Mariam Aghajan

Affiliations

Ionis Pharmaceuticals, Carlsbad, CA, USA.

Publications (21)

Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Mara Caputo , Yeshwant Kurhe , Sima Kumari , Emmelie Cansby , Manoj Amrutkar , Eli Scandalis , Sheri L Booten , Marcus Ståhlman , Jan Borén , Hanns-Ulrich Marschall , Margit Mahlapuu

Antisense Oligonucleotide-Mediated Silencing of Mitochondrial Fusion and Fission Factors Modulates Mitochondrial Dynamics and Rescues Mitochondrial Dysfunction.

Nucleic acid therapeutics

Avec: Daniel A Garcia , Andrew F Powers , Thomas A Bell , Shuling Guo ,

Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption.

bioRxiv : the preprint server for biology

Avec: Milankumar Prajapati , Jared Z Zhang , Grace S Chong , Lauren Chiu , Courtney J Mercadante , Heather L Kowalski , Olga Antipova , Barry Lai , Martina Ralle , Brian P Jackson , Tracy Punshon , Shuling Guo , Thomas B Bartnikas

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice.

JCI insight

Avec: Sheri L Booten , Magnus Althage , Christopher E Hart , Anette Ericsson , Ingela Maxvall , Joseph Ochaba , Angela Menschik-Lundin , Judith Hartleib , Steven Kuntz , Danielle Gattis , Christine Ahlström , Andrew T Watt , Jeffery A Engelhardt , Brett P Monia , Maria Chiara Magnone , Shuling Guo

Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis.

Autophagy

Avec: Wenqi Cui , Aishwarya Sathyanarayan , Michael Lopresti , Chi Chen , Douglas G Mashek

Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry

The Journal of pharmacology and experimental therapeutics

Avec: Thomas A Zanardi , Birgit Korbmacher , Laura Boone , Jeffrey A Engelhardt , Yanfeng Wang , Sebastien Burel , Bobby Prill , Shuling Guo , Scott P Henry

Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Ya-Wen Yang , Bibek Poudel , Julia Frederick , Poonam Dhillon , Rojesh Shrestha , Ziyuan Ma , Junnan Wu , Koji Okamoto , Jeffrey B Kopp , Sheri L Booten , Danielle Gattis , Andrew T Watt , Matthew Palmer , Katalin Susztak

Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity.

Blood

Avec: Carla Casu , Mariateresa Pettinato , Alison Liu , Vania Lo Presti , Maria Rosa Lidonnici , Kevin A Munoz , Emir O'Hara , Violante Olivari , Simona Maria Di Modica , Sheri Booten , Shuling Guo , Garry Neil , Reem Miari , Nir Shapir , Inbal Zafir-Lavie , Hagit Domev , Giuliana Ferrari , Despina Sitara , Antonella Nai , Stefano Rivella

Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.

The Journal of clinical investigation

Avec: Sanda Win , Robert Wm Min , Christopher Q Chen , Jun Zhang , Yibu Chen , Meng Li , Ayako Suzuki , Manal F Abdelmalek , Ying Wang , Filbert Wm Aung , Anna Mae Diehl , Roger J Davis , Tin A Than , Neil Kaplowitz

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.

Cellular and molecular gastroenterology and hepatology

Avec: Emmelie Cansby , Esther Nuñez-Durán , Elin Magnusson , Manoj Amrutkar , Sheri L Booten , Nagaraj M Kulkarni , L Thomas Svensson , Jan Borén , Hanns-Ulrich Marschall , Margit Mahlapuu

Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice.

PloS one

Avec: Carla Casu , Alison Liu , Gianluca De Rosa , Audrey Low , Aae Suzuki , Sayantani Sinha , Yelena Z Ginzburg , Charles Abrams , Shuling Guo , Stefano Rivella

Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis.

Hepatology (Baltimore, Md.)

Avec: Sanda Win , Robert W M Min , Jun Zhang , Gary Kanel , Brad Wanken , Yibu Chen , Meng Li , Ying Wang , Ayako Suzuki , Filbert W M Aung , Susan F Murray , Tin A Than , Neil Kaplowitz

Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency.

JCI insight

Avec: Milankumar Prajapati , Jared Z Zhang , Lauren Chiu , Grace S Chong , Courtney J Mercadante , Heather L Kowalski , Bradley S Delaney , Jessica A Anderson , Shuling Guo , Thomas B Bartnikas

Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations.

Nucleic acid therapeutics

Avec: Lulu Huang , Tianna Quesenberry , Audrey Low , Susan F Murray , Brett P Monia , Shuling Guo

Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver.

iScience

Avec: Tatsuya Yamada , Daisuke Murata , David E Kleiner , Robert Anders , Avi Z Rosenberg , Jeffrey Kaplan , James P Hamilton , Moshe Levi , Nae-Yuh Wang , Ted M Dawson , Toru Yanagawa , Andrew F Powers , Miho Iijima , Hiromi Sesaki

Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency.

bioRxiv : the preprint server for biology

Avec: Milankumar Prajapati , Jared Z Zhang , Courtney J Mercadante , Heather L Kowalski , Bradley Delaney , Jessica A Anderson , Shuling Guo , Thomas B Bartnikas

A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates

American journal of physiology. Gastrointestinal and liver physiology

Avec: Mariateresa Pettinato , Shuling Guo , Letizia Bavuso Volpe , Rossana Carleo , Antonella Nai , Alessia Pagani , Sandro Altamura , Laura Silvestri

A novel and translational role for autophagy in antisense oligonucleotide trafficking and activity.

Nucleic acids research

Avec: Joseph Ochaba , Andrew F Powers , Kaitlyn A Tremble , Sarah Greenlee , Noah M Post , John E Matson , A Robert MacLeod , Shuling Guo ,

Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity.

The Journal of biological chemistry

Avec: Andrea Iorga , Katherine Donovan , Layla Shojaie , Heather Johnson , Janet Kwok , Jo Suda , Brian T Lee , Ling Shao , Zhang-Xu Liu , Lily Dara

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data.

ESC heart failure

Avec: Nicholas J Viney , Shuling Guo , Li-Jung Tai , Brenda F Baker , Shiangtung W Jung , Rosie Z Yu , Sheri Booten , Heather Murray , Todd Machemer , Sebastien Burel , Sue Murray , Gustavo Buchele , Sotirios Tsimikas , Eugene Schneider , Richard S Geary , Merrill D Benson , Brett P Monia

A single approach to targeting transferrin receptor 2 corrects iron and erythropoietic defects in murine models of anemia of inflammation and chronic kidney disease.

Kidney international

Avec: Violante Olivari , Simona Maria Di Modica , Maria Rosa Lidonnici , Celia Cordero-Sanchez , Emanuele Tanzi , Mariateresa Pettinato , Alessia Pagani , Francesca Tiboni , Laura Silvestri , Shuling Guo , Giuliana Ferrari , Antonella Nai

Réseau de co-auteurs

Shuling Guo 13 collaborations

Sheri L Booten 4 collaborations

Andrew F Powers 3 collaborations

Milankumar Prajapati 3 collaborations

Jared Z Zhang 3 collaborations

Courtney J Mercadante 3 collaborations

Heather L Kowalski 3 collaborations

Thomas B Bartnikas 3 collaborations

Brett P Monia 3 collaborations

Mariateresa Pettinato 3 collaborations

Antonella Nai 3 collaborations

Emmelie Cansby 2 collaborations

Manoj Amrutkar 2 collaborations

Jan Borén 2 collaborations

Hanns-Ulrich Marschall 2 collaborations

Margit Mahlapuu 2 collaborations

Grace S Chong 2 collaborations

Lauren Chiu 2 collaborations

Joseph Ochaba 2 collaborations

Danielle Gattis 2 collaborations

Andrew T Watt 2 collaborations

Sebastien Burel 2 collaborations

Carla Casu 2 collaborations

Alison Liu 2 collaborations

Maria Rosa Lidonnici 2 collaborations

Violante Olivari 2 collaborations

Simona Maria Di Modica 2 collaborations

Sheri Booten 2 collaborations

Giuliana Ferrari 2 collaborations

Stefano Rivella 2 collaborations

Sanda Win 2 collaborations

Jun Zhang 2 collaborations

Yibu Chen 2 collaborations

Meng Li 2 collaborations

Ayako Suzuki 2 collaborations

Ying Wang 2 collaborations

Tin A Than 2 collaborations

Neil Kaplowitz 2 collaborations

Audrey Low 2 collaborations

Susan F Murray 2 collaborations

Jessica A Anderson 2 collaborations

Alessia Pagani 2 collaborations

Laura Silvestri 2 collaborations

Mara Caputo 1 collaboration

Yeshwant Kurhe 1 collaboration

Sima Kumari 1 collaboration

Eli Scandalis 1 collaboration

Marcus Ståhlman 1 collaboration

Daniel A Garcia 1 collaboration

Thomas A Bell 1 collaboration

Olga Antipova 1 collaboration

Barry Lai 1 collaboration

Martina Ralle 1 collaboration

Brian P Jackson 1 collaboration

Tracy Punshon 1 collaboration

Magnus Althage 1 collaboration

Christopher E Hart 1 collaboration

Anette Ericsson 1 collaboration

Ingela Maxvall 1 collaboration

Angela Menschik-Lundin 1 collaboration

Judith Hartleib 1 collaboration

Steven Kuntz 1 collaboration

Christine Ahlström 1 collaboration

Jeffery A Engelhardt 1 collaboration

Maria Chiara Magnone 1 collaboration

Wenqi Cui 1 collaboration

Aishwarya Sathyanarayan 1 collaboration

Michael Lopresti 1 collaboration

Chi Chen 1 collaboration

Douglas G Mashek 1 collaboration

Thomas A Zanardi 1 collaboration

Birgit Korbmacher 1 collaboration

Laura Boone 1 collaboration

Jeffrey A Engelhardt 1 collaboration

Yanfeng Wang 1 collaboration

Bobby Prill 1 collaboration

Scott P Henry 1 collaboration

Ya-Wen Yang 1 collaboration

Bibek Poudel 1 collaboration

Julia Frederick 1 collaboration

Poonam Dhillon 1 collaboration

Rojesh Shrestha 1 collaboration

Ziyuan Ma 1 collaboration

Junnan Wu 1 collaboration

Koji Okamoto 1 collaboration

Jeffrey B Kopp 1 collaboration

Matthew Palmer 1 collaboration

Katalin Susztak 1 collaboration

Vania Lo Presti 1 collaboration

Kevin A Munoz 1 collaboration

Emir O'Hara 1 collaboration

Garry Neil 1 collaboration

Reem Miari 1 collaboration

Nir Shapir 1 collaboration

Inbal Zafir-Lavie 1 collaboration

Hagit Domev 1 collaboration

Despina Sitara 1 collaboration

Robert Wm Min 1 collaboration

Christopher Q Chen 1 collaboration

Manal F Abdelmalek 1 collaboration

Filbert Wm Aung 1 collaboration

Anna Mae Diehl 1 collaboration

Roger J Davis 1 collaboration

Esther Nuñez-Durán 1 collaboration

Elin Magnusson 1 collaboration

Nagaraj M Kulkarni 1 collaboration

L Thomas Svensson 1 collaboration

Gianluca De Rosa 1 collaboration

Aae Suzuki 1 collaboration

Sayantani Sinha 1 collaboration

Yelena Z Ginzburg 1 collaboration

Charles Abrams 1 collaboration

Robert W M Min 1 collaboration

Gary Kanel 1 collaboration

Brad Wanken 1 collaboration

Filbert W M Aung 1 collaboration

Bradley S Delaney 1 collaboration

Lulu Huang 1 collaboration

Tianna Quesenberry 1 collaboration

Tatsuya Yamada 1 collaboration

Daisuke Murata 1 collaboration

David E Kleiner 1 collaboration

Robert Anders 1 collaboration

Avi Z Rosenberg 1 collaboration

Jeffrey Kaplan 1 collaboration

James P Hamilton 1 collaboration

Moshe Levi 1 collaboration

Nae-Yuh Wang 1 collaboration

Ted M Dawson 1 collaboration

Toru Yanagawa 1 collaboration

Miho Iijima 1 collaboration

Hiromi Sesaki 1 collaboration

Bradley Delaney 1 collaboration

Letizia Bavuso Volpe 1 collaboration

Rossana Carleo 1 collaboration

Sandro Altamura 1 collaboration

Kaitlyn A Tremble 1 collaboration

Sarah Greenlee 1 collaboration

Noah M Post 1 collaboration

John E Matson 1 collaboration

A Robert MacLeod 1 collaboration

Andrea Iorga 1 collaboration

Katherine Donovan 1 collaboration

Layla Shojaie 1 collaboration

Heather Johnson 1 collaboration

Janet Kwok 1 collaboration

Jo Suda 1 collaboration

Brian T Lee 1 collaboration

Ling Shao 1 collaboration

Zhang-Xu Liu 1 collaboration

Lily Dara 1 collaboration

Nicholas J Viney 1 collaboration

Li-Jung Tai 1 collaboration

Brenda F Baker 1 collaboration

Shiangtung W Jung 1 collaboration

Rosie Z Yu 1 collaboration

Heather Murray 1 collaboration

Todd Machemer 1 collaboration

Sue Murray 1 collaboration

Gustavo Buchele 1 collaboration

Sotirios Tsimikas 1 collaboration

Eugene Schneider 1 collaboration

Richard S Geary 1 collaboration

Merrill D Benson 1 collaboration

Celia Cordero-Sanchez 1 collaboration

Emanuele Tanzi 1 collaboration

Francesca Tiboni 1 collaboration