Matthias S Leisegang

Affiliations

Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany.
German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Theodor Stern-Kai 7, Frankfurt, Germany.

Publications (27)

Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS.

European heart journal

Avec: Sofia-Iris Bibli , Stefan Günther , Beatrice Pflüger-Müller , James A Oo , Cindy Höper , Sandra Seredinski , Michail Yekelchyk , Thomas Schmitz-Rixen , Christoph Schürmann , Jiong Hu , Mario Looso , Fragiska Sigala , Reinier A Boon , Ingrid Fleming , Ralf P Brandes

Interaction of Bartonella henselae with Fibronectin Represents the Molecular Basis for Adhesion to Host Cells.

Microbiology spectrum

Avec: Diana J Vaca , Arno Thibau , Johan Malmström , Dirk Linke , Johannes A Eble , Wibke Ballhorn , Martin Schaller , Lotta Happonen , Volkhard A J Kempf

Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Alix Tröster , Michael DiPrima , Nathalie Jores , Denis Kudlinzki , Sridhar Sreeramulu , Santosh L Gande , Verena Linhard , Damian Ludig , Alexander Schug , Krishna Saxena , Maria Reinecke , Stephanie Heinzlmeir , Jan Wollenhaupt , Frank Lennartz , Manfred S Weiss , Bernhard Kuster , Giovanna Tosato , Harald Schwalbe

RNA-DNA triplexes: molecular mechanisms and functional relevance.

Trends in biochemical sciences

Avec: Timothy Warwick , Julia Stötzel , Ralf P Brandes

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2.

Cell reports

Avec: James A Oo , Katalin Pálfi , Timothy Warwick , Ilka Wittig , Cristian Prieto-Garcia , Vigor Matkovic , Ines Tomašković , Frederike Boos , Judit Izquierdo Ponce , Tom Teichmann , Kirill Petriukov , Shaza Haydar , Lars Maegdefessel , Zhiyuan Wu , Minh Duc Pham , Jaya Krishnan , Andrew H Baker , Stefan Günther , Helle D Ulrich , Ivan Dikic , Ralf P Brandes

The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.

Basic research in cardiology

Avec: Frederike Boos , James A Oo , Timothy Warwick , Stefan Günther , Judit Izquierdo Ponce , Melina Lopez , Diba Rafii , Giulia Buchmann , Minh Duc Pham , Zahraa S Msheik , Tianfu Li , Sandra Seredinski , Shaza Haydar , Sepide Kashefiolasl , Karl H Plate , Rüdiger Behr , Matthias Mietsch , Jaya Krishnan , Soni S Pullamsetti , Sofia-Iris Bibli , Rabea Hinkel , Andrew H Baker , Reinier A Boon , Marcel H Schulz , Ilka Wittig , Francis J Miller , Ralf P Brandes ,

Vitamin D-A New Perspective in Treatment of Cerebral Vasospasm.

Neurosurgery

Avec: Sepide Kashefiolasl , Valeska Helfinger , Christoph Schürmann , Beatrice Pflüger-Müller , Voahanginirina Randriamboavonjy , Andrea E Vasconez , Geert Carmeliet , Klaus Badenhoop , Gudrun Hintereder , Volker Seifert , Katrin Schröder , Juergen Konczalla , Ralf P Brandes

Long non-coding RNAs: novel regulators of cellular physiology and function.

Pflugers Archiv : European journal of physiology

Avec: James A Oo , Ralf P Brandes ,

A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions.

Briefings in bioinformatics

Avec: Timothy Warwick , Sandra Seredinski , Nina M Krause , Jasleen Kaur Bains , Lara Althaus , James A Oo , Alessandro Bonetti , Anne Dueck , Stefan Engelhardt , Harald Schwalbe , Marcel H Schulz , Ralf P Brandes

ncOrtho: efficient and reliable identification of miRNA orthologs.

Nucleic acids research

Avec: Felix Langschied , Ralf P Brandes , Ingo Ebersberger

Computational Methods to Study DNA:DNA:RNA Triplex Formation by lncRNAs.

Non-coding RNA

Avec: Timothy Warwick , Ralf P Brandes ,

DGK and DZHK position paper on genome editing: basic science applications and future perspective.

Basic research in cardiology

Avec: Ralf P Brandes , Anne Dueck , Stefan Engelhardt , Manuel Kaulich , Christian Kupatt , Maria Teresa De Angelis , Ferdinand le Noble , Alessandra Moretti , Oliver J Müller , Boris V Skryabin , Thomas Thum , Wolfgang Wurst

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Acta physiologica (Oxford, England)

Avec: Andrea E Vasconez , Patrick Janetzko , James A Oo , Beatrice Pflüger-Müller , Corina Ratiu , Lunda Gu , Kristian Helin , Gerd Geisslinger , Ingrid Fleming , Katrin Schröder , Christian Fork , Ralf P Brandes ,

The histone demethylase PHF8 facilitates alternative splicing of the histocompatibility antigen HLA-G.

FEBS letters

Avec: Lunda Gu , Jens Preussner , Stefan Günther , Juliane Hitzel , Corina Ratiu , Andreas Weigert , Wei Chen , Eva C Schwarz , Mario Looso , Christian Fork , Ralf P Brandes

The polarity protein Scrib limits atherosclerosis development in mice.

Cardiovascular research

Avec: Christoph Schürmann , Franziska L Dienst , Katalin Pálfi , Andrea E Vasconez , James A Oo , ShengPeng Wang , Giulia K Buchmann , Stefan Offermanns , Bart van de Sluis , Stefan Günther , Patrick O Humbert , Eunjee Lee , Jun Zhu , Andreas Weigert , Praveen Mathoor , Ilka Wittig , Christoph Kruse , Ralf P Brandes

ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth.

The EMBO journal

Avec: Annika Karger , Siavash Mansouri , Andreas Weigert , Stefan Günther , Carsten Kuenne , Ilka Wittig , Sven Zukunft , Stephan Klatt , Blerina Aliraj , Laura V Klotz , Hauke Winter , Poornima Mahavadi , Ingrid Fleming , Clemens Ruppert , Biruta Witte , Ibrahim Alkoudmani , Stefan Gattenlöhner , Friedrich Grimminger , Werner Seeger , Soni Savai Pullamsetti , Rajkumar Savai

Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence.

Circulation research

Avec: Jiong Hu , Mario Looso , Maria-Kyriaki Drekolia , Janina Wittig , Janina Mettner , Christina Karantanou , Anastasia Kyselova , Gabrjela Dumbovic , Xiaoming Li , Yuanyuan Li , Stefan Guenther , David John , Mauro Siragusa , Sven Zukunft , James A Oo , Ilka Wittig , Susanne Hille , Andreas Weigert , Stefan Knapp , Ralf P Brandes , Oliver J Müller , Andreas Papapetropoulos , Fragiska Sigala , Gergana Dobreva , Baktybek Kojonazarov , Ingrid Fleming , Sofia-Iris Bibli

LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses.

International journal of molecular sciences

Avec: Frederike Lam , Ralf P Brandes

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.

Nature communications

Avec: D Julia Trembinski , Diewertje I Bink , Kosta Theodorou , Janina Sommer , Ariane Fischer , Anke van Bergen , Chao-Chung Kuo , Ivan G Costa , Christoph Schürmann , Ralf P Brandes , Tijna Alekseeva , Boris Brill , Astrid Wietelmann , Christopher N Johnson , Alexander Spring-Connell , Manuel Kaulich , Stanislas Werfel , Stefan Engelhardt , Marc N Hirt , Kaja Yorgan , Thomas Eschenhagen , Luisa Kirchhof , Patrick Hofmann , Nicolas Jaé , Ilka Wittig , Nazha Hamdani , Corinne Bischof , Jaya Krishnan , Riekelt H Houtkooper , Stefanie Dimmeler , Reinier A Boon

The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells.

Basic research in cardiology

Avec: Beatrice Pflüger-Müller , James A Oo , Jan Heering , Timothy Warwick , Ewgenij Proschak , Stefan Günther , Mario Looso , Flávia Rezende , Christian Fork , Gerd Geisslinger , Dominique Thomas , Robert Gurke , Dieter Steinhilber , Marcel Schulz , Ralf P Brandes

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.

Redox biology

Avec: Sofia-Iris Bibli , Jiong Hu , Janina Wittig , Sven Zukunft , Andrea Kapasakalidi , Beate Fisslthaler , Diamantis Tsilimigras , Georgios Zografos , Konstantinos Filis , Ralf P Brandes , Andreas Papapetropoulos , Fragiska Sigala , Ingrid Fleming

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease.

Circulation research

Avec: João P Monteiro , Julie Rodor , Axelle Caudrillier , Jessica P Scanlon , Ana-Mishel Spiroski , Tatiana Dudnakova , Beatrice Pflüger-Müller , Alena Shmakova , Alex von Kriegsheim , Lin Deng , Richard S Taylor , John R Wilson-Kanamori , Shiau-Haln Chen , Kevin Stewart , Adrian Thomson , Tijana Mitić , John D McClure , Jean Iynikkel , Patrick W F Hadoke , Laura Denby , Angela C Bradshaw , Paola Caruso , Nicholas W Morrell , Jason C Kovacic , Igor Ulitsky , Neil C Henderson , Andrea Caporali , Ralf P Brandes , Andrew H Baker

ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting.

Scientific reports

Avec: James A Oo , Barnabas Irmer , Stefan Günther , Timothy Warwick , Katalin Pálfi , Judit Izquierdo Ponce , Tom Teichmann , Beatrice Pflüger-Müller , Ralf Gilsbach , Ralf P Brandes ,

Mapping the Endothelial Cell

Circulation

Avec: Sofia-Iris Bibli , Jiong Hu , Mario Looso , Andreas Weigert , Corina Ratiu , Janina Wittig , Maria Kyriaki Drekolia , Lukas Tombor , Voahanginirina Randriamboavonjy , Philipp Goymann , Fredy Delgado Lagos , Beate Fisslthaler , Sven Zukunft , Anastasia Kyselova , Alberto Fernando Oliveira Justo , Juliana Heidler , Diamantis Tsilimigras , Ralf P Brandes , Stefanie Dimmeler , Andreas Papapetropoulos , Stefan Knapp , Stefan Offermanns , Ilka Wittig , Stephen L Nishimura , Fragiska Sigala , Ingrid Fleming

DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells.

Molecular therapy. Nucleic acids

Avec: Sandra Seredinski , Frederike Boos , Stefan Günther , James A Oo , Timothy Warwick , Judit Izquierdo Ponce , Felix F Lillich , Ewgenij Proschak , Stefan Knapp , Ralf Gilsbach , Beatrice Pflüger-Müller , Ralf P Brandes ,

Integrative analysis of epigenetics data identifies gene-specific regulatory elements.

Nucleic acids research

Avec: Florian Schmidt , Alexander Marx , Nina Baumgarten , Marie Hebel , Martin Wegner , Manuel Kaulich , Ralf P Brandes , Jonathan Göke , Jilles Vreeken , Marcel H Schulz

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex.

Nature communications

Avec: Jasleen Kaur Bains , Sandra Seredinski , James A Oo , Nina M Krause , Chao-Chung Kuo , Stefan Günther , Nevcin Sentürk Cetin , Timothy Warwick , Can Cao , Frederike Boos , Judit Izquierdo Ponce , Shaza Haydar , Rebecca Bednarz , Chanil Valasarajan , Dominik C Fuhrmann , Jens Preussner , Mario Looso , Soni S Pullamsetti , Marcel H Schulz , Hendrik R A Jonker , Christian Richter , Flávia Rezende , Ralf Gilsbach , Beatrice Pflüger-Müller , Ilka Wittig , Ingrid Grummt , Teodora Ribarska , Ivan G Costa , Harald Schwalbe , Ralf P Brandes

Réseau de co-auteurs

Ralf P Brandes 24 collaborations

James A Oo 12 collaborations

Stefan Günther 10 collaborations

Timothy Warwick 9 collaborations

Beatrice Pflüger-Müller 8 collaborations

Ilka Wittig 8 collaborations

Mario Looso 6 collaborations

Ingrid Fleming 6 collaborations

Sofia-Iris Bibli 5 collaborations

Sandra Seredinski 5 collaborations

Judit Izquierdo Ponce 5 collaborations

Andreas Weigert 5 collaborations

Christoph Schürmann 4 collaborations

Jiong Hu 4 collaborations

Fragiska Sigala 4 collaborations

Frederike Boos 4 collaborations

Marcel H Schulz 4 collaborations

Sven Zukunft 4 collaborations

Reinier A Boon 3 collaborations

Harald Schwalbe 3 collaborations

Katalin Pálfi 3 collaborations

Shaza Haydar 3 collaborations

Jaya Krishnan 3 collaborations

Andrew H Baker 3 collaborations

Andrea E Vasconez 3 collaborations

Stefan Engelhardt 3 collaborations

Manuel Kaulich 3 collaborations

Corina Ratiu 3 collaborations

Christian Fork 3 collaborations

Janina Wittig 3 collaborations

Stefan Knapp 3 collaborations

Andreas Papapetropoulos 3 collaborations

Ralf Gilsbach 3 collaborations

Tom Teichmann 2 collaborations

Minh Duc Pham 2 collaborations

Sepide Kashefiolasl 2 collaborations

Soni S Pullamsetti 2 collaborations

Voahanginirina Randriamboavonjy 2 collaborations

Katrin Schröder 2 collaborations

Nina M Krause 2 collaborations

Jasleen Kaur Bains 2 collaborations

Anne Dueck 2 collaborations

Oliver J Müller 2 collaborations

Lunda Gu 2 collaborations

Gerd Geisslinger 2 collaborations

Jens Preussner 2 collaborations

Stefan Offermanns 2 collaborations

Anastasia Kyselova 2 collaborations

Chao-Chung Kuo 2 collaborations

Ivan G Costa 2 collaborations

Stefanie Dimmeler 2 collaborations

Ewgenij Proschak 2 collaborations

Flávia Rezende 2 collaborations

Beate Fisslthaler 2 collaborations

Diamantis Tsilimigras 2 collaborations

Cindy Höper 1 collaboration

Michail Yekelchyk 1 collaboration

Thomas Schmitz-Rixen 1 collaboration

Diana J Vaca 1 collaboration

Arno Thibau 1 collaboration

Johan Malmström 1 collaboration

Dirk Linke 1 collaboration

Johannes A Eble 1 collaboration

Wibke Ballhorn 1 collaboration

Martin Schaller 1 collaboration

Lotta Happonen 1 collaboration

Volkhard A J Kempf 1 collaboration

Alix Tröster 1 collaboration

Michael DiPrima 1 collaboration

Nathalie Jores 1 collaboration

Denis Kudlinzki 1 collaboration

Sridhar Sreeramulu 1 collaboration

Santosh L Gande 1 collaboration

Verena Linhard 1 collaboration

Damian Ludig 1 collaboration

Alexander Schug 1 collaboration

Krishna Saxena 1 collaboration

Maria Reinecke 1 collaboration

Stephanie Heinzlmeir 1 collaboration

Jan Wollenhaupt 1 collaboration

Frank Lennartz 1 collaboration

Manfred S Weiss 1 collaboration

Bernhard Kuster 1 collaboration

Giovanna Tosato 1 collaboration

Julia Stötzel 1 collaboration

Cristian Prieto-Garcia 1 collaboration

Vigor Matkovic 1 collaboration

Ines Tomašković 1 collaboration

Kirill Petriukov 1 collaboration

Lars Maegdefessel 1 collaboration

Zhiyuan Wu 1 collaboration

Helle D Ulrich 1 collaboration

Ivan Dikic 1 collaboration

Melina Lopez 1 collaboration

Diba Rafii 1 collaboration

Giulia Buchmann 1 collaboration

Zahraa S Msheik 1 collaboration

Tianfu Li 1 collaboration

Karl H Plate 1 collaboration

Rüdiger Behr 1 collaboration

Matthias Mietsch 1 collaboration

Rabea Hinkel 1 collaboration

Francis J Miller 1 collaboration

Valeska Helfinger 1 collaboration

Geert Carmeliet 1 collaboration

Klaus Badenhoop 1 collaboration

Gudrun Hintereder 1 collaboration

Volker Seifert 1 collaboration

Juergen Konczalla 1 collaboration

Lara Althaus 1 collaboration

Alessandro Bonetti 1 collaboration

Felix Langschied 1 collaboration

Ingo Ebersberger 1 collaboration

Christian Kupatt 1 collaboration

Maria Teresa De Angelis 1 collaboration

Ferdinand le Noble 1 collaboration

Alessandra Moretti 1 collaboration

Boris V Skryabin 1 collaboration

Thomas Thum 1 collaboration

Wolfgang Wurst 1 collaboration

Patrick Janetzko 1 collaboration

Kristian Helin 1 collaboration

Juliane Hitzel 1 collaboration

Wei Chen 1 collaboration

Eva C Schwarz 1 collaboration

Franziska L Dienst 1 collaboration

ShengPeng Wang 1 collaboration

Giulia K Buchmann 1 collaboration

Bart van de Sluis 1 collaboration

Patrick O Humbert 1 collaboration

Eunjee Lee 1 collaboration

Jun Zhu 1 collaboration

Praveen Mathoor 1 collaboration

Christoph Kruse 1 collaboration

Annika Karger 1 collaboration

Siavash Mansouri 1 collaboration

Carsten Kuenne 1 collaboration

Stephan Klatt 1 collaboration

Blerina Aliraj 1 collaboration

Laura V Klotz 1 collaboration

Hauke Winter 1 collaboration

Poornima Mahavadi 1 collaboration

Clemens Ruppert 1 collaboration

Biruta Witte 1 collaboration

Ibrahim Alkoudmani 1 collaboration

Stefan Gattenlöhner 1 collaboration

Friedrich Grimminger 1 collaboration

Werner Seeger 1 collaboration

Soni Savai Pullamsetti 1 collaboration

Rajkumar Savai 1 collaboration

Maria-Kyriaki Drekolia 1 collaboration

Janina Mettner 1 collaboration

Christina Karantanou 1 collaboration

Gabrjela Dumbovic 1 collaboration

Xiaoming Li 1 collaboration

Yuanyuan Li 1 collaboration

Stefan Guenther 1 collaboration

David John 1 collaboration

Mauro Siragusa 1 collaboration

Susanne Hille 1 collaboration

Gergana Dobreva 1 collaboration

Baktybek Kojonazarov 1 collaboration

Frederike Lam 1 collaboration

D Julia Trembinski 1 collaboration

Diewertje I Bink 1 collaboration

Kosta Theodorou 1 collaboration

Janina Sommer 1 collaboration

Ariane Fischer 1 collaboration

Anke van Bergen 1 collaboration

Tijna Alekseeva 1 collaboration

Boris Brill 1 collaboration

Astrid Wietelmann 1 collaboration

Christopher N Johnson 1 collaboration

Alexander Spring-Connell 1 collaboration

Stanislas Werfel 1 collaboration

Marc N Hirt 1 collaboration

Kaja Yorgan 1 collaboration

Thomas Eschenhagen 1 collaboration

Luisa Kirchhof 1 collaboration

Patrick Hofmann 1 collaboration

Nicolas Jaé 1 collaboration

Nazha Hamdani 1 collaboration

Corinne Bischof 1 collaboration

Riekelt H Houtkooper 1 collaboration

Jan Heering 1 collaboration

Dominique Thomas 1 collaboration

Robert Gurke 1 collaboration

Dieter Steinhilber 1 collaboration

Marcel Schulz 1 collaboration

Andrea Kapasakalidi 1 collaboration

Georgios Zografos 1 collaboration

Konstantinos Filis 1 collaboration

João P Monteiro 1 collaboration

Julie Rodor 1 collaboration

Axelle Caudrillier 1 collaboration

Jessica P Scanlon 1 collaboration

Ana-Mishel Spiroski 1 collaboration

Tatiana Dudnakova 1 collaboration

Alena Shmakova 1 collaboration

Alex von Kriegsheim 1 collaboration

Lin Deng 1 collaboration

Richard S Taylor 1 collaboration

John R Wilson-Kanamori 1 collaboration

Shiau-Haln Chen 1 collaboration

Kevin Stewart 1 collaboration

Adrian Thomson 1 collaboration

Tijana Mitić 1 collaboration

John D McClure 1 collaboration

Jean Iynikkel 1 collaboration

Patrick W F Hadoke 1 collaboration

Laura Denby 1 collaboration

Angela C Bradshaw 1 collaboration

Paola Caruso 1 collaboration

Nicholas W Morrell 1 collaboration

Jason C Kovacic 1 collaboration

Igor Ulitsky 1 collaboration

Neil C Henderson 1 collaboration

Andrea Caporali 1 collaboration

Barnabas Irmer 1 collaboration

Maria Kyriaki Drekolia 1 collaboration

Lukas Tombor 1 collaboration

Philipp Goymann 1 collaboration

Fredy Delgado Lagos 1 collaboration

Alberto Fernando Oliveira Justo 1 collaboration

Juliana Heidler 1 collaboration

Stephen L Nishimura 1 collaboration

Felix F Lillich 1 collaboration

Florian Schmidt 1 collaboration

Alexander Marx 1 collaboration

Nina Baumgarten 1 collaboration

Marie Hebel 1 collaboration

Martin Wegner 1 collaboration

Jonathan Göke 1 collaboration

Jilles Vreeken 1 collaboration

Nevcin Sentürk Cetin 1 collaboration

Can Cao 1 collaboration

Rebecca Bednarz 1 collaboration

Chanil Valasarajan 1 collaboration

Dominik C Fuhrmann 1 collaboration

Hendrik R A Jonker 1 collaboration

Christian Richter 1 collaboration

Ingrid Grummt 1 collaboration

Teodora Ribarska 1 collaboration