Jolanta Grembecka

Affiliations

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Publications (22)

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex.

Leukemia

Avec: Luisa Schmidt , Elizabeth Heyes , Lisa Scheiblecker , Thomas Eder , Giacomo Volpe , Jon Frampton , Claus Nerlov , Peter Valent , Florian Grebien

Increased slow dynamics defines ligandability of BTB domains.

Nature communications

Avec: Vladlena Kharchenko , Brian M Linhares , Megan Borregard , Iwona Czaban , Mariusz Jaremko , Tomasz Cierpicki , Łukasz Jaremko

MRG15 activates histone methyltransferase activity of ASH1L by recruiting it to the nucleosomes.

Structure (London, England : 1993)

Avec: Samah Al-Harthi , Hao Li , Alyssa Winkler , Kacper Szczepski , Jing Deng , Tomasz Cierpicki , Łukasz Jaremko

Combination of menin and kinase inhibitors as an effective treatment for leukemia with NUP98 translocations.

Leukemia

Avec: Hongzhi Miao , Dong Chen , James Ropa , Trupta Purohit , EunGi Kim , Maria-Luisa Sulis , Adolfo Ferrando , Tomasz Cierpicki ,

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.

Molecular cancer research : MCR

Avec: Jennifer A Jiménez , April A Apfelbaum , Allegra G Hawkins , Laurie K Svoboda , Abhijay Kumar , Ramon Ocadiz Ruiz , Alessandra X Garcia , Elena Haarer , Zeribe C Nwosu , Joshua Bradin , Trupta Purohit , Dong Chen , Tomasz Cierpicki , Costas A Lyssiotis , Elizabeth R Lawlor

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

Experimental hematology

Avec: Yufei Chen , Kenneth L Jones , Konstantinos Anastassiadis , Andrea Kranz , A Francis Stewart , Matthew Meyerson , Patricia Ernst

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.

Nature chemical biology

Avec: Shirish Shukla , Weijiang Ying , Felicia Gray , Yiwu Yao , Miranda L Simes , Qingjie Zhao , Hongzhi Miao , Hyo Je Cho , Paula González-Alonso , Alyssa Winkler , George Lund , Trupta Purohit , EunGi Kim , Xiaotian Zhang , Joshua M Ray , Shihan He , Caroline Nikolaidis , Juliano Ndoj , Jingya Wang , Łukasz Jaremko , Mariusz Jaremko , Russell J H Ryan , Monica L Guzman , Tomasz Cierpicki

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.

Nature communications

Avec: David S Rogawski , Jing Deng , Hao Li , Hongzhi Miao , Dmitry Borkin , Trupta Purohit , Jiho Song , Jennifer Chase , Shuangjiang Li , Juliano Ndoj , Szymon Klossowski , EunGi Kim , Fengbiao Mao , Bo Zhou , James Ropa , Marta Z Krotoska , Zhuang Jin , Patricia Ernst , Xiaomin Feng , Gang Huang , Kenichi Nishioka , Samantha Kelly , Miao He , Bo Wen , Duxin Sun , Andrew Muntean , Yali Dou , Ivan Maillard , Tomasz Cierpicki ,

Applications of oxetanes in drug discovery and medicinal chemistry.

European journal of medicinal chemistry

Avec: Guang Huang , Devon Hucek , Tomasz Cierpicki ,

Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.

European journal of medicinal chemistry

Avec: Paulina Fortuna , Brian M Linhares , Trupta Purohit , Jonathan Pollock , Tomasz Cierpicki , Łukasz Berlicki

Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer.

Science advances

Avec: Chunhua Wan , Sylvia Mahara , Claire Sun , Anh Doan , Hui Kheng Chua , Dakang Xu , Jia Bian , Yue Li , Danxi Zhu , Dhanya Sooraj , Tomasz Cierpicki , Ron Firestein

Development of potent dimeric inhibitors of GAS41 YEATS domain.

Cell chemical biology

Avec: Dymytrii Listunov , Brian M Linhares , EunGi Kim , Alyssa Winkler , Miranda L Simes , Sidney Weaver , Hyo Je Cho , Alexandrea Rizo , Sergey Zolov , Venkateshwar G Keshamouni , Tomasz Cierpicki

Thioamides in medicinal chemistry and as small molecule therapeutic agents.

European journal of medicinal chemistry

Avec: Guang Huang , Tomasz Cierpicki ,

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.

The Journal of clinical investigation

Avec: Szymon Klossowski , Hongzhi Miao , Katarzyna Kempinska , Tao Wu , Trupta Purohit , EunGi Kim , Brian M Linhares , Dong Chen , Gloria Jih , Eric Perkey , Huang Huang , Miao He , Bo Wen , Yi Wang , Ke Yu , Stanley Chun-Wei Lee , Gwenn Danet-Desnoyers , Winifred Trotman , Malathi Kandarpa , Anitria Cotton , Omar Abdel-Wahab , Hongwei Lei , Yali Dou , Monica Guzman , Luke Peterson , Tanja Gruber , Sarah Choi , Duxin Sun , Pingda Ren , Lian-Sheng Li , Yi Liu , Francis Burrows , Ivan Maillard , Tomasz Cierpicki ,

Covalent inhibition of NSD1 histone methyltransferase.

Nature chemical biology

Avec: Huang Huang , Christina A Howard , Sergei Zari , Hyo Je Cho , Shirish Shukla , Hao Li , Juliano Ndoj , Paula González-Alonso , Caroline Nikolaidis , Joshua Abbott , David S Rogawski , Mykhaylo A Potopnyk , Katarzyna Kempinska , Hongzhi Miao , Trupta Purohit , Andrew Henderson , Anna Mapp , Maria Luisa Sulis , Adolfo Ferrando , Tomasz Cierpicki

Combined MAPK Pathway and HDAC Inhibition Breaks Melanoma.

Cancer discovery

Avec: David B Lombard , Tomasz Cierpicki ,

Clinically Defined Mutations in

Cancer research communications

Avec: Suzann Duan , Sulaiman Sheriff , Uloma B Elvis-Offiah , Brandon L Witten , Travis W Sawyer , Sinju Sundaresan , Tomasz Cierpicki , Juanita L Merchant

Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia.

Cancer discovery

Avec: Xue Qing David Wang , Dandan Fan , Qinyu Han , Yiman Liu , Hongzhi Miao , Xinyu Wang , Qinglan Li , Dong Chen , Haley Gore , Pamela Himadewi , Gerd P Pfeifer , Tomasz Cierpicki , Jianzhong Su , Shasha Chong , Liling Wan , Xiaotian Zhang

Drug-resistant menin variants retain high binding affinity and interactions with MLL1.

The Journal of biological chemistry

Avec: Joshua Ray , Bradley Clegg , Tomasz Cierpicki

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.

Future medicinal chemistry

Avec: Brian M Linhares , Tomasz Cierpicki

2-Aminobenzothiazoles in anticancer drug design and discovery.

Bioorganic chemistry

Avec: Guang Huang , Tomasz Cierpicki ,

Ziftomenib in relapsed or refractory acute myeloid leukaemia (KOMET-001): a multicentre, open-label, multi-cohort, phase 1 trial.

The Lancet. Oncology

Avec: Eunice S Wang , Ghayas C Issa , Harry P Erba , Jessica K Altman , Pau Montesinos , Stephane DeBotton , Roland B Walter , Kristen Pettit , Michael R Savona , Mithun Vinod Shah , Marina Kremyanskaya , Maria R Baer , James M Foran , Gary Schiller , Lionel Adès , Mael Heiblig , Celine Berthon , Pierre Peterlin , Eduardo Rodríguez-Arbolí , Olga Salamero , Mrinal M Patnaik , Cristina Papayannidis , Tomasz Cierpicki , Bradley Clegg , Joshua Ray , Brian M Linhares , Kun Nie , Amitava Mitra , Julie Mackey Ahsan , Marilyn Tabachri , Harris S Soifer , Daniel Corum , Mollie Leoni , Stephen Dale , Amir T Fathi

Réseau de co-auteurs

Tomasz Cierpicki 20 collaborations

Trupta Purohit 7 collaborations

Brian M Linhares 6 collaborations

Hongzhi Miao 6 collaborations

EunGi Kim 5 collaborations

Dong Chen 4 collaborations

Łukasz Jaremko 3 collaborations

Hao Li 3 collaborations

Alyssa Winkler 3 collaborations

Hyo Je Cho 3 collaborations

Juliano Ndoj 3 collaborations

Guang Huang 3 collaborations

Mariusz Jaremko 2 collaborations

Jing Deng 2 collaborations

James Ropa 2 collaborations

Adolfo Ferrando 2 collaborations

Patricia Ernst 2 collaborations

Shirish Shukla 2 collaborations

Miranda L Simes 2 collaborations

Paula González-Alonso 2 collaborations

Xiaotian Zhang 2 collaborations

Caroline Nikolaidis 2 collaborations

David S Rogawski 2 collaborations

Szymon Klossowski 2 collaborations

Miao He 2 collaborations

Bo Wen 2 collaborations

Duxin Sun 2 collaborations

Yali Dou 2 collaborations

Ivan Maillard 2 collaborations

Katarzyna Kempinska 2 collaborations

Huang Huang 2 collaborations

Joshua Ray 2 collaborations

Bradley Clegg 2 collaborations

Luisa Schmidt 1 collaboration

Elizabeth Heyes 1 collaboration

Lisa Scheiblecker 1 collaboration

Thomas Eder 1 collaboration

Giacomo Volpe 1 collaboration

Jon Frampton 1 collaboration

Claus Nerlov 1 collaboration

Peter Valent 1 collaboration

Florian Grebien 1 collaboration

Vladlena Kharchenko 1 collaboration

Megan Borregard 1 collaboration

Iwona Czaban 1 collaboration

Samah Al-Harthi 1 collaboration

Kacper Szczepski 1 collaboration

Maria-Luisa Sulis 1 collaboration

Jennifer A Jiménez 1 collaboration

April A Apfelbaum 1 collaboration

Allegra G Hawkins 1 collaboration

Laurie K Svoboda 1 collaboration

Abhijay Kumar 1 collaboration

Ramon Ocadiz Ruiz 1 collaboration

Alessandra X Garcia 1 collaboration

Elena Haarer 1 collaboration

Zeribe C Nwosu 1 collaboration

Joshua Bradin 1 collaboration

Costas A Lyssiotis 1 collaboration

Elizabeth R Lawlor 1 collaboration

Yufei Chen 1 collaboration

Kenneth L Jones 1 collaboration

Konstantinos Anastassiadis 1 collaboration

Andrea Kranz 1 collaboration

A Francis Stewart 1 collaboration

Matthew Meyerson 1 collaboration

Weijiang Ying 1 collaboration

Felicia Gray 1 collaboration

Yiwu Yao 1 collaboration

Qingjie Zhao 1 collaboration

George Lund 1 collaboration

Joshua M Ray 1 collaboration

Shihan He 1 collaboration

Jingya Wang 1 collaboration

Russell J H Ryan 1 collaboration

Monica L Guzman 1 collaboration

Dmitry Borkin 1 collaboration

Jiho Song 1 collaboration

Jennifer Chase 1 collaboration

Shuangjiang Li 1 collaboration

Fengbiao Mao 1 collaboration

Bo Zhou 1 collaboration

Marta Z Krotoska 1 collaboration

Zhuang Jin 1 collaboration

Xiaomin Feng 1 collaboration

Gang Huang 1 collaboration

Kenichi Nishioka 1 collaboration

Samantha Kelly 1 collaboration

Andrew Muntean 1 collaboration

Devon Hucek 1 collaboration

Paulina Fortuna 1 collaboration

Jonathan Pollock 1 collaboration

Łukasz Berlicki 1 collaboration

Chunhua Wan 1 collaboration

Sylvia Mahara 1 collaboration

Claire Sun 1 collaboration

Anh Doan 1 collaboration

Hui Kheng Chua 1 collaboration

Dakang Xu 1 collaboration

Jia Bian 1 collaboration

Yue Li 1 collaboration

Danxi Zhu 1 collaboration

Dhanya Sooraj 1 collaboration

Ron Firestein 1 collaboration

Dymytrii Listunov 1 collaboration

Sidney Weaver 1 collaboration

Alexandrea Rizo 1 collaboration

Sergey Zolov 1 collaboration

Venkateshwar G Keshamouni 1 collaboration

Tao Wu 1 collaboration

Gloria Jih 1 collaboration

Eric Perkey 1 collaboration

Yi Wang 1 collaboration

Ke Yu 1 collaboration

Stanley Chun-Wei Lee 1 collaboration

Gwenn Danet-Desnoyers 1 collaboration

Winifred Trotman 1 collaboration

Malathi Kandarpa 1 collaboration

Anitria Cotton 1 collaboration

Omar Abdel-Wahab 1 collaboration

Hongwei Lei 1 collaboration

Monica Guzman 1 collaboration

Luke Peterson 1 collaboration

Tanja Gruber 1 collaboration

Sarah Choi 1 collaboration

Pingda Ren 1 collaboration

Lian-Sheng Li 1 collaboration

Yi Liu 1 collaboration

Francis Burrows 1 collaboration

Christina A Howard 1 collaboration

Sergei Zari 1 collaboration

Joshua Abbott 1 collaboration

Mykhaylo A Potopnyk 1 collaboration

Andrew Henderson 1 collaboration

Anna Mapp 1 collaboration

Maria Luisa Sulis 1 collaboration

David B Lombard 1 collaboration

Suzann Duan 1 collaboration

Sulaiman Sheriff 1 collaboration

Uloma B Elvis-Offiah 1 collaboration

Brandon L Witten 1 collaboration

Travis W Sawyer 1 collaboration

Sinju Sundaresan 1 collaboration

Juanita L Merchant 1 collaboration

Xue Qing David Wang 1 collaboration

Dandan Fan 1 collaboration

Qinyu Han 1 collaboration

Yiman Liu 1 collaboration

Xinyu Wang 1 collaboration

Qinglan Li 1 collaboration

Haley Gore 1 collaboration

Pamela Himadewi 1 collaboration

Gerd P Pfeifer 1 collaboration

Jianzhong Su 1 collaboration

Shasha Chong 1 collaboration

Liling Wan 1 collaboration

Eunice S Wang 1 collaboration

Ghayas C Issa 1 collaboration

Harry P Erba 1 collaboration

Jessica K Altman 1 collaboration

Pau Montesinos 1 collaboration

Stephane DeBotton 1 collaboration

Roland B Walter 1 collaboration

Kristen Pettit 1 collaboration

Michael R Savona 1 collaboration

Mithun Vinod Shah 1 collaboration

Marina Kremyanskaya 1 collaboration

Maria R Baer 1 collaboration

James M Foran 1 collaboration

Gary Schiller 1 collaboration

Lionel Adès 1 collaboration

Mael Heiblig 1 collaboration

Celine Berthon 1 collaboration

Pierre Peterlin 1 collaboration

Eduardo Rodríguez-Arbolí 1 collaboration

Olga Salamero 1 collaboration

Mrinal M Patnaik 1 collaboration

Cristina Papayannidis 1 collaboration

Kun Nie 1 collaboration

Amitava Mitra 1 collaboration

Julie Mackey Ahsan 1 collaboration

Marilyn Tabachri 1 collaboration

Harris S Soifer 1 collaboration

Daniel Corum 1 collaboration

Mollie Leoni 1 collaboration

Stephen Dale 1 collaboration

Amir T Fathi 1 collaboration