Nicole Polain

Affiliations

Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Health Research Building, Discovery Way, Murdoch 6150, Australia.

ORCID: 0000-0003-0020-3687

Publications (5)

Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD.

International journal of molecular sciences

Avec: Alistair Wood , Yuval Gurfinkel , Wesley Lamont , Sarah Lyn Rea

Functional and structural consequences of TBK1 missense variants in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Neurobiology of disease

Avec: Yuval Gurfinkel , Krushna Sonar , Penelope Nice , Ricardo L Mancera , Sarah Lyn Rea

ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation.

Molecular and cellular neurosciences

Avec: A D Foster , P Downing , E Figredo , N Polain , A Stott , R Layfield , S L Rea

The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function.

PloS one

Avec: Melanie A Sultana , Carmel Cluning , Wai-Sin Kwong , Nathan J Pavlos , Thomas Ratajczak , John P Walsh , Jiake Xu , Sarah L Rea

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death.

Scientific reports

Avec: A D Foster , L L Flynn , C Cluning , F Cheng , J M Davidson , A Lee , N Polain , R Mejzini , N Farrawell , J J Yerbury , R Layfield , P A Akkari , S L Rea

Réseau de co-auteurs

Yuval Gurfinkel 2 collaborations

Sarah Lyn Rea 2 collaborations

A D Foster 2 collaborations

N Polain 2 collaborations

R Layfield 2 collaborations

S L Rea 2 collaborations

Alistair Wood 1 collaboration

Wesley Lamont 1 collaboration

Krushna Sonar 1 collaboration

Penelope Nice 1 collaboration

Ricardo L Mancera 1 collaboration

P Downing 1 collaboration

E Figredo 1 collaboration

A Stott 1 collaboration

Melanie A Sultana 1 collaboration

Carmel Cluning 1 collaboration

Wai-Sin Kwong 1 collaboration

Nathan J Pavlos 1 collaboration

Thomas Ratajczak 1 collaboration

John P Walsh 1 collaboration

Jiake Xu 1 collaboration

Sarah L Rea 1 collaboration

L L Flynn 1 collaboration

C Cluning 1 collaboration

F Cheng 1 collaboration

J M Davidson 1 collaboration

A Lee 1 collaboration

R Mejzini 1 collaboration

N Farrawell 1 collaboration

J J Yerbury 1 collaboration

P A Akkari 1 collaboration