Mahmoud A Bassal

Affiliations

Harvard Stem Cell Institute, Harvard Medical School, Boston, USA.
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

ORCID: http://orcid.org/0000-0003-4322-2968

Publications (22)

Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia.

Nature communications

Avec: Saumya E Samaraweera , Kelly Lim , Brooks A Benard , Sheree Bailey , Satinder Kaur , Paul Leo , John Toubia , Chloe Thompson-Peach , Tran Nguyen , Kyaw Ze Ya Maung , Debora A Casolari , Diana G Iarossi , Ilaria S Pagani , Jason Powell , Stuart Pitson , Siria Natera , Ute Roessner , Ian D Lewis , Anna L Brown , Daniel G Tenen , Nirmal Robinson , David M Ross , Ravindra Majeti , Thomas J Gonda , Daniel Thomas , Richard J D'Andrea

Long noncoding RNA-mediated activation of PROTOR1/PRR5-AKT signaling shunt downstream of PI3K in triple-negative breast cancer.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Zhenbo Tu , Yi Hu , Devesh Raizada , Daniel G Tenen , Antoine E Karnoub

The Interplay between Dysregulated Metabolism and Epigenetics in Cancer.

Biomolecules

Avec: Mahmoud Adel Bassal

Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation.

Nature communications

Avec: Carla L Esposito , Ida Autiero , Annamaria Sandomenico , H Li , Maria L Ibba , Dongfang Wang , Lucrezia Rinaldi , Simone Ummarino , Giulia Gaggi , Marta Borchiellini , Piotr Swiderski , Menotti Ruvo , Silvia Catuogno , Alexander K Ebralidze , Marcin Kortylewski , Vittorio de Franciscis , Annalisa Di Ruscio

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer.

Communications biology

Avec: Giorgia Maroni , Indira Krishnan , Chee Wai Fhu , Virginia Savova , Rapolas Zilionis , Valerie A Maymi , Nicole Pandell , Eva Csizmadia , Junyan Zhang , Barbara Storti , Julio Castaño , Riccardo Panella , Jia Li , Corinne E Gustafson , Sam Fox , Rachel D Levy , Claire V Meyerovitz , Peter J Tramontozzi , Kimberly Vermilya , Assunta De Rienzo , Stefania Crucitta , Daniela S Bassères , Marla Weetall , Art Branstrom , Alessandra Giorgetti , Raffaele Ciampi , Marzia Del Re , Romano Danesi , Ranieri Bizzarri , Henry Yang , Olivier Kocher , Allon M Klein , Robert S Welner , Raphael Bueno , Maria Cristina Magli , John G Clohessy , Azhar Ali , Daniel G Tenen , Elena Levantini

A modified CUT&RUN protocol and analysis pipeline to identify transcription factor binding sites in human cell lines.

STAR protocols

Avec: Nikki Ruoxi Kong , Li Chai , Daniel Geoffrey Tenen , Mahmoud Adel Bassal

New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation.

Gastroenterology

Avec: Justin L Tan , Feng Li , Joanna Z Yeo , Kol Jia Yong , Guo Hao Ng , May Yin Lee , Chung Yan Leong , Hong Kee Tan , Chan-Shuo Wu , Bee Hui Liu , Tim H Chan , Zi Hui Tan , Yun Shen Chan , Siyu Wang , Zhi Han Lim , Tan Boon Toh , Lissa Hooi , Kia Ngee Low , Siming Ma , Nikki R Kong , Alicia J Stein , Yue Wu , Matan T Thangavelu , Atsushi Suzuki , Giridharan Periyasamy , John M Asara , Yock Young Dan , Glenn K Bonney , Edward K Chow , Guo-Dong Lu , Huck Hui Ng , Yoganathan Kanagasundaram , Siew Bee Ng , Wai Leong Tam , Daniel G Tenen , Li Chai

E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates.

Science immunology

Avec: Anaïs Wanet , Sweta B Patel , Francisco Marchi , Samanta A Mariani , Nouraiz Ahmed , Haoran Zhang , Marta Borchiellini , Sisi Chen , Junyan Zhang , Annalisa Di Ruscio , Kensuke Miyake , Mindy Tsai , Anuya Paranjape , Shin-Young Park , Hajime Karasuyama , Timm Schroeder , Elaine Dzierzak , Stephen J Galli , Daniel G Tenen , Robert S Welner

Metabolic alterations mediated by STAT3 promotes drug persistence in CML.

Leukemia

Avec: Sweta B Patel , Travis Nemkov , Davide Stefanoni , Gloria A Benavides , Brittany L Crown , Victoria R Matkins , Virginia Camacho , Valeriya Kuznetsova , Ashley T Hoang , Danielle E Tenen , Samuel L Wolock , Jihye Park , Li Ying , Zongliang Yue , Jake Y Chen , Henry Yang , Daniel G Tenen , Paul Brent Ferrell , Rui Lu , Victor Darley-Usmar , Angelo D'Alessandro , Ravi Bhatia , Robert S Welner

Pseudogene-mediated DNA demethylation leads to oncogene activation.

Science advances

Avec: Junsu Kwon , Yanjing V Liu , Chong Gao , Adrianna I Jones , Junyu Yang , Zhiyuan Chen , Ying Li , Henry Yang , Leilei Chen , Annalisa Di Ruscio , Yvonne Tay , Li Chai , Daniel G Tenen

Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy.

The New England journal of medicine

Avec: Yao-Chung Liu , Junsu Kwon , Emiliano Fabiani , Zhijian Xiao , Yanjing V Liu , Matilde Y Follo , Jinqin Liu , Huijun Huang , Chong Gao , Jun Liu , Giulia Falconi , Lia Valentini , Carmelo Gurnari , Carlo Finelli , Lucio Cocco , Jin-Hwang Liu , Adrianna I Jones , Junyu Yang , Henry Yang , Julie A I Thoms , Ashwin Unnikrishnan , John E Pimanda , Rongqing Pan , Maria T Voso , Daniel G Tenen , Li Chai

PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development.

Communications biology

Avec: Xinhui Zhao , Boris Bartholdy , Yukiya Yamamoto , Erica K Evans , Meritxell Alberich-Jordà , Philipp B Staber , Touati Benoukraf , Pu Zhang , Junyan Zhang , Bon Q Trinh , John D Crispino , Trang Hoang , Daniel G Tenen

NAD Modulates DNA Methylation and Cell Differentiation.

Cells

Avec: Simone Ummarino , Clinton Hausman , Giulia Gaggi , Lucrezia Rinaldi , Yanzhou Zhang , Andy Joe Seelam , Ikei S Kobayashi , Marta Borchiellini , Alexander K Ebralidze , Barbara Ghinassi , Bon Q Trinh , Susumu S Kobayashi , Annalisa Di Ruscio

Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression.

Cell reports

Avec: Nikki R Kong , Hong Kee Tan , Jesse V Kurland , Kol Jia Yong , John J Young , Yang Yang , Fudong Li , Jonathan D Lee , Yue Liu , Chan-Shuo Wu , Alicia Stein , Hongbo R Luo , Leslie E Silberstein , Martha L Bulyk , Daniel G Tenen , Li Chai

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.

Cell reports

Avec: Giacomo Canesin , Annalisa Di Ruscio , Mailin Li , Simone Ummarino , Andreas Hedblom , Reeham Choudhury , Agnieszka Krzyzanowska , Eva Csizmadia , Macarena Palominos , Anna Stiehm , Alexander Ebralidze , Shao-Yong Chen , Ping Zhao , Emanuela Tolosano , Laurence Hurley , Anders Bjartell , Daniel G Tenen , Barbara Wegiel

Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice.

Science translational medicine

Avec: Chenxi Qiu , Onder Albayram , Asami Kondo , Bin Wang , Nami Kim , Ken Arai , Cheng-Yu Tsai , Megan K Herbert , Kazuo Washida , Peter Angeli , Shingo Kozono , Joseph E Stucky , Sean Baxley , Yu-Min Lin , Yan Sun , Alexander Rotenberg , Barbara J Caldarone , Eileen H Bigio , Xiaochun Chen , Daniel G Tenen , Mark Zeidel , Eng H Lo , Xiao Zhen Zhou , Kun Ping Lu

Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML.

Blood

Avec: Bon Q Trinh , Simone Ummarino , Yanzhou Zhang , Alexander K Ebralidze , Tuan M Nguyen , Gerwin Heller , Rory Coffey , Danielle E Tenen , Emiel van der Kouwe , Emiliano Fabiani , Carmelo Gurnari , Chan-Shuo Wu , Vladimir Espinosa Angarica , Henry Yang , Sisi Chen , Hong Zhang , Abby R Thurm , Francisco Marchi , Elena Levantini , Philipp B Staber , Pu Zhang , Maria Teresa Voso , Pier Paolo Pandolfi , Susumu S Kobayashi , Li Chai , Annalisa Di Ruscio , Daniel G Tenen

ChIP-AP: an integrated analysis pipeline for unbiased ChIP-seq analysis.

Briefings in bioinformatics

Avec: Jeremiah Suryatenggara , Kol Jia Yong , Danielle E Tenen , Daniel G Tenen ,

Ex Vivo Expansion of Phenotypic and Transcriptomic Chronic Myeloid Leukemia Stem Cells.

Experimental hematology

Avec: Sweta B Patel , Valeriya Kuznetsova , Victoria R Matkins , Alana M Franceski , Robert S Welner

SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis.

bioRxiv : the preprint server for biology

Avec: Kim Anh L Vu , Kalpana Kumari , Bee Hui Liu , Chong Gao , Feng Li , Jing Ping Tang , Danilo Maddalo , Douglas S Auld , Dominick E Casalena , Xi Tian , Miao Liu , Shiva Moein , Viktoriia Iakovleva , Justin L Tan , Alicia J Stein , Qiling Zhou , Patrick D Fischer , Logan H Sigua , Jun Qi , Haribabu Arthanari , Daniel G Tenen , Li Chai

Targeting transcription factors through an IMiD independent zinc finger domain.

bioRxiv : the preprint server for biology

Avec: Bee Hui Liu , Miao Liu , Sridhar Radhakrishnan , Chaitanya Kumar Jaladanki , Chong Gao , Jing Ping Tang , Kalpana Kumari , Mei Lin Go , Kim Anh L Vu , Hyuk-Soo Seo , Kijun Song , Xi Tian , Li Feng , Justin L Tan , Haribabu Arthanari , Jun Qi , Sirano Dhe-Paganon , Hao Fan , Daniel G Tenen , Li Chai

Tumor-suppressive activities for pogo transposable element derived with KRAB domain via ribosome biogenesis restriction.

Molecular cell

Avec: Zhenbo Tu , George W Bell , Yanzhou Zhang , Yi Hu , Liza M Quintana , Deeptha Gokul , Daniel G Tenen , Antoine E Karnoub

Réseau de co-auteurs

Daniel G Tenen 17 collaborations

Li Chai 8 collaborations

Annalisa Di Ruscio 6 collaborations

Henry Yang 5 collaborations

Simone Ummarino 4 collaborations

Robert S Welner 4 collaborations

Chong Gao 4 collaborations

Marta Borchiellini 3 collaborations

Alexander K Ebralidze 3 collaborations

Junyan Zhang 3 collaborations

Justin L Tan 3 collaborations

Kol Jia Yong 3 collaborations

Chan-Shuo Wu 3 collaborations

Bee Hui Liu 3 collaborations

Sweta B Patel 3 collaborations

Danielle E Tenen 3 collaborations

Bon Q Trinh 3 collaborations

Yanzhou Zhang 3 collaborations

Zhenbo Tu 2 collaborations

Yi Hu 2 collaborations

Antoine E Karnoub 2 collaborations

Mahmoud Adel Bassal 2 collaborations

Lucrezia Rinaldi 2 collaborations

Giulia Gaggi 2 collaborations

Eva Csizmadia 2 collaborations

Elena Levantini 2 collaborations

Feng Li 2 collaborations

Hong Kee Tan 2 collaborations

Nikki R Kong 2 collaborations

Alicia J Stein 2 collaborations

Francisco Marchi 2 collaborations

Sisi Chen 2 collaborations

Victoria R Matkins 2 collaborations

Valeriya Kuznetsova 2 collaborations

Junsu Kwon 2 collaborations

Yanjing V Liu 2 collaborations

Adrianna I Jones 2 collaborations

Junyu Yang 2 collaborations

Emiliano Fabiani 2 collaborations

Carmelo Gurnari 2 collaborations

Philipp B Staber 2 collaborations

Pu Zhang 2 collaborations

Susumu S Kobayashi 2 collaborations

Kim Anh L Vu 2 collaborations

Kalpana Kumari 2 collaborations

Jing Ping Tang 2 collaborations

Xi Tian 2 collaborations

Miao Liu 2 collaborations

Jun Qi 2 collaborations

Haribabu Arthanari 2 collaborations

Saumya E Samaraweera 1 collaboration

Kelly Lim 1 collaboration

Brooks A Benard 1 collaboration

Sheree Bailey 1 collaboration

Satinder Kaur 1 collaboration

Paul Leo 1 collaboration

John Toubia 1 collaboration

Chloe Thompson-Peach 1 collaboration

Tran Nguyen 1 collaboration

Kyaw Ze Ya Maung 1 collaboration

Debora A Casolari 1 collaboration

Diana G Iarossi 1 collaboration

Ilaria S Pagani 1 collaboration

Jason Powell 1 collaboration

Stuart Pitson 1 collaboration

Siria Natera 1 collaboration

Ute Roessner 1 collaboration

Ian D Lewis 1 collaboration

Anna L Brown 1 collaboration

Nirmal Robinson 1 collaboration

David M Ross 1 collaboration

Ravindra Majeti 1 collaboration

Thomas J Gonda 1 collaboration

Daniel Thomas 1 collaboration

Richard J D'Andrea 1 collaboration

Devesh Raizada 1 collaboration

Carla L Esposito 1 collaboration

Ida Autiero 1 collaboration

Annamaria Sandomenico 1 collaboration

H Li 1 collaboration

Maria L Ibba 1 collaboration

Dongfang Wang 1 collaboration

Piotr Swiderski 1 collaboration

Menotti Ruvo 1 collaboration

Silvia Catuogno 1 collaboration

Marcin Kortylewski 1 collaboration

Vittorio de Franciscis 1 collaboration

Giorgia Maroni 1 collaboration

Indira Krishnan 1 collaboration

Chee Wai Fhu 1 collaboration

Virginia Savova 1 collaboration

Rapolas Zilionis 1 collaboration

Valerie A Maymi 1 collaboration

Nicole Pandell 1 collaboration

Barbara Storti 1 collaboration

Julio Castaño 1 collaboration

Riccardo Panella 1 collaboration

Jia Li 1 collaboration

Corinne E Gustafson 1 collaboration

Sam Fox 1 collaboration

Rachel D Levy 1 collaboration

Claire V Meyerovitz 1 collaboration

Peter J Tramontozzi 1 collaboration

Kimberly Vermilya 1 collaboration

Assunta De Rienzo 1 collaboration

Stefania Crucitta 1 collaboration

Daniela S Bassères 1 collaboration

Marla Weetall 1 collaboration

Art Branstrom 1 collaboration

Alessandra Giorgetti 1 collaboration

Raffaele Ciampi 1 collaboration

Marzia Del Re 1 collaboration

Romano Danesi 1 collaboration

Ranieri Bizzarri 1 collaboration

Olivier Kocher 1 collaboration

Allon M Klein 1 collaboration

Raphael Bueno 1 collaboration

Maria Cristina Magli 1 collaboration

John G Clohessy 1 collaboration

Azhar Ali 1 collaboration

Nikki Ruoxi Kong 1 collaboration

Daniel Geoffrey Tenen 1 collaboration

Joanna Z Yeo 1 collaboration

Guo Hao Ng 1 collaboration

May Yin Lee 1 collaboration

Chung Yan Leong 1 collaboration

Tim H Chan 1 collaboration

Zi Hui Tan 1 collaboration

Yun Shen Chan 1 collaboration

Siyu Wang 1 collaboration

Zhi Han Lim 1 collaboration

Tan Boon Toh 1 collaboration

Lissa Hooi 1 collaboration

Kia Ngee Low 1 collaboration

Siming Ma 1 collaboration

Yue Wu 1 collaboration

Matan T Thangavelu 1 collaboration

Atsushi Suzuki 1 collaboration

Giridharan Periyasamy 1 collaboration

John M Asara 1 collaboration

Yock Young Dan 1 collaboration

Glenn K Bonney 1 collaboration

Edward K Chow 1 collaboration

Guo-Dong Lu 1 collaboration

Huck Hui Ng 1 collaboration

Yoganathan Kanagasundaram 1 collaboration

Siew Bee Ng 1 collaboration

Wai Leong Tam 1 collaboration

Anaïs Wanet 1 collaboration

Samanta A Mariani 1 collaboration

Nouraiz Ahmed 1 collaboration

Haoran Zhang 1 collaboration

Kensuke Miyake 1 collaboration

Mindy Tsai 1 collaboration

Anuya Paranjape 1 collaboration

Shin-Young Park 1 collaboration

Hajime Karasuyama 1 collaboration

Timm Schroeder 1 collaboration

Elaine Dzierzak 1 collaboration

Stephen J Galli 1 collaboration

Travis Nemkov 1 collaboration

Davide Stefanoni 1 collaboration

Gloria A Benavides 1 collaboration

Brittany L Crown 1 collaboration

Virginia Camacho 1 collaboration

Ashley T Hoang 1 collaboration

Samuel L Wolock 1 collaboration

Jihye Park 1 collaboration

Li Ying 1 collaboration

Zongliang Yue 1 collaboration

Jake Y Chen 1 collaboration

Paul Brent Ferrell 1 collaboration

Rui Lu 1 collaboration

Victor Darley-Usmar 1 collaboration

Angelo D'Alessandro 1 collaboration

Ravi Bhatia 1 collaboration

Zhiyuan Chen 1 collaboration

Ying Li 1 collaboration

Leilei Chen 1 collaboration

Yvonne Tay 1 collaboration

Yao-Chung Liu 1 collaboration

Zhijian Xiao 1 collaboration

Matilde Y Follo 1 collaboration

Jinqin Liu 1 collaboration

Huijun Huang 1 collaboration

Jun Liu 1 collaboration

Giulia Falconi 1 collaboration

Lia Valentini 1 collaboration

Carlo Finelli 1 collaboration

Lucio Cocco 1 collaboration

Jin-Hwang Liu 1 collaboration

Julie A I Thoms 1 collaboration

Ashwin Unnikrishnan 1 collaboration

John E Pimanda 1 collaboration

Rongqing Pan 1 collaboration

Maria T Voso 1 collaboration

Xinhui Zhao 1 collaboration

Boris Bartholdy 1 collaboration

Yukiya Yamamoto 1 collaboration

Erica K Evans 1 collaboration

Meritxell Alberich-Jordà 1 collaboration

Touati Benoukraf 1 collaboration

John D Crispino 1 collaboration

Trang Hoang 1 collaboration

Clinton Hausman 1 collaboration

Andy Joe Seelam 1 collaboration

Ikei S Kobayashi 1 collaboration

Barbara Ghinassi 1 collaboration

Jesse V Kurland 1 collaboration

John J Young 1 collaboration

Yang Yang 1 collaboration

Fudong Li 1 collaboration

Jonathan D Lee 1 collaboration

Yue Liu 1 collaboration

Alicia Stein 1 collaboration

Hongbo R Luo 1 collaboration

Leslie E Silberstein 1 collaboration

Martha L Bulyk 1 collaboration

Giacomo Canesin 1 collaboration

Mailin Li 1 collaboration

Andreas Hedblom 1 collaboration

Reeham Choudhury 1 collaboration

Agnieszka Krzyzanowska 1 collaboration

Macarena Palominos 1 collaboration

Anna Stiehm 1 collaboration

Alexander Ebralidze 1 collaboration

Shao-Yong Chen 1 collaboration

Ping Zhao 1 collaboration

Emanuela Tolosano 1 collaboration

Laurence Hurley 1 collaboration

Anders Bjartell 1 collaboration

Barbara Wegiel 1 collaboration

Chenxi Qiu 1 collaboration

Onder Albayram 1 collaboration

Asami Kondo 1 collaboration

Bin Wang 1 collaboration

Nami Kim 1 collaboration

Ken Arai 1 collaboration

Cheng-Yu Tsai 1 collaboration

Megan K Herbert 1 collaboration

Kazuo Washida 1 collaboration

Peter Angeli 1 collaboration

Shingo Kozono 1 collaboration

Joseph E Stucky 1 collaboration

Sean Baxley 1 collaboration

Yu-Min Lin 1 collaboration

Yan Sun 1 collaboration

Alexander Rotenberg 1 collaboration

Barbara J Caldarone 1 collaboration

Eileen H Bigio 1 collaboration

Xiaochun Chen 1 collaboration

Mark Zeidel 1 collaboration

Eng H Lo 1 collaboration

Xiao Zhen Zhou 1 collaboration

Kun Ping Lu 1 collaboration

Tuan M Nguyen 1 collaboration

Gerwin Heller 1 collaboration

Rory Coffey 1 collaboration

Emiel van der Kouwe 1 collaboration

Vladimir Espinosa Angarica 1 collaboration

Hong Zhang 1 collaboration

Abby R Thurm 1 collaboration

Maria Teresa Voso 1 collaboration

Pier Paolo Pandolfi 1 collaboration

Jeremiah Suryatenggara 1 collaboration

Alana M Franceski 1 collaboration

Danilo Maddalo 1 collaboration

Douglas S Auld 1 collaboration

Dominick E Casalena 1 collaboration

Shiva Moein 1 collaboration

Viktoriia Iakovleva 1 collaboration

Qiling Zhou 1 collaboration

Patrick D Fischer 1 collaboration

Logan H Sigua 1 collaboration

Sridhar Radhakrishnan 1 collaboration

Chaitanya Kumar Jaladanki 1 collaboration

Mei Lin Go 1 collaboration

Hyuk-Soo Seo 1 collaboration

Kijun Song 1 collaboration

Li Feng 1 collaboration

Sirano Dhe-Paganon 1 collaboration

Hao Fan 1 collaboration

George W Bell 1 collaboration

Liza M Quintana 1 collaboration

Deeptha Gokul 1 collaboration