Jeffrey A Pfefferkorn

Affiliations

Internal Medicine Research Unit, Pfizer Inc, Cambridge, MA, USA.

Publications (10)

ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.

Nature medicine

Avec: Roberto A Calle , Neeta B Amin , Santos Carvajal-Gonzalez , Trenton T Ross , Arthur Bergman , Sudeepta Aggarwal , Collin Crowley , Anthony Rinaldi , Jessica Mancuso , Naresh Aggarwal , Veena Somayaji , Malgorzata Inglot , Theresa A Tuthill , Kou Kou , Magalie Boucher , Greg Tesz , Robert Dullea , Kendra K Bence , Albert M Kim , William P Esler

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Journal of medicinal chemistry

Avec: Kim Huard , Aaron C Smith , Gregg Cappon , Robert L Dow , David J Edmonds , Ayman El-Kattan , William P Esler , Dilinie P Fernando , David A Griffith , Amit S Kalgutkar , Trenton T Ross , Scott W Bagley , David Beebe , Yi-An Bi , Shawn Cabral , Collin Crowley , Shawn D Doran , Matthew S Dowling , Spiros Liras , Vincent Mascitti , Mark Niosi , Jana Polivkova , Cathy Préville , David A Price , Andre Shavnya , Norimitsu Shirai , Andrew H Smith , James R Southers , David A Tess , Benjamin A Thuma , Manthena V Varma , Xiaojing Yang

Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems.

Cellular and molecular gastroenterology and hepatology

Avec: Trenton T Ross , Collin Crowley , Kenneth L Kelly , Anthony Rinaldi , David A Beebe , Matthew P Lech , Robert V Martinez , Santos Carvajal-Gonzalez , Magalie Boucher , Dinesh Hirenallur-Shanthappa , Jeffrey Morin , Alan C Opsahl , Sarah R Vargas , Kendra K Bence , William P Esler

De novo lipogenesis is essential for platelet production in humans.

Nature metabolism

Avec: Kenneth L Kelly , William J Reagan , Gabriele E Sonnenberg , Michelle Clasquin , Katherine Hales , Shoh Asano , Paul A Amor , Santos Carvajal-Gonzalez , Norimitsu Shirai , Marcy D Matthews , Kelvin W Li , Marc K Hellerstein , Nicholas B Vera , Trenton T Ross , Gregg Cappon , Arthur Bergman , Clare Buckeridge , Zhongyuan Sun , Enida Ziso Qejvanaj , Theodore Schmahai , David Beebe , William P Esler

Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.

Science translational medicine

Avec: William P Esler , Gregory J Tesz , Marc K Hellerstein , Carine Beysen , Raja Sivamani , Scott M Turner , Steven M Watkins , Paul A Amor , Santos Carvajal-Gonzalez , Frank J Geoly , Kathleen E Biddle , Julie J Purkal , Mark Fitch , Clare Buckeridge , Annette M Silvia , David A Griffith , Matthew Gorgoglione , Lauren Hassoun , Suzana S Bosanac , Nicholas B Vera , Timothy P Rolph , Gabriele E Sonnenberg

Effect of Hepatic Organic Anion-Transporting Polypeptide 1B Inhibition and Chronic Kidney Disease on the Pharmacokinetics of a Liver-Targeted Glucokinase Activator: A Model-Based Evaluation.

Clinical pharmacology and therapeutics

Avec: Arthur Bergman , Yi-An Bi , Sumathy Mathialagan , John Litchfield , David J Kazierad , Manthena V S Varma

Quantitation of Urinary Acylcarnitines by DMS-MS/MS Uncovers the Effects of Total Body Irradiation in Cancer Patients.

Journal of the American Society for Mass Spectrometry

Avec: Nicholas B Vera , Stephen L Coy , Evagelia C Laiakis , Albert J Fornace , Michelle Clasquin , Christopher A Barker , Paul Vouros

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

Journal of medicinal chemistry

Avec: Kentaro Futatsugi , Aaron C Smith , Meihua Tu , Brian Raymer , Kay Ahn , Steven B Coffey , Matthew S Dowling , Dilinie P Fernando , Jemy A Gutierrez , Kim Huard , Jayasankar Jasti , Amit S Kalgutkar , John D Knafels , Jayvardhan Pandit , Kevin D Parris , Sylvie Perez , David A Price , Tim Ryder , Andre Shavnya , Ingrid A Stock , Andy S Tsai , Gregory J Tesz , Benjamin A Thuma , Yan Weng , Hanna M Wisniewska , Gang Xing , Jun Zhou , Thomas V Magee

Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.

Molecular metabolism

Avec: Jemy A Gutierrez , Wei Liu , Sylvie Perez , Gang Xing , Gabriele Sonnenberg , Kou Kou , Matt Blatnik , Richard Allen , Yan Weng , Nicholas B Vera , Kristin Chidsey , Arthur Bergman , Veena Somayaji , Collin Crowley , Michelle F Clasquin , Anu Nigam , Melissa A Fulham , Derek M Erion , Trenton T Ross , William P Esler , Thomas V Magee , Kendra K Bence , Morris J Birnbaum , Gregory J Tesz

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

Journal of medicinal chemistry

Avec: Kentaro Futatsugi , Shawn Cabral , Daniel W Kung , Kim Huard , Esther Lee , Markus Boehm , Jonathan Bauman , Ronald W Clark , Steven B Coffey , Collin Crowley , Anne-Marie Dechert-Schmitt , Matthew S Dowling , Robert Dullea , James R Gosset , Amit S Kalgutkar , Kou Kou , Qifang Li , Yajing Lian , Paula M Loria , Allyn T Londregan , Mark Niosi , Christine Orozco , John C Pettersen , Jana Polivkova , Trenton T Ross , Raman Sharma , Ingrid A Stock , Gregory Tesz , Hanna Wisniewska , Bryan Goodwin , David A Price

Réseau de co-auteurs

Trenton T Ross 6 collaborations

William P Esler 6 collaborations

Collin Crowley 5 collaborations

Santos Carvajal-Gonzalez 4 collaborations

Arthur Bergman 4 collaborations

Nicholas B Vera 4 collaborations

Kou Kou 3 collaborations

Kendra K Bence 3 collaborations

Kim Huard 3 collaborations

Amit S Kalgutkar 3 collaborations

Matthew S Dowling 3 collaborations

David A Price 3 collaborations

Gregory J Tesz 3 collaborations

Anthony Rinaldi 2 collaborations

Veena Somayaji 2 collaborations

Magalie Boucher 2 collaborations

Robert Dullea 2 collaborations

Aaron C Smith 2 collaborations

Gregg Cappon 2 collaborations

Dilinie P Fernando 2 collaborations

David A Griffith 2 collaborations

David Beebe 2 collaborations

Yi-An Bi 2 collaborations

Shawn Cabral 2 collaborations

Mark Niosi 2 collaborations

Jana Polivkova 2 collaborations

Andre Shavnya 2 collaborations

Norimitsu Shirai 2 collaborations

Benjamin A Thuma 2 collaborations

Kenneth L Kelly 2 collaborations

Gabriele E Sonnenberg 2 collaborations

Michelle Clasquin 2 collaborations

Paul A Amor 2 collaborations

Marc K Hellerstein 2 collaborations

Clare Buckeridge 2 collaborations

Kentaro Futatsugi 2 collaborations

Steven B Coffey 2 collaborations

Jemy A Gutierrez 2 collaborations

Sylvie Perez 2 collaborations

Ingrid A Stock 2 collaborations

Yan Weng 2 collaborations

Gang Xing 2 collaborations

Thomas V Magee 2 collaborations

Roberto A Calle 1 collaboration

Neeta B Amin 1 collaboration

Sudeepta Aggarwal 1 collaboration

Jessica Mancuso 1 collaboration

Naresh Aggarwal 1 collaboration

Malgorzata Inglot 1 collaboration

Theresa A Tuthill 1 collaboration

Greg Tesz 1 collaboration

Albert M Kim 1 collaboration

Robert L Dow 1 collaboration

David J Edmonds 1 collaboration

Ayman El-Kattan 1 collaboration

Scott W Bagley 1 collaboration

Shawn D Doran 1 collaboration

Spiros Liras 1 collaboration

Vincent Mascitti 1 collaboration

Cathy Préville 1 collaboration

Andrew H Smith 1 collaboration

James R Southers 1 collaboration

David A Tess 1 collaboration

Manthena V Varma 1 collaboration

Xiaojing Yang 1 collaboration

David A Beebe 1 collaboration

Matthew P Lech 1 collaboration

Robert V Martinez 1 collaboration

Dinesh Hirenallur-Shanthappa 1 collaboration

Jeffrey Morin 1 collaboration

Alan C Opsahl 1 collaboration

Sarah R Vargas 1 collaboration

William J Reagan 1 collaboration

Katherine Hales 1 collaboration

Shoh Asano 1 collaboration

Marcy D Matthews 1 collaboration

Kelvin W Li 1 collaboration

Zhongyuan Sun 1 collaboration

Enida Ziso Qejvanaj 1 collaboration

Theodore Schmahai 1 collaboration

Carine Beysen 1 collaboration

Raja Sivamani 1 collaboration

Scott M Turner 1 collaboration

Steven M Watkins 1 collaboration

Frank J Geoly 1 collaboration

Kathleen E Biddle 1 collaboration

Julie J Purkal 1 collaboration

Mark Fitch 1 collaboration

Annette M Silvia 1 collaboration

Matthew Gorgoglione 1 collaboration

Lauren Hassoun 1 collaboration

Suzana S Bosanac 1 collaboration

Timothy P Rolph 1 collaboration

Sumathy Mathialagan 1 collaboration

John Litchfield 1 collaboration

David J Kazierad 1 collaboration

Manthena V S Varma 1 collaboration

Stephen L Coy 1 collaboration

Evagelia C Laiakis 1 collaboration

Albert J Fornace 1 collaboration

Christopher A Barker 1 collaboration

Paul Vouros 1 collaboration

Meihua Tu 1 collaboration

Brian Raymer 1 collaboration

Kay Ahn 1 collaboration

Jayasankar Jasti 1 collaboration

John D Knafels 1 collaboration

Jayvardhan Pandit 1 collaboration

Kevin D Parris 1 collaboration

Tim Ryder 1 collaboration

Andy S Tsai 1 collaboration

Hanna M Wisniewska 1 collaboration

Jun Zhou 1 collaboration

Wei Liu 1 collaboration

Gabriele Sonnenberg 1 collaboration

Matt Blatnik 1 collaboration

Richard Allen 1 collaboration

Kristin Chidsey 1 collaboration

Michelle F Clasquin 1 collaboration

Anu Nigam 1 collaboration

Melissa A Fulham 1 collaboration

Derek M Erion 1 collaboration

Morris J Birnbaum 1 collaboration

Daniel W Kung 1 collaboration

Esther Lee 1 collaboration

Markus Boehm 1 collaboration

Jonathan Bauman 1 collaboration

Ronald W Clark 1 collaboration

Anne-Marie Dechert-Schmitt 1 collaboration

James R Gosset 1 collaboration

Qifang Li 1 collaboration

Yajing Lian 1 collaboration

Paula M Loria 1 collaboration

Allyn T Londregan 1 collaboration

Christine Orozco 1 collaboration

John C Pettersen 1 collaboration

Raman Sharma 1 collaboration

Gregory Tesz 1 collaboration

Hanna Wisniewska 1 collaboration

Bryan Goodwin 1 collaboration