Luke H Rhym

Affiliations

The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Publications (7)

Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone.

Nature biomedical engineering

Avec: Ryan Reshke , James A Taylor , Alexandre Savard , Huishan Guo , Piotr S Kowalski , My Tran Trung , Charles Campbell , Wheaton Little , Daniel G Anderson , Derrick Gibbings

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope.

Nature communications

Avec: Tingting Jiang , Jordana M Henderson , Kevin Coote , Yi Cheng , Hillary C Valley , Xiao-Ou Zhang , Qin Wang , Yueying Cao , Gregory A Newby , Hermann Bihler , Martin Mense , Zhiping Weng , Daniel G Anderson , Anton P McCaffrey , David R Liu , Wen Xue

Adenine base editing in an adult mouse model of tyrosinaemia.

Nature biomedical engineering

Avec: Chun-Qing Song , Tingting Jiang , Michelle Richter , Luke W Koblan , Maria Paz Zafra , Emma M Schatoff , Jordan L Doman , Yueying Cao , Lukas E Dow , Lihua Julie Zhu , Daniel G Anderson , David R Liu , Hao Yin , Wen Xue

Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles.

Biomaterials

Avec: James C Kaczmarek , Asha Kumari Patel , Umberto Capasso Palmiero , Balkrishen Bhat , Michael W Heartlein , Frank DeRosa , Daniel G Anderson

Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA.

Nature biomedical engineering

Avec: Bowen Li , Allen Yujie Jiang , Idris Raji , Caroline Atyeo , Theresa M Raimondo , Akiva G R Gordon , Tahoura Samad , Corina MacIsaac , Jacob Witten , Haseeb Mughal , Taras M Chicz , Yue Xu , Ryan P McNamara , Sangeeta Bhatia , Galit Alter , Robert Langer , Daniel G Anderson

Nanoscale delivery platforms for RNA therapeutics: Challenges and the current state of the art.

Med (New York, N.Y.)

Avec: Daniel G Anderson

Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery.

Nature biomedical engineering

Avec: Rajith S Manan , Antonius Koller , Georgina Stephanie , Daniel G Anderson

Réseau de co-auteurs

Daniel G Anderson 7 collaborations

Tingting Jiang 2 collaborations

Yueying Cao 2 collaborations

David R Liu 2 collaborations

Wen Xue 2 collaborations

Ryan Reshke 1 collaboration

James A Taylor 1 collaboration

Alexandre Savard 1 collaboration

Huishan Guo 1 collaboration

Piotr S Kowalski 1 collaboration

My Tran Trung 1 collaboration

Charles Campbell 1 collaboration

Wheaton Little 1 collaboration

Derrick Gibbings 1 collaboration

Jordana M Henderson 1 collaboration

Kevin Coote 1 collaboration

Yi Cheng 1 collaboration

Hillary C Valley 1 collaboration

Xiao-Ou Zhang 1 collaboration

Qin Wang 1 collaboration

Gregory A Newby 1 collaboration

Hermann Bihler 1 collaboration

Martin Mense 1 collaboration

Zhiping Weng 1 collaboration

Anton P McCaffrey 1 collaboration

Chun-Qing Song 1 collaboration

Michelle Richter 1 collaboration

Luke W Koblan 1 collaboration

Maria Paz Zafra 1 collaboration

Emma M Schatoff 1 collaboration

Jordan L Doman 1 collaboration

Lukas E Dow 1 collaboration

Lihua Julie Zhu 1 collaboration

Hao Yin 1 collaboration

James C Kaczmarek 1 collaboration

Asha Kumari Patel 1 collaboration

Umberto Capasso Palmiero 1 collaboration

Balkrishen Bhat 1 collaboration

Michael W Heartlein 1 collaboration

Frank DeRosa 1 collaboration

Bowen Li 1 collaboration

Allen Yujie Jiang 1 collaboration

Idris Raji 1 collaboration

Caroline Atyeo 1 collaboration

Theresa M Raimondo 1 collaboration

Akiva G R Gordon 1 collaboration

Tahoura Samad 1 collaboration

Corina MacIsaac 1 collaboration

Jacob Witten 1 collaboration

Haseeb Mughal 1 collaboration

Taras M Chicz 1 collaboration

Yue Xu 1 collaboration

Ryan P McNamara 1 collaboration

Sangeeta Bhatia 1 collaboration

Galit Alter 1 collaboration

Robert Langer 1 collaboration

Rajith S Manan 1 collaboration

Antonius Koller 1 collaboration

Georgina Stephanie 1 collaboration