Jean-Louis Reymond

Affiliations

Department of Chemistry and Biochemistry, National Center for Competence in Research NCCR TransCure, University of Bern, Freiestrasse 3, CH-3012 Bern;, Email: jean-louis.reymond@dcb.unibe.ch.

Publications (28)

Exploring Chemical Space with Machine Learning.

Chimia

Avec: Josep Arús-Pous , Mahendra Awale , Daniel Probst ,

One molecular fingerprint to rule them all: drugs, biomolecules, and the metabolome.

Journal of cheminformatics

Avec: Alice Capecchi , Daniel Probst ,

The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4.

Chemical communications (Cambridge, England)

Avec: Xingguang Cai , Sacha Javor , Bee Ha Gan , Thilo Köhler ,

A Potent and Selective Janus Kinase Inhibitor with a Chiral 3D-Shaped Triquinazine Ring System from Chemical Space.

Angewandte Chemie (International ed. in English)

Avec: Kris Meier , Josep Arús-Pous ,

Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library.

ChemMedChem

Avec: Jonai Pujol-Giménez , Marion Poirier , Sven Bühlmann , Céline Schuppisser , Rajesh Bhardwaj , Mahendra Awale , Ricardo Visini , Sacha Javor , Matthias A Hediger ,

Expanding Bioactive Fragment Space with the Generated Database GDB-13s.

Journal of chemical information and modeling

Avec: Ye Buehler ,

Machine Learning Guided Discovery of Non-Hemolytic Membrane Disruptive Anticancer Peptides.

ChemMedChem

Avec: Elena Zakharova , Markus Orsi , Alice Capecchi ,

Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments.

Journal of virology

Avec: Janine Vetter , Guido Papa , Michael Seyffert , Kapila Gunasekera , Giuditta De Lorenzo , Mahesa Wiesendanger , Cornel Fraefel , Oscar R Burrone , Catherine Eichwald

Organic Catalytic Activity as a Method for Agnostic Life Detection.

Astrobiology

Avec: Christos D Georgiou , Christopher McKay ,

SMILES-based deep generative scaffold decorator for de-novo drug design.

Journal of cheminformatics

Avec: Josep Arús-Pous , Atanas Patronov , Esben Jannik Bjerrum , Christian Tyrchan , Hongming Chen , Ola Engkvist

Optimizing TRPM4 inhibitors in the MHFP6 chemical space.

European journal of medicinal chemistry

Avec: Clémence Delalande , Mahendra Awale , Matthias Rubin , Daniel Probst , Lijo C Ozhathil , Jürg Gertsch , Hugues Abriel ,

Web-Based Tools for Polypharmacology Prediction.

Methods in molecular biology (Clifton, N.J.)

Avec: Mahendra Awale ,

Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration.

Bioconjugate chemistry

Avec: Marc Heitz , Susanna Zamolo , Sacha Javor ,

Predicting enzymatic reactions with a molecular transformer.

Chemical science

Avec: David Kreutter , Philippe Schwaller ,

An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate.

Angewandte Chemie (International ed. in English)

Avec: Dina Erzina , Alice Capecchi , Sacha Javor ,

Machine learning designs non-hemolytic antimicrobial peptides.

Chemical science

Avec: Alice Capecchi , Xingguang Cai , Hippolyte Personne , Thilo Köhler , Christian van Delden ,

What can reaction databases teach us about Buchwald-Hartwig cross-couplings?

Chemical science

Avec: Martin Fitzner , Georg Wuitschik , Raffael J Koller , Jean-Michel Adam , Torsten Schindler ,

A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography.

RSC chemical biology

Avec: Stéphane Baeriswyl , Hippolyte Personne , Ivan Di Bonaventura , Thilo Köhler , Christian van Delden , Achim Stocker , Sacha Javor ,

Synergistic effects of antimicrobial peptide dendrimer-chitosan polymer conjugates against Pseudomonas aeruginosa.

Carbohydrate polymers

Avec: Viorica Patrulea , Bee-Ha Gan , Karl Perron , Xingguang Cai , Philippe Abdel-Sayed , Emmanuelle Sublet , Verena Ducret , Natalia Porroche Nerhot , Lee Ann Applegate , Gerrit Borchard , Olivier Jordan

Reaction classification and yield prediction using the differential reaction fingerprint DRFP.

Digital discovery

Avec: Daniel Probst , Philippe Schwaller ,

Can large language models predict antimicrobial peptide activity and toxicity?

RSC medicinal chemistry

Avec: Markus Orsi ,

One chiral fingerprint to find them all.

Journal of cheminformatics

Avec: Markus Orsi ,

Peptide dendrimers transfecting CRISPR/Cas9 plasmid DNA: optimization and mechanism.

RSC chemical biology

Avec: Susanna Zamolo , Elena Zakharova , Lise Boursinhac , Florian Hollfelder , Tamis Darbre ,

Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.

Nature communications

Avec: Ana S Ramírez , Mario de Capitani , Giorgio Pesciullesi , Julia Kowal , Joël S Bloch , Rossitza N Irobalieva , Markus Aebi , Kaspar P Locher

Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption.

ACS infectious diseases

Avec: Etienne Bonvin , Hippolyte Personne , Thierry Paschoud , Jérémie Reusser , Bee-Ha Gan , Alexandre Luscher , Thilo Köhler , Christian van Delden ,

Automatic Extraction of Reaction Templates for Synthesis Prediction.

Chimia

Avec: Amol Thakkar ,

Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy

Avec: Fatma Ben Jeddou , Léna Falconnet , Alexandre Luscher , Thissa Siriwardena , Christian van Delden , Thilo Köhler

Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain.

Chemical science

Avec: Amol Thakkar , Thierry Kogej , Ola Engkvist , Esben Jannik Bjerrum

Réseau de co-auteurs

Sacha Javor 5 collaborations

Thilo Köhler 5 collaborations

Mahendra Awale 4 collaborations

Daniel Probst 4 collaborations

Alice Capecchi 4 collaborations

Christian van Delden 4 collaborations

Josep Arús-Pous 3 collaborations

Xingguang Cai 3 collaborations

Markus Orsi 3 collaborations

Hippolyte Personne 3 collaborations

Elena Zakharova 2 collaborations

Esben Jannik Bjerrum 2 collaborations

Ola Engkvist 2 collaborations

Susanna Zamolo 2 collaborations

Philippe Schwaller 2 collaborations

Bee-Ha Gan 2 collaborations

Alexandre Luscher 2 collaborations

Amol Thakkar 2 collaborations

Bee Ha Gan 1 collaboration

Kris Meier 1 collaboration

Jonai Pujol-Giménez 1 collaboration

Marion Poirier 1 collaboration

Sven Bühlmann 1 collaboration

Céline Schuppisser 1 collaboration

Rajesh Bhardwaj 1 collaboration

Ricardo Visini 1 collaboration

Matthias A Hediger 1 collaboration

Ye Buehler 1 collaboration

Janine Vetter 1 collaboration

Guido Papa 1 collaboration

Michael Seyffert 1 collaboration

Kapila Gunasekera 1 collaboration

Giuditta De Lorenzo 1 collaboration

Mahesa Wiesendanger 1 collaboration

Cornel Fraefel 1 collaboration

Oscar R Burrone 1 collaboration

Catherine Eichwald 1 collaboration

Christos D Georgiou 1 collaboration

Christopher McKay 1 collaboration

Atanas Patronov 1 collaboration

Christian Tyrchan 1 collaboration

Hongming Chen 1 collaboration

Clémence Delalande 1 collaboration

Matthias Rubin 1 collaboration

Lijo C Ozhathil 1 collaboration

Jürg Gertsch 1 collaboration

Hugues Abriel 1 collaboration

Marc Heitz 1 collaboration

David Kreutter 1 collaboration

Dina Erzina 1 collaboration

Martin Fitzner 1 collaboration

Georg Wuitschik 1 collaboration

Raffael J Koller 1 collaboration

Jean-Michel Adam 1 collaboration

Torsten Schindler 1 collaboration

Stéphane Baeriswyl 1 collaboration

Ivan Di Bonaventura 1 collaboration

Achim Stocker 1 collaboration

Viorica Patrulea 1 collaboration

Karl Perron 1 collaboration

Philippe Abdel-Sayed 1 collaboration

Emmanuelle Sublet 1 collaboration

Verena Ducret 1 collaboration

Natalia Porroche Nerhot 1 collaboration

Lee Ann Applegate 1 collaboration

Gerrit Borchard 1 collaboration

Olivier Jordan 1 collaboration

Lise Boursinhac 1 collaboration

Florian Hollfelder 1 collaboration

Tamis Darbre 1 collaboration

Ana S Ramírez 1 collaboration

Mario de Capitani 1 collaboration

Giorgio Pesciullesi 1 collaboration

Julia Kowal 1 collaboration

Joël S Bloch 1 collaboration

Rossitza N Irobalieva 1 collaboration

Markus Aebi 1 collaboration

Kaspar P Locher 1 collaboration

Etienne Bonvin 1 collaboration

Thierry Paschoud 1 collaboration

Jérémie Reusser 1 collaboration

Fatma Ben Jeddou 1 collaboration

Léna Falconnet 1 collaboration

Thissa Siriwardena 1 collaboration

Thierry Kogej 1 collaboration