Kunikazu Moribe

Affiliations

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

Publications (49)

Correlation between drug dissolution and resistance to water-induced phase separation in solid dispersion formulations revealed by solid-state NMR spectroscopy.

International journal of pharmaceutics

Avec: Hitomi Okada , Keisuke Ueda , Yuki Yasuda , Kenjirou Higashi , Motoki Inoue , Masataka Ito , Shuji Noguchi , Kohsaku Kawakami ,

Molecular Mobility Suppression of Ibuprofen-Rich Amorphous Nanodroplets by HPMC Revealed by NMR Relaxometry and Its Significance with Respect to Crystallization Inhibition.

Molecular pharmaceutics

Avec: Keisuke Ueda , Neo Yamamoto , Kenjirou Higashi ,

Development of nobiletin-methyl hesperidin amorphous solid dispersion: Novel application of methyl hesperidin as an excipient for hot-melt extrusion.

International journal of pharmaceutics

Avec: Masazumi Iwashita , Kohjiro Hashizume , Masahiro Umehara , Takaaki Ishigami , Shintaro Onishi , Masaki Yamamoto , Kenjirou Higashi ,

Computational approach to elucidate the formation and stabilization mechanism of amorphous formulation using molecular dynamics simulation and fragment molecular orbital calculation.

International journal of pharmaceutics

Avec: Xiaohan Ma , Kenjirou Higashi , Kaori Fukuzawa , Keisuke Ueda , Kazunori Kadota , Yuichi Tozuka , Etsuo Yonemochi ,

Variable-Temperature NMR Analysis of the Thermodynamics of Polymer Partitioning between Aqueous and Drug-Rich Phases and Its Significance for Amorphous Formulations.

Molecular pharmaceutics

Avec: Keisuke Ueda , Kenjirou Higashi , Lynne S Taylor

The nanostructure of rod-like ascorbyl dipalmitate nanoparticles stabilized by a small amount of DSPE-PEG.

International journal of pharmaceutics

Avec: Ziqiao Chen , Kenjirou Higashi , Ryuhei Shidara , Keisuke Ueda , Takeshi Morita , Waree Limwikrant , Keiji Yamamoto ,

Multistep Crystallization of Pharmaceutical Amorphous Nanoparticles via a Cognate Pathway of Oriented Attachment: Direct Evidence of Nonclassical Crystallization for Organic Molecules.

Nano letters

Avec: Ziqiao Chen , Kenjirou Higashi , Keisuke Ueda ,

Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids.

Nanoscale

Avec: Ziqiao Chen , Kenjirou Higashi , Yuki Shigehisa , Keisuke Ueda , Keiji Yamamoto ,

Application of solid-state

International journal of pharmaceutics

Avec: Keisuke Ueda , Hitomi Okada , Zhijing Zhao , Kenjirou Higashi ,

[Design Features in the Molecular-level Development of Solid Pharmaceutical Formulations Based on Supramolecular Structures].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Avec: Kenjirou Higashi , Keisuke Ueda ,

Intermolecular Interactions between Drugs and Aminoalkyl Methacrylate Copolymer in Solution to Enhance the Concentration of Poorly Water-Soluble Drugs.

Chemical & pharmaceutical bulletin

Avec: Kenjirou Higashi , Keisuke Ueda ,

Effect of drug-coformer interactions on drug dissolution from a coamorphous in mesoporous silica.

International journal of pharmaceutics

Avec: Arif Budiman , Kenjirou Higashi , Keisuke Ueda ,

Nanostructure and Molecular-Level Characterization of Aminoalkyl Methacrylate Copolymer and the Impact on Drug Solubilization Ability.

Molecular pharmaceutics

Avec: Yuta Okamoto , Kenjirou Higashi , Takeshi Morita , Keisuke Ueda , Sayaka Mukaide , Junpei Takeda , Masatoshi Karashima , Yukihiro Ikeda ,

Novel Prognostic Score for recurrent or metastatic head and neck cancer patients treated with Nivolumab.

Scientific reports

Avec: Kiyoshi Minohara , Takuma Matoba , Daisuke Kawakita , Gaku Takano , Keisuke Oguri , Akihiro Murashima , Kazuhiro Nakai , Sho Iwaki , Wataru Hojo , Ayano Matsumura , Shinya Ozaki , Taijiro Ozawa , Ikuma Harata , Nobukazu Tanaka , Shinichiro Maseki , Hiroshi Tsuge , Sae Imaizumi , Shoji Mitsuya , Kazuho Moribe , Shinichi Esaki , Shinichi Iwasaki

Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals.

Langmuir : the ACS journal of surfaces and colloids

Avec: Arisa Ishimoto , Hiroshi Sasako , Masaki Omori , Kenjirou Higashi , Keisuke Ueda , Kazuo Koyama ,

Ready-to-Use-Type Lyophilized Lipid Nanoparticle Formulation for the Postencapsulation of Messenger RNA.

ACS nano

Avec: Hiroki Tanaka , Shinya Hagiwara , Daiki Shirane , Takuma Yamakawa , Yuka Sato , Chika Matsumoto , Kota Ishizaki , Miho Hishinuma , Katsuyuki Chida , Kasumi Sasaki , Etsuo Yonemochi , Keisuke Ueda , Kenjirou Higashi , Takashi Tadokoro , Katsumi Maenaka , Sakura Taneichi , Yuta Nakai , Kota Tange , Yu Sakurai , Hidetaka Akita

Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 1: Effects of Polymer and Drug Chiralities.

Molecular pharmaceutics

Avec: Keisuke Ueda , Kenjirou Higashi ,

Impact of Colloidal Drug-Rich Droplet Size and Amorphous Solubility on Drug Membrane Permeability: A Comprehensive Analysis.

Journal of pharmaceutical sciences

Avec: Keisuke Ueda , Shiryu Takemoto , Kenjirou Higashi ,

Stabilization mechanism of amorphous carbamazepine by transglycosylated rutin, a non-polymeric amorphous additive with a high glass transition temperature.

International journal of pharmaceutics

Avec: Chisa Aoki , Xiaohan Ma , Kenjirou Higashi , Yuya Ishizuka , Keisuke Ueda , Kazunori Kadota , Kaori Fukuzawa , Yuichi Tozuka , Kohsaku Kawakami , Etsuo Yonemochi ,

Unveiling the Interaction Potential Surface between Drug-Entrapped Polymeric Micelles Clarifying the High Drug Nanocarrier Efficiency.

Nano letters

Avec: Takeshi Morita , Sayaka Mukaide , Ziqiao Chen , Kenjirou Higashi , Hiroshi Imamura , Tomonari Sumi

Clarification of the Dissolution Mechanism of an Indomethacin/Saccharin/Polyvinylpyrrolidone Ternary Solid Dispersion by NMR Spectroscopy.

Journal of pharmaceutical sciences

Avec: Mami Kosaka , Kenjirou Higashi , Misaki Nishimura , Keisuke Ueda ,

Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles.

Molecular pharmaceutics

Avec: Yushi Sunazuka , Keisuke Ueda , Kenjirou Higashi , Koichi Wada ,

Effect of Acetaminophen on Poloxamer 407 Micelles and Hydrogels: The Relationship between Structural and Physical Properties.

Langmuir : the ACS journal of surfaces and colloids

Avec: Fumie Sakuma , Kenjirou Higashi , Keisuke Ueda , Takeshi Morita , Daisuke Iohara , Fumitoshi Hirayama ,

Designing a Novel Coamorphous Salt Formulation of Telmisartan with Amlodipine to Enhance Permeability and Oral Absorption.

Molecular pharmaceutics

Avec: Yuta Hatanaka , Hiromasa Uchiyama , Shun Kaneko , Keisuke Ueda , Kenjirou Higashi , Shingo Furukawa , Mai Takase , Shinya Yamanaka , Kazunori Kadota , Yuichi Tozuka

Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR.

Molecular pharmaceutics

Avec: Sudeshna Kundu , Kenjirou Higashi , Makoto Takamizawa , Keisuke Ueda , Waree Limwikrant , Keiji Yamamoto ,

The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles.

Pharmaceutics

Avec: Jessica Anindita , Hiroki Tanaka , Takuma Yamakawa , Yuka Sato , Chika Matsumoto , Kota Ishizaki , Taiji Oyama , Satoko Suzuki , Keisuke Ueda , Kenjirou Higashi , Kasumi Sasaki , Yumika Ogura , Etsuo Yonemochi , Yu Sakurai , Hiroto Hatakeyama , Hidetaka Akita

Enhanced Antipsoriatic Activity of Mycophenolic Acid Against the TNF-α-Induced HaCaT Cell Proliferation by Conjugated Poloxamer Micelles.

Journal of pharmaceutical sciences

Avec: Wiwat Supasena , Chawanphat Muangnoi , Wuttinont Thaweesest , Chalermkiat Songkram , Keisuke Ueda , Kenjirou Higashi , Somboon Tanasupawat , Pornchai Rojsitthisak

Effect of molecular weight of hypromellose on mucin diffusion and oral absorption behavior of fenofibrate nanocrystal.

International journal of pharmaceutics

Avec: Keisuke Ueda , Takaaki Iwai , Yushi Sunazuka , Ziqiao Chen , Nao Kato , Kenjirou Higashi ,

A Novel Drug-Drug Cocrystal of Levofloxacin and Metacetamol: Reduced Hygroscopicity and Improved Photostability of Levofloxacin.

Journal of pharmaceutical sciences

Avec: Taeko Shinozaki , Makoto Ono , Kenjirou Higashi ,

Enteric complex layer-coated controlled release of capsaicin from phytosterol/γ-cyclodextrin microparticles via guest exchange reaction with taurocholic acid.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Hiroshi Sasako , Kazuo Koyama , Kenjirou Higashi , Keisuke Ueda , Arisa Ishimoto ,

Formation mechanism of amorphous drug nanoparticles using the antisolvent precipitation method elucidated by varying the preparation temperature.

International journal of pharmaceutics

Avec: Chikako Morikawa , Keisuke Ueda , Masaki Omori , Kenjirou Higashi ,

Mechanistic study of preparation of drug/polymer/surfactant ternary hot extrudates to obtain small and stable drug nanocrystal suspensions.

International journal of pharmaceutics

Avec: Katsuhiko Omagari , Keisuke Ueda , Zhao Zhijing , Kenjirou Higashi , Motoki Inoue , Toshiro Fukami ,

Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles.

International journal of pharmaceutics

Avec: Naho Hanada , Kenjirou Higashi , Zhijing Zhao , Keisuke Ueda ,

Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid-Liquid Phase Separation.

Molecular pharmaceutics

Avec: Etsushi Yoshikawa , Keisuke Ueda , Rei Hakata , Kenjirou Higashi ,

Unveiling the flavone-solubilizing effects of α-glucosyl rutin and hesperidin: probing structural differences through NMR and SAXS analyses.

Food & function

Avec: Kazunori Kadota , Tero Kämäräinen , Fumie Sakuma , Keisuke Ueda , Kenjirou Higashi , Hiromasa Uchiyama , Katsuhiko Minoura , Yuichi Tozuka

NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Keisuke Ueda , Yui Sakagawa , Tomoki Saito , Fumie Sakuma , Hiroki Tanaka , Hidetaka Akita , Kenjirou Higashi ,

Selection on milk production and conformation traits during the last two decades in Japan.

Asian-Australasian journal of animal sciences

Avec: Kenji Togashi , Takefumi Osawa , Kazunori Adachi , Kazuhito Kurogi , Kota Tokunaka , Takanori Yasumori , Tsutomu Takahashi , Kimihiro Moribe

Effects of preselection of genotyped animals on reliability and bias of genomic prediction in dairy cattle.

Asian-Australasian journal of animal sciences

Avec: Kenji Togashi , Kazunori Adachi , Kazuhito Kurogi , Takanori Yasumori , Kouichi Tokunaka , Atsushi Ogino , Yoshiyuki Miyazaki , Toshio Watanabe , Tsutomu Takahashi , Kimihiro Moribe

Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation.

International journal of pharmaceutics

Avec: Keisuke Ueda , Kenjirou Higashi ,

Cryo-TEM and AFM Observation of the Time-Dependent Evolution of Amorphous Probucol Nanoparticles Formed by the Aqueous Dispersion of Ternary Solid Dispersions.

Molecular pharmaceutics

Avec: Zhijing Zhao , Hiroaki Katai , Kenjirou Higashi , Keisuke Ueda , Kohsaku Kawakami ,

Effect of Drug-Polymer Interactions through Hypromellose Acetate Succinate Substituents on the Physical Stability on Solid Dispersions Studied by Fourier-Transform Infrared and Solid-State Nuclear Magnetic Resonance.

Molecular pharmaceutics

Avec: Yuya Ishizuka , Keisuke Ueda , Hitomi Okada , Junpei Takeda , Masatoshi Karashima , Koji Yazawa , Kenjirou Higashi , Kohsaku Kawakami , Yukihiro Ikeda ,

Transition from Amorphous Cyclosporin A Nanoparticles to Size-Reduced Stable Nanocrystals in a Poloxamer 407 Solution.

Molecular pharmaceutics

Avec: Ziqiao Chen , Kenjirou Higashi , Keisuke Ueda ,

Carotid Endarterectomy Requiring Removal of the Superior Horn of Thyroid Cartilage: Case Report and Literature Review.

NMC case report journal

Avec: Takayuki Ishikawa , Kazuho Moribe , Keishi Ito , Ryusuke Kabeya

Amorphous Drug Solubility and Maximum Free Drug Concentrations in Cyclodextrin Solutions: A Quantitative Study Using NMR Diffusometry.

Molecular pharmaceutics

Avec: Keisuke Ueda , Kenjirou Higashi ,

Revealing the mechanism of morphological variation of amorphous drug nanoparticles formed by aqueous dispersion of ternary solid dispersion.

International journal of pharmaceutics

Avec: Zhijing Zhao , Kenjirou Higashi , Keisuke Ueda ,

Unusual Correlation between the Apparent Amorphous Solubility of a Drug and Solubilizer Concentration Revealed by NMR Analysis.

Molecular pharmaceutics

Avec: Keisuke Ueda , Kenjirou Higashi ,

New liposome-radionuclide-chelate combination for tumor targeting and rapid healthy tissue clearance.

Journal of controlled release : official journal of the Controlled Release Society

Avec: Izumi O Umeda , Yusuke Koike , Mayumi Ogata , Emi Kaneko , Shusei Hamamichi , Tomoya Uehara , Yasushi Arano , Tadayuki Takahashi , Hirofumi Fujii

Quantitative Analysis of Drug Supersaturation Region by Temperature-Variable Nuclear Magnetic Resonance Measurements, Part 2: Effects of Solubilizer.

Molecular pharmaceutics

Avec: Keisuke Ueda , Kenjirou Higashi ,

Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin.

International journal of pharmaceutics

Avec: Mengyao Liu , Kenjirou Higashi , Keisuke Ueda ,

Réseau de co-auteurs

Kenjirou Higashi 44 collaborations

Keisuke Ueda 41 collaborations

Ziqiao Chen 6 collaborations

Kohsaku Kawakami 4 collaborations

Kazunori Kadota 4 collaborations

Yuichi Tozuka 4 collaborations

Etsuo Yonemochi 4 collaborations

Takeshi Morita 4 collaborations

Zhijing Zhao 4 collaborations

Hitomi Okada 3 collaborations

Keiji Yamamoto 3 collaborations

Hiroki Tanaka 3 collaborations

Hidetaka Akita 3 collaborations

Fumie Sakuma 3 collaborations

Motoki Inoue 2 collaborations

Xiaohan Ma 2 collaborations

Kaori Fukuzawa 2 collaborations

Waree Limwikrant 2 collaborations

Sayaka Mukaide 2 collaborations

Junpei Takeda 2 collaborations

Masatoshi Karashima 2 collaborations

Yukihiro Ikeda 2 collaborations

Kazuho Moribe 2 collaborations

Arisa Ishimoto 2 collaborations

Hiroshi Sasako 2 collaborations

Masaki Omori 2 collaborations

Kazuo Koyama 2 collaborations

Takuma Yamakawa 2 collaborations

Yuka Sato 2 collaborations

Chika Matsumoto 2 collaborations

Kota Ishizaki 2 collaborations

Kasumi Sasaki 2 collaborations

Yu Sakurai 2 collaborations

Yuya Ishizuka 2 collaborations

Yushi Sunazuka 2 collaborations

Hiromasa Uchiyama 2 collaborations

Kenji Togashi 2 collaborations

Kazunori Adachi 2 collaborations

Kazuhito Kurogi 2 collaborations

Takanori Yasumori 2 collaborations

Tsutomu Takahashi 2 collaborations

Kimihiro Moribe 2 collaborations

Yuki Yasuda 1 collaboration

Masataka Ito 1 collaboration

Shuji Noguchi 1 collaboration

Neo Yamamoto 1 collaboration

Masazumi Iwashita 1 collaboration

Kohjiro Hashizume 1 collaboration

Masahiro Umehara 1 collaboration

Takaaki Ishigami 1 collaboration

Shintaro Onishi 1 collaboration

Masaki Yamamoto 1 collaboration

Lynne S Taylor 1 collaboration

Ryuhei Shidara 1 collaboration

Yuki Shigehisa 1 collaboration

Arif Budiman 1 collaboration

Yuta Okamoto 1 collaboration

Kiyoshi Minohara 1 collaboration

Takuma Matoba 1 collaboration

Daisuke Kawakita 1 collaboration

Gaku Takano 1 collaboration

Keisuke Oguri 1 collaboration

Akihiro Murashima 1 collaboration

Kazuhiro Nakai 1 collaboration

Sho Iwaki 1 collaboration

Wataru Hojo 1 collaboration

Ayano Matsumura 1 collaboration

Shinya Ozaki 1 collaboration

Taijiro Ozawa 1 collaboration

Ikuma Harata 1 collaboration

Nobukazu Tanaka 1 collaboration

Shinichiro Maseki 1 collaboration

Hiroshi Tsuge 1 collaboration

Sae Imaizumi 1 collaboration

Shoji Mitsuya 1 collaboration

Shinichi Esaki 1 collaboration

Shinichi Iwasaki 1 collaboration

Shinya Hagiwara 1 collaboration

Daiki Shirane 1 collaboration

Miho Hishinuma 1 collaboration

Katsuyuki Chida 1 collaboration

Takashi Tadokoro 1 collaboration

Katsumi Maenaka 1 collaboration

Sakura Taneichi 1 collaboration

Yuta Nakai 1 collaboration

Kota Tange 1 collaboration

Shiryu Takemoto 1 collaboration

Chisa Aoki 1 collaboration

Hiroshi Imamura 1 collaboration

Tomonari Sumi 1 collaboration

Mami Kosaka 1 collaboration

Misaki Nishimura 1 collaboration

Koichi Wada 1 collaboration

Daisuke Iohara 1 collaboration

Fumitoshi Hirayama 1 collaboration

Yuta Hatanaka 1 collaboration

Shun Kaneko 1 collaboration

Shingo Furukawa 1 collaboration

Mai Takase 1 collaboration

Shinya Yamanaka 1 collaboration

Sudeshna Kundu 1 collaboration

Makoto Takamizawa 1 collaboration

Jessica Anindita 1 collaboration

Taiji Oyama 1 collaboration

Satoko Suzuki 1 collaboration

Yumika Ogura 1 collaboration

Hiroto Hatakeyama 1 collaboration

Wiwat Supasena 1 collaboration

Chawanphat Muangnoi 1 collaboration

Wuttinont Thaweesest 1 collaboration

Chalermkiat Songkram 1 collaboration

Somboon Tanasupawat 1 collaboration

Pornchai Rojsitthisak 1 collaboration

Takaaki Iwai 1 collaboration

Nao Kato 1 collaboration

Taeko Shinozaki 1 collaboration

Makoto Ono 1 collaboration

Chikako Morikawa 1 collaboration

Katsuhiko Omagari 1 collaboration

Zhao Zhijing 1 collaboration

Toshiro Fukami 1 collaboration

Naho Hanada 1 collaboration

Etsushi Yoshikawa 1 collaboration

Rei Hakata 1 collaboration

Tero Kämäräinen 1 collaboration

Katsuhiko Minoura 1 collaboration

Yui Sakagawa 1 collaboration

Tomoki Saito 1 collaboration

Takefumi Osawa 1 collaboration

Kota Tokunaka 1 collaboration

Kouichi Tokunaka 1 collaboration

Atsushi Ogino 1 collaboration

Yoshiyuki Miyazaki 1 collaboration

Toshio Watanabe 1 collaboration

Hiroaki Katai 1 collaboration

Koji Yazawa 1 collaboration

Takayuki Ishikawa 1 collaboration

Keishi Ito 1 collaboration

Ryusuke Kabeya 1 collaboration

Izumi O Umeda 1 collaboration

Yusuke Koike 1 collaboration

Mayumi Ogata 1 collaboration

Emi Kaneko 1 collaboration

Shusei Hamamichi 1 collaboration

Tomoya Uehara 1 collaboration

Yasushi Arano 1 collaboration

Tadayuki Takahashi 1 collaboration

Hirofumi Fujii 1 collaboration

Mengyao Liu 1 collaboration