Philippe E Mangeot

Affiliations

CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France.

Publications (11)

Nanoblades allow high-level genome editing in murine and human organoids.

Molecular therapy. Nucleic acids

Avec: Victor Tiroille , Adrien Krug , Emma Bokobza , Michel Kahi , Mattijs Bulcaen , Marjolein M Ensinck , Maarten H Geurts , Delilah Hendriks , François Vermeulen , Frédéric Larbret , Alejandra Gutierrez-Guerrero , Yu Chen , Indra Van Zundert , Susana Rocha , Anne C Rios , Louise Medaer , Rik Gijsbers , Hans Clevers , Marianne S Carlon , Frédéric Bost , Els Verhoeyen

Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins.

Nature communications

Avec: Valérie Risson , Floriane Fusil , Aline Marnef , Emilie Laurent , Juliana Blin , Virginie Mournetas , Emmanuelle Massouridès , Thibault J M Sohier , Antoine Corbin , Fabien Aubé , Marie Teixeira , Christian Pinset , Laurent Schaeffer , Gaëlle Legube , François-Loïc Cosset , Els Verhoeyen , Théophile Ohlmann , Emiliano P Ricci

Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Laurène Meyniel-Schicklin , Jérôme Amaudrut , Pierre Mallinjoud , Fabrice Guillier , Laetitia Lines , Anne Aublin-Gex , Caroline Scholtes , Claire Punginelli , Stéphane Joly , Florence Vasseur , Evelyne Manet , Henri Gruffat , Thomas Henry , Farès Halitim , Jean-Laurent Paparin , Peter Machin , Raphaël Darteil , Diane Sampson , Ivan Mikaelian , Lydie Lane , Vincent Navratil , Marie-Pierre Golinelli-Cohen , Fabiola Terzi , Patrice André , Vincent Lotteau , Jacky Vonderscher , Eric C Meldrum , Benoit de Chassey

A homozygous mutation in the human selenocysteine tRNA gene impairs UGA recoding activity and selenoproteome regulation by selenium.

Nucleic acids research

Avec: Caroline Vindry , Olivia Guillin , Philippe Wolff , Paul Marie , Franck Mortreux , Théophile Ohlmann , Laurent Chavatte

Delivery of the Cas9/sgRNA Ribonucleoprotein Complex in Immortalized and Primary Cells via Virus-like Particles ("Nanoblades").

Journal of visualized experiments : JoVE

Avec: Laura Guiguettaz , Thibault J M Sohier , Emiliano P Ricci

A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch.

eLife

Avec: Hélène Duplus-Bottin , Martin Spichty , Gérard Triqueneaux , Christophe Place , Philippe Emmanuel Mangeot , Théophile Ohlmann , Franck Vittoz , Gaël Yvert

Baboon Envelope Pseudotyped "Nanoblades" Carrying Cas9/gRNA Complexes Allow Efficient Genome Editing in Human T, B, and CD34

Frontiers in genome editing

Avec: Alejandra Gutierrez-Guerrero , Maria Jimena Abrey Recalde , Caroline Costa , Ornellie Bernadin , Séverine Périan , Floriane Fusil , Gisèle Froment , Adriana Martinez-Turtos , Adrien Krug , Francisco Martin , Karim Benabdellah , Emiliano P Ricci , Simone Giovannozzi , Rik Gijsbers , Eduard Ayuso , François-Loïc Cosset , Els Verhoeyen

CRISPR-Cas9 Targeting of Hepatitis B Virus Covalently Closed Circular DNA Generates Transcriptionally Active Episomal Variants.

mBio

Avec: Maria Guadalupe Martinez , Emmanuel Combe , Aurore Inchauspe , Philippe Emmanuel Mangeot , Elodie Delberghe , Fleur Chapus , Gregory Neveu , Antoine Alam , Kara Carter , Barbara Testoni , Fabien Zoulim

A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair.

Genes & development

Avec: Aline Marnef , Anne-Laure Finoux , Coline Arnould , Emmanuelle Guillou , Virginie Daburon , Vincent Rocher , Thomas Mangeat , Emiliano P Ricci , Gaëlle Legube

A Versatile Strategy to Reduce UGA-Selenocysteine Recoding Efficiency of the Ribosome Using CRISPR-Cas9-Viral-Like-Particles Targeting Selenocysteine-tRNA

Cells

Avec: Caroline Vindry , Olivia Guillin , Théophile Ohlmann , Laurent Chavatte

Loop extrusion as a mechanism for formation of DNA damage repair foci.

Nature

Avec: Coline Arnould , Vincent Rocher , Anne-Laure Finoux , Thomas Clouaire , Kevin Li , Felix Zhou , Pierre Caron , Emiliano P Ricci , Raphaël Mourad , James E Haber , Daan Noordermeer , Gaëlle Legube

Réseau de co-auteurs

Emiliano P Ricci 5 collaborations

Théophile Ohlmann 4 collaborations

Els Verhoeyen 3 collaborations

Gaëlle Legube 3 collaborations

Adrien Krug 2 collaborations

Alejandra Gutierrez-Guerrero 2 collaborations

Rik Gijsbers 2 collaborations

Floriane Fusil 2 collaborations

Aline Marnef 2 collaborations

Thibault J M Sohier 2 collaborations

François-Loïc Cosset 2 collaborations

Caroline Vindry 2 collaborations

Olivia Guillin 2 collaborations

Laurent Chavatte 2 collaborations

Philippe Emmanuel Mangeot 2 collaborations

Anne-Laure Finoux 2 collaborations

Coline Arnould 2 collaborations

Vincent Rocher 2 collaborations

Victor Tiroille 1 collaboration

Emma Bokobza 1 collaboration

Michel Kahi 1 collaboration

Mattijs Bulcaen 1 collaboration

Marjolein M Ensinck 1 collaboration

Maarten H Geurts 1 collaboration

Delilah Hendriks 1 collaboration

François Vermeulen 1 collaboration

Frédéric Larbret 1 collaboration

Yu Chen 1 collaboration

Indra Van Zundert 1 collaboration

Susana Rocha 1 collaboration

Anne C Rios 1 collaboration

Louise Medaer 1 collaboration

Hans Clevers 1 collaboration

Marianne S Carlon 1 collaboration

Frédéric Bost 1 collaboration

Valérie Risson 1 collaboration

Emilie Laurent 1 collaboration

Juliana Blin 1 collaboration

Virginie Mournetas 1 collaboration

Emmanuelle Massouridès 1 collaboration

Antoine Corbin 1 collaboration

Fabien Aubé 1 collaboration

Marie Teixeira 1 collaboration

Christian Pinset 1 collaboration

Laurent Schaeffer 1 collaboration

Laurène Meyniel-Schicklin 1 collaboration

Jérôme Amaudrut 1 collaboration

Pierre Mallinjoud 1 collaboration

Fabrice Guillier 1 collaboration

Laetitia Lines 1 collaboration

Anne Aublin-Gex 1 collaboration

Caroline Scholtes 1 collaboration

Claire Punginelli 1 collaboration

Stéphane Joly 1 collaboration

Florence Vasseur 1 collaboration

Evelyne Manet 1 collaboration

Henri Gruffat 1 collaboration

Thomas Henry 1 collaboration

Farès Halitim 1 collaboration

Jean-Laurent Paparin 1 collaboration

Peter Machin 1 collaboration

Raphaël Darteil 1 collaboration

Diane Sampson 1 collaboration

Ivan Mikaelian 1 collaboration

Lydie Lane 1 collaboration

Vincent Navratil 1 collaboration

Marie-Pierre Golinelli-Cohen 1 collaboration

Fabiola Terzi 1 collaboration

Patrice André 1 collaboration

Vincent Lotteau 1 collaboration

Jacky Vonderscher 1 collaboration

Eric C Meldrum 1 collaboration

Benoit de Chassey 1 collaboration

Philippe Wolff 1 collaboration

Paul Marie 1 collaboration

Franck Mortreux 1 collaboration

Laura Guiguettaz 1 collaboration

Hélène Duplus-Bottin 1 collaboration

Martin Spichty 1 collaboration

Gérard Triqueneaux 1 collaboration

Christophe Place 1 collaboration

Franck Vittoz 1 collaboration

Gaël Yvert 1 collaboration

Maria Jimena Abrey Recalde 1 collaboration

Caroline Costa 1 collaboration

Ornellie Bernadin 1 collaboration

Séverine Périan 1 collaboration

Gisèle Froment 1 collaboration

Adriana Martinez-Turtos 1 collaboration

Francisco Martin 1 collaboration

Karim Benabdellah 1 collaboration

Simone Giovannozzi 1 collaboration

Eduard Ayuso 1 collaboration

Maria Guadalupe Martinez 1 collaboration

Emmanuel Combe 1 collaboration

Aurore Inchauspe 1 collaboration

Elodie Delberghe 1 collaboration

Fleur Chapus 1 collaboration

Gregory Neveu 1 collaboration

Antoine Alam 1 collaboration

Kara Carter 1 collaboration

Barbara Testoni 1 collaboration

Fabien Zoulim 1 collaboration

Emmanuelle Guillou 1 collaboration

Virginie Daburon 1 collaboration

Thomas Mangeat 1 collaboration

Thomas Clouaire 1 collaboration

Kevin Li 1 collaboration

Felix Zhou 1 collaboration

Pierre Caron 1 collaboration

Raphaël Mourad 1 collaboration

James E Haber 1 collaboration

Daan Noordermeer 1 collaboration