Mioara Larion

Affiliations

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Publications (32)

Cysteine is a limiting factor for glioma proliferation and survival.

Molecular oncology

Avec: Victor Ruiz-Rodado , Tyrone Dowdy , Adrian Lita , Tamalee Kramp , Meili Zhang , Jinkyu Jung , Ana Dios-Esponera , Lumin Zhang , Christel C Herold-Mende , Kevin Camphausen , Mark R Gilbert ,

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets.

British journal of cancer

Avec: Sue Han , Yang Liu , Sabrina J Cai , Mingyu Qian , Jianyi Ding , Mark R Gilbert , Chunzhang Yang

Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas.

Neuro-oncology

Avec: Victor Ruiz-Rodado , Tathiane M Malta , Tomohiro Seki , Adrian Lita , Tyrone Dowdy , Orieta Celiku , Alejandra Cavazos-Saldana , Aiguo Li , Yang Liu , Sue Han , Wei Zhang , Hua Song , Dionne Davis , Sunmin Lee , Jane B Trepel , Thais S Sabedot , Jeeva Munasinghe , Chunzhang Yang , Christel Herold-Mende , Mark R Gilbert , Murali Krishna Cherukuri , Houtan Noushmehr ,

Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding.

Cell

Avec: Matthew Thomas Doyle , John R Jimah , Tyrone Dowdy , Shannon I Ohlemacher , Jenny E Hinshaw , Harris D Bernstein

Advances in measuring cancer cell metabolism with subcellular resolution.

Nature methods

Avec: Victor Ruiz-Rodado , Adrian Lita ,

Targeting the sphingolipid rheostat in IDH1

bioRxiv : the preprint server for biology

Avec: Tyrone Dowdy , Helena Muley Vilamu , Adrian Lita , Aiguo Li , Tomohiro Yamasaki , Lumin Zhang , Raj Chari , Hua Song , Meili Zhang , Wei Zhang , Nicole Briceno , Dionne Davis , Mark R Gilbert ,

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Di Yu , Yang Liu , Yiqiang Zhou , Victor Ruiz-Rodado , Guowang Xu , Chunzhang Yang

Toward Single-Organelle Lipidomics in Live Cells.

Analytical chemistry

Avec: Adrian Lita , Andrey N Kuzmin , Artem Pliss , Alexander Baev , Alexander Rzhevskii , Mark R Gilbert , Paras N Prasad

IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation.

Neuro-oncology

Avec: Armin Mortazavi , Islam Fayed , Muzna Bachani , Tyrone Dowdy , Jahandar Jahanipour , Anas Khan , Jemima Owotade , Stuart Walbridge , Sara K Inati , Joseph Steiner , Jing Wu , Mark Gilbert , Chun Zhang Yang , Dragan Maric , Alexander Ksendzovsky , Kareem A Zaghloul

Metabolic plasticity of IDH1

Cancer & metabolism

Avec: Victor Ruiz-Rodado , Adrian Lita , Tyrone Dowdy , Orieta Celiku , Alejandra Cavazos Saldana , Herui Wang , Chun Zhang Yang , Raj Chari , Aiguo Li , Wei Zhang , Hua Song , Meili Zhang , Susie Ahn , Dionne Davis , Xiang Chen , Zhengping Zhuang , Christel Herold-Mende , Kylie J Walters , Mark R Gilbert ,

Sphingolipid Pathway as a Source of Vulnerability in IDH1

Cancers

Avec: Tyrone Dowdy , Lumin Zhang , Orieta Celiku , Sriya Movva , Adrian Lita , Victor Ruiz-Rodado , Mark R Gilbert ,

A Single-Organelle Optical Omics Platform for Cell Science and Biomarker Discovery.

Analytical chemistry

Avec: Artem Pliss , Andrey N Kuzmin , Adrian Lita , Rahul Kumar , Orieta Celiku , G Ekin Atilla-Gokcumen , Omer Gokcumen , Dhyan Chandra , Paras N Prasad

Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty.

Biology

Avec: Alexandru Vasincu , Răzvan-Nicolae Rusu , Daniela-Carmen Ababei , Mădălina Larion , Walther Bild , Gabriela Dumitrița Stanciu , Carmen Solcan , Veronica Bild

TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis.

Science signaling

Avec: Thierry Gauthier , Chen Yao , Tyrone Dowdy , Wenwen Jin , Yun-Ji Lim , Liliana C Patiño , Na Liu , Shannon I Ohlemacher , Andrew Bynum , Rida Kazmi , Carole A Bewley , Mladen Mitrovic , Daniel Martin , Robert J Morell , Michael Eckhaus , Roxane Tussiwand , John J O'Shea , WanJun Chen

Resolving Challenges in Detection and Quantification of D-2-hydroxyglutarate and L-2-hydroxyglutarate via LC/MS.

bioRxiv : the preprint server for biology

Avec: Tyrone Dowdy ,

Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma.

Cancer & metabolism

Avec: L Ren , V Ruiz-Rodado , T Dowdy , S Huang , S H Issaq , J Beck , H Wang , C Tran Hoang , A Lita , M Larion , A K LeBlanc

Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma.

Scientific reports

Avec: Virginia Rodriguez , Rolanda Bailey , Mark R Gilbert

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies.

Frontiers in oncology

Avec: Nivedita M Ratnam , Heather M Sonnemann , Stephen C Frederico , Huanwen Chen , Marsha-Kay N D Hutchinson , Tyrone Dowdy , Caitlin M Reid , Jinkyu Jung , Wei Zhang , Hua Song , Meili Zhang , Dionne Davis , Amber J Giles , Mark R Gilbert

Raman-based machine learning platform reveals unique metabolic differences between IDHmut and IDHwt glioma.

Neuro-oncology

Avec: Adrian Lita , Joel Sjöberg , David Păcioianu , Nicoleta Siminea , Orieta Celiku , Tyrone Dowdy , Andrei Păun , Mark R Gilbert , Houtan Noushmehr , Ion Petre ,

Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.

bioRxiv : the preprint server for biology

Avec: Helena Muley , Tyrone Dowdy , Faris Zaibaq , George Karadimov , Aiguo Li , Hua Song , Meili Zhang , Wei Zhang , Zalman Wong , Laurence Zhang , Adrian Lita ,

Targeting the Sphingolipid Rheostat in Gliomas.

International journal of molecular sciences

Avec: Faris Zaibaq , Tyrone Dowdy ,

Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse model.

Frontiers in oncology

Avec: Victor Ruiz-Rodado , Tyrone Dowdy , Adrian Lita , Tamalee Kramp , Meili Zhang , Dorela Shuboni-Mulligan , Christel Herold-Mende , Terri S Armstrong , Mark R Gilbert , Kevin Camphausen ,

T cell exhaustion in malignant gliomas.

Trends in cancer

Avec: Matthew B Watowich , Mark R Gilbert ,

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.

Cancer research

Avec: Choh Yeung , Anna E Gibson , Sameer H Issaq , Nobu Oshima , Joshua T Baumgart , Leah D Edessa , Ganesha Rai , Daniel J Urban , Michelle S Johnson , Gloria A Benavides , Giuseppe L Squadrito , Marielle E Yohe , Haiyan Lei , Sandy Eldridge , John Hamre , Tyrone Dowdy , Victor Ruiz-Rodado , Adrian Lita , Arnulfo Mendoza , Jack F Shern , Lee J Helman , Gordon M Stott , Murali C Krishna , Matthew D Hall , Victor Darley-Usmar , Leonard M Neckers , Christine M Heske

Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma.

Cancers

Avec: Victor Ruiz-Rodado , Tomohiro Seki , Tyrone Dowdy , Adrian Lita , Meili Zhang , Sue Han , Chunzhang Yang , Murali K Cherukuri , Mark R Gilbert ,

Magnetic resonance spectroscopy for the study of cns malignancies.

Progress in nuclear magnetic resonance spectroscopy

Avec: Victor Ruiz-Rodado , Jeffery R Brender , Murali K Cherukuri , Mark R Gilbert ,

IDH1 mutations induce organelle defects via dysregulated phospholipids.

Nature communications

Avec: Adrian Lita , Artem Pliss , Andrey Kuzmin , Tomohiro Yamasaki , Lumin Zhang , Tyrone Dowdy , Christina Burks , Natalia de Val , Orieta Celiku , Victor Ruiz-Rodado , Elena-Raluca Nicoli , Michael Kruhlak , Thorkell Andresson , Sudipto Das , Chunzhang Yang , Rebecca Schmitt , Christel Herold-Mende , Mark R Gilbert , Paras N Prasad ,

Probabilistic model checking of cancer metabolism.

Scientific reports

Avec: Meir D Friedenberg , Adrian Lita , Mark R Gilbert , Orieta Celiku

Single cell metabolism: current and future trends.

Metabolomics : Official journal of the Metabolomic Society

Avec: Ahmed Ali , Shawn Davidson , Ernest Fraenkel , Ian Gilmore , Thomas Hankemeier , Jennifer A Kirwan , Andrew N Lane , Ingela Lanekoff , Laura-Isobel McCall , Michael Murphy , Jonathan V Sweedler , Caigang Zhu

A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma.

The EMBO journal

Avec: Matei A Banu , Athanassios Dovas , Michael G Argenziano , Wenting Zhao , Colin P Sperring , Henar Cuervo Grajal , Zhouzerui Liu , Dominique Mo Higgins , Misha Amini , Brianna Pereira , Ling F Ye , Aayushi Mahajan , Nelson Humala , Julia L Furnari , Pavan S Upadhyayula , Fereshteh Zandkarimi , Trang Tt Nguyen , Damian Teasley , Peter B Wu , Li Hai , Charles Karan , Tyrone Dowdy , Aida Razavilar , Markus D Siegelin , Jan Kitajewski , Jeffrey N Bruce , Brent R Stockwell , Peter A Sims , Peter Canoll

The patatin-like protein PlpD forms structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane.

Nature communications

Avec: Sarah E Hanson , Tyrone Dowdy , Matthew Thomas Doyle , Harris D Bernstein

DMT1 contributes to MF- 438 - mediated inhibition of glioma cells.

bioRxiv : the preprint server for biology

Avec: Laurence Zhang , Tomohiro Yamasaki , Tyrone Dowdy ,

Réseau de co-auteurs

Tyrone Dowdy 20 collaborations

Mark R Gilbert 16 collaborations

Adrian Lita 15 collaborations

Victor Ruiz-Rodado 11 collaborations

Meili Zhang 7 collaborations

Orieta Celiku 7 collaborations

Chunzhang Yang 5 collaborations

Wei Zhang 5 collaborations

Hua Song 5 collaborations

Lumin Zhang 4 collaborations

Aiguo Li 4 collaborations

Dionne Davis 4 collaborations

Christel Herold-Mende 4 collaborations

Sue Han 3 collaborations

Yang Liu 3 collaborations

Tomohiro Yamasaki 3 collaborations

Artem Pliss 3 collaborations

Paras N Prasad 3 collaborations

Tamalee Kramp 2 collaborations

Jinkyu Jung 2 collaborations

Kevin Camphausen 2 collaborations

Tomohiro Seki 2 collaborations

Houtan Noushmehr 2 collaborations

Matthew Thomas Doyle 2 collaborations

Shannon I Ohlemacher 2 collaborations

Harris D Bernstein 2 collaborations

Raj Chari 2 collaborations

Andrey N Kuzmin 2 collaborations

Chun Zhang Yang 2 collaborations

Faris Zaibaq 2 collaborations

Laurence Zhang 2 collaborations

Murali K Cherukuri 2 collaborations

Ana Dios-Esponera 1 collaboration

Christel C Herold-Mende 1 collaboration

Sabrina J Cai 1 collaboration

Mingyu Qian 1 collaboration

Jianyi Ding 1 collaboration

Tathiane M Malta 1 collaboration

Alejandra Cavazos-Saldana 1 collaboration

Sunmin Lee 1 collaboration

Jane B Trepel 1 collaboration

Thais S Sabedot 1 collaboration

Jeeva Munasinghe 1 collaboration

Murali Krishna Cherukuri 1 collaboration

John R Jimah 1 collaboration

Jenny E Hinshaw 1 collaboration

Helena Muley Vilamu 1 collaboration

Nicole Briceno 1 collaboration

Di Yu 1 collaboration

Yiqiang Zhou 1 collaboration

Guowang Xu 1 collaboration

Alexander Baev 1 collaboration

Alexander Rzhevskii 1 collaboration

Armin Mortazavi 1 collaboration

Islam Fayed 1 collaboration

Muzna Bachani 1 collaboration

Jahandar Jahanipour 1 collaboration

Anas Khan 1 collaboration

Jemima Owotade 1 collaboration

Stuart Walbridge 1 collaboration

Sara K Inati 1 collaboration

Joseph Steiner 1 collaboration

Jing Wu 1 collaboration

Mark Gilbert 1 collaboration

Dragan Maric 1 collaboration

Alexander Ksendzovsky 1 collaboration

Kareem A Zaghloul 1 collaboration

Alejandra Cavazos Saldana 1 collaboration

Herui Wang 1 collaboration

Susie Ahn 1 collaboration

Xiang Chen 1 collaboration

Zhengping Zhuang 1 collaboration

Kylie J Walters 1 collaboration

Sriya Movva 1 collaboration

Rahul Kumar 1 collaboration

G Ekin Atilla-Gokcumen 1 collaboration

Omer Gokcumen 1 collaboration

Dhyan Chandra 1 collaboration

Alexandru Vasincu 1 collaboration

Răzvan-Nicolae Rusu 1 collaboration

Daniela-Carmen Ababei 1 collaboration

Mădălina Larion 1 collaboration

Walther Bild 1 collaboration

Gabriela Dumitrița Stanciu 1 collaboration

Carmen Solcan 1 collaboration

Veronica Bild 1 collaboration

Thierry Gauthier 1 collaboration

Chen Yao 1 collaboration

Wenwen Jin 1 collaboration

Yun-Ji Lim 1 collaboration

Liliana C Patiño 1 collaboration

Na Liu 1 collaboration

Andrew Bynum 1 collaboration

Rida Kazmi 1 collaboration

Carole A Bewley 1 collaboration

Mladen Mitrovic 1 collaboration

Daniel Martin 1 collaboration

Robert J Morell 1 collaboration

Michael Eckhaus 1 collaboration

Roxane Tussiwand 1 collaboration

John J O'Shea 1 collaboration

WanJun Chen 1 collaboration

L Ren 1 collaboration

V Ruiz-Rodado 1 collaboration

T Dowdy 1 collaboration

S Huang 1 collaboration

S H Issaq 1 collaboration

J Beck 1 collaboration

H Wang 1 collaboration

C Tran Hoang 1 collaboration

A Lita 1 collaboration

M Larion 1 collaboration

A K LeBlanc 1 collaboration

Virginia Rodriguez 1 collaboration

Rolanda Bailey 1 collaboration

Nivedita M Ratnam 1 collaboration

Heather M Sonnemann 1 collaboration

Stephen C Frederico 1 collaboration

Huanwen Chen 1 collaboration

Marsha-Kay N D Hutchinson 1 collaboration

Caitlin M Reid 1 collaboration

Amber J Giles 1 collaboration

Joel Sjöberg 1 collaboration

David Păcioianu 1 collaboration

Nicoleta Siminea 1 collaboration

Andrei Păun 1 collaboration

Ion Petre 1 collaboration

Helena Muley 1 collaboration

George Karadimov 1 collaboration

Zalman Wong 1 collaboration

Dorela Shuboni-Mulligan 1 collaboration

Terri S Armstrong 1 collaboration

Matthew B Watowich 1 collaboration

Choh Yeung 1 collaboration

Anna E Gibson 1 collaboration

Sameer H Issaq 1 collaboration

Nobu Oshima 1 collaboration

Joshua T Baumgart 1 collaboration

Leah D Edessa 1 collaboration

Ganesha Rai 1 collaboration

Daniel J Urban 1 collaboration

Michelle S Johnson 1 collaboration

Gloria A Benavides 1 collaboration

Giuseppe L Squadrito 1 collaboration

Marielle E Yohe 1 collaboration

Haiyan Lei 1 collaboration

Sandy Eldridge 1 collaboration

John Hamre 1 collaboration

Arnulfo Mendoza 1 collaboration

Jack F Shern 1 collaboration

Lee J Helman 1 collaboration

Gordon M Stott 1 collaboration

Murali C Krishna 1 collaboration

Matthew D Hall 1 collaboration

Victor Darley-Usmar 1 collaboration

Leonard M Neckers 1 collaboration

Christine M Heske 1 collaboration

Jeffery R Brender 1 collaboration

Andrey Kuzmin 1 collaboration

Christina Burks 1 collaboration

Natalia de Val 1 collaboration

Elena-Raluca Nicoli 1 collaboration

Michael Kruhlak 1 collaboration

Thorkell Andresson 1 collaboration

Sudipto Das 1 collaboration

Rebecca Schmitt 1 collaboration

Meir D Friedenberg 1 collaboration

Ahmed Ali 1 collaboration

Shawn Davidson 1 collaboration

Ernest Fraenkel 1 collaboration

Ian Gilmore 1 collaboration

Thomas Hankemeier 1 collaboration

Jennifer A Kirwan 1 collaboration

Andrew N Lane 1 collaboration

Ingela Lanekoff 1 collaboration

Laura-Isobel McCall 1 collaboration

Michael Murphy 1 collaboration

Jonathan V Sweedler 1 collaboration

Caigang Zhu 1 collaboration

Matei A Banu 1 collaboration

Athanassios Dovas 1 collaboration

Michael G Argenziano 1 collaboration

Wenting Zhao 1 collaboration

Colin P Sperring 1 collaboration

Henar Cuervo Grajal 1 collaboration

Zhouzerui Liu 1 collaboration

Dominique Mo Higgins 1 collaboration

Misha Amini 1 collaboration

Brianna Pereira 1 collaboration

Ling F Ye 1 collaboration

Aayushi Mahajan 1 collaboration

Nelson Humala 1 collaboration

Julia L Furnari 1 collaboration

Pavan S Upadhyayula 1 collaboration

Fereshteh Zandkarimi 1 collaboration

Trang Tt Nguyen 1 collaboration

Damian Teasley 1 collaboration

Peter B Wu 1 collaboration

Li Hai 1 collaboration

Charles Karan 1 collaboration

Aida Razavilar 1 collaboration

Markus D Siegelin 1 collaboration

Jan Kitajewski 1 collaboration

Jeffrey N Bruce 1 collaboration

Brent R Stockwell 1 collaboration

Peter A Sims 1 collaboration

Peter Canoll 1 collaboration

Sarah E Hanson 1 collaboration