Juha-Matti Savola

Affiliations

Teva Pharmaceuticals International GmbH, Basel, Switzerland.

Publications (16)

Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect.

Clinical pharmacology in drug development

Avec: Frank Schneider , David Stamler , Margaret Bradbury , Pippa S Loupe , Edward Hellriegel , Donna S Cox , Mark Forrest Gordon , Laura Rabinovich-Guilatt

Additional Safety and Exploratory Efficacy Data at 48 and 60 Months from Open-HART, an Open-Label Extension Study of Pridopidine in Huntington Disease.

Journal of Huntington's disease

Avec: Andrew McGarry , Peggy Auinger , Karl Kieburtz , Michal Geva , Munish Mehra , Victor Abler , Igor D Grachev , Mark Forrest Gordon , Sanjay Gandhi , Spyridon Papapetropoulos , Michael Hayden

Long-Term Deutetrabenazine Treatment for Tardive Dyskinesia Is Associated With Sustained Benefits and Safety: A 3-Year, Open-Label Extension Study.

Frontiers in neurology

Avec: Robert A Hauser , Hadas Barkay , Hubert H Fernandez , Stewart A Factor , Joohi Jimenez-Shahed , Nicholas Gross , Leslie Marinelli , Amanda Wilhelm , Jessica Alexander , Mark Forrest Gordon , Karen E Anderson

Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.

Movement disorders : official journal of the Movement Disorder Society

Avec: Tom H Johnston , Michal Geva , Lilach Steiner , Aric Orbach , Spyros Papapetropoulos , Ian J Reynolds , Paula Ravenscroft , Michael Hill , Susan H Fox , Jonathan M Brotchie , Ralph Laufer , Michael R Hayden

Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [

European journal of nuclear medicine and molecular imaging

Avec: Igor D Grachev , Philipp M Meyer , Georg A Becker , Marcus Bronzel , Doug Marsteller , Gina Pastino , Ole Voges , Laura Rabinovich , Helena Knebel , Franziska Zientek , Michael Rullmann , Bernhard Sattler , Marianne Patt , Thilo Gerhards , Maria Strauss , Andreas Kluge , Peter Brust , Mark F Gordon , Michal Geva , Swen Hesse , Henryk Barthel , Michael R Hayden , Osama Sabri

Safety and Efficacy of Flexible-Dose Deutetrabenazine in Children and Adolescents With Tourette Syndrome: A Randomized Clinical Trial.

JAMA network open

Avec: Joseph Jankovic , Barbara Coffey , Daniel O Claassen , Joohi Jimenez-Shahed , Barry J Gertz , Elizabeth A Garofalo , David A Stamler , Maria Wieman , Mark Forrest Gordon , Jessica Alexander , Hadas Barkay , Eran Harary

A PET-CT study on neuroinflammation in Huntington's disease patients participating in a randomized trial with laquinimod.

Brain communications

Avec: Andreas-Antonios Roussakis , Marta Gennaro , Mark Forrest Gordon , Ralf Reilmann , Beth Borowsky , Gail Rynkowski , Nicholas P Lao-Kaim , Zoe Papoutsou , Michael R Hayden , David R Owen , Nicola Kalk , Anne Lingford-Hughes , Roger N Gunn , Graham Searle , Sarah J Tabrizi , Paola Piccini

Safety and Efficacy of Long-Term Deutetrabenazine Use in Children and Adolescents with Tics Associated with Tourette Syndrome: An Open-Label Extension Study.

Movement disorders clinical practice

Avec: Joseph Jankovic , Barbara Coffey , Daniel O Claassen , Joohi Jimenez-Shahed , Barry J Gertz , Elizabeth A Garofalo , David A Stamler , Maria Wieman , Eran Harary , Jessica Alexander , Hadas Barkay , Mark Forrest Gordon

Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study.

The Lancet. Neurology

Avec: Ralf Reilmann , Karen E Anderson , Andrew Feigin , Sarah J Tabrizi , Blair R Leavitt , Julie C Stout , Paola Piccini , Robin Schubert , Pippa Loupe , Anna Wickenberg , Beth Borowsky , Gail Rynkowski , Rita Volkinshtein , Thomas Li , Michael Hayden , Mark Forrest Gordon , Auteur inconnu

Quantification of Motor Function in Huntington Disease Patients Using Wearable Sensor Devices.

Digital biomarkers

Avec: Mark Forrest Gordon , Igor D Grachev , Itzik Mazeh , Yonatan Dolan , Ralf Reilmann , Pippa S Loupe , Shai Fine , Leehee Navon-Perry , Nicholas Gross , Spyros Papapetropoulos , Michael R Hayden

Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers.

Clinical and translational science

Avec: Frank Schneider , Margaret Bradbury , Thomas A Baillie , David Stamler , Edward Hellriegel , Donna S Cox , Pippa S Loupe , Laura Rabinovich-Guilatt

Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study.

The Lancet. Neurology

Avec: Ralf Reilmann , Andrew McGarry , Igor D Grachev , Beth Borowsky , Eli Eyal , Nicholas Gross , Douglas Langbehn , Robin Schubert , Anna Teige Wickenberg , Spyros Papapetropoulos , Michael Hayden , Ferdinando Squitieri , Karl Kieburtz , G Bernhard Landwehrmeyer , Auteur inconnu , Auteur inconnu

Efficacy and Safety of Fixed-Dose Deutetrabenazine in Children and Adolescents for Tics Associated With Tourette Syndrome: A Randomized Clinical Trial.

JAMA network open

Avec: Barbara Coffey , Joseph Jankovic , Daniel O Claassen , Joohi Jimenez-Shahed , Barry J Gertz , Elizabeth A Garofalo , David A Stamler , Maria Wieman , Mark Forrest Gordon , Jessica K Alexander , Hadas Barkay , Eran Harary

Minimal clinically important change in Abnormal Involuntary Movement Scale score in tardive dyskinesia as assessed in pivotal trials of deutetrabenazine.

Parkinsonism & related disorders

Avec: Robert A Hauser , Hadas Barkay , Amanda Wilhelm , Maria Wieman , Mark Forrest Gordon

The Safety of Deutetrabenazine for Chorea in Huntington Disease: An Open-Label Extension Study.

CNS drugs

Avec: Samuel Frank , Claudia Testa , Mary C Edmondson , Jody Goldstein , Elise Kayson , Blair R Leavitt , David Oakes , Christine O'Neill , Christina Vaughan , Jacquelyn Whaley , Nicholas Gross , Mark Forrest Gordon , Auteur inconnu

Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease.

Neurology and therapy

Avec: Samuel Frank , Karen E Anderson , Hubert H Fernandez , Robert A Hauser , Daniel O Claassen , David Stamler , Stewart A Factor , Joohi Jimenez-Shahed , Hadas Barkay , Amanda Wilhelm , Jessica K Alexander , Nayla Chaijale , Steve Barash , Mark Forrest Gordon , Maria Chen

Réseau de co-auteurs

Mark Forrest Gordon 12 collaborations

Hadas Barkay 6 collaborations

Joohi Jimenez-Shahed 5 collaborations

Igor D Grachev 4 collaborations

Nicholas Gross 4 collaborations

Michael R Hayden 4 collaborations

Daniel O Claassen 4 collaborations

Maria Wieman 4 collaborations

Ralf Reilmann 4 collaborations

None None 4 collaborations

David Stamler 3 collaborations

Pippa S Loupe 3 collaborations

Michal Geva 3 collaborations

Michael Hayden 3 collaborations

Robert A Hauser 3 collaborations

Amanda Wilhelm 3 collaborations

Jessica Alexander 3 collaborations

Karen E Anderson 3 collaborations

Spyros Papapetropoulos 3 collaborations

Joseph Jankovic 3 collaborations

Barbara Coffey 3 collaborations

Barry J Gertz 3 collaborations

Elizabeth A Garofalo 3 collaborations

David A Stamler 3 collaborations

Eran Harary 3 collaborations

Beth Borowsky 3 collaborations

Frank Schneider 2 collaborations

Margaret Bradbury 2 collaborations

Edward Hellriegel 2 collaborations

Donna S Cox 2 collaborations

Laura Rabinovich-Guilatt 2 collaborations

Andrew McGarry 2 collaborations

Karl Kieburtz 2 collaborations

Hubert H Fernandez 2 collaborations

Stewart A Factor 2 collaborations

Gail Rynkowski 2 collaborations

Sarah J Tabrizi 2 collaborations

Paola Piccini 2 collaborations

Blair R Leavitt 2 collaborations

Robin Schubert 2 collaborations

Jessica K Alexander 2 collaborations

Samuel Frank 2 collaborations

Peggy Auinger 1 collaboration

Munish Mehra 1 collaboration

Victor Abler 1 collaboration

Sanjay Gandhi 1 collaboration

Spyridon Papapetropoulos 1 collaboration

Leslie Marinelli 1 collaboration

Tom H Johnston 1 collaboration

Lilach Steiner 1 collaboration

Aric Orbach 1 collaboration

Ian J Reynolds 1 collaboration

Paula Ravenscroft 1 collaboration

Michael Hill 1 collaboration

Susan H Fox 1 collaboration

Jonathan M Brotchie 1 collaboration

Ralph Laufer 1 collaboration

Philipp M Meyer 1 collaboration

Georg A Becker 1 collaboration

Marcus Bronzel 1 collaboration

Doug Marsteller 1 collaboration

Gina Pastino 1 collaboration

Ole Voges 1 collaboration

Laura Rabinovich 1 collaboration

Helena Knebel 1 collaboration

Franziska Zientek 1 collaboration

Michael Rullmann 1 collaboration

Bernhard Sattler 1 collaboration

Marianne Patt 1 collaboration

Thilo Gerhards 1 collaboration

Maria Strauss 1 collaboration

Andreas Kluge 1 collaboration

Peter Brust 1 collaboration

Mark F Gordon 1 collaboration

Swen Hesse 1 collaboration

Henryk Barthel 1 collaboration

Osama Sabri 1 collaboration

Andreas-Antonios Roussakis 1 collaboration

Marta Gennaro 1 collaboration

Nicholas P Lao-Kaim 1 collaboration

Zoe Papoutsou 1 collaboration

David R Owen 1 collaboration

Nicola Kalk 1 collaboration

Anne Lingford-Hughes 1 collaboration

Roger N Gunn 1 collaboration

Graham Searle 1 collaboration

Andrew Feigin 1 collaboration

Julie C Stout 1 collaboration

Pippa Loupe 1 collaboration

Anna Wickenberg 1 collaboration

Rita Volkinshtein 1 collaboration

Thomas Li 1 collaboration

Itzik Mazeh 1 collaboration

Yonatan Dolan 1 collaboration

Shai Fine 1 collaboration

Leehee Navon-Perry 1 collaboration

Thomas A Baillie 1 collaboration

Eli Eyal 1 collaboration

Douglas Langbehn 1 collaboration

Anna Teige Wickenberg 1 collaboration

Ferdinando Squitieri 1 collaboration

G Bernhard Landwehrmeyer 1 collaboration

Claudia Testa 1 collaboration

Mary C Edmondson 1 collaboration

Jody Goldstein 1 collaboration

Elise Kayson 1 collaboration

David Oakes 1 collaboration

Christine O'Neill 1 collaboration

Christina Vaughan 1 collaboration

Jacquelyn Whaley 1 collaboration

Nayla Chaijale 1 collaboration

Steve Barash 1 collaboration

Maria Chen 1 collaboration