Piotr Stępnicki

Affiliations

Medical University of Lublin, Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modelling Lab, POLAND.

Publications (14)

Discovery and in vitro Evaluation of Novel Serotonin 5-HT2A Receptor Ligands Identified Through Virtual Screening.

ChemMedChem

Avec: Agata Zięba , Damian Bartuzi , Dariusz Matosiuk , Tomasz M Wróbel , Tuomo Laitinen , Marián Castro , Agnieszka Anna Kaczor

Current Approaches and Tools Used in Drug Development against Parkinson's Disease.

Biomolecules

Avec: Oliwia Koszła , Agata Zięba , Angelika Grudzińska , Dariusz Matosiuk , Agnieszka A Kaczor

Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes.

Scientific reports

Avec: Damian Bartuzi , Ewa Kędzierska , Katarzyna M Targowska-Duda , Oliwia Koszła , Tomasz M Wróbel , Simon Jademyr , Tadeusz Karcz , Katarzyna Szczepańska , Olga Wronikowska-Denysiuk , Grażyna Biała , Jadwiga Handzlik , Jesper L Kristensen , Antti Poso , Agnieszka A Kaczor

Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation.

Journal of enzyme inhibition and medicinal chemistry

Avec: Olga Wronikowska-Denysiuk , Agata Zięba , Katarzyna M Targowska-Duda , Agata Bartyzel , Martyna Z Wróbel , Tomasz M Wróbel , Klaudia Szałaj , Andrzej Chodkowski , Karolina Mirecka , Barbara Budzyńska , Emilia Fornal , Jadwiga Turło , Marián Castro , Agnieszka A Kaczor

Overcoming Depression with 5-HT

International journal of molecular sciences

Avec: Agata Zięba , Dariusz Matosiuk , Agnieszka A Kaczor

Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety.

ChemMedChem

Avec: Magda Kondej , Tomasz M Wróbel , Katarzyna M Targowska-Duda , Antón Leandro Martínez , Oliwia Koszła , Agata Zięba , Alba Paz , Olga Wronikowska-Denysiuk , Maria I Loza , Marián Castro , Agnieszka A Kaczor

What are the challenges with multi-targeted drug design for complex diseases?

Expert opinion on drug discovery

Avec: Agata Zięba , Dariusz Matosiuk , Agnieszka A Kaczor

Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.

European journal of medicinal chemistry

Avec: Katarzyna M Targowska-Duda , Antón L Martínez , Agata Zięba , Olga Wronikowska-Denysiuk , Martyna Z Wróbel , Agata Bartyzel , Alicja Trzpil , Tomasz M Wróbel , Andrzej Chodkowski , Karolina Mirecka , Tadeusz Karcz , Katarzyna Szczepańska , Maria I Loza , Barbara Budzyńska , Jadwiga Turło , Jadwiga Handzlik , Emilia Fornal , Ewa Poleszak , Marián Castro , Agnieszka A Kaczor

Development and Characterization of Novel Selective, Non-Basic Dopamine D

Molecules (Basel, Switzerland)

Avec: Sylwia Wośko , Agata Bartyzel , Agata Zięba , Damian Bartuzi , Klaudia Szałaj , Tomasz M Wróbel , Emilia Fornal , Jens Carlsson , Ewa Kędzierska , Ewa Poleszak , Marián Castro , Agnieszka A Kaczor

Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.

European journal of medicinal chemistry

Avec: Magda Kondej , Tomasz M Wróbel , Andrea G Silva , Oliwia Koszła , Ewa Kędzierska , Agata Bartyzel , Grażyna Biała , Dariusz Matosiuk , Maria I Loza , Marián Castro , Agnieszka A Kaczor

N-(3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}propyl)-1H-indazole-3-carboxamide (D2AAK3) as a potential antipsychotic: In vitro, in silico and in vivo evaluation of a multi-target ligand.

Neurochemistry international

Avec: Agnieszka A Kaczor , Katarzyna M Targowska-Duda , Andrea G Silva , Oliwia Koszła , Ewa Kędzierska , Angelika Grudzińska , Marta Kruk-Słomka , Grażyna Biała , Marián Castro

The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases.

International journal of molecular sciences

Avec: Oliwia Koszła , Przemysław Sołek , Sylwia Woźniak , Ewa Kędzierska , Tomasz M Wróbel , Magda Kondej , Aneta Archała , Grażyna Biała , Dariusz Matosiuk , Agnieszka A Kaczor

Multi-targeted drug design strategies for the treatment of schizophrenia.

Expert opinion on drug discovery

Avec: Magda Kondej , Oliwia Koszła , Justyna Żuk , Agnieszka A Kaczor

Screening and Structure-Activity Relationship of D2AAK1 Derivatives for Potential Application in the Treatment of Neurodegenerative Diseases.

Molecules (Basel, Switzerland)

Avec: Oliwia Koszła , Przemysław Sołek , Agnieszka A Kaczor

Réseau de co-auteurs

Agnieszka A Kaczor 13 collaborations

Agata Zięba 8 collaborations

Tomasz M Wróbel 8 collaborations

Oliwia Koszła 8 collaborations

Marián Castro 7 collaborations

Dariusz Matosiuk 6 collaborations

Ewa Kędzierska 5 collaborations

Katarzyna M Targowska-Duda 5 collaborations

Olga Wronikowska-Denysiuk 4 collaborations

Grażyna Biała 4 collaborations

Agata Bartyzel 4 collaborations

Magda Kondej 4 collaborations

Damian Bartuzi 3 collaborations

Emilia Fornal 3 collaborations

Maria I Loza 3 collaborations

Angelika Grudzińska 2 collaborations

Tadeusz Karcz 2 collaborations

Katarzyna Szczepańska 2 collaborations

Jadwiga Handzlik 2 collaborations

Martyna Z Wróbel 2 collaborations

Klaudia Szałaj 2 collaborations

Andrzej Chodkowski 2 collaborations

Karolina Mirecka 2 collaborations

Barbara Budzyńska 2 collaborations

Jadwiga Turło 2 collaborations

Ewa Poleszak 2 collaborations

Andrea G Silva 2 collaborations

Przemysław Sołek 2 collaborations

Tuomo Laitinen 1 collaboration

Agnieszka Anna Kaczor 1 collaboration

Simon Jademyr 1 collaboration

Jesper L Kristensen 1 collaboration

Antti Poso 1 collaboration

Antón Leandro Martínez 1 collaboration

Alba Paz 1 collaboration

Antón L Martínez 1 collaboration

Alicja Trzpil 1 collaboration

Sylwia Wośko 1 collaboration

Jens Carlsson 1 collaboration

Marta Kruk-Słomka 1 collaboration

Sylwia Woźniak 1 collaboration

Aneta Archała 1 collaboration

Justyna Żuk 1 collaboration