Martin E Dowty

Affiliations

Medicine Design (M.E.D), Inflammation and Immunology (T.H.L., J.-B.T.), and Clinical Pharmacology (C.B.), Pfizer Inc., Cambridge, Massachusetts; Medicine Design (J.N.B., A.C.D., A.K.-A., R.S., G.S.W., J.L., T.C.G.) and Clinical Pharmacology (S.T.), Pfizer Inc., Groton, Connecticut; and Clinical Pharmacology, Pfizer Inc., New York, New York (B.K.M.) martin.dowty@pfizer.com.

Publications (22)

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Jonathan N Bauman , Angela C Doran , Amanda King-Ahmad , Raman Sharma , Gregory S Walker , Jian Lin , Tsung H Lin , Jean-Baptiste Telliez , Sakambari Tripathy , Theunis C Goosen , Christopher Banfield , Bimal K Malhotra ,

Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients.

Clinical pharmacology in drug development

Avec: Jim H Hughes , Ruolun Qiu , Christopher Banfield , Timothy Nicholas

Drug metabolism and disposition: the biological fate of chemicals

Avec: Ruolun Qiu , Alyssa Dantonio , Mark Niosi , Angela Doran , Amanda Balesano , Stephen W Wright , Gregory S Walker , Raman Sharma

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Ritlecitinib, a Janus Kinase 3 and Tyrosine-Protein Kinase Family Inhibitor, in Humans.

Drug metabolism and disposition: the biological fate of chemicals

Avec: Jonathan N Bauman , Angela C Doran , Gabrielle M Gualtieri , Brian Hee , Timothy Strelevitz , Matthew A Cerny , Christopher Banfield , Anna Plotka , Xiaoxing Wang , Vivek S Purohit ,

A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a

Clinical pharmacology in drug development

Avec: Ravi Shankar P Singh , Mikhail Salganik , Joanne I Brodfuehrer , Gregory S Walker , Raman Sharma , Jean S Beebe , Spencer I Danto

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.

Journal of medicinal chemistry

Avec: Brian S Gerstenberger , Catherine Ambler , Eric P Arnold , Mary-Ellen Banker , Matthew F Brown , James D Clark , Alpay Dermenci , Andrew Fensome , Susan Fish , Matthew M Hayward , Martin Hegen , Brett D Hollingshead , John D Knafels , David W Lin , Tsung H Lin , Dafydd R Owen , Eddine Saiah , Raman Sharma , Felix F Vajdos , Li Xing , Xiaojing Yang , Xin Yang , Stephen W Wright

Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Journal of clinical pharmacology

Avec: Ellen Q Wang , Vu Le , Melissa O'Gorman , Sakambari Tripathy , Lisy Wang , Bimal K Malhotra

Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals.

European journal of drug metabolism and pharmacokinetics

Avec: Xiaoxing Wang , Sakambari Tripathy , Vu H Le , Yeamin Huh , Madelyn Curto , Jennifer A Winton , Melissa T O'Gorman , Gary Chan , Bimal K Malhotra

Evaluation of the Impact of Ritlecitinib on Organic Cation Transporters Using Sumatriptan and Biomarkers as Probes.

Journal of clinical pharmacology

Avec: Xiaoxing Wang , Vivek Purohit , David Rodrigues , Lina Luo , Sumathy Mathialagan , William Carey , Anna Plotka , Hindu Kalluru , O'Gorman Melissa , Julia Kaplan , Yeamin Huh , Manoli Vourvahis , Robert M Wolk

A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a

British journal of clinical pharmacology

Avec: Ruolun Qiu , Raman Sharma , Hua Wei , Leonid Kirkovsky , Yifan Zhou , David D A Martin , Christopher Banfield ,

Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified-Release Dosage Form.

Clinical pharmacology and therapeutics

Avec: Vivek Purohit , Kazuko Sagawa , Hao-Jui Hsu , Joseph Kushner , Susanna Tse , Jian Lin , Andrew Blanchard , Arnab Mukherjee , Vu Le , Cheng Chang

Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug-Drug Interactions or in Special Populations: An Example Using Tofacitinib.

Journal of clinical pharmacology

Avec: Susanna Tse , Sujatha Menon , Pankaj Gupta , Sriram Krishnaswami

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences.

Scientific reports

Avec: Brian S Gerstenberger , Mary Ellen Banker , James D Clark , Andrew Fensome , Roger Gifford , Matthew C Griffor , Martin Hegen , Brett D Hollingshead , John D Knafels , Tsung H Lin , James F Smith , Felix F Vajdos

Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.

Bioorganic & medicinal chemistry

Avec: Andrew Fensome , Catherine M Ambler , Eric Arnold , Mary Ellen Banker , James D Clark , Ivan V Efremov , Andrew Flick , Brian S Gerstenberger , Roger S Gifford , Ariamala Gopalsamy , Martin Hegen , Jason Jussif , David C Limburg , Tsung H Lin , Betsy S Pierce , Raman Sharma , John I Trujillo , Felix F Vajdos , Fabien Vincent , Zhao-Kui Wan , Li Xing , Xiaojing Yang , Xin Yang

Safety and Pharmacokinetics of the Oral TYK2 Inhibitor PF-06826647: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study.

Clinical and translational science

Avec: Ravi Shankar P Singh , Vivek Pradhan , Erika S Roberts , Matthew Scaramozza , Elizabeth Kieras , Jeremy D Gale , Elena Peeva , Michael S Vincent , Anindita Banerjee , Andrew Fensome , Peter Winkle , Christopher Tehlirian

Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers.

The Journal of allergy and clinical immunology

Avec: Emma Guttman-Yassky , Ana B Pavel , Aisleen Diaz , Ning Zhang , Ester Del Duca , Yeriel Estrada , Brett King , Anindita Banerjee , Christopher Banfield , Lori Ann Cox , Karen Page , Michael S Vincent , Weidong Zhang , Linda Zhu , Elena Peeva

Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity.

Pharmaceutical research

Avec: Yeamin Huh , Anna Plotka , Hua Wei , Julia Kaplan , Nancy Raha , Justin Towner , Vivek S Purohit , Robert Wolk , Manoli Vourvahis , Amanda King-Ahmad , Sumathy Mathialagan , Mark A West , Sarah Lazzaro , Sangwoo Ryu , A David Rodrigues

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition.

Pharmacology research & perspectives

Avec: Tsung H Lin , Michael I Jesson , Martin Hegen , David A Martin , Vaibhav Katkade , Sujatha Menon , Jean-Baptiste Telliez

Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites.

Journal of clinical pharmacology

Avec: Ellen Q Wang , Vu Le , Jennifer A Winton , Sakambari Tripathy , Sangeeta Raje , Lisy Wang , Bimal K Malhotra

Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals.

European journal of drug metabolism and pharmacokinetics

Avec: Xiaoxing Wang , Ann Wouters , Svitlana Tatulych , Carol A Connell , Vu H Le , Sakambari Tripathy , Melissa T O'Gorman , Jennifer A Winton , Natalie Yin , Hernan Valdez , Bimal K Malhotra

Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model.

The AAPS journal

Avec: Anas Saadeddin , Vivek Purohit , Yeamin Huh , Mei Wong , Aurelia Maulny , Kazuko Sagawa

Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.

Clinical pharmacology and therapeutics

Avec: Micaela B Reddy , Tamara D Cabalu , Loeckie de Zwart , Diane Ramsden , Kunal S Taskar , Justine Badée , Jayaprakasam Bolleddula , Laurent Boulu , Qiang Fu , Masakatsu Kotsuma , Alix F Leblanc , Gareth Lewis , Guiqing Liang , Neil Parrott , Venkatesh Pilla Reddy , Chandra Prakash , Kushal Shah , Kenichi Umehara , Dwaipayan Mukherjee , Jessica Rehmel , Niresh Hariparsad

Réseau de co-auteurs

Raman Sharma 6 collaborations

Tsung H Lin 5 collaborations

Sakambari Tripathy 5 collaborations

Christopher Banfield 5 collaborations

Bimal K Malhotra 5 collaborations

Xiaoxing Wang 4 collaborations

Andrew Fensome 4 collaborations

Martin Hegen 4 collaborations

Yeamin Huh 4 collaborations

Gregory S Walker 3 collaborations

Ruolun Qiu 3 collaborations

Anna Plotka 3 collaborations

Brian S Gerstenberger 3 collaborations

James D Clark 3 collaborations

Felix F Vajdos 3 collaborations

Vu Le 3 collaborations

Jennifer A Winton 3 collaborations

Vivek Purohit 3 collaborations

Jonathan N Bauman 2 collaborations

Angela C Doran 2 collaborations

Amanda King-Ahmad 2 collaborations

Jian Lin 2 collaborations

Jean-Baptiste Telliez 2 collaborations

Stephen W Wright 2 collaborations

Vivek S Purohit 2 collaborations

Ravi Shankar P Singh 2 collaborations

Brett D Hollingshead 2 collaborations

John D Knafels 2 collaborations

Li Xing 2 collaborations

Xiaojing Yang 2 collaborations

Xin Yang 2 collaborations

Ellen Q Wang 2 collaborations

Lisy Wang 2 collaborations

Vu H Le 2 collaborations

Melissa T O'Gorman 2 collaborations

Sumathy Mathialagan 2 collaborations

Julia Kaplan 2 collaborations

Manoli Vourvahis 2 collaborations

Hua Wei 2 collaborations

Kazuko Sagawa 2 collaborations

Susanna Tse 2 collaborations

Sujatha Menon 2 collaborations

Mary Ellen Banker 2 collaborations

Elena Peeva 2 collaborations

Michael S Vincent 2 collaborations

Anindita Banerjee 2 collaborations

Theunis C Goosen 1 collaboration

Jim H Hughes 1 collaboration

Timothy Nicholas 1 collaboration

Alyssa Dantonio 1 collaboration

Mark Niosi 1 collaboration

Angela Doran 1 collaboration

Amanda Balesano 1 collaboration

Gabrielle M Gualtieri 1 collaboration

Brian Hee 1 collaboration

Timothy Strelevitz 1 collaboration

Matthew A Cerny 1 collaboration

Mikhail Salganik 1 collaboration

Joanne I Brodfuehrer 1 collaboration

Jean S Beebe 1 collaboration

Spencer I Danto 1 collaboration

Catherine Ambler 1 collaboration

Eric P Arnold 1 collaboration

Mary-Ellen Banker 1 collaboration

Matthew F Brown 1 collaboration

Alpay Dermenci 1 collaboration

Susan Fish 1 collaboration

Matthew M Hayward 1 collaboration

David W Lin 1 collaboration

Dafydd R Owen 1 collaboration

Eddine Saiah 1 collaboration

Melissa O'Gorman 1 collaboration

Madelyn Curto 1 collaboration

Gary Chan 1 collaboration

David Rodrigues 1 collaboration

Lina Luo 1 collaboration

William Carey 1 collaboration

Hindu Kalluru 1 collaboration

O'Gorman Melissa 1 collaboration

Robert M Wolk 1 collaboration

Leonid Kirkovsky 1 collaboration

Yifan Zhou 1 collaboration

David D A Martin 1 collaboration

Hao-Jui Hsu 1 collaboration

Joseph Kushner 1 collaboration

Andrew Blanchard 1 collaboration

Arnab Mukherjee 1 collaboration

Cheng Chang 1 collaboration

Pankaj Gupta 1 collaboration

Sriram Krishnaswami 1 collaboration

Roger Gifford 1 collaboration

Matthew C Griffor 1 collaboration

James F Smith 1 collaboration

Catherine M Ambler 1 collaboration

Eric Arnold 1 collaboration

Ivan V Efremov 1 collaboration

Andrew Flick 1 collaboration

Roger S Gifford 1 collaboration

Ariamala Gopalsamy 1 collaboration

Jason Jussif 1 collaboration

David C Limburg 1 collaboration

Betsy S Pierce 1 collaboration

John I Trujillo 1 collaboration

Fabien Vincent 1 collaboration

Zhao-Kui Wan 1 collaboration

Vivek Pradhan 1 collaboration

Erika S Roberts 1 collaboration

Matthew Scaramozza 1 collaboration

Elizabeth Kieras 1 collaboration

Jeremy D Gale 1 collaboration

Peter Winkle 1 collaboration

Christopher Tehlirian 1 collaboration

Emma Guttman-Yassky 1 collaboration

Ana B Pavel 1 collaboration

Aisleen Diaz 1 collaboration

Ning Zhang 1 collaboration

Ester Del Duca 1 collaboration

Yeriel Estrada 1 collaboration

Brett King 1 collaboration

Lori Ann Cox 1 collaboration

Karen Page 1 collaboration

Weidong Zhang 1 collaboration

Linda Zhu 1 collaboration

Nancy Raha 1 collaboration

Justin Towner 1 collaboration

Robert Wolk 1 collaboration

Mark A West 1 collaboration

Sarah Lazzaro 1 collaboration

Sangwoo Ryu 1 collaboration

A David Rodrigues 1 collaboration

Michael I Jesson 1 collaboration

David A Martin 1 collaboration

Vaibhav Katkade 1 collaboration

Sangeeta Raje 1 collaboration

Ann Wouters 1 collaboration

Svitlana Tatulych 1 collaboration

Carol A Connell 1 collaboration

Natalie Yin 1 collaboration

Hernan Valdez 1 collaboration

Anas Saadeddin 1 collaboration

Mei Wong 1 collaboration

Aurelia Maulny 1 collaboration

Micaela B Reddy 1 collaboration

Tamara D Cabalu 1 collaboration

Loeckie de Zwart 1 collaboration

Diane Ramsden 1 collaboration

Kunal S Taskar 1 collaboration

Justine Badée 1 collaboration

Jayaprakasam Bolleddula 1 collaboration

Laurent Boulu 1 collaboration

Qiang Fu 1 collaboration

Masakatsu Kotsuma 1 collaboration

Alix F Leblanc 1 collaboration

Gareth Lewis 1 collaboration

Guiqing Liang 1 collaboration

Neil Parrott 1 collaboration

Venkatesh Pilla Reddy 1 collaboration

Chandra Prakash 1 collaboration

Kushal Shah 1 collaboration

Kenichi Umehara 1 collaboration

Dwaipayan Mukherjee 1 collaboration

Jessica Rehmel 1 collaboration

Niresh Hariparsad 1 collaboration