Jeffrey J Babon

Affiliations

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Vic 3052, Australia.
Department of Medical Biology, The University of Melbourne, Parkville, Vic 3050, Australia.

Publications (27)

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6Rα).

The Biochemical journal

Avec: Dina Stockwell , Ladina DiRago , Jian-Guo Zhang , Artem Laktyushin , Jose Villadangos , Alan Ching , Satoshi Ishido , Douglas J Hilton , Warren S Alexander , Nicos A Nicola

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

Nature communications

Avec: Edmond M Linossi , Kunlun Li , Gianluca Veggiani , Cyrus Tan , Farhad Dehkhoda , Colin Hockings , Dale J Calleja , Narelle Keating , Rebecca Feltham , Andrew J Brooks , Shawn S Li , Sachdev S Sidhu , Nadia J Kershaw , Sandra E Nicholson

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.

Nature communications

Avec: Shuwei Liang , Eric Tran , Xin Du , Jiajun Dong , Harrison Sudholz , Hao Chen , Zihan Qu , Nicholas D Huntington , Nadia J Kershaw , Zhong-Yin Zhang , Jonathan B Baell , Florian Wiede , Tony Tiganis

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9.

Proteomics

Avec: Jarrod J Sandow , Andrew I Webb , Dina Stockwell , Nadia J Kershaw , Cyrus Tan , Satoshi Ishido , Warren S Alexander , Douglas J Hilton , Nicos A Nicola

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.

Nature immunology

Avec: Mary Speir , Cameron J Nowell , Alyce A Chen , Joanne A O'Donnell , Isaac S Shamie , Paul R Lakin , Akshay A D'Cruz , Roman O Braun , Jeff J Babon , Rowena S Lewis , Meghan Bliss-Moreau , Inbar Shlomovitz , Shu Wang , Louise H Cengia , Anca I Stoica , Razq Hakem , Michelle A Kelliher , Lorraine A O'Reilly , Heather Patsiouras , Kate E Lawlor , Edie Weller , Nathan E Lewis , Andrew W Roberts , Motti Gerlic , Ben A Croker

Dissecting the molecular control of Interleukin 6 signaling using the M1 cell line.

Cytokine

Avec: Rhiannon Morris , Douglas J Hilton , Andrew Jarratt ,

NMR measurement of biomolecular translational and rotational motion for evaluating changes of protein oligomeric state in solution.

European biophysics journal : EBJ

Avec: Shenggen Yao , David W Keizer , Frances Separovic

Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease.

Leukemia

Avec: Kira Behrens , Maria Kauppi , Elizabeth M Viney , Andrew J Kueh , Craig D Hyland , Tracy A Willson , Liam Salleh , Carolyn A de Graaf , Marco J Herold , Nicos A Nicola , Warren S Alexander

Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR.

Langmuir : the ACS journal of surfaces and colloids

Avec: Thomas G Meikle , David W Keizer , Calum J Drummond , Frances Separovic , Charlotte E Conn , Shenggen Yao

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.

The Journal of experimental medicine

Avec: Cynthia Louis , Fernando Souza-Fonseca-Guimaraes , Yuyan Yang , Damian D'Silva , Tobias Kratina , Laura Dagley , Soroor Hediyeh-Zadeh , Jai Rautela , Seth Lucian Masters , Melissa J Davis , Bogoljub Ciric , Eric Vivier , Warren S Alexander , Nicholas D Huntington , Ian P Wicks

Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.

The Journal of experimental medicine

Avec: Yaoyuan Zhang , Rhiannon Morris , Grant J Brown , Ayla May D Lorenzo , Xiangpeng Meng , Nadia J Kershaw , Pamudika Kiridena , Gaétan Burgio , Simon Gross , Jean Y Cappello , Qian Shen , Hao Wang , Cynthia Turnbull , Tom Lea-Henry , Maurice Stanley , Zhijia Yu , Fiona D Ballard , Aaron Chuah , James C Lee , Ann-Maree Hatch , Anselm Enders , Seth L Masters , Alexander P Headley , Peter Trnka , Dominic Mallon , Jeffery T Fletcher , Giles D Walters , Mario Šestan , Marija Jelušić , Matthew C Cook , Vicki Athanasopoulos , David A Fulcher , Carola G Vinuesa , Julia I Ellyard

The JAK-STAT pathway: from structural biology to cytokine engineering.

Signal transduction and targeted therapy

Avec: You Lv , Jianxun Qi , Longxing Cao , Guohuang Fan , Jiajia Lang , Jin Zhang , Pengbing Mi , Bostjan Kobe , Faming Wang

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids.

Journal of magnetic resonance (San Diego, Calif. : 1997)

Avec: Thomas G Meikle , Ashish Sethi , David W Keizer , Frances Separovic , Paul R Gooley , Charlotte E Conn , Shenggen Yao

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.

Nature communications

Avec: Rhiannon Morris , Yaoyuan Zhang , Julia I Ellyard , Carola G Vinuesa , James M Murphy , Artem Laktyushin , Nadia J Kershaw ,

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs.

The Biochemical journal

Avec: Lung-Yu Liang , Michael Roy , Christopher R Horne , Jarrod J Sandow , Minglyanna Surudoi , Laura F Dagley , Samuel N Young , Toby Dite , Peter W Janes , Onisha Patel , James M Murphy , Isabelle S Lucet

The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo.

Cytokine

Avec: Karen Doggett , Narelle Keating , Farhad Dehkhoda , Grace M Bidgood , Lizeth G Meza Guzman , Evelyn Leong , Andrew Kueh , Nicos A Nicola , Nadia J Kershaw , Warren S Alexander , Sandra E Nicholson

Structure guided studies of the interaction between PTP1B and JAK.

Communications biology

Avec: Rhiannon Morris , Narelle Keating , Cyrus Tan , Hao Chen , Artem Laktyushin , Tamanna Saiyed , Nicholas P D Liau , Nicos A Nicola , Tony Tiganis , Nadia J Kershaw ,

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1.

Cancers

Avec: Nicholas P D Liau , Artem Laktyushin , Rhiannon Morris , Jarrod J Sandow , Nicos A Nicola , Nadia J Kershaw ,

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.

Nature communications

Avec: Simon H Jiang , Vicki Athanasopoulos , Julia I Ellyard , Aaron Chuah , Jean Cappello , Amelia Cook , Savit B Prabhu , Jacob Cardenas , Jinghua Gu , Maurice Stanley , Jonathan A Roco , Ilenia Papa , Mehmet Yabas , Giles D Walters , Gaetan Burgio , Kathryn McKeon , James M Byers , Charlotte Burrin , Anselm Enders , Lisa A Miosge , Pablo F Canete , Marija Jelusic , Velibor Tasic , Adrian C Lungu , Stephen I Alexander , Arthur R Kitching , David A Fulcher , Nan Shen , Todor Arsov , Paul A Gatenby , Jeff J Babon , Dominic F Mallon , Carmen de Lucas Collantes , Eric A Stone , Philip Wu , Matthew A Field , Thomas D Andrews , Eun Cho , Virginia Pascual , Matthew C Cook , Carola G Vinuesa

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR.

The journal of physical chemistry. B

Avec: Thomas G Meikle , David W Keizer , Calum J Drummond , Frances Separovic , Charlotte E Conn , Shenggen Yao

Persistence of myelofibrosis treated with ruxolitinib: biology and clinical implications.

Haematologica

Avec: David M Ross , Denis Tvorogov , Daniel Thomas

Optimization of Phosphotyrosine Peptides that Target the SH2 Domain of SOCS1 and Block Substrate Ubiquitination.

ACS chemical biology

Avec: Hao Chen , Yuntong Wu , Kunlun Li , Iain Currie , Narelle Keating , Farhad Dehkhoda , Christoph Grohmann , Sandra E Nicholson , Brad E Sleebs

TLR7 gain-of-function genetic variation causes human lupus.

Nature

Avec: Grant J Brown , Pablo F Cañete , Hao Wang , Arti Medhavy , Josiah Bones , Jonathan A Roco , Yuke He , Yuting Qin , Jean Cappello , Julia I Ellyard , Katharine Bassett , Qian Shen , Gaetan Burgio , Yaoyuan Zhang , Cynthia Turnbull , Xiangpeng Meng , Phil Wu , Eun Cho , Lisa A Miosge , T Daniel Andrews , Matt A Field , Denis Tvorogov , Angel F Lopez , Cristina Aparicio López , África Gónzalez-Murillo , Daniel Clemente Garulo , Virginia Pascual , Tess Levy , Eric J Mallack , Daniel G Calame , Timothy Lotze , James R Lupski , Huihua Ding , Tomalika R Ullah , Giles D Walters , Mark E Koina , Matthew C Cook , Nan Shen , Carmen de Lucas Collantes , Ben Corry , Michael P Gantier , Vicki Athanasopoulos , Carola G Vinuesa

The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis.

Pharmaceuticals (Basel, Switzerland)

Avec: Rhiannon Morris , Liesl Butler , Andrew Perkins , Nadia J Kershaw ,

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.

Bioscience reports

Avec: Kunlun Li , Lizeth G Meza Guzman , Lachlan Whitehead , Evelyn Leong , Andrew Kueh , Warren S Alexander , Nadia J Kershaw , Karen Doggett , Sandra E Nicholson

Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.

Nature communications

Avec: Kaiseal T G Sarson-Lawrence , Joshua M Hardy , Josephine Iaria , Dina Stockwell , Kira Behrens , Tamanna Saiyed , Cyrus Tan , Leila Jebeli , Nichollas E Scott , Toby A Dite , Nicos A Nicola , Andrew P Leis , Nadia J Kershaw

Small molecule drug discovery targeting the JAK-STAT pathway.

Pharmacological research

Avec: You Lv , Pengbing Mi , Guohuang Fan , Jianxun Qi , Longxing Cao , Jiajia Lang , Jin Zhang , Faming Wang , Bostjan Kobe

Réseau de co-auteurs

Nadia J Kershaw 11 collaborations

Nicos A Nicola 7 collaborations

Warren S Alexander 6 collaborations

Rhiannon Morris 6 collaborations

Artem Laktyushin 4 collaborations

Cyrus Tan 4 collaborations

Narelle Keating 4 collaborations

Sandra E Nicholson 4 collaborations

Shenggen Yao 4 collaborations

David W Keizer 4 collaborations

Frances Separovic 4 collaborations

Carola G Vinuesa 4 collaborations

Julia I Ellyard 4 collaborations

Dina Stockwell 3 collaborations

Douglas J Hilton 3 collaborations

Kunlun Li 3 collaborations

Farhad Dehkhoda 3 collaborations

Hao Chen 3 collaborations

Jarrod J Sandow 3 collaborations

Thomas G Meikle 3 collaborations

Charlotte E Conn 3 collaborations

Yaoyuan Zhang 3 collaborations

Giles D Walters 3 collaborations

Matthew C Cook 3 collaborations

Vicki Athanasopoulos 3 collaborations

Satoshi Ishido 2 collaborations

Nicholas D Huntington 2 collaborations

Tony Tiganis 2 collaborations

Jeff J Babon 2 collaborations

Kira Behrens 2 collaborations

Calum J Drummond 2 collaborations

Grant J Brown 2 collaborations

Xiangpeng Meng 2 collaborations

Qian Shen 2 collaborations

Hao Wang 2 collaborations

Cynthia Turnbull 2 collaborations

Maurice Stanley 2 collaborations

Aaron Chuah 2 collaborations

Anselm Enders 2 collaborations

David A Fulcher 2 collaborations

You Lv 2 collaborations

Jianxun Qi 2 collaborations

Longxing Cao 2 collaborations

Guohuang Fan 2 collaborations

Jiajia Lang 2 collaborations

Jin Zhang 2 collaborations

Pengbing Mi 2 collaborations

Bostjan Kobe 2 collaborations

Faming Wang 2 collaborations

James M Murphy 2 collaborations

Karen Doggett 2 collaborations

Lizeth G Meza Guzman 2 collaborations

Evelyn Leong 2 collaborations

Andrew Kueh 2 collaborations

Tamanna Saiyed 2 collaborations

Nicholas P D Liau 2 collaborations

Jean Cappello 2 collaborations

Jonathan A Roco 2 collaborations

Gaetan Burgio 2 collaborations

Lisa A Miosge 2 collaborations

Nan Shen 2 collaborations

Carmen de Lucas Collantes 2 collaborations

Eun Cho 2 collaborations

Virginia Pascual 2 collaborations

Denis Tvorogov 2 collaborations

Ladina DiRago 1 collaboration

Jian-Guo Zhang 1 collaboration

Jose Villadangos 1 collaboration

Alan Ching 1 collaboration

Edmond M Linossi 1 collaboration

Gianluca Veggiani 1 collaboration

Colin Hockings 1 collaboration

Dale J Calleja 1 collaboration

Rebecca Feltham 1 collaboration

Andrew J Brooks 1 collaboration

Shawn S Li 1 collaboration

Sachdev S Sidhu 1 collaboration

Shuwei Liang 1 collaboration

Eric Tran 1 collaboration

Xin Du 1 collaboration

Jiajun Dong 1 collaboration

Harrison Sudholz 1 collaboration

Zihan Qu 1 collaboration

Zhong-Yin Zhang 1 collaboration

Jonathan B Baell 1 collaboration

Florian Wiede 1 collaboration

Andrew I Webb 1 collaboration

Mary Speir 1 collaboration

Cameron J Nowell 1 collaboration

Alyce A Chen 1 collaboration

Joanne A O'Donnell 1 collaboration

Isaac S Shamie 1 collaboration

Paul R Lakin 1 collaboration

Akshay A D'Cruz 1 collaboration

Roman O Braun 1 collaboration

Rowena S Lewis 1 collaboration

Meghan Bliss-Moreau 1 collaboration

Inbar Shlomovitz 1 collaboration

Shu Wang 1 collaboration

Louise H Cengia 1 collaboration

Anca I Stoica 1 collaboration

Razq Hakem 1 collaboration

Michelle A Kelliher 1 collaboration

Lorraine A O'Reilly 1 collaboration

Heather Patsiouras 1 collaboration

Kate E Lawlor 1 collaboration

Edie Weller 1 collaboration

Nathan E Lewis 1 collaboration

Andrew W Roberts 1 collaboration

Motti Gerlic 1 collaboration

Ben A Croker 1 collaboration

Andrew Jarratt 1 collaboration

Maria Kauppi 1 collaboration

Elizabeth M Viney 1 collaboration

Andrew J Kueh 1 collaboration

Craig D Hyland 1 collaboration

Tracy A Willson 1 collaboration

Liam Salleh 1 collaboration

Carolyn A de Graaf 1 collaboration

Marco J Herold 1 collaboration

Cynthia Louis 1 collaboration

Fernando Souza-Fonseca-Guimaraes 1 collaboration

Yuyan Yang 1 collaboration

Damian D'Silva 1 collaboration

Tobias Kratina 1 collaboration

Laura Dagley 1 collaboration

Soroor Hediyeh-Zadeh 1 collaboration

Jai Rautela 1 collaboration

Seth Lucian Masters 1 collaboration

Melissa J Davis 1 collaboration

Bogoljub Ciric 1 collaboration

Eric Vivier 1 collaboration

Ian P Wicks 1 collaboration

Ayla May D Lorenzo 1 collaboration

Pamudika Kiridena 1 collaboration

Gaétan Burgio 1 collaboration

Simon Gross 1 collaboration

Jean Y Cappello 1 collaboration

Tom Lea-Henry 1 collaboration

Zhijia Yu 1 collaboration

Fiona D Ballard 1 collaboration

James C Lee 1 collaboration

Ann-Maree Hatch 1 collaboration

Seth L Masters 1 collaboration

Alexander P Headley 1 collaboration

Peter Trnka 1 collaboration

Dominic Mallon 1 collaboration

Jeffery T Fletcher 1 collaboration

Mario Šestan 1 collaboration

Marija Jelušić 1 collaboration

Ashish Sethi 1 collaboration

Paul R Gooley 1 collaboration

Lung-Yu Liang 1 collaboration

Michael Roy 1 collaboration

Christopher R Horne 1 collaboration

Minglyanna Surudoi 1 collaboration

Laura F Dagley 1 collaboration

Samuel N Young 1 collaboration

Toby Dite 1 collaboration

Peter W Janes 1 collaboration

Onisha Patel 1 collaboration

Isabelle S Lucet 1 collaboration

Grace M Bidgood 1 collaboration

Simon H Jiang 1 collaboration

Amelia Cook 1 collaboration

Savit B Prabhu 1 collaboration

Jacob Cardenas 1 collaboration

Jinghua Gu 1 collaboration

Ilenia Papa 1 collaboration

Mehmet Yabas 1 collaboration

Kathryn McKeon 1 collaboration

James M Byers 1 collaboration

Charlotte Burrin 1 collaboration

Pablo F Canete 1 collaboration

Marija Jelusic 1 collaboration

Velibor Tasic 1 collaboration

Adrian C Lungu 1 collaboration

Stephen I Alexander 1 collaboration

Arthur R Kitching 1 collaboration

Todor Arsov 1 collaboration

Paul A Gatenby 1 collaboration

Dominic F Mallon 1 collaboration

Eric A Stone 1 collaboration

Philip Wu 1 collaboration

Matthew A Field 1 collaboration

Thomas D Andrews 1 collaboration

David M Ross 1 collaboration

Daniel Thomas 1 collaboration

Yuntong Wu 1 collaboration

Iain Currie 1 collaboration

Christoph Grohmann 1 collaboration

Brad E Sleebs 1 collaboration

Pablo F Cañete 1 collaboration

Arti Medhavy 1 collaboration

Josiah Bones 1 collaboration

Yuke He 1 collaboration

Yuting Qin 1 collaboration

Katharine Bassett 1 collaboration

Phil Wu 1 collaboration

T Daniel Andrews 1 collaboration

Matt A Field 1 collaboration

Angel F Lopez 1 collaboration

Cristina Aparicio López 1 collaboration

África Gónzalez-Murillo 1 collaboration

Daniel Clemente Garulo 1 collaboration

Tess Levy 1 collaboration

Eric J Mallack 1 collaboration

Daniel G Calame 1 collaboration

Timothy Lotze 1 collaboration

James R Lupski 1 collaboration

Huihua Ding 1 collaboration

Tomalika R Ullah 1 collaboration

Mark E Koina 1 collaboration

Ben Corry 1 collaboration

Michael P Gantier 1 collaboration

Liesl Butler 1 collaboration

Andrew Perkins 1 collaboration

Lachlan Whitehead 1 collaboration

Kaiseal T G Sarson-Lawrence 1 collaboration

Joshua M Hardy 1 collaboration

Josephine Iaria 1 collaboration

Leila Jebeli 1 collaboration

Nichollas E Scott 1 collaboration

Toby A Dite 1 collaboration

Andrew P Leis 1 collaboration