Laura E Edgington-Mitchell

Affiliations

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, 3052, Australia; Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, Bluestone Center for Clinical Research, New York, NY, 10010, USA.

Publications (25)

Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease.

Neuropharmacology

Avec: Jianming Liao , Chun Chen , Eun Hee Ahn , Xia Liu , Hua Li , Zhonghua Lu , Shuping Ming , Keqiang Ye

Cathepsin X deficiency alters the processing and localisation of cathepsin L and impairs cleavage of a nuclear cathepsin L substrate.

Biological chemistry

Avec: Bangyan Xu , Bethany M Anderson , Simon J Mountford , Philip E Thompson , Justine D Mintern ,

Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes.

ACS chemical biology

Avec: Simon J Mountford , Bethany M Anderson , Bangyan Xu , Elean S V Tay , Monika Szabo , My-Linh Hoang , Jiayin Diao , Luigi Aurelio , Rhiannon I Campden , Erik Lindström , Erica K Sloan , Robin M Yates , Nigel W Bunnett , Philip E Thompson ,

MHC Class II Ubiquitination Regulates Dendritic Cell Function and Immunity.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Kayla R Wilson , Devi Jenika , Annabelle B Blum , Christophe Macri , Bangyan Xu , Haiyin Liu , Patrick Schriek , Dominik Schienstock , Lauren Francis , F Victor Makota , Satoshi Ishido , Scott N Mueller , Mireille H Lahoud , Irina Caminschi , Jose A Villadangos , Justine D Mintern

Ion mobility-based enrichment-free N-terminomics analysis reveals novel legumain substrates in murine spleen.

Molecular & cellular proteomics : MCP

Avec: Alexander R Ziegler , Antoine Dufour , Nichollas E Scott ,

TLR9-dependent dendritic cell maturation promotes IL-6-mediated upregulation of cathepsin X.

Immunology and cell biology

Avec: Bangyan Xu , Bethany M Anderson , Justine D Mintern ,

Correction: Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.

PloS one

Avec: Michele S Y Tan , Dara Davison , Mateo I Sanchez , Bethany M Anderson , Stephen Howell , Ambrosius P Snijders , Edgar Deu

Cathepsin S Evokes PAR

Cancers

Avec: Nguyen Huu Tu , Kenji Inoue , Elyssa Chen , Bethany M Anderson , Caroline M Sawicki , Nicole N Scheff , Hung D Tran , Dong H Kim , Robel G Alemu , Lei Yang , John C Dolan , Cheng Z Liu , Malvin N Janal , Rocco Latorre , Dane D Jensen , Nigel W Bunnett , Brian L Schmidt

Eat, prey, love: Pathogen-mediated subversion of lysosomal biology.

Current opinion in immunology

Avec: Lauren E Bird , Hayley J Newton

Chemical Tools to Image the Activity of PAR-Cleaving Proteases.

ACS bio & med chem Au

Avec: Irene Y Lee , Piyapa Tantisirivat ,

Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.

PloS one

Avec: Michele S Y Tan , Dara Davison , Mateo I Sanchez , Bethany M Anderson , Stephen Howell , Ambrosius Snijders , Edgar Deu

Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions.

Pain reports

Avec: Maria Roitman , Jon Mangum , James Ziogas , Alexios A Adamides , Paul Myles , Hearan Choo-Bunnett , Nigel W Bunnett , Jenny M Gunnersen

C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.

Molecular cancer therapeutics

Avec: Kecheng Lei , Seong Su Kang , Eun Hee Ahn , Chun Chen , Jianming Liao , Xia Liu , Hua Li , Lingjing Jin , Keqiang Ye

Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells.

iScience

Avec: Man Lyang Kim , Melinda Y Hardy , Sri H Ramarathinam , Shan Zou Chung , Amy K Russell , Iain Currie , Brad E Sleebs , Anthony W Purcell , Jason A Tye-Din , Ian P Wicks

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86.

Nature communications

Avec: Haiyin Liu , Kayla R Wilson , Ashley M Firth , Christophe Macri , Patrick Schriek , Annabelle B Blum , Javiera Villar , Samuel Wormald , Mitch Shambrook , Bangyan Xu , Hui Jing Lim , Hamish E G McWilliam , Andrew F Hill , Irina Caminschi , Mireille H Lahoud , Elodie Segura , Marco J Herold , Jose A Villadangos , Justine D Mintern

Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Nguyen Huu Tu , Dane D Jensen , Bethany M Anderson , Elyssa Chen , Nestor N Jimenez-Vargas , Nicole N Scheff , Kenji Inoue , Hung D Tran , John C Dolan , Tamaryn A Meek , Morley D Hollenberg , Cheng Z Liu , Stephen J Vanner , Malvin N Janal , Nigel W Bunnett , Brian L Schmidt

N-Terminomics/TAILS Profiling of Macrophages after Chemical Inhibition of Legumain.

Biochemistry

Avec: Bethany M Anderson , Luiz G N de Almeida , Henna Sekhon , Daniel Young , Antoine Dufour ,

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.

ACS chemical biology

Avec: Marilyn H Gordon , Anthonia Anowai , Daniel Young , Nabangshu Das , Rhiannon I Campden , Henna Sekhon , Zoe Myers , Barbara Mainoli , Sameeksha Chopra , Peter S Thuy-Boun , Jayachandran Kizhakkedathu , Gurmeet Bindra , Humberto B Jijon , Steven Heitman , Robin Yates , Dennis W Wolan , Wallace K MacNaughton , Antoine Dufour

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.

Scientific reports

Avec: Bethany M Anderson , Daniel P Poole , Luigi Aurelio , Garrett Z Ng , Markus Fleischmann , Paulina Kasperkiewicz , Celine Morissette , Marcin Drag , Ian R van Driel , Brian L Schmidt , Stephen J Vanner , Nigel W Bunnett ,

Proteomics and Imaging in Crohn's Disease: TAILS of Unlikely Allies.

Trends in pharmacological sciences

Avec: Barbara Mainoli , Simon Hirota , Cathy Lu , Antoine Dufour

High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections - Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils.

Biological procedures online

Avec: Niina Aaltonen , Prosanta K Singha , Hermina Jakupović , Thomas Wirth , Haritha Samaranayake , Sanna Pasonen-Seppänen , Kirsi Rilla , Markku Varjosalo , Paulina Kasperkiewicz , Marcin Drag , Sara Kälvälä , Eemeli Moisio , Juha R Savinainen , Jarmo T Laitinen

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.

PLoS pathogens

Avec: Carlo Giannangelo , Ghizal Siddiqui , Amanda De Paoli , Bethany M Anderson , Susan A Charman , Darren J Creek

Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice.

Molecular psychiatry

Avec: Eun Hee Ahn , Kecheng Lei , Seong Su Kang , Zhi-Hao Wang , Xia Liu , Wei Hong , Yu Tian Wang , Lingjing Jin , Keqiang Ye

Protease-activated receptors in health and disease.

Physiological reviews

Avec: Chloe J Peach , Nigel W Bunnett , Brian L Schmidt

N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain.

Journal of cellular physiology

Avec: Alexander R Ziegler , Bethany M Anderson , Rocco Latorre , Rachel M McQuade , Antoine Dufour , Brian L Schmidt , Nigel W Bunnett , Nichollas E Scott ,

Réseau de co-auteurs

Bethany M Anderson 11 collaborations

Nigel W Bunnett 7 collaborations

Bangyan Xu 5 collaborations

Antoine Dufour 5 collaborations

Brian L Schmidt 5 collaborations

Justine D Mintern 4 collaborations

Eun Hee Ahn 3 collaborations

Xia Liu 3 collaborations

Keqiang Ye 3 collaborations

Jianming Liao 2 collaborations

Chun Chen 2 collaborations

Hua Li 2 collaborations

Simon J Mountford 2 collaborations

Philip E Thompson 2 collaborations

Luigi Aurelio 2 collaborations

Rhiannon I Campden 2 collaborations

Kayla R Wilson 2 collaborations

Annabelle B Blum 2 collaborations

Christophe Macri 2 collaborations

Haiyin Liu 2 collaborations

Patrick Schriek 2 collaborations

Mireille H Lahoud 2 collaborations

Irina Caminschi 2 collaborations

Jose A Villadangos 2 collaborations

Alexander R Ziegler 2 collaborations

Nichollas E Scott 2 collaborations

Michele S Y Tan 2 collaborations

Dara Davison 2 collaborations

Mateo I Sanchez 2 collaborations

Stephen Howell 2 collaborations

Edgar Deu 2 collaborations

Nguyen Huu Tu 2 collaborations

Kenji Inoue 2 collaborations

Elyssa Chen 2 collaborations

Nicole N Scheff 2 collaborations

Hung D Tran 2 collaborations

John C Dolan 2 collaborations

Cheng Z Liu 2 collaborations

Malvin N Janal 2 collaborations

Rocco Latorre 2 collaborations

Dane D Jensen 2 collaborations

Kecheng Lei 2 collaborations

Seong Su Kang 2 collaborations

Lingjing Jin 2 collaborations

Stephen J Vanner 2 collaborations

Henna Sekhon 2 collaborations

Daniel Young 2 collaborations

Barbara Mainoli 2 collaborations

Paulina Kasperkiewicz 2 collaborations

Marcin Drag 2 collaborations

Zhonghua Lu 1 collaboration

Shuping Ming 1 collaboration

Elean S V Tay 1 collaboration

Monika Szabo 1 collaboration

My-Linh Hoang 1 collaboration

Jiayin Diao 1 collaboration

Erik Lindström 1 collaboration

Erica K Sloan 1 collaboration

Robin M Yates 1 collaboration

Devi Jenika 1 collaboration

Dominik Schienstock 1 collaboration

Lauren Francis 1 collaboration

F Victor Makota 1 collaboration

Satoshi Ishido 1 collaboration

Scott N Mueller 1 collaboration

Ambrosius P Snijders 1 collaboration

Caroline M Sawicki 1 collaboration

Dong H Kim 1 collaboration

Robel G Alemu 1 collaboration

Lei Yang 1 collaboration

Lauren E Bird 1 collaboration

Hayley J Newton 1 collaboration

Irene Y Lee 1 collaboration

Piyapa Tantisirivat 1 collaboration

Ambrosius Snijders 1 collaboration

Maria Roitman 1 collaboration

Jon Mangum 1 collaboration

James Ziogas 1 collaboration

Alexios A Adamides 1 collaboration

Paul Myles 1 collaboration

Hearan Choo-Bunnett 1 collaboration

Jenny M Gunnersen 1 collaboration

Man Lyang Kim 1 collaboration

Melinda Y Hardy 1 collaboration

Sri H Ramarathinam 1 collaboration

Shan Zou Chung 1 collaboration

Amy K Russell 1 collaboration

Iain Currie 1 collaboration

Brad E Sleebs 1 collaboration

Anthony W Purcell 1 collaboration

Jason A Tye-Din 1 collaboration

Ian P Wicks 1 collaboration

Ashley M Firth 1 collaboration

Javiera Villar 1 collaboration

Samuel Wormald 1 collaboration

Mitch Shambrook 1 collaboration

Hui Jing Lim 1 collaboration

Hamish E G McWilliam 1 collaboration

Andrew F Hill 1 collaboration

Elodie Segura 1 collaboration

Marco J Herold 1 collaboration

Nestor N Jimenez-Vargas 1 collaboration

Tamaryn A Meek 1 collaboration

Morley D Hollenberg 1 collaboration

Luiz G N de Almeida 1 collaboration

Marilyn H Gordon 1 collaboration

Anthonia Anowai 1 collaboration

Nabangshu Das 1 collaboration

Zoe Myers 1 collaboration

Sameeksha Chopra 1 collaboration

Peter S Thuy-Boun 1 collaboration

Jayachandran Kizhakkedathu 1 collaboration

Gurmeet Bindra 1 collaboration

Humberto B Jijon 1 collaboration

Steven Heitman 1 collaboration

Robin Yates 1 collaboration

Dennis W Wolan 1 collaboration

Wallace K MacNaughton 1 collaboration

Daniel P Poole 1 collaboration

Garrett Z Ng 1 collaboration

Markus Fleischmann 1 collaboration

Celine Morissette 1 collaboration

Ian R van Driel 1 collaboration

Simon Hirota 1 collaboration

Cathy Lu 1 collaboration

Niina Aaltonen 1 collaboration

Prosanta K Singha 1 collaboration

Hermina Jakupović 1 collaboration

Thomas Wirth 1 collaboration

Haritha Samaranayake 1 collaboration

Sanna Pasonen-Seppänen 1 collaboration

Kirsi Rilla 1 collaboration

Markku Varjosalo 1 collaboration

Sara Kälvälä 1 collaboration

Eemeli Moisio 1 collaboration

Juha R Savinainen 1 collaboration

Jarmo T Laitinen 1 collaboration

Carlo Giannangelo 1 collaboration

Ghizal Siddiqui 1 collaboration

Amanda De Paoli 1 collaboration

Susan A Charman 1 collaboration

Darren J Creek 1 collaboration

Zhi-Hao Wang 1 collaboration

Wei Hong 1 collaboration

Yu Tian Wang 1 collaboration

Chloe J Peach 1 collaboration

Rachel M McQuade 1 collaboration