Lamya S Shihabuddin

Affiliations

Rare and Neurological Diseases Therapeutic Area, Sanofi, 49 New York Avenue, Framingham, MA, 01701, USA.

Publications (11)

Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease.

Alzheimer's research & therapy

Avec: James C Dodge , Thomas J Tamsett , Christopher M Treleaven , Tatyana V Taksir , Peter Piepenhagen , S Pablo Sardi , Seng H Cheng ,

Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis.

Scientific reports

Avec: James C Dodge , Jinlong Yu , S Pablo Sardi ,

Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: James C Dodge , Elizabeth H Jensen , Jinlong Yu , S Pablo Sardi , Allison R Bialas , Tatyana V Taksir , Dinesh S Bangari ,

Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics.

Neurobiology of disease

Avec: Lisa M Stanek , Jie Bu ,

Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson's disease enrolled in PPMI.

NPJ Parkinson's disease

Avec: Young Eun Huh , Hyejung Park , Ming Sum Ruby Chiang , Idil Tuncali , Ganqiang Liu , Joseph J Locascio , Julia Shirvan , Samantha J Hutten , Melissa S Rotunno , Catherine Viel , Bing Wang , Sergio Pablo Sardi , Clemens R Scherzer

Viral alpha-synuclein knockdown prevents spreading synucleinopathy.

Brain communications

Avec: Sindhu Menon , Rikke H Kofoed , Fadl Nabbouh , Kristiana Xhima , Yasmeen Al-Fahoum , Tammy Langman , Howard T J Mount , S Pablo Sardi , Paul E Fraser , Joel C Watts , Isabelle Aubert , Anurag Tandon

Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit.

Nature neuroscience

Avec: Meaghan Van Alstyne , Ivan Tattoli , Nicolas Delestrée , Yocelyn Recinos , Eileen Workman , Chaolin Zhang , George Z Mentis , Livio Pellizzoni

Cerebrospinal fluid proteomics implicates the granin family in Parkinson's disease.

Scientific reports

Avec: Melissa S Rotunno , Monica Lane , Wenfei Zhang , Pavlina Wolf , Petra Oliva , Catherine Viel , Anne-Marie Wills , Roy N Alcalay , Clemens R Scherzer , Kate Zhang , S Pablo Sardi

Viral delivery of a microRNA to Gba to the mouse central nervous system models neuronopathic Gaucher disease.

Neurobiology of disease

Avec: Kasey L Jackson , Catherine Viel , Jennifer Clarke , Jie Bu , Monyrath Chan , Bing Wang , S Pablo Sardi

Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.

Scientific reports

Avec: Catherine Viel , Jennifer Clarke , Can Kayatekin , Amy M Richards , Ming Sum R Chiang , Hyejung Park , Bing Wang , S Pablo Sardi

The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites.

Molecular therapy. Methods & clinical development

Avec: Rikke Hahn Kofoed , Kate Noseworthy , Kathleen Wu , Shuruthisai Sivadas , Lisa Stanek , Bradford Elmer , Kullervo Hynynen , Isabelle Aubert

Réseau de co-auteurs

S Pablo Sardi 7 collaborations

Catherine Viel 4 collaborations

James C Dodge 3 collaborations

Bing Wang 3 collaborations

Tatyana V Taksir 2 collaborations

Jinlong Yu 2 collaborations

Jie Bu 2 collaborations

Hyejung Park 2 collaborations

Melissa S Rotunno 2 collaborations

Clemens R Scherzer 2 collaborations

Isabelle Aubert 2 collaborations

Jennifer Clarke 2 collaborations

Thomas J Tamsett 1 collaboration

Christopher M Treleaven 1 collaboration

Peter Piepenhagen 1 collaboration

Seng H Cheng 1 collaboration

Elizabeth H Jensen 1 collaboration

Allison R Bialas 1 collaboration

Dinesh S Bangari 1 collaboration

Lisa M Stanek 1 collaboration

Young Eun Huh 1 collaboration

Ming Sum Ruby Chiang 1 collaboration

Idil Tuncali 1 collaboration

Ganqiang Liu 1 collaboration

Joseph J Locascio 1 collaboration

Julia Shirvan 1 collaboration

Samantha J Hutten 1 collaboration

Sergio Pablo Sardi 1 collaboration

Sindhu Menon 1 collaboration

Rikke H Kofoed 1 collaboration

Fadl Nabbouh 1 collaboration

Kristiana Xhima 1 collaboration

Yasmeen Al-Fahoum 1 collaboration

Tammy Langman 1 collaboration

Howard T J Mount 1 collaboration

Paul E Fraser 1 collaboration

Joel C Watts 1 collaboration

Anurag Tandon 1 collaboration

Meaghan Van Alstyne 1 collaboration

Ivan Tattoli 1 collaboration

Nicolas Delestrée 1 collaboration

Yocelyn Recinos 1 collaboration

Eileen Workman 1 collaboration

Chaolin Zhang 1 collaboration

George Z Mentis 1 collaboration

Livio Pellizzoni 1 collaboration

Monica Lane 1 collaboration

Wenfei Zhang 1 collaboration

Pavlina Wolf 1 collaboration

Petra Oliva 1 collaboration

Anne-Marie Wills 1 collaboration

Roy N Alcalay 1 collaboration

Kate Zhang 1 collaboration

Kasey L Jackson 1 collaboration

Monyrath Chan 1 collaboration

Can Kayatekin 1 collaboration

Amy M Richards 1 collaboration

Ming Sum R Chiang 1 collaboration

Rikke Hahn Kofoed 1 collaboration

Kate Noseworthy 1 collaboration

Kathleen Wu 1 collaboration

Shuruthisai Sivadas 1 collaboration

Lisa Stanek 1 collaboration

Bradford Elmer 1 collaboration

Kullervo Hynynen 1 collaboration