Masae Ikura

Affiliations

Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8501, Japan.

Publications (36)

Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety.

Science signaling

Avec: Benjamin M M Grant , Masahiro Enomoto , Sung-In Back , Ki-Young Lee , Teklab Gebregiworgis , Noboru Ishiyama , Mitsuhiko Ikura , Christopher B Marshall

NMR in integrated biophysical drug discovery for RAS: past, present, and future.

Journal of biomolecular NMR

Avec: Christopher B Marshall , Fenneke KleinJan , Teklab Gebregiworgis , Ki-Young Lee , Zhenhao Fang , Ben J Eves , Ningdi F Liu , Geneviève M C Gasmi-Seabrook , Masahiro Enomoto , Mitsuhiko Ikura

Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.

Cell reports

Avec: Qingci Zhao , Ryu Fujimiya , Satoshi Kubo , Christopher B Marshall , Mitsuhiko Ikura , Ichio Shimada , Noritaka Nishida

Expression and Purification of Calmodulin for NMR and Other Biophysical Applications.

Methods in molecular biology (Clifton, N.J.)

Avec: Benjamin M M Grant , Christopher B Marshall , Mitsuhiko Ikura

Discontinuation of oral amphotericin B therapy does not influence the pharmacokinetics of tacrolimus in heart transplant patients.

International journal of clinical pharmacology and therapeutics

Avec: Megumi Ikura , Tsutomu Nakamura , Takaya Uno , Kazuki Nakagita , Hiromi Takenaka , Sachi Matsuda , Ryosuke Oda , Kyoichi Wada , Yuji Hattori , Osamu Seguchi , Masanobu Yanase , Naoki Hayakawa , Norihide Fukushima

Risk Assessment of Neutropenia during Low-Dose Valganciclovir Prophylaxis for Heart Transplant Recipients.

Biological & pharmaceutical bulletin

Avec: Mai Otokubo , Kyoichi Wada , Megumi Ikura , Kotoka Hayase , Takaya Uno , Kazuki Nakagita , Naoki Hayakawa , Takuya Watanabe , Osamu Seguchi , Norihide Fukushima , Tsutomu Nakamura

Early acute kidney injury after tacrolimus administration in heart transplant recipients receiving basiliximab induction therapy.

International journal of clinical pharmacology and therapeutics

Avec: Megumi Ikura , Tsutomu Nakamura , Kyoichi Wada , Rikako Nagata , Tomoko Ueno , Kazuyoshi Kawabata , Fumiki Yoshihara , Takuya Watanabe , Yasumasa Tsukamoto

Effect of Therapeutic Modification on Outcomes in Heart Transplantation Over the Past Two Decades - A Single-Center Experience in Japan.

Circulation journal : official journal of the Japanese Circulation Society

Avec: Masanobu Yanase , Keiichiro Iwasaki , Takuya Watanabe , Osamu Seguchi , Seiko Nakajima , Kensuke Kuroda , Hiroki Mochizuki , Sachi Matsuda , Hiromi Takenaka , Megumi Ikura , Naoki Tadokoro , Satsuki Fukushima , Tomoyuki Fujita , Hatsue Ishibashi-Ueda , Takeshi Nakatani , Soichiro Kitamura , Junjiro Kobayashi , Kenichi Tsujita , Hisao Ogawa , Norihide Fukushima

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.

The Journal of cell biology

Avec: Mihai L Azoitei , Jungsik Noh , Daniel J Marston , Philippe Roudot , Christopher B Marshall , Timothy A Daugird , Sidney L Lisanza , María-José Sandí , Mitsu Ikura , John Sondek , Robert Rottapel , Klaus M Hahn , Gaudenz Danuser

Influence of Induction Therapy Using Basiliximab With Delayed Tacrolimus Administration in Heart Transplant Recipients - Comparison With Standard Tacrolimus-Based Triple Immunosuppression.

Circulation journal : official journal of the Japanese Circulation Society

Avec: Takuya Watanabe , Masanobu Yanase , Osamu Seguchi , Tomoyuki Fujita , Toshimitsu Hamasaki , Seiko Nakajima , Kensuke Kuroda , Yuto Kumai , Koichi Toda , Keiichiro Iwasaki , Yuki Kimura , Hiroki Mochizuki , Eiji Anegawa , Yasumori Sujino , Nobuichiro Yagi , Koichi Yoshitake , Kyoichi Wada , Sachi Matsuda , Hiromi Takenaka , Megumi Ikura , Kazuki Nakagita , Shin Yajima , Yorihiko Matsumoto , Naoki Tadokoro , Takashi Kakuta , Satsuki Fukushima , Hatsue Ishibashi-Ueda , Junjiro Kobayashi , Norihide Fukushima

The p.E152K-STIM1 mutation deregulates Ca

Journal of cell science

Avec: Miguel Burgos , Reginald Philippe , Fabrice Antigny , Paul Buscaglia , Emmanuelle Masson , Sreya Mukherjee , Pauline Dubar , Cédric Le Maréchal , Florence Campeotto , Nicolas Lebonvallet , Maud Frieden , Juan Llopis , Beatriz Domingo , Peter B Stathopulos , Mitsuhiko Ikura , Wesley Brooks , Wayne Guida , Jian-Min Chen , Claude Ferec , Thierry Capiod , Olivier Mignen

The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.

Angewandte Chemie (International ed. in English)

Avec: Ki-Young Lee , Mitsuhiko Ikura , Christopher B Marshall

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2.

bioRxiv : the preprint server for biology

Avec: Yuou Wang , Alex Yemelyanov , Christopher D Go , Sun Kim , Jeanne M Quinn , Annette S Flozak , Phuong M Le , Shannon Liang , Anne Claude-Gingras , Mitsu Ikura , Noboru Ishiyama , Cara J Gottardi

Venous Screening Activities at the Site of Hokkaido East Iburi Earthquake: Report from the Result of Venous Screening in Preventive Awareness Activities.

Annals of vascular diseases

Avec: Keisuke Kamada , Daiki Uchida , Hiroko Okuda , Atsuhiro Koya , Seima Ohira , Maiko Ikura , Shinsuke Kikuchi , Kazuhiko Hanzawa , Nobuyoshi Azuma

Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.

Protein science : a publication of the Protein Society

Avec: Ningdi F Liu , Masahiro Enomoto , Christopher B Marshall , Mitsuhiko Ikura

Functional impacts of the ubiquitin-proteasome system on DNA damage recognition in global genome nucleotide excision repair.

Scientific reports

Avec: Wataru Sakai , Mayumi Yuasa-Sunagawa , Masayuki Kusakabe , Aiko Kishimoto , Takeshi Matsui , Yuki Kaneko , Jun-Ichi Akagi , Nicolas Huyghe , Tsuyoshi Ikura , Fumio Hanaoka , Masayuki Yokoi , Kaoru Sugasawa

Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain.

Journal of molecular biology

Avec: Masahiro Enomoto , Tadateru Nishikawa , Sung-In Back , Noboru Ishiyama , Le Zheng , Peter B Stathopulos , Mitsuhiko Ikura

Lung Cancer Driven by BRAF

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Avec: Ku-Geng Huo , Hirotsugu Notsuda , Zhenhao Fang , Ningdi Feng Liu , Teklab Gebregiworgis , Quan Li , Nhu-An Pham , Ming Li , Ni Liu , Frances A Shepherd , Christopher B Marshall , Mitsuhiko Ikura , Nadeem Moghal , Ming-Sound Tsao

Regulation of GTPase function by autophosphorylation.

Molecular cell

Avec: Christian W Johnson , Hyuk-Soo Seo , Elizabeth M Terrell , Moon-Hee Yang , Fenneke KleinJan , Teklab Gebregiworgis , Genevieve M C Gasmi-Seabrook , Ezekiel A Geffken , Jimit Lakhani , Kijun Song , Puspalata Bashyal , Olesja Popow , Joao A Paulo , Andrea Liu , Carla Mattos , Christopher B Marshall , Mitsuhiko Ikura , Deborah K Morrison , Sirano Dhe-Paganon , Kevin M Haigis

AdjustSense: Adaptive 3D Sensing System with Adjustable Spatio-Temporal Resolution and Measurement Range Using High-Speed Omnidirectional Camera and Direct Drive Motor.

Sensors (Basel, Switzerland)

Avec: Mikihiro Ikura , Sarthak Pathak , Jun Younes Louhi Kasahara , Atsushi Yamashita , Hajime Asama

Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Zhenhao Fang , Ki-Young Lee , Ku-Geng Huo , Geneviève Gasmi-Seabrook , Le Zheng , Nadeem Moghal , Ming-Sound Tsao , Mitsuhiko Ikura , Christopher B Marshall

Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Nature communications

Avec: Yoshihito Kano , Teklab Gebregiworgis , Christopher B Marshall , Nikolina Radulovich , Betty P K Poon , Jonathan St-Germain , Jonathan D Cook , Ivette Valencia-Sama , Benjamin M M Grant , Silvia Gabriela Herrera , Jinmin Miao , Brian Raught , Meredith S Irwin , Jeffrey E Lee , Jen Jen Yeh , Zhong-Yin Zhang , Ming-Sound Tsao , Mitsuhiko Ikura , Michael Ohh

Epigenetic interplays between DNA demethylation and histone methylation for protecting oncogenesis.

Journal of biochemistry

Avec: Kanji Furuya , Tsuyoshi Ikura

Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin.

Journal of cell science

Avec: Cao Nguyen Duong , Randy Brückner , Martina Schmitt , Astrid F Nottebaum , Laura J Braun , Marika Meyer Zu Brickwedde , Ute Ipe , Hermann Vom Bruch , Hans R Schöler , Giuseppe Trapani , Britta Trappmann , Mirsana P Ebrahimkutty , Stephan Huveneers , Johan de Rooij , Noboru Ishiyama , Mitsuhiko Ikura , Dietmar Vestweber

Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.

The Journal of cell biology

Avec: Arun A Chandrakumar , Étienne Coyaud , Christopher B Marshall , Mitsuhiko Ikura , Brian Raught , Robert Rottapel

Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.

Journal of molecular biology

Avec: Ben J Eves , Teklab Gebregiworgis , Geneviève M C Gasmi-Seabrook , Douglas A Kuntz , Gilbert G Privé , Christopher B Marshall , Mitsuhiko Ikura

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.

European journal of cell biology

Avec: Teklab Gebregiworgis , Jonathan Yui-Lai Chan , Douglas A Kuntz , Gilbert G Privé , Christopher B Marshall , Mitsuhiko Ikura

Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Wenguang He , Geneviève M C Gasmi-Seabrook , Mitsuhiko Ikura , Jeffrey E Lee , Michael Ohh

Does stromal interaction molecule-1 have five senses?

Cell calcium

Avec: Peter B Stathopulos , Mitsuhiko Ikura

A Non-Canonical Calmodulin Target Motif Comprising a Polybasic Region and Lipidated Terminal Residue Regulates Localization.

International journal of molecular sciences

Avec: Benjamin M M Grant , Masahiro Enomoto , Mitsuhiko Ikura , Christopher B Marshall

Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Angewandte Chemie (International ed. in English)

Avec: Ki-Young Lee , Zhenhao Fang , Masahiro Enomoto , Genevieve Gasmi-Seabrook , Le Zheng , Shohei Koide , Mitsuhiko Ikura , Christopher B Marshall

Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.

Chemical science

Avec: Ki-Young Lee , Masahiro Enomoto , Teklab Gebregiworgis , Geneviève M C Gasmi-Seabrook , Mitsuhiko Ikura , Christopher B Marshall

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

Nature communications

Avec: Teklab Gebregiworgis , Yoshihito Kano , Jonathan St-Germain , Nikolina Radulovich , Molly L Udaskin , Ahmet Mentes , Richard Huang , Betty P K Poon , Wenguang He , Ivette Valencia-Sama , Claire M Robinson , Melissa Huestis , Jinmin Miao , Jen Jen Yeh , Zhong-Yin Zhang , Meredith S Irwin , Jeffrey E Lee , Ming-Sound Tsao , Brian Raught , Christopher B Marshall , Michael Ohh , Mitsuhiko Ikura

Impact of Nuclear

Molecular and cellular biology

Avec: Kanji Furuya , Tomonari Matsuda , Tsuyoshi Ikura

Machine learning extracts oncogenic-specific γ-H2AX foci formation pattern upon genotoxic stress.

Genes to cells : devoted to molecular & cellular mechanisms

Avec: Kanji Furuya , Tsuyoshi Ikura

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Protein expression and purification

Avec: Takashi Saitoh , Ha-Neul Kim , Riku Narita , Ibuki Ohtsuka , Weiyu Mo , Ki-Young Lee , Masahiro Enomoto , Geneviève M C Gasmi-Seabrook , Christopher B Marshall , Mitsuhiko Ikura

Réseau de co-auteurs

Mitsuhiko Ikura 23 collaborations

Christopher B Marshall 19 collaborations

Teklab Gebregiworgis 9 collaborations

Masahiro Enomoto 8 collaborations

Ki-Young Lee 7 collaborations

Geneviève M C Gasmi-Seabrook 5 collaborations

Megumi Ikura 5 collaborations

Benjamin M M Grant 4 collaborations

Noboru Ishiyama 4 collaborations

Zhenhao Fang 4 collaborations

Kyoichi Wada 4 collaborations

Osamu Seguchi 4 collaborations

Norihide Fukushima 4 collaborations

Takuya Watanabe 4 collaborations

Tsuyoshi Ikura 4 collaborations

Ming-Sound Tsao 4 collaborations

Tsutomu Nakamura 3 collaborations

Kazuki Nakagita 3 collaborations

Hiromi Takenaka 3 collaborations

Sachi Matsuda 3 collaborations

Masanobu Yanase 3 collaborations

Peter B Stathopulos 3 collaborations

Le Zheng 3 collaborations

Brian Raught 3 collaborations

Jeffrey E Lee 3 collaborations

Michael Ohh 3 collaborations

Kanji Furuya 3 collaborations

Sung-In Back 2 collaborations

Fenneke KleinJan 2 collaborations

Ben J Eves 2 collaborations

Ningdi F Liu 2 collaborations

Takaya Uno 2 collaborations

Naoki Hayakawa 2 collaborations

Keiichiro Iwasaki 2 collaborations

Seiko Nakajima 2 collaborations

Kensuke Kuroda 2 collaborations

Hiroki Mochizuki 2 collaborations

Naoki Tadokoro 2 collaborations

Satsuki Fukushima 2 collaborations

Tomoyuki Fujita 2 collaborations

Hatsue Ishibashi-Ueda 2 collaborations

Junjiro Kobayashi 2 collaborations

Mitsu Ikura 2 collaborations

Robert Rottapel 2 collaborations

Ku-Geng Huo 2 collaborations

Nadeem Moghal 2 collaborations

Yoshihito Kano 2 collaborations

Nikolina Radulovich 2 collaborations

Betty P K Poon 2 collaborations

Jonathan St-Germain 2 collaborations

Ivette Valencia-Sama 2 collaborations

Jinmin Miao 2 collaborations

Meredith S Irwin 2 collaborations

Jen Jen Yeh 2 collaborations

Zhong-Yin Zhang 2 collaborations

Douglas A Kuntz 2 collaborations

Gilbert G Privé 2 collaborations

Wenguang He 2 collaborations

Qingci Zhao 1 collaboration

Ryu Fujimiya 1 collaboration

Satoshi Kubo 1 collaboration

Ichio Shimada 1 collaboration

Noritaka Nishida 1 collaboration

Ryosuke Oda 1 collaboration

Yuji Hattori 1 collaboration

Mai Otokubo 1 collaboration

Kotoka Hayase 1 collaboration

Rikako Nagata 1 collaboration

Tomoko Ueno 1 collaboration

Kazuyoshi Kawabata 1 collaboration

Fumiki Yoshihara 1 collaboration

Yasumasa Tsukamoto 1 collaboration

Takeshi Nakatani 1 collaboration

Soichiro Kitamura 1 collaboration

Kenichi Tsujita 1 collaboration

Hisao Ogawa 1 collaboration

Mihai L Azoitei 1 collaboration

Jungsik Noh 1 collaboration

Daniel J Marston 1 collaboration

Philippe Roudot 1 collaboration

Timothy A Daugird 1 collaboration

Sidney L Lisanza 1 collaboration

María-José Sandí 1 collaboration

John Sondek 1 collaboration

Klaus M Hahn 1 collaboration

Gaudenz Danuser 1 collaboration

Toshimitsu Hamasaki 1 collaboration

Yuto Kumai 1 collaboration

Koichi Toda 1 collaboration

Yuki Kimura 1 collaboration

Eiji Anegawa 1 collaboration

Yasumori Sujino 1 collaboration

Nobuichiro Yagi 1 collaboration

Koichi Yoshitake 1 collaboration

Shin Yajima 1 collaboration

Yorihiko Matsumoto 1 collaboration

Takashi Kakuta 1 collaboration

Miguel Burgos 1 collaboration

Reginald Philippe 1 collaboration

Fabrice Antigny 1 collaboration

Paul Buscaglia 1 collaboration

Emmanuelle Masson 1 collaboration

Sreya Mukherjee 1 collaboration

Pauline Dubar 1 collaboration

Cédric Le Maréchal 1 collaboration

Florence Campeotto 1 collaboration

Nicolas Lebonvallet 1 collaboration

Maud Frieden 1 collaboration

Juan Llopis 1 collaboration

Beatriz Domingo 1 collaboration

Wesley Brooks 1 collaboration

Wayne Guida 1 collaboration

Jian-Min Chen 1 collaboration

Claude Ferec 1 collaboration

Thierry Capiod 1 collaboration

Olivier Mignen 1 collaboration

Yuou Wang 1 collaboration

Alex Yemelyanov 1 collaboration

Christopher D Go 1 collaboration

Sun Kim 1 collaboration

Jeanne M Quinn 1 collaboration

Annette S Flozak 1 collaboration

Phuong M Le 1 collaboration

Shannon Liang 1 collaboration

Anne Claude-Gingras 1 collaboration

Cara J Gottardi 1 collaboration

Keisuke Kamada 1 collaboration

Daiki Uchida 1 collaboration

Hiroko Okuda 1 collaboration

Atsuhiro Koya 1 collaboration

Seima Ohira 1 collaboration

Maiko Ikura 1 collaboration

Shinsuke Kikuchi 1 collaboration

Kazuhiko Hanzawa 1 collaboration

Nobuyoshi Azuma 1 collaboration

Wataru Sakai 1 collaboration

Mayumi Yuasa-Sunagawa 1 collaboration

Masayuki Kusakabe 1 collaboration

Aiko Kishimoto 1 collaboration

Takeshi Matsui 1 collaboration

Yuki Kaneko 1 collaboration

Jun-Ichi Akagi 1 collaboration

Nicolas Huyghe 1 collaboration

Fumio Hanaoka 1 collaboration

Masayuki Yokoi 1 collaboration

Kaoru Sugasawa 1 collaboration

Tadateru Nishikawa 1 collaboration

Hirotsugu Notsuda 1 collaboration

Ningdi Feng Liu 1 collaboration

Quan Li 1 collaboration

Nhu-An Pham 1 collaboration

Ming Li 1 collaboration

Ni Liu 1 collaboration

Frances A Shepherd 1 collaboration

Christian W Johnson 1 collaboration

Hyuk-Soo Seo 1 collaboration

Elizabeth M Terrell 1 collaboration

Moon-Hee Yang 1 collaboration

Genevieve M C Gasmi-Seabrook 1 collaboration

Ezekiel A Geffken 1 collaboration

Jimit Lakhani 1 collaboration

Kijun Song 1 collaboration

Puspalata Bashyal 1 collaboration

Olesja Popow 1 collaboration

Joao A Paulo 1 collaboration

Andrea Liu 1 collaboration

Carla Mattos 1 collaboration

Deborah K Morrison 1 collaboration

Sirano Dhe-Paganon 1 collaboration

Kevin M Haigis 1 collaboration

Mikihiro Ikura 1 collaboration

Sarthak Pathak 1 collaboration

Jun Younes Louhi Kasahara 1 collaboration

Atsushi Yamashita 1 collaboration

Hajime Asama 1 collaboration

Geneviève Gasmi-Seabrook 1 collaboration

Jonathan D Cook 1 collaboration

Silvia Gabriela Herrera 1 collaboration

Cao Nguyen Duong 1 collaboration

Randy Brückner 1 collaboration

Martina Schmitt 1 collaboration

Astrid F Nottebaum 1 collaboration

Laura J Braun 1 collaboration

Marika Meyer Zu Brickwedde 1 collaboration

Ute Ipe 1 collaboration

Hermann Vom Bruch 1 collaboration

Hans R Schöler 1 collaboration

Giuseppe Trapani 1 collaboration

Britta Trappmann 1 collaboration

Mirsana P Ebrahimkutty 1 collaboration

Stephan Huveneers 1 collaboration

Johan de Rooij 1 collaboration

Dietmar Vestweber 1 collaboration

Arun A Chandrakumar 1 collaboration

Étienne Coyaud 1 collaboration

Jonathan Yui-Lai Chan 1 collaboration

Genevieve Gasmi-Seabrook 1 collaboration

Shohei Koide 1 collaboration

Molly L Udaskin 1 collaboration

Ahmet Mentes 1 collaboration

Richard Huang 1 collaboration

Claire M Robinson 1 collaboration

Melissa Huestis 1 collaboration

Tomonari Matsuda 1 collaboration

Takashi Saitoh 1 collaboration

Ha-Neul Kim 1 collaboration

Riku Narita 1 collaboration

Ibuki Ohtsuka 1 collaboration

Weiyu Mo 1 collaboration