 1 collaboration

Martina Wagner 1 collaboration

Johannes Goerl 1 collaboration

Xenia Wezler 1 collaboration

Guy Georges 1 collaboration

Ansgar M Kollmeier 1 collaboration

Markus Rabenhold 1 collaboration

Franziska Wandrer 1 collaboration

Stephanie Liebig 1 collaboration

Michael P Manns 1 collaboration

Andreas Teufel 1 collaboration

Timo Itzel 1 collaboration

Thomas Longerich 1 collaboration

Olaf Maier 1 collaboration

Klaus Schulze-Osthoff 1 collaboration

Martina S Lutz 1 collaboration

Kai Ling Liang 1 collaboration

Juliette Roels 1 collaboration

Marieke Lavaert 1 collaboration

Tom Putteman 1 collaboration

Lena Boehme 1 collaboration

Laurentijn Tilleman 1 collaboration

Imke Velghe 1 collaboration

Inge Van de Walle 1 collaboration

Stephanie Sontag 1 collaboration

Jolien Vandewalle 1 collaboration

Bart Vandekerckhove 1 collaboration

Georges Leclercq 1 collaboration

Pieter Van Vlierberghe 1 collaboration

Claude Libert 1 collaboration

Filip Van Nieuwerburgh 1 collaboration

Gina Doody 1 collaboration

Martin Zenke 1 collaboration

Tom Taghon 1 collaboration

Leila Abassi 1 collaboration

Federico Bertoglio 1 collaboration

Željka Mačak Šafranko 1 collaboration

Thomas Schirrmann 1 collaboration

Marina Greweling-Pils 1 collaboration

Fawad Khan 1 collaboration

Maeva Katzmarzyk 1 collaboration

Henning Jacobsen 1 collaboration

Natascha Gödecke 1 collaboration

Philip Alexander Heine 1 collaboration

André Frenzel 1 collaboration

Helena Nowack 1 collaboration

Stefan Dübel 1 collaboration

Ivan-Christian Kurolt 1 collaboration

Alemka Markotić 1 collaboration

Maren Schubert 1 collaboration

Michael Hust 1 collaboration

Luka Čičin-Šain 1 collaboration

Marcus J Gerald 1 collaboration

Jerome Ricard 1 collaboration

Bharadwaj Nandakumar 1 collaboration

Gary H Blumenthal 1 collaboration

Raushaun Williams 1 collaboration

Karen A Moxon 1 collaboration

Diana Darowski 1 collaboration

John Challier 1 collaboration

Vesna Pulko 1 collaboration

Lydia J Hanisch 1 collaboration

Wei Xu 1 collaboration

Ekkehard Mössner 1 collaboration

Stefan Klostermann 1 collaboration

Pablo Umana 1 collaboration

Claudia Böhm 1 collaboration

Martin Raasch 1 collaboration

Alexander S Mosig 1 collaboration

Myriam Fabre 1 collaboration

Cristina Ferrer 1 collaboration

Saioa Domínguez-Hormaetxe 1 collaboration

Bruno Bockorny 1 collaboration

Laura Murias 1 collaboration

Stephan A Eisler 1 collaboration

So Young Lee 1 collaboration

María dM Vivanco 1 collaboration

Pedro P López-Casas 1 collaboration

Sofia Perea 1 collaboration

Muhammad Abbas 1 collaboration

Wolfgang Richter 1 collaboration

Laureano Simon 1 collaboration

Manuel Hidalgo 1 collaboration

Irini Papazian 1 collaboration

Eleni Tsoukala 1 collaboration

Athena Boutou 1 collaboration

Maria Karamita 1 collaboration

Konstantinos Kambas 1 collaboration

Lida Iliopoulou 1 collaboration

Maria C Denis 1 collaboration

George Kollias 1 collaboration

Hans Lassmann 1 collaboration

Lesley Probert 1 collaboration

Prajakta Oak 1 collaboration

Eva-Maria Hansbauer 1 collaboration

Andrea Allersdorfer 1 collaboration

Karoline Utschick 1 collaboration

Alexandra Winter 1 collaboration

Christina Grasmüller 1 collaboration

Gunther Galler 1 collaboration

Jan-Peter Mayer 1 collaboration

Benjamin Weiche 1 collaboration

Josef Prassler 1 collaboration

Christine Rothe 1 collaboration

Kayla L Nguyen 1 collaboration

Ishaan J Bhatt 1 collaboration

Shruti Gupta 1 collaboration

Nazaf Showkat 1 collaboration

Wolfgang S Lieb 1 collaboration

Jonas Honer 1 collaboration

Dennis Birnstock 1 collaboration

Daniela Stöhr 1 collaboration

Jens O Schmid 1 collaboration

Tobias B Beigl 1 collaboration

Alexandra Mack 1 collaboration

Daniela S Maichl 1 collaboration

Kai Cao 1 collaboration

Beate Budai 1 collaboration

Stephen W G Tait 1 collaboration

Cathrin Hagenlocher 1 collaboration

Nadine Pollak 1 collaboration

Tania Del Rivero 1 collaboration

Elizabeth K Pruzinsky 1 collaboration

Michael J Rosalino 1 collaboration

Markus Harder 1 collaboration

Sarah Ring 1 collaboration

Kirstin A Zettlitz 1 collaboration

Nivetha Krishna Moorthy 1 collaboration

Stephan Eisler 1 collaboration

Sara Weirich 1 collaboration

Sophia Steinlein 1 collaboration

Nathalie Peters 1 collaboration

Camille Vaslin 1 collaboration

Henri Zanker 1 collaboration

Marie-Ann Dhaen 1 collaboration

Stefanie Herrmann 1 collaboration

Vittoria Massafra 1 collaboration

Sofia Tundo 1 collaboration

Aline Dietzig 1 collaboration

Axel Ducret 1 collaboration

Hendrik Knoetgen 1 collaboration

Martin Steegmaier 1 collaboration

Andrea Romagnani 1 collaboration

Yvonne A Nagel 1 collaboration

Greta Del Mistro 1 collaboration

Shamala Riemann 1 collaboration

Sebastian Schindler 1 collaboration

Stefan Beissert 1 collaboration

Aurelien Ginolhac 1 collaboration

Rashi Halder 1 collaboration

Luana Presta 1 collaboration

Lasse Sinkkonen 1 collaboration

Thomas Sauter 1 collaboration

Dagmar Kulms 1 collaboration

Nicole Janssen 1 collaboration

Thomas Sell 1 collaboration

Svetlana Kalmykova 1 collaboration

Marc-H Dahlke 1 collaboration

Christine Sers 1 collaboration

Markus Morkel 1 collaboration

Matthias Schwab 1 collaboration

Timon Fiedler 1 collaboration

Jan Bauer 1 collaboration

Iskra Paro 1 collaboration

Wanda Douwenga 1 collaboration

Evelien Houben 1 collaboration

Bieke Broux 1 collaboration

Niels Hellings 1 collaboration

Wia Baron 1 collaboration

Jon D Laman 1 collaboration

Janice M Reichert 1 collaboration