John H Bushweller

Affiliations

Department of Molecular Physiology and Biological Physics and Chemistry, University of Virginia, Charlottesville, VA; and.

Publications (15)

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.

Blood

Avec: Christopher P Mill , Warren Fiskus , Courtney D DiNardo , Yimin Qian , Kanak Raina , Kimal Rajapakshe , Dimuthu Perera , Cristian Coarfa , Tapan M Kadia , Joseph D Khoury , Dyana T Saenz , David N Saenz , Anuradha Illendula , Koichi Takahashi , Steven M Kornblau , Michael R Green , Andrew P Futreal , Craig M Crews , Kapil N Bhalla

Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators.

The American journal of pathology

Avec: Michael O'Hare , Dhanesh Amarnani , Hannah A B Whitmore , Miranda An , Claudia Marino , Leslie Ramos , Santiago Delgado-Tirado , Xinyao Hu , Natalia Chmielewska , Anita Chandrahas , Antonia Fitzek , Fabian Heinrich , Stefan Steurer , Benjamin Ondruschka , Markus Glatzel , Susanne Krasemann , Diego Sepulveda-Falla , David Lagares , Julien Pedron , Paul Liu , Joseph F Arboleda-Velasquez , Leo A Kim

Targeting transcription factors in cancer - from undruggable to reality.

Nature reviews. Cancer

Avec:

BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity.

Blood cancer discovery

Avec: Charles R Schmidt , Nicholas J Achille , Aravinda Kuntimaddi , Adam M Boulton , Benjamin I Leach , Shubin Zhang , Nancy J Zeleznik-Le ,

Protein Disulfide Exchange by the Intramembrane Enzymes DsbB, DsbD, and CcdA.

Journal of molecular biology

Avec:

Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin.

Molecular pharmacology

Avec: Mateusz P Czub , Adam M Boulton , Ettore J Rastelli , Nikhil R Tasker , Taber S Maskrey , Isabella K Blanco , Kelley E McQueeney , Wladek Minor , Peter Wipf , Elizabeth R Sharlow , John S Lazo

Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability.

Nature communications

Avec: Jason P Wray , Elitza M Deltcheva , Charlotta Boiers , Simon Е Richardson , Jyoti Bikram Chhetri , John Brown , Sladjana Gagrica , Yanping Guo , Anuradha Illendula , Joost H A Martens , Hendrik G Stunnenberg , Rachael Nimmo , Tariq Enver

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

Leukemia

Avec: Nan Zhou , Alvaro Gutierrez-Uzquiza , Xiang Yu Zheng , Renxu Chang , Dan T Vogl , Alfred L Garfall , Luca Bernabei , Anita Saraf , Laurence Florens , Michael P Washburn , Anuradha Illendula , Luca Busino

An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation.

Blood

Avec: Lei Yu , Greggory Myers , Chia-Jui Ku , Emily Schneider , Yu Wang , Sharon A Singh , Natee Jearawiriyapaisarn , Andrew White , Takashi Moriguchi , Rami Khoriaty , Masayuki Yamamoto , Michael G Rosenfeld , Julien Pedron , Kim-Chew Lim , James Douglas Engel

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.

Science advances

Avec: Kee-Beom Kim , Ashish Kabra , Dong-Wook Kim , Yongming Xue , Yuanjian Huang , Pei-Chi Hou , Yunpeng Zhou , Leilani J Miranda , Jae-Il Park , Xiaobing Shi , Timothy P Bender , Kwon-Sik Park

Small-Molecule Inhibitors of the MLL1 CXXC Domain, an Epigenetic Reader of DNA Methylation.

ACS medicinal chemistry letters

Avec: Hanuman P Kalmode , Izabella Podsiadly , Ashish Kabra , Adam Boulton , Prabhakar Reddy , Yan Gao , Christopher Li ,

Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking.

Oncotarget

Avec: Joshua T Rose , Eliana Moskovitz , Joseph R Boyd , Jonathan A Gordon , Nicole A Bouffard , Andrew J Fritz , Anuradha Illendula , Jane B Lian , Janet L Stein , Sayyed K Zaidi , Gary S Stein

The interaction between RUNX2 and core binding factor beta as a potential therapeutic target in canine osteosarcoma.

Veterinary and comparative oncology

Avec: Fernando Alegre , Amanda R Ormonde , Dayn R Godinez , Anuradha Illendula , Luke A Wittenburg

TNF-α signaling regulates RUNX1 function in endothelial cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Hannah A B Whitmore , Dhanesh Amarnani , Michael O'Hare , Santiago Delgado-Tirado , Lucia Gonzalez-Buendia , Miranda An , Julien Pedron , Joseph F Arboleda-Velasquez , Leo A Kim

N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia.

Science advances

Avec: Philomina Sona Peramangalam , Sridevi Surapally , Anthony J Veltri , Shikan Zheng , Robert Burns , Nan Zhu , Sridhar Rao , Carsten Muller-Tidow , John A Pulikkan

Réseau de co-auteurs

Anuradha Illendula 5 collaborations

Julien Pedron 3 collaborations

Michael O'Hare 2 collaborations

Dhanesh Amarnani 2 collaborations

Hannah A B Whitmore 2 collaborations

Miranda An 2 collaborations

Santiago Delgado-Tirado 2 collaborations

Joseph F Arboleda-Velasquez 2 collaborations

Leo A Kim 2 collaborations

Adam M Boulton 2 collaborations

Ashish Kabra 2 collaborations

Christopher P Mill 1 collaboration

Warren Fiskus 1 collaboration

Courtney D DiNardo 1 collaboration

Yimin Qian 1 collaboration

Kanak Raina 1 collaboration

Kimal Rajapakshe 1 collaboration

Dimuthu Perera 1 collaboration

Cristian Coarfa 1 collaboration

Tapan M Kadia 1 collaboration

Joseph D Khoury 1 collaboration

Dyana T Saenz 1 collaboration

David N Saenz 1 collaboration

Koichi Takahashi 1 collaboration

Steven M Kornblau 1 collaboration

Michael R Green 1 collaboration

Andrew P Futreal 1 collaboration

Craig M Crews 1 collaboration

Kapil N Bhalla 1 collaboration

Claudia Marino 1 collaboration

Leslie Ramos 1 collaboration

Xinyao Hu 1 collaboration

Natalia Chmielewska 1 collaboration

Anita Chandrahas 1 collaboration

Antonia Fitzek 1 collaboration

Fabian Heinrich 1 collaboration

Stefan Steurer 1 collaboration

Benjamin Ondruschka 1 collaboration

Markus Glatzel 1 collaboration

Susanne Krasemann 1 collaboration

Diego Sepulveda-Falla 1 collaboration

David Lagares 1 collaboration

Paul Liu 1 collaboration

Charles R Schmidt 1 collaboration

Nicholas J Achille 1 collaboration

Aravinda Kuntimaddi 1 collaboration

Benjamin I Leach 1 collaboration

Shubin Zhang 1 collaboration

Nancy J Zeleznik-Le 1 collaboration

Mateusz P Czub 1 collaboration

Ettore J Rastelli 1 collaboration

Nikhil R Tasker 1 collaboration

Taber S Maskrey 1 collaboration

Isabella K Blanco 1 collaboration

Kelley E McQueeney 1 collaboration

Wladek Minor 1 collaboration

Peter Wipf 1 collaboration

Elizabeth R Sharlow 1 collaboration

John S Lazo 1 collaboration

Jason P Wray 1 collaboration

Elitza M Deltcheva 1 collaboration

Charlotta Boiers 1 collaboration

Simon Е Richardson 1 collaboration

Jyoti Bikram Chhetri 1 collaboration

John Brown 1 collaboration

Sladjana Gagrica 1 collaboration

Yanping Guo 1 collaboration

Joost H A Martens 1 collaboration

Hendrik G Stunnenberg 1 collaboration

Rachael Nimmo 1 collaboration

Tariq Enver 1 collaboration

Nan Zhou 1 collaboration

Alvaro Gutierrez-Uzquiza 1 collaboration

Xiang Yu Zheng 1 collaboration

Renxu Chang 1 collaboration

Dan T Vogl 1 collaboration

Alfred L Garfall 1 collaboration

Luca Bernabei 1 collaboration

Anita Saraf 1 collaboration

Laurence Florens 1 collaboration

Michael P Washburn 1 collaboration

Luca Busino 1 collaboration

Lei Yu 1 collaboration

Greggory Myers 1 collaboration

Chia-Jui Ku 1 collaboration

Emily Schneider 1 collaboration

Yu Wang 1 collaboration

Sharon A Singh 1 collaboration

Natee Jearawiriyapaisarn 1 collaboration

Andrew White 1 collaboration

Takashi Moriguchi 1 collaboration

Rami Khoriaty 1 collaboration

Masayuki Yamamoto 1 collaboration

Michael G Rosenfeld 1 collaboration

Kim-Chew Lim 1 collaboration

James Douglas Engel 1 collaboration

Kee-Beom Kim 1 collaboration

Dong-Wook Kim 1 collaboration

Yongming Xue 1 collaboration

Yuanjian Huang 1 collaboration

Pei-Chi Hou 1 collaboration

Yunpeng Zhou 1 collaboration

Leilani J Miranda 1 collaboration

Jae-Il Park 1 collaboration

Xiaobing Shi 1 collaboration

Timothy P Bender 1 collaboration

Kwon-Sik Park 1 collaboration

Hanuman P Kalmode 1 collaboration

Izabella Podsiadly 1 collaboration

Adam Boulton 1 collaboration

Prabhakar Reddy 1 collaboration

Yan Gao 1 collaboration

Christopher Li 1 collaboration

Joshua T Rose 1 collaboration

Eliana Moskovitz 1 collaboration

Joseph R Boyd 1 collaboration

Jonathan A Gordon 1 collaboration

Nicole A Bouffard 1 collaboration

Andrew J Fritz 1 collaboration

Jane B Lian 1 collaboration

Janet L Stein 1 collaboration

Sayyed K Zaidi 1 collaboration

Gary S Stein 1 collaboration

Fernando Alegre 1 collaboration

Amanda R Ormonde 1 collaboration

Dayn R Godinez 1 collaboration

Luke A Wittenburg 1 collaboration

Lucia Gonzalez-Buendia 1 collaboration

Philomina Sona Peramangalam 1 collaboration

Sridevi Surapally 1 collaboration

Anthony J Veltri 1 collaboration

Shikan Zheng 1 collaboration

Robert Burns 1 collaboration

Nan Zhu 1 collaboration

Sridhar Rao 1 collaboration

Carsten Muller-Tidow 1 collaboration

John A Pulikkan 1 collaboration