Paolo Lusso

Affiliations

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

Publications (20)

Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.

PLoS pathogens

Avec: Xueqiao Liu , Hong-Su Park , Yumiko Matsuoka , Celia Santos , Lijuan Yang , Cindy Luongo , Ian N Moore , Reed F Johnson , Nicole L Garza , Peng Zhang , Sonja M Best , Ursula J Buchholz , Cyril Le Nouën

A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.

bioRxiv : the preprint server for biology

Avec: Mohammad M Sajadi , Abdolrahim Abbasi , Zahra Rikhtegaran Tehrani , Christine Siska , Rutilio Clark , Woo Chi , Michael S Seaman , Dieter Mielke , Kshitij Wagh , Qingbo Liu , Taylor Jumpa , Randal R Ketchem , Dung N Nguyen , Willaim D Tolbert , Brian G Pierce , Ben Atkinson , Derrick Deming , Megan Sprague , Andrew Asakawa , David Ferrer , Yasmin Dunn , Sarah Calvillo , Rui Yin , Johnathan D Guest , Bette Korber , Bryan T Mayer , Alicia H Sato , Xin Ouyang , Scott Foulke , Parham Habibzadeh , Maryam Karimi , Arash Aslanabadi , Mahsa Hojabri , Saman Saadat , Roza Zareidoodeji , Mateusz Kędzior , Edwin Pozharski , Alonso Heredia , David Montefiori , Guido Ferrari , Marzena Pazgier , George K Lewis , Joseph G Jardine , Anthony DeVico

Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants.

Cell reports

Avec: Zhaochun Chen , Peng Zhang , Yumiko Matsuoka , Yaroslav Tsybovsky , Kamille West , Celia Santos , Lisa F Boyd , Hanh Nguyen , Anna Pomerenke , Tyler Stephens , Adam S Olia , Baoshan Zhang , Valeria De Giorgi , Michael R Holbrook , Robin Gross , Elena Postnikova , Nicole L Garza , Reed F Johnson , David H Margulies , Peter D Kwong , Harvey J Alter , Ursula J Buchholz , Patrizia Farci

A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.

Nature medicine

Avec: Peng Zhang , Elisabeth Narayanan , Qingbo Liu , Yaroslav Tsybovsky , Kristin Boswell , Shilei Ding , Zonghui Hu , Dean Follmann , Yin Lin , Huiyi Miao , Hana Schmeisser , Denise Rogers , Samantha Falcone , Sayda M Elbashir , Vladimir Presnyak , Kapil Bahl , Madhu Prabhakaran , Xuejun Chen , Edward K Sarfo , David R Ambrozak , Rajeev Gautam , Malcom A Martin , Joanna Swerczek , Richard Herbert , Deborah Weiss , Johnathan Misamore , Giuseppe Ciaramella , Sunny Himansu , Guillaume Stewart-Jones , Adrian McDermott , Richard A Koup , John R Mascola , Andrés Finzi , Andrea Carfi , Anthony S Fauci ,

Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.

mBio

Avec: Peng Zhang , Alice L Kwon , Christina Guzzo , Qingbo Liu , Hana Schmeisser , Huiyi Miao , Yin Lin , Raffaello Cimbro , Jinghe Huang , Mark Connors , Stephen D Schmidt , Michael A Dolan , Anthony A Armstrong ,

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques.

bioRxiv : the preprint server for biology

Avec: Cyril Le Nouën , Christine E Nelson , Xueqiao Liu , Hong-Su Park , Yumiko Matsuoka , Cindy Luongo , Celia Santos , Lijuan Yang , Richard Herbert , Ashley Castens , Ian N Moore , Temeri Wilder-Kofie , Rashida Moore , April Walker , Peng Zhang , Reed F Johnson , Nicole L Garza , Laura E Via , Shirin Munir , Daniel Barber , Ursula J Buchholz

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention.

mAbs

Avec: Young D Kwon , Mangaiarkarasi Asokan , Jason Gorman , Baoshan Zhang , Qingbo Liu , Mark K Louder , Bob C Lin , Krisha McKee , Amarendra Pegu , Raffaello Verardi , Eun Sung Yang , Vrc Production Program , Kevin Carlton , Nicole A Doria-Rose , John R Mascola , Peter D Kwong

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys.

Cell

Quaternary Interaction of the HIV-1 Envelope Trimer with CD4 and Neutralizing Antibodies.

Viruses

Avec: Qingbo Liu , Peng Zhang ,

Extremely potent monoclonal antibodies neutralize Omicron and other SARS-CoV-2 variants.

medRxiv : the preprint server for health sciences

Avec: Zhaochun Chen , Peng Zhang , Yumiko Matsuoka , Yaroslav Tsybovsky , Kamille West , Celia Santos , Lisa F Boyd , Hanh Nguyen , Anna Pomerenke , Tyler Stephens , Adam S Olia , Valeria De Giorgi , Michael R Holbrook , Robin Gross , Elena Postnikova , Nicole L Garza , Reed F Johnson , David H Margulies , Peter D Kwong , Harvey J Alter , Ursula J Buchholz , Patrizia Farci

P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.

Retrovirology

Avec: Jonathan Burnie , Arvin Tejnarine Persaud , Laxshaginee Thaya , Qingbo Liu , Huiyi Miao , Stephen Grabinsky , Vanessa Norouzi , Vera A Tang , Christina Guzzo

Design of soluble HIV-1 envelope trimers free of covalent gp120-gp41 bonds with prevalent native-like conformation.

Cell reports

Avec: Peng Zhang , Jason Gorman , Yaroslav Tsybovsky , Maolin Lu , Qingbo Liu , Vinay Gopan , Mamta Singh , Yin Lin , Huiyi Miao , Yuna Seo , Alice Kwon , Adam S Olia , Gwo-Yu Chuang , Hui Geng , Yen-Ting Lai , Tongqing Zhou , John R Mascola , Walther Mothes , Peter D Kwong ,

Integrin α4β7 in HIV-1 infection: A critical review.

Journal of leukocyte biology

Avec: Qingbo Liu ,

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.

JCI insight

Avec: David Easterhoff , Justin Pollara , Kan Luo , Benjamin Janus , Neelakshi Gohain , LaTonya D Williams , Matthew Zirui Tay , Anthony Monroe , Kristina Peachman , Misook Choe , Susie Min , Peng Zhang , Eden P Go , Heather Desaire , Mattia Bonsignori , Kwan-Ki Hwang , Charles Beck , Matina Kakalis , Robert J O'Connell , Sandhya Vasan , Jerome H Kim , Nelson L Michael , Jean-Louis Excler , Merlin L Robb , Supachai Rerks-Ngarm , Jaranit Kaewkungwal , Punnee Pitisuttithum , Sorachai Nitayaphan , Faruk Sinangil , James Tartaglia , Sanjay Phogat , Kevin Wiehe , Kevin O Saunders , David C Montefiori , Georgia D Tomaras , M Anthony Moody , James Arthos , Mangala Rao , M Gordon Joyce , Gilad Ofek , Guido Ferrari , Barton F Haynes

Improvement of antibody functionality by structure-guided paratope engraftment.

Nature communications

Avec: Qingbo Liu , Yen-Ting Lai , Peng Zhang , Mark K Louder , Amarendra Pegu , Reda Rawi , Mangaiarkarasi Asokan , Xuejun Chen , Chen-Hsiang Shen , Gwo-Yu Chuang , Eun Sung Yang , Huiyi Miao , Yuge Wang , Anthony S Fauci , Peter D Kwong , John R Mascola ,

Rational Engraftment of Quaternary-Interactive Acidic Loops for Anti-HIV-1 Antibody Improvement.

Journal of virology

Avec: Qingbo Liu , Peng Zhang , Huiyi Miao , Yin Lin , Young Do Kwon , Peter D Kwong , Zahra Rikhtegaran-Tehrani , Michael S Seaman , Anthony L DeVico , Mohammad M Sajadi ,

Distinct Cytokine Profiles Correlate with Disease Severity and Outcome in Longitudinal Studies of Acute Hepatitis B Virus and Hepatitis D Virus Infection in Chimpanzees.

mBio

Avec: Ronald E Engle , Davide De Battista , Emily J Danoff , Hanh Nguyen , Zhaochun Chen , Robert H Purcell , Patrizia Farci

Anti-PF4 antibodies associated with disease severity in COVID-19.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Qingbo Liu , Huiyi Miao , Shuai Li , Peng Zhang , Gloria F Gerber , Dean Follmann , Hongkai Ji , Scott L Zeger , Daniel S Chertow , Thomas C Quinn , Matthew L Robinson , Thomas S Kickler , Richard E Rothman , Katherine Z J Fenstermacher , Evan M Braunstein , Andrea L Cox , Patrizia Farci , Anthony S Fauci ,

Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters.

bioRxiv : the preprint server for biology

Increased neutralization potency and breadth elicited by a SARS-CoV-2 mRNA vaccine forming virus-like particles.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Peng Zhang , Samantha Falcone , Yaroslav Tsybovsky , Mamta Singh , Vinay Gopan , Huiyi Miao , Yuna Seo , Denise Rogers , Isabella Renzi , Yen-Ting Lai , Elisabeth Narayanan , Guillaume Stewart-Jones , Sunny Himansu , Andrea Carfi , Anthony S Fauci ,

Réseau de co-auteurs

Peng Zhang 15 collaborations

Qingbo Liu 11 collaborations

Huiyi Miao 8 collaborations

Yumiko Matsuoka 6 collaborations

Celia Santos 6 collaborations

Reed F Johnson 6 collaborations

Nicole L Garza 6 collaborations

Ursula J Buchholz 6 collaborations

Peter D Kwong 6 collaborations

Yaroslav Tsybovsky 5 collaborations

Xueqiao Liu 4 collaborations

Hong-Su Park 4 collaborations

Lijuan Yang 4 collaborations

Cindy Luongo 4 collaborations

Ian N Moore 4 collaborations

Cyril Le Nouën 4 collaborations

Patrizia Farci 4 collaborations

Yin Lin 4 collaborations

John R Mascola 4 collaborations

Anthony S Fauci 4 collaborations

Zhaochun Chen 3 collaborations

Hanh Nguyen 3 collaborations

Adam S Olia 3 collaborations

Richard Herbert 3 collaborations

Yen-Ting Lai 3 collaborations

Sonja M Best 2 collaborations

Mohammad M Sajadi 2 collaborations

Michael S Seaman 2 collaborations

Guido Ferrari 2 collaborations

Kamille West 2 collaborations

Lisa F Boyd 2 collaborations

Anna Pomerenke 2 collaborations

Tyler Stephens 2 collaborations

Baoshan Zhang 2 collaborations

Valeria De Giorgi 2 collaborations

Michael R Holbrook 2 collaborations

Robin Gross 2 collaborations

Elena Postnikova 2 collaborations

David H Margulies 2 collaborations

Harvey J Alter 2 collaborations

Elisabeth Narayanan 2 collaborations

Dean Follmann 2 collaborations

Hana Schmeisser 2 collaborations

Denise Rogers 2 collaborations

Samantha Falcone 2 collaborations

Xuejun Chen 2 collaborations

Sunny Himansu 2 collaborations

Guillaume Stewart-Jones 2 collaborations

Andrea Carfi 2 collaborations

Christina Guzzo 2 collaborations

Christine E Nelson 2 collaborations

Ashley Castens 2 collaborations

Temeri Wilder-Kofie 2 collaborations

Rashida Moore 2 collaborations

April Walker 2 collaborations

Laura E Via 2 collaborations

Shirin Munir 2 collaborations

Mangaiarkarasi Asokan 2 collaborations

Jason Gorman 2 collaborations

Mark K Louder 2 collaborations

Amarendra Pegu 2 collaborations

Eun Sung Yang 2 collaborations

Vinay Gopan 2 collaborations

Mamta Singh 2 collaborations

Yuna Seo 2 collaborations

Gwo-Yu Chuang 2 collaborations

Abdolrahim Abbasi 1 collaboration

Zahra Rikhtegaran Tehrani 1 collaboration

Christine Siska 1 collaboration

Rutilio Clark 1 collaboration

Woo Chi 1 collaboration

Dieter Mielke 1 collaboration

Kshitij Wagh 1 collaboration

Taylor Jumpa 1 collaboration

Randal R Ketchem 1 collaboration

Dung N Nguyen 1 collaboration

Willaim D Tolbert 1 collaboration

Brian G Pierce 1 collaboration

Ben Atkinson 1 collaboration

Derrick Deming 1 collaboration

Megan Sprague 1 collaboration

Andrew Asakawa 1 collaboration

David Ferrer 1 collaboration

Yasmin Dunn 1 collaboration

Sarah Calvillo 1 collaboration

Rui Yin 1 collaboration

Johnathan D Guest 1 collaboration

Bette Korber 1 collaboration

Bryan T Mayer 1 collaboration

Alicia H Sato 1 collaboration

Xin Ouyang 1 collaboration

Scott Foulke 1 collaboration

Parham Habibzadeh 1 collaboration

Maryam Karimi 1 collaboration

Arash Aslanabadi 1 collaboration

Mahsa Hojabri 1 collaboration

Saman Saadat 1 collaboration

Roza Zareidoodeji 1 collaboration

Mateusz Kędzior 1 collaboration

Edwin Pozharski 1 collaboration

Alonso Heredia 1 collaboration

David Montefiori 1 collaboration

Marzena Pazgier 1 collaboration

George K Lewis 1 collaboration

Joseph G Jardine 1 collaboration

Anthony DeVico 1 collaboration

Kristin Boswell 1 collaboration

Shilei Ding 1 collaboration

Zonghui Hu 1 collaboration

Sayda M Elbashir 1 collaboration

Vladimir Presnyak 1 collaboration

Kapil Bahl 1 collaboration

Madhu Prabhakaran 1 collaboration

Edward K Sarfo 1 collaboration

David R Ambrozak 1 collaboration

Rajeev Gautam 1 collaboration

Malcom A Martin 1 collaboration

Joanna Swerczek 1 collaboration

Deborah Weiss 1 collaboration

Johnathan Misamore 1 collaboration

Giuseppe Ciaramella 1 collaboration

Adrian McDermott 1 collaboration

Richard A Koup 1 collaboration

Andrés Finzi 1 collaboration

Alice L Kwon 1 collaboration

Raffaello Cimbro 1 collaboration

Jinghe Huang 1 collaboration

Mark Connors 1 collaboration

Stephen D Schmidt 1 collaboration

Michael A Dolan 1 collaboration

Anthony A Armstrong 1 collaboration

Daniel Barber 1 collaboration

Young D Kwon 1 collaboration

Bob C Lin 1 collaboration

Krisha McKee 1 collaboration

Raffaello Verardi 1 collaboration

Vrc Production Program 1 collaboration

Kevin Carlton 1 collaboration

Nicole A Doria-Rose 1 collaboration

Daniel L Barber 1 collaboration

Jonathan Burnie 1 collaboration

Arvin Tejnarine Persaud 1 collaboration

Laxshaginee Thaya 1 collaboration

Stephen Grabinsky 1 collaboration

Vanessa Norouzi 1 collaboration

Vera A Tang 1 collaboration

Maolin Lu 1 collaboration

Alice Kwon 1 collaboration

Hui Geng 1 collaboration

Tongqing Zhou 1 collaboration

Walther Mothes 1 collaboration

David Easterhoff 1 collaboration

Justin Pollara 1 collaboration

Kan Luo 1 collaboration

Benjamin Janus 1 collaboration

Neelakshi Gohain 1 collaboration

LaTonya D Williams 1 collaboration

Matthew Zirui Tay 1 collaboration

Anthony Monroe 1 collaboration

Kristina Peachman 1 collaboration

Misook Choe 1 collaboration

Susie Min 1 collaboration

Eden P Go 1 collaboration

Heather Desaire 1 collaboration

Mattia Bonsignori 1 collaboration

Kwan-Ki Hwang 1 collaboration

Charles Beck 1 collaboration

Matina Kakalis 1 collaboration

Robert J O'Connell 1 collaboration

Sandhya Vasan 1 collaboration

Jerome H Kim 1 collaboration

Nelson L Michael 1 collaboration

Jean-Louis Excler 1 collaboration

Merlin L Robb 1 collaboration

Supachai Rerks-Ngarm 1 collaboration

Jaranit Kaewkungwal 1 collaboration

Punnee Pitisuttithum 1 collaboration

Sorachai Nitayaphan 1 collaboration

Faruk Sinangil 1 collaboration

James Tartaglia 1 collaboration

Sanjay Phogat 1 collaboration

Kevin Wiehe 1 collaboration

Kevin O Saunders 1 collaboration

David C Montefiori 1 collaboration

Georgia D Tomaras 1 collaboration

M Anthony Moody 1 collaboration

James Arthos 1 collaboration

Mangala Rao 1 collaboration

M Gordon Joyce 1 collaboration

Gilad Ofek 1 collaboration

Barton F Haynes 1 collaboration

Reda Rawi 1 collaboration

Chen-Hsiang Shen 1 collaboration

Yuge Wang 1 collaboration

Young Do Kwon 1 collaboration

Zahra Rikhtegaran-Tehrani 1 collaboration

Anthony L DeVico 1 collaboration

Ronald E Engle 1 collaboration

Davide De Battista 1 collaboration

Emily J Danoff 1 collaboration

Robert H Purcell 1 collaboration

Shuai Li 1 collaboration

Gloria F Gerber 1 collaboration

Hongkai Ji 1 collaboration

Scott L Zeger 1 collaboration

Daniel S Chertow 1 collaboration

Thomas C Quinn 1 collaboration

Matthew L Robinson 1 collaboration

Thomas S Kickler 1 collaboration

Richard E Rothman 1 collaboration

Katherine Z J Fenstermacher 1 collaboration

Evan M Braunstein 1 collaboration

Andrea L Cox 1 collaboration

Isabella Renzi 1 collaboration