N Chomont

Affiliations

Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université de Montréal, QC, Canada.
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.

Publications (70)

Potential for Virus Endogenization in Humans through Testicular Germ Cell Infection: the Case of HIV.

Journal of virology

Avec: Dominique Mahé , Giulia Matusali , Claire Deleage , Raquel L L S Alvarenga , Anne-Pascale Satie , Amélie Pagliuzza , Romain Mathieu , Sylvain Lavoué , Bernard Jégou , Luiz R de França , Nicolas Chomont , Laurent Houzet , Antoine D Rolland , Nathalie Dejucq-Rainsford

Viral Blips After Treatment Initiation During Acute Human Immunodeficiency Virus Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Trevor A Crowell , Suteeraporn Pinyakorn , Carlo Sacdalan , Eugène Kroon , Donn J Colby , Suwanna Puttamaswin , Sasiwimol Ubolyam , Rapee Trichavaroj , Oratai Butterworth , Ellen Turk , Corinne Mccullough , Nicolas Chomont , Mark de Souza , Merlin L Robb , Nittaya Phanuphak , Jintanat Ananworanich , Auteur inconnu

Preferential Infection of α4β7+ Memory CD4+ T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Andrey Tokarev , Lyle R McKinnon , Amélie Pagliuzza , Aida Sivro , Tosin E Omole , Eugene Kroon , Nitiya Chomchey , Nittaya Phanuphak , Alexandra Schuetz , Merlin L Robb , Michael A Eller , Jintanat Ananworanich , Nicolas Chomont , Diane L Bolton

Brief Report: Subclinical Carotid Artery Atherosclerosis Is Associated With Increased Expression of Peripheral Blood IL-32 Isoforms Among Women Living With HIV.

Journal of acquired immune deficiency syndromes (1999)

Avec: Mohamed El-Far , David B Hanna , Madeleine Durand , Etienne Larouche-Anctil , Mohamed Sylla , Carl Chartrand-Lefebvre , Guy Cloutier , Jean Philippe Goulet , Seble Kassaye , Roksana Karim , Jorge R Kizer , Audrey L French , Stephen J Gange , Jason M Lazar , Howard N Hodis , Jean-Pierre Routy , Petronela Ancuta , Nicolas Chomont , Alan L Landay , Robert C Kaplan , Cécile L Tremblay

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia.

Nature communications

Avec: Basiel Cole , Laurens Lambrechts , Pierre Gantner , Ytse Noppe , Noah Bonine , Wojciech Witkowski , Lennie Chen , Sarah Palmer , James I Mullins , Nicolas Chomont , Marion Pardons , Linos Vandekerckhove

Camu Camu effects on microbial translocation and systemic immune activation in ART-treated people living with HIV: protocol of the single-arm non-randomised Camu Camu prebiotic pilot study (CIHR/CTN PT032).

BMJ open

Avec: Stéphane Isnard , Brandon Fombuena , Jing Ouyang , Léna Royston , John Lin , Simeng Bu , Nancy Sheehan , Peter L Lakatos , Talat Bessissow , Nicolas Chomont , Marina Klein , Bertrand Lebouché , Cecilia T Costiniuk , Bertrand Routy , André Marette , Jean-Pierre Routy , Auteur inconnu

Persistent HIV transcription and variable antiretroviral drug penetration in lymph nodes during plasma viral suppression.

AIDS (London, England)

Avec: Courtney V Fletcher , Eugène Kroon , Timothy Schacker , Suteeraporn Pinyakorn , Nicolas Chomont , Suthat Chottanapund , Peeriya Prueksakaew , Khunthalee Benjapornpong , Supranee Buranapraditkun , Nittaya Phanuphak , Jintanat Ananworanich , Sandhya Vasan , Denise Hsu , Auteur inconnu

Virologie (Montrouge, France)

Avec: Armando Espinosa Ortiz , Alessandro Modica , Rémi Fromentin , Nicolas Chomont

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4

bioRxiv : the preprint server for biology

Avec: Augustine Fert , Jonathan Richard , Laurence Raymond Marchand , Delphine Planas , Jean-Pierre Routy , Nicolas Chomont , Andrés Finzi , Petronela Ancuta

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.

Nature communications

Avec: Elsa Brunet-Ratnasingham , Sacha Morin , Haley E Randolph , Marjorie Labrecque , Justin Bélair , Raphaël Lima-Barbosa , Amélie Pagliuzza , Lorie Marchitto , Michael Hultström , Julia Niessl , Rose Cloutier , Alina M Sreng Flores , Nathalie Brassard , Mehdi Benlarbi , Jérémie Prévost , Shilei Ding , Sai Priya Anand , Gérémy Sannier , Amanda Marks , Dick Wågsäter , Eric Bareke , Hugo Zeberg , Miklos Lipcsey , Robert Frithiof , Anders Larsson , Sirui Zhou , Tomoko Nakanishi , David Morrison , Dani Vezina , Catherine Bourassa , Gabrielle Gendron-Lepage , Halima Medjahed , Floriane Point , Jonathan Richard , Catherine Larochelle , Alexandre Prat , Janet L Cunningham , Nathalie Arbour , Madeleine Durand , J Brent Richards , Kevin Moon , Nicolas Chomont , Andrés Finzi , Martine Tétreault , Luis Barreiro , Guy Wolf , Daniel E Kaufmann

Metformin facilitates viral reservoir reactivation and their recognition by anti-HIV-1 envelope antibodies.

iScience

Avec: Augustine Fert , Jonathan Richard , Laurence Raymond Marchand , Delphine Planas , Jean-Pierre Routy , Nicolas Chomont , Andrés Finzi , Petronela Ancuta

T cell migration potentiates HIV infection by enhancing viral fusion and integration.

Cell reports

Avec: Paul Lopez , Oluwaseun Ajibola , Amelie Pagliuzza , Romaniya Zayats , Wan Hon Koh , Alon Herschhorn , Nicolas Chomont , Thomas T Murooka

Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes.

Nature communications

Avec: Caroline Dufour , Corentin Richard , Marion Pardons , Marta Massanella , Antoine Ackaoui , Ben Murrell , Bertrand Routy , Réjean Thomas , Jean-Pierre Routy , Rémi Fromentin , Nicolas Chomont

Effects of Oral Cannabinoids on Systemic Inflammation and Viral Reservoir Markers in People with HIV on Antiretroviral Therapy: Results of the CTN PT028 Pilot Clinical Trial.

Cells

Avec: Ralph-Sydney Mboumba Bouassa , Eve Comeau , Yulia Alexandrova , Amélie Pagliuzza , Alexis Yero , Suzanne Samarani , Judy Needham , Joel Singer , Terry Lee , Florian Bobeuf , Claude Vertzagias , Giada Sebastiani , Shari Margolese , Enrico Mandarino , Marina B Klein , Bertrand Lebouché , Jean-Pierre Routy , Nicolas Chomont , Cecilia T Costiniuk , Mohammad-Ali Jenabian

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype.

Research square

Avec: Hongshuo Song , Manukumar Marichannegowda , Saini Setua , Meera Bose , Eric Sanders-Buell , David King , Michelle Zemil , Lindsay Wieczorek , Felisa Diaz-Mendez , Nicolas Chomont , Rasmi Thomas , Leilani Francisco , Leigh Anne Eller , Victoria Polonis , Sodsai Tovanabutra , Yutaka Tagaya , Nelson Michael , Merlin Robb

Isotretinoin promotes elimination of translation-competent HIV latent reservoirs in CD4T cells.

PLoS pathogens

Avec: J Natalie Howard , Callie Levinger , Selase Deletsu , Rémi Fromentin , Nicolas Chomont , Alberto Bosque , Auteur inconnu

Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption.

Nature medicine

Avec: Donn J Colby , Michal Sarnecki , Dan H Barouch , Somporn Tipsuk , Daniel J Stieh , Eugène Kroon , Alexandra Schuetz , Jintana Intasan , Carlo Sacdalan , Suteeraporn Pinyakorn , Pornsuk Grandin , Hongshuo Song , Sodsai Tovanabutra , Zhanna Shubin , Dohoon Kim , Dominic Paquin-Proulx , Michael A Eller , Rasmi Thomas , Mark de Souza , Lindsay Wieczorek , Victoria R Polonis , Amélie Pagliuzza , Nicolas Chomont , Lauren Peter , Joseph P Nkolola , Johan Vingerhoets , Carla Truyers , Maria G Pau , Hanneke Schuitemaker , Nittaya Phanuphak , Nelson Michael , Merlin L Robb , Frank L Tomaka , Jintanat Ananworanich

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy.

Cell reports

Avec: Marion Pardons , Rémi Fromentin , Amélie Pagliuzza , Jean-Pierre Routy , Nicolas Chomont

Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.

Journal of virology

Avec: Eunok Lee , Susanne von Stockenstrom , Vincent Morcilla , Lina Odevall , Bonnie Hiener , Wei Shao , Wendy Hartogensis , Peter Bacchetti , Jeffrey Milush , Teri Liegler , Elizabeth Sinclair , Hiroyu Hatano , Rebecca Hoh , Ma Somsouk , Peter Hunt , Eli Boritz , Daniel Douek , Remi Fromentin , Nicolas Chomont , Steven G Deeks , Frederick M Hecht , Sarah Palmer

Oral cannabinoids in people living with HIV on effective antiretroviral therapy: CTN PT028-study protocol for a pilot randomised trial to assess safety, tolerability and effect on immune activation.

BMJ open

Avec: Cecilia T Costiniuk , Zahra Saneei , Jean-Pierre Routy , Shari Margolese , Enrico Mandarino , Joel Singer , Bertrand Lebouché , Joseph Cox , Jason Szabo , Marie-Josée Brouillette , Marina B Klein , Nicolas Chomont , Mohammad-Ali Jenabian

Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation.

The Journal of infectious diseases

Avec: Eileen P Scully , Monica Gandhi , Rowena Johnston , Rebecca Hoh , Ainsley Lockhart , Curtis Dobrowolski , Amélie Pagliuzza , Jeffrey M Milush , Christopher A Baker , Valerie Girling , Arlvin Ellefson , Robert Gorelick , Jeffrey Lifson , Marcus Altfeld , Galit Alter , Marcelle Cedars , Ajantha Solomon , Sharon R Lewin , Jonathan Karn , Nicolas Chomont , Peter Bacchetti , Steven G Deeks

Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates With Immune Response.

The Journal of infectious diseases

Avec: Guoxin Wu , Paul Zuck , Shih Lin Goh , Jeffrey M Milush , Poonam Vohra , Joseph K Wong , Ma Somsouk , Steven A Yukl , Barbara L Shacklett , Nicolas Chomont , Ashley T Haase , Hiroyu Hatano , Timothy W Schacker , Steven G Deeks , Daria J Hazuda , Peter W Hunt , Bonnie J Howell

Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis.

Frontiers in immunology

Avec: Mohamed El-Far , Madeleine Durand , Isabelle Turcotte , Etienne Larouche-Anctil , Mohamed Sylla , Sarah Zaidan , Carl Chartrand-Lefebvre , Rémi Bunet , Hardik Ramani , Manel Sadouni , Irina Boldeanu , Annie Chamberland , Sylvie Lesage , Jean-Guy Baril , Benoit Trottier , Réjean Thomas , Emmanuel Gonzalez , Ali Filali-Mouhim , Jean-Philippe Goulet , Jeffrey A Martinson , Seble Kassaye , Roksana Karim , Jorge R Kizer , Audrey L French , Stephen J Gange , Petronela Ancuta , Jean-Pierre Routy , David B Hanna , Robert C Kaplan , Nicolas Chomont , Alan L Landay , Cécile L Tremblay

Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Emmanouil Papasavvas , Livio Azzoni , Brian N Ross , Matthew Fair , Zhe Yuan , Kwasi Gyampoh , Agnieszka Mackiewicz , Amanda C Sciorillo , Amelie Pagliuzza , Steven M Lada , Guoxin Wu , Shih Lin Goh , Carolyn Bahnck-Teets , Daniel J Holder , Paul D Zuck , Mohammad Damra , Kenneth M Lynn , Pablo Tebas , Karam Mounzer , Jay R Kostman , Mohamed Abdel-Mohsen , Douglas Richman , Nicolas Chomont , Bonnie J Howell , Luis J Montaner

Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study.

The Lancet. Microbe

Avec: Marta Massanella , Rachel A Bender Ignacio , Javier R Lama , Amélie Pagliuzza , Sayan Dasgupta , Ricardo Alfaro , Jessica Rios , Carmela Ganoza , Delia Pinto-Santini , Trupti Gilada , Ann Duerr , Nicolas Chomont

Detecting Sources of Immune Activation and Viral Rebound in HIV Infection.

Journal of virology

Avec: Stephen W Wietgrefe , Lijie Duan , Jodi Anderson , Guillermo Marqués , Mark Sanders , Nathan W Cummins , Andrew D Badley , Curtis Dobrowolski , Jonathan Karn , Amélie Pagliuzza , Nicolas Chomont , Gérémy Sannier , Mathieu Dubé , Daniel E Kaufmann , Paul Zuck , Guoxin Wu , Bonnie J Howell , Cavan Reilly , Alon Herschhorn , Timothy W Schacker , Ashley T Haase

Association Between the Development of Subclinical Cardiovascular Disease and Human Immunodeficiency Virus (HIV) Reservoir Markers in People With HIV on Suppressive Antiretroviral Therapy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Isabelle Turcotte , Mohamed El-Far , Manel Sadouni , Carl Chartrand-Lefebvre , Ali Filali-Mouhim , Rémi Fromentin , Annie Chamberland , Mohammad-Ali Jenabian , Jean-Guy Baril , Benoit Trottier , Réjean Thomas , Cécile L Tremblay , Madeleine Durand , Nicolas Chomont , Auteur inconnu

Willingness of Older Canadians with HIV to Participate in HIV Cure Research Near and After the End of Life: A Mixed-Method Study.

AIDS research and human retroviruses

Avec: David Lessard , Karine Dubé , Martin Bilodeau , Patrick Keeler , Shari Margolese , Ron Rosenes , Liliya Sinyavskaya , Madeleine Durand , Erika Benko , Colin Kovacs , Charlotte Guerlotté , Wangari Tharao , Keresa Arnold , Renée Masching , Darien Taylor , José Sousa , Mario Ostrowski , Jeff Taylor , Andy Kaytes , Davey Smith , Sara Gianella , Nicolas Chomont , Jonathan B Angel , Jean-Pierre Routy , Éric A Cohen , Bertrand Lebouché , Cecilia T Costiniuk

Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.

Nature communications

Avec: Maria Pino , Amélie Pagliuzza , M Betina Pampena , Claire Deleage , Elise G Viox , Kevin Nguyen , Inbo Shim , Adam Zhang , Justin L Harper , Sadia Samer , Colin T King , Barbara Cervasi , Kiran P Gill , Stephanie Ehnert , Sherrie M Jean , Michael L Freeman , Jeffrey D Lifson , Deanna Kulpa , Michael R Betts , Nicolas Chomont , Michael M Lederman , Mirko Paiardini

Interplay between the Lung Microbiome, Pulmonary Immunity and Viral Reservoirs in People Living with HIV under Antiretroviral Therapy.

Viruses

Avec: Zihui Wang , Mohammad-Ali Jenabian , Yulia Alexandrova , Amélie Pagliuzza , Ron Olivenstein , Suzanne Samarani , Nicolas Chomont , Steven W Kembel , Cecilia T Costiniuk

HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy.

Journal of virology

Avec: Christina Mallarino-Haeger , Maria Pino , Elise G Viox , Amélie Pagliuzza , Colin T King , Kevin Nguyen , Justin L Harper , Sol Del Mar Aldrete , Barbara Cervasi , Keith A Delman , Michael C Lowe , Nicolas Chomont , Vincent C Marconi , Mirko Paiardini

HIV rapidly targets a diverse pool of CD4

Immunity

Avec: Pierre Gantner , Supranee Buranapraditkun , Amélie Pagliuzza , Caroline Dufour , Marion Pardons , Julie L Mitchell , Eugène Kroon , Carlo Sacdalan , Nicha Tulmethakaan , Suteeraporn Pinyakorn , Merlin L Robb , Nittaya Phanuphak , Jintanat Ananworanich , Denise Hsu , Sandhya Vasan , Lydie Trautmann , Rémi Fromentin , Nicolas Chomont

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8

EBioMedicine

Avec: Mariela P Cabral-Piccin , Laura Papagno , Xavier Lahaye , Federico Perdomo-Celis , Stevenn Volant , Eoghann White , Valérie Monceaux , Sian Llewellyn-Lacey , Rémi Fromentin , David A Price , Nicolas Chomont , Nicolas Manel , Asier Saez-Cirion , Victor Appay

Plasmatic HIV-1 soluble gp120 is associated with correlates of immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.

The Journal of infectious diseases

Avec: Mehdi Benlarbi , Jonathan Richard , Catherine Bourassa , William D Tolbert , Carl Chartrand-Lefebvre , Gabrielle Gendron-Lepage , Mohamed Sylla , Mohamed El-Far , Marc Messier-Peet , Camille Guertin , Isabelle Turcotte , Rémi Fromentin , Myriam Maude Verly , Jérémie Prévost , Andrew Clark , Walther Mothes , Daniel E Kaufmann , Frank Maldarelli , Nicolas Chomont , Philippe Bégin , Cécile Tremblay , Jean-Guy Baril , Benoit Trottier , Sylvie Trottier , Ralf Duerr , Marzena Pazgier , Madeleine Durand , Andrés Finzi

Plasma SARS-CoV-2 RNA elimination and RAGE kinetics distinguish COVID-19 severity.

Clinical & translational immunology

Avec: Xiaoyan Deng , Pierre Gantner , Julia Forestell , Amélie Pagliuzza , Elsa Brunet-Ratnasingham , Madeleine Durand , Daniel E Kaufmann , Nicolas Chomont , Morgan Craig

Is the Central Nervous System Reservoir a Hurdle for an HIV Cure?

Viruses

Avec: Nazanin Mohammadzadeh , Nicolas Chomont , Jerome Estaquier , Eric A Cohen , Christopher Power

IL-32 Drives the Differentiation of Cardiotropic CD4+ T-Cells Carrying HIV DNA in People Living with HIV.

The Journal of infectious diseases

Avec: H Ramani , A Gosselin , R Bunet , M A Jenabian , M Sylla , A Pagliuzza , C Chartrand-Lefebvre , J P Routy , J P Goulet , R Thomas , B Trottier , V Martel-Laferrière , C Fortin , R Fromentin , A Landay , M Durand , P Ancuta , M El-Far , C Tremblay

Tracking coreceptor switch of the transmitted/founder HIV-1 identifies co-evolution of HIV-1 antigenicity, coreceptor usage and CD4 subset targeting: the RV217 acute infection cohort study.

EBioMedicine

Avec: Manukumar Honnayakanahalli Marichannegowda , Michelle Zemil , Lindsay Wieczorek , Eric Sanders-Buell , Meera Bose , Anne Marie O'Sullivan , David King , Leilani Francisco , Felisa Diaz-Mendez , Saini Setua , Nicolas Chomont , Nittaya Phanuphak , Jintanat Ananworanich , Denise Hsu , Sandhya Vasan , Nelson L Michael , Leigh Anne Eller , Sodsai Tovanabutra , Yutaka Tagaya , Merlin L Robb , Victoria R Polonis , Hongshuo Song

Similar Viral and Immune Characteristics of Kaposi Sarcoma in ART-treated People Living With HIV and Older Patients With Classic Kaposi Sarcoma.

Open forum infectious diseases

Avec: Léna Royston , Aude Jary , Carolina A Berini , Tsoarello Mabanga , John Lin , Amélie Pagliuzza , Nicolas Chomont , Ivan V Litvinov , Alexandra Calmy , Valentin Leducq , Vincent Calvez , Anne-Geneviève Marcelin , Stéphane Isnard , Jean-Pierre Routy

Modeling HIV-1 Latency Using Primary CD4

Journal of virology

Avec: Hiroshi Takata , Cari Kessing , Aaron Sy , Noemia Lima , Julia Sciumbata , Luisa Mori , R Brad Jones , Nicolas Chomont , Nelson L Michael , Susana Valente , Lydie Trautmann

Clinical Correlates of Human Immunodeficiency Virus-1 (HIV-1) DNA and Inducible HIV-1 RNA Reservoirs in Peripheral Blood in Children With Perinatally Acquired HIV-1 Infection With Sustained Virologic Suppression for at Least 5 Years.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Ari Bitnun , Doris G Ransy , Jason Brophy , Fatima Kakkar , Michael Hawkes , Lindy Samson , Bayader Annabi , Amélie Pagliuzza , Jacob-Adams Morand , Laura Sauve , Nicolas Chomont , Stephanie Lavoie , John Kim , Paul Sandstrom , Paul A Wender , Terry Lee , Joel Singer , Stanley E Read , Hugo Soudeyns , Auteur inconnu

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment.

Journal of visualized experiments : JoVE

Avec: Syim Salahuddin , Elaine Thomson , Oussama Méziane , Omar Farnos , Amélie Pagliuzza , Nicolas Chomont , Ron Olivenstein , Cecilia Costiniuk , Mohammad-Ali Jenabian

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

PLoS pathogens

Avec: Marion Pardons , Amy E Baxter , Marta Massanella , Amélie Pagliuzza , Rémi Fromentin , Caroline Dufour , Louise Leyre , Jean-Pierre Routy , Daniel E Kaufmann , Nicolas Chomont

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

BMJ open

Avec: Jean-Pierre Routy , Stéphane Isnard , Vikram Mehraj , Mario Ostrowski , Nicolas Chomont , Petronela Ancuta , Rosalie Ponte , Delphine Planas , Franck P Dupuy , Jonathan B Angel , Auteur inconnu

HIV Diversity and Genetic Compartmentalization in Blood and Testes during Suppressive Antiretroviral Therapy.

Journal of virology

Avec: Rachel L Miller , Rosalie Ponte , Bradley R Jones , Natalie N Kinloch , Fredrick H Omondi , Mohammad-Ali Jenabian , Franck P Dupuy , Remi Fromentin , Pierre Brassard , Vikram Mehraj , Nicolas Chomont , Art F Y Poon , Jeffrey B Joy , Zabrina L Brumme , Jean-Pierre Routy , Auteur inconnu

Avec: Evan M Cale , Hongjun Bai , Meera Bose , Michael A Messina , Donn J Colby , Eric Sanders-Buell , Bethany Dearlove , Yifan Li , Emily Engeman , Daniel Silas , Anne Marie O'Sullivan , Brendan Mann , Suteeraporn Pinyakorn , Jintana Intasan , Khunthalee Benjapornpong , Carlo Sacdalan , Eugène Kroon , Nittaya Phanuphak , Robert Gramzinski , Sandhya Vasan , Merlin L Robb , Nelson L Michael , Rebecca M Lynch , Robert T Bailer , Amélie Pagliuzza , Nicolas Chomont , Amarendra Pegu , Nicole A Doria-Rose , Lydie Trautmann , Trevor A Crowell , John R Mascola , Jintanat Ananworanich , Sodsai Tovanabutra , Morgane Rolland , Auteur inconnu

Assessing the Suitability of Next-Generation Viral Outgrowth Assays to Measure Human Immunodeficiency Virus 1 Latent Reservoir Size.

The Journal of infectious diseases

Avec: Mars Stone , Daniel I S Rosenbloom , Peter Bacchetti , Xutao Deng , Melanie Dimapasoc , Sheila Keating , Sonia Bakkour , Douglas D Richman , John W Mellors , Steven G Deeks , Jun Lai , Subul Beg , Janet D Siliciano , Amélie Pagliuzza , Nicolas Chomont , Carol Lackman-Smith , Roger G Ptak , Michael P Busch

Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality.

Science advances

Avec: Elsa Brunet-Ratnasingham , Sai Priya Anand , Pierre Gantner , Alina Dyachenko , Gaël Moquin-Beaudry , Nathalie Brassard , Guillaume Beaudoin-Bussières , Amélie Pagliuzza , Romain Gasser , Mehdi Benlarbi , Floriane Point , Jérémie Prévost , Annemarie Laumaea , Julia Niessl , Manon Nayrac , Gérémy Sannier , Catherine Orban , Marc Messier-Peet , Guillaume Butler-Laporte , David R Morrison , Sirui Zhou , Tomoko Nakanishi , Marianne Boutin , Jade Descôteaux-Dinelle , Gabrielle Gendron-Lepage , Guillaume Goyette , Catherine Bourassa , Halima Medjahed , Laetitia Laurent , Rose-Marie Rébillard , Jonathan Richard , Mathieu Dubé , Rémi Fromentin , Nathalie Arbour , Alexandre Prat , Catherine Larochelle , Madeleine Durand , J Brent Richards , Michaël Chassé , Martine Tétreault , Nicolas Chomont , Andrés Finzi , Daniel E Kaufmann

Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.

PLoS pathogens

Avec: Maria Pino , Susan Pereira Ribeiro , Amélie Pagliuzza , Khader Ghneim , Anum Khan , Emily Ryan , Justin L Harper , Colin T King , Sarah Welbourn , Luca Micci , Sol Aldrete , Keith A Delman , Theron Stuart , Michael Lowe , Jason M Brenchley , Cynthia A Derdeyn , Kirk Easley , Rafick P Sekaly , Nicolas Chomont , Mirko Paiardini , Vincent C Marconi

Loss of CD96 Expression as a Marker of HIV-Specific CD8

Frontiers in immunology

Avec: Rémi Bunet , Manon Nayrac , Hardik Ramani , Mohamed Sylla , Madeleine Durand , Carl Chartrand-Lefebvre , Jean-Pierre Routy , Alan L Landay , Jean-Francois Gauchat , Nicolas Chomont , Petronela Ancuta , Daniel E Kaufmann , Nicole Bernard , Cécile L Tremblay , Mohamed El-Far

Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Chris Y Chiu , Judy J Chang , Ashanti I Dantanarayana , Ajantha Solomon , Vanessa A Evans , Rachel Pascoe , Céline Gubser , Lydie Trautman , Rémi Fromentin , Nicolas Chomont , James H McMahon , Paul U Cameron , Thomas A Rasmussen , Sharon R Lewin

Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.

Viruses

Avec: Dominique Fournelle , Fatima Mostefai , Elsa Brunet-Ratnasingham , Raphaël Poujol , Jean-Christophe Grenier , José Héctor Gálvez , Amélie Pagliuzza , Inès Levade , Sandrine Moreira , Mehdi Benlarbi , Guillaume Beaudoin-Bussières , Gabrielle Gendron-Lepage , Catherine Bourassa , Alexandra Tauzin , Simon Grandjean Lapierre , Nicolas Chomont , Andrés Finzi , Daniel E Kaufmann , Morgan Craig , Julie G Hussin

Plasmatic HIV-1 soluble gp120 is associated with immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.

medRxiv : the preprint server for health sciences

Donating One's Body to HIV Cure Research Through Canadian Medical Assistance in Dying: A Case Study.

Current HIV research

Avec: David Lessard , Bertrand Lebouché , André Morneau , Martin Bilodeau , Ron Rosenes , Justin Sanders , Nicolas Chomont , Patrick Keeler , Karine Dubé , Shari Margolese , Mohammad-Ali Jenabian , Christopher Power , Jean-Pierre Routy , Jonathan B Angel , Eric A Cohen , Cecilia T Costiniuk

Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy.

EBioMedicine

Avec: Julia Niessl , Amy E Baxter , Antigoni Morou , Elsa Brunet-Ratnasingham , Gérémy Sannier , Gabrielle Gendron-Lepage , Jonathan Richard , Gloria-Gabrielle Delgado , Nathalie Brassard , Isabelle Turcotte , Rémi Fromentin , Nicole F Bernard , Nicolas Chomont , Jean-Pierre Routy , Mathieu Dubé , Andrés Finzi , Daniel E Kaufmann

Continuous Prophylactic Antiretrovirals/Antiretroviral Therapy Since Birth Reduces Seeding and Persistence of the Viral Reservoir in Children Vertically Infected With Human Immunodeficiency Virus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Avec: Marta Massanella , Thanyawee Puthanakit , Louise Leyre , Thidarat Jupimai , Panadda Sawangsinth , Mark de Souza , Piyarat Suntarattiwong , Pope Kosalarksa , Thitiporn Borkird , Suparat Kanjanavanit , Kulkanya Chokephaibulkit , Rawiwan Hansudewechakul , Witaya Petdachai , Julie L Mitchell , Merlin L Robb , Lydie Trautmann , Jintanat Ananworanich , Nicolas Chomont , Auteur inconnu

High levels of genetically intact HIV in HLA-DR+ memory T cells indicates their value for reservoir studies.

AIDS (London, England)

Avec: Bethany A Horsburgh , Eunok Lee , Bonnie Hiener , John-Sebastian Eden , Timothy E Schlub , Susanne von Stockenstrom , Lina Odevall , Jeffrey M Milush , Teri Liegler , Elizabeth Sinclair , Rebecca Hoh , Eli A Boritz , Daniel C Douek , Remi Fromentin , Nicolas Chomont , Steven G Deeks , Frederick M Hecht , Sarah Palmer

Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection.

Science translational medicine

Avec: Louise Leyre , Eugène Kroon , Claire Vandergeeten , Carlo Sacdalan , Donn J Colby , Supranee Buranapraditkun , Alexandra Schuetz , Nitiya Chomchey , Mark de Souza , Wendy Bakeman , Rémi Fromentin , Suteeraporn Pinyakorn , Siriwat Akapirat , Rapee Trichavaroj , Suthat Chottanapund , Sopark Manasnayakorn , Rungsun Rerknimitr , Phandee Wattanaboonyoungcharoen , Jerome H Kim , Sodsai Tovanabutra , Timothy W Schacker , Robert O'Connell , Victor G Valcour , Praphan Phanuphak , Merlin L Robb , Nelson Michael , Lydie Trautmann , Nittaya Phanuphak , Jintanat Ananworanich , Nicolas Chomont , Auteur inconnu

Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.

The Journal of infectious diseases

Avec: Jenny L Anderson , Gabriela Khoury , Rémi Fromentin , Ajantha Solomon , Nicolas Chomont , Elizabeth Sinclair , Jeffrey M Milush , Wendy Hartogensis , Peter Bacchetti , Michael Roche , Carolin Tumpach , Matthew Gartner , Matthew C Pitman , Christine Lorrie Epling , Rebecca Hoh , Frederick M Hecht , Ma Somsouk , Paul U Cameron , Steven G Deeks , Sharon R Lewin

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4

Nature communications

Avec: Rémi Fromentin , Sandrina DaFonseca , Cecilia T Costiniuk , Mohamed El-Far , Francesco Andrea Procopio , Frederick M Hecht , Rebecca Hoh , Steven G Deeks , Daria J Hazuda , Sharon R Lewin , Jean-Pierre Routy , Rafick-Pierre Sékaly , Nicolas Chomont

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4

Cell metabolism

Avec: José Carlos Valle-Casuso , Mathieu Angin , Stevenn Volant , Caroline Passaes , Valérie Monceaux , Anastassia Mikhailova , Katia Bourdic , Véronique Avettand-Fenoel , Faroudy Boufassa , Marc Sitbon , Olivier Lambotte , Maria-Isabel Thoulouze , Michaela Müller-Trutwin , Nicolas Chomont , Asier Sáez-Cirión

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy.

Frontiers in microbiology

Avec: Eunok Lee , Peter Bacchetti , Jeffery Milush , Wei Shao , Eli Boritz , Daniel Douek , Remi Fromentin , Teri Liegler , Rebecca Hoh , Steve G Deeks , Frederick M Hecht , Nicolas Chomont , Sarah Palmer

Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity.

Cell reports

Avec: Gérémy Sannier , Mathieu Dubé , Caroline Dufour , Corentin Richard , Nathalie Brassard , Gloria-Gabrielle Delgado , Amélie Pagliuzza , Amy E Baxter , Julia Niessl , Elsa Brunet-Ratnasingham , Roxanne Charlebois , Bertrand Routy , Jean-Pierre Routy , Rémi Fromentin , Nicolas Chomont , Daniel E Kaufmann

The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription.

PLoS pathogens

Avec: Afam A Okoye , Rémi Fromentin , Hiroshi Takata , Jessica H Brehm , Yoshinori Fukazawa , Bryan Randall , Marion Pardons , Vincent Tai , Jun Tang , Jeremy Smedley , Michael Axthelm , Jeffrey D Lifson , Louis J Picker , David Favre , Lydie Trautmann , Nicolas Chomont

Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de

Pathogens & immunity

Avec: Delphine Planas , Augustine Fert , Yuwei Zhang , Jean-Philippe Goulet , Jonathan Richard , Andrés Finzi , Maria Julia Ruiz , Laurence Raymond Marchand , Debashree Chatterjee , Huicheng Chen , Tomas Raul Wiche Salinas , Annie Gosselin , Eric A Cohen , Jean-Pierre Routy , Nicolas Chomont , Petronela Ancuta

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