James W Janetka

Affiliations

6Department of Medicine, Oncology Division, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 USA.

Publications (21)

Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine.

Communications biology

Avec: Makiko Kawaguchi , Koji Yamamoto , Naoki Takeda , Tsuyoshi Fukushima , Fumiki Yamashita , Katsuaki Sato , Kenichiro Kitamura , Yoshitaka Hippo , Hiroaki Kataoka

Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2.

Future medicinal chemistry

Avec: Vishnu C Damalanka ,

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression.

Journal of medicinal chemistry

Avec: Vishnu C Damalanka , Jorine J L P Voss , Matthew W Mahoney , Tina Primeau , Shunqiang Li , Lidija Klampfer ,

Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.

Protein science : a publication of the Protein Society

Avec: Matthew W Mahoney , Jonathan Helander , Anoopjit S Kooner , Mariah Norman , Vishnu C Damalanka , Paolo De Bona , Paulina Kasperkiewicz , Wioletta Rut , Marcin Poreba , Maithri M Kashipathy , Kevin P Battaile , Scott Lovell , Anthony J O'Donoghue , Charles S Craik , Marcin Drag ,

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.

Journal of medicinal chemistry

Avec: Amarendar Reddy Maddirala , Roger Klein , Jerome S Pinkner , Vasilios Kalas , Scott J Hultgren ,

Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin.

MedChemComm

Avec: Vishnu C Damalanka , Scott A Wildman ,

Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer.

Cellular and molecular life sciences : CMLS

Avec: Vivian Truong Jones , Ramona Graves-Deal , Zheng Cao , Galina Bogatcheva , Marisol A Ramirez , Sarah J Harmych , James N Higginbotham , Vineeta Sharma , Vishnu C Damalanka , Claudia C Wahoski , Neeraj Joshi , Maria Johnson Irudayam , Joseph T Roland , Gregory D Ayers , Qi Liu , Robert J Coffey , Bhuminder Singh

Mechanism-Based Macrocyclic Inhibitors of Serine Proteases.

Journal of medicinal chemistry

Avec: Vishnu C Damalanka , Victoria Banas , Paolo De Bona , Maithri M Kashipathy , Kevin Battaile , Scott Lovell ,

Efficacy of host cell serine protease inhibitor MM3122 against SARS-CoV-2 for treatment and prevention of COVID-19.

Journal of virology

Avec: Adrianus C M Boon , Traci L Bricker , Ethan J Fritch , Sarah R Leist , Kendra Gully , Ralph S Baric , Rachel L Graham , Brigid V Troan , Matthew Mahoney ,

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics.

Scientific reports

Avec: Rahul Tyagi , Mostafa A Elfawal , Scott A Wildman , Jon Helander , Christina A Bulman , Judy Sakanari , Bruce A Rosa , Paul J Brindley , Raffi V Aroian , Makedonka Mitreva

Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.

Journal of medicinal chemistry

Avec: Vishnu C Damalanka , Zhenfu Han , Partha Karmakar , Anthony J O'Donoghue , Florencia La Greca , Tommy Kim , Shishir M Pant , Jonathan Helander , Juha Klefström , Charles S Craik ,

A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.

PLoS pathogens

Avec: Lisa K McLellan , Michael R McAllaster , Arthur S Kim , Ľubomíra Tóthová , Patrick D Olson , Jerome S Pinkner , Allyssa L Daugherty , Teri N Hreha , Daved H Fremont , Scott J Hultgren , Herbert W Virgin , David A Hunstad

An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease.

Pathogens (Basel, Switzerland)

Avec: Rahul Tyagi , Christina A Bulman , Fidelis Cho-Ngwa , Chelsea Fischer , Chris Marcellino , Michelle R Arkin , James H McKerrow , Case W McNamara , Matthew Mahoney , Nancy Tricoche , Shabnam Jawahar , Sara Lustigman , Judy Sakanari , Makedonka Mitreva

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.

bioRxiv : the preprint server for biology

Avec: Matthew Mahoney , Vishnu C Damalanka , Michael A Tartell , Dong Hee Chung , André Luiz Lourenco , Dustin Pwee , Anne E Mayer Bridwell , Markus Hoffmann , Jorine Voss , Partha Karmakar , Nurit Azouz , Andrea M Klingler , Paul W Rothlauf , Cassandra E Thompson , Melody Lee , Lidija Klampfer , Christina Stallings , Marc E Rothenberg , Stefan Pöhlmann , Sean P Whelan , Anthony J O'Donoghue , Charles S Craik ,

Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).

Bioorganic & medicinal chemistry

Avec: Bin Yang , Alexander W Hird , Michael S Bodnarchuk , Xiaolan Zheng , Les Dakin , Qibin Su , Kevin Daly , Robert Godin , Maureen M Hattersley , Patrick Brassil , Sean Redmond , Daniel John Russell ,

Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.

Journal of medicinal chemistry

Avec: Allen T Hopper , Ziping Yang , Jennifer Barks , Mary Savari Dhason , Qiuling Wang , L David Sibley

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Matthew Mahoney , Vishnu C Damalanka , Michael A Tartell , Dong Hee Chung , André Luiz Lourenço , Dustin Pwee , Anne E Mayer Bridwell , Markus Hoffmann , Jorine Voss , Partha Karmakar , Nurit P Azouz , Andrea M Klingler , Paul W Rothlauf , Cassandra E Thompson , Melody Lee , Lidija Klampfer , Christina L Stallings , Marc E Rothenberg , Stefan Pöhlmann , Sean P J Whelan , Anthony J O'Donoghue , Charles S Craik ,

Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.

Journal of medicinal chemistry

Avec: Amarendar Reddy Maddirala , Jerome S Pinkner , Kevin Tamadonfar , Denise Sanick , Scott J Hultgren ,

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19.

bioRxiv : the preprint server for biology

Avec: Adrianus C M Boon , Traci L Bricker , Ethan J Fritch , Sarah R Leist , Kendra Gully , Ralph S Baric , Rachel L Graham , Brigid V Troan , Matthew Mahoney ,

Small Molecule Antagonists of the DNA Repair ERCC1/XPA Protein-Protein Interaction.

ChemMedChem

Avec: Robert Obermann , Bereket Yemane , Cassie Jarvis , Francisco M Franco , Yevhenii Kyriukha , William Nolan , Beth Gohara , Andrzej M Krezel , Scott A Wildman ,

Aspartyl Protease Inhibitors as Anti-Filarial Drugs.

Pathogens (Basel, Switzerland)

Avec: Liana Beld , Hyeim Jung , Christina A Bulman , Bruce A Rosa , Peter U Fischer , Sara Lustigman , Judy A Sakanari , Makedonka Mitreva

Réseau de co-auteurs

Vishnu C Damalanka 9 collaborations

Matthew Mahoney 5 collaborations

Anthony J O'Donoghue 4 collaborations

Charles S Craik 4 collaborations

Lidija Klampfer 3 collaborations

Jerome S Pinkner 3 collaborations

Scott J Hultgren 3 collaborations

Scott A Wildman 3 collaborations

Christina A Bulman 3 collaborations

Makedonka Mitreva 3 collaborations

Partha Karmakar 3 collaborations

Matthew W Mahoney 2 collaborations

Jonathan Helander 2 collaborations

Paolo De Bona 2 collaborations

Maithri M Kashipathy 2 collaborations

Scott Lovell 2 collaborations

Amarendar Reddy Maddirala 2 collaborations

Adrianus C M Boon 2 collaborations

Traci L Bricker 2 collaborations

Ethan J Fritch 2 collaborations

Sarah R Leist 2 collaborations

Kendra Gully 2 collaborations

Ralph S Baric 2 collaborations

Rachel L Graham 2 collaborations

Brigid V Troan 2 collaborations

Rahul Tyagi 2 collaborations

Judy Sakanari 2 collaborations

Bruce A Rosa 2 collaborations

Sara Lustigman 2 collaborations

Michael A Tartell 2 collaborations

Dong Hee Chung 2 collaborations

Dustin Pwee 2 collaborations

Anne E Mayer Bridwell 2 collaborations

Markus Hoffmann 2 collaborations

Jorine Voss 2 collaborations

Andrea M Klingler 2 collaborations

Paul W Rothlauf 2 collaborations

Cassandra E Thompson 2 collaborations

Melody Lee 2 collaborations

Marc E Rothenberg 2 collaborations

Stefan Pöhlmann 2 collaborations

Makiko Kawaguchi 1 collaboration

Koji Yamamoto 1 collaboration

Naoki Takeda 1 collaboration

Tsuyoshi Fukushima 1 collaboration

Fumiki Yamashita 1 collaboration

Katsuaki Sato 1 collaboration

Kenichiro Kitamura 1 collaboration

Yoshitaka Hippo 1 collaboration

Hiroaki Kataoka 1 collaboration

Jorine J L P Voss 1 collaboration

Tina Primeau 1 collaboration

Shunqiang Li 1 collaboration

Anoopjit S Kooner 1 collaboration

Mariah Norman 1 collaboration

Paulina Kasperkiewicz 1 collaboration

Wioletta Rut 1 collaboration

Marcin Poreba 1 collaboration

Kevin P Battaile 1 collaboration

Marcin Drag 1 collaboration

Roger Klein 1 collaboration

Vasilios Kalas 1 collaboration

Vivian Truong Jones 1 collaboration

Ramona Graves-Deal 1 collaboration

Zheng Cao 1 collaboration

Galina Bogatcheva 1 collaboration

Marisol A Ramirez 1 collaboration

Sarah J Harmych 1 collaboration

James N Higginbotham 1 collaboration

Vineeta Sharma 1 collaboration

Claudia C Wahoski 1 collaboration

Neeraj Joshi 1 collaboration

Maria Johnson Irudayam 1 collaboration

Joseph T Roland 1 collaboration

Gregory D Ayers 1 collaboration

Qi Liu 1 collaboration

Robert J Coffey 1 collaboration

Bhuminder Singh 1 collaboration

Victoria Banas 1 collaboration

Kevin Battaile 1 collaboration

Mostafa A Elfawal 1 collaboration

Jon Helander 1 collaboration

Paul J Brindley 1 collaboration

Raffi V Aroian 1 collaboration

Zhenfu Han 1 collaboration

Florencia La Greca 1 collaboration

Tommy Kim 1 collaboration

Shishir M Pant 1 collaboration

Juha Klefström 1 collaboration

Lisa K McLellan 1 collaboration

Michael R McAllaster 1 collaboration

Arthur S Kim 1 collaboration

Ľubomíra Tóthová 1 collaboration

Patrick D Olson 1 collaboration

Allyssa L Daugherty 1 collaboration

Teri N Hreha 1 collaboration

Daved H Fremont 1 collaboration

Herbert W Virgin 1 collaboration

David A Hunstad 1 collaboration

Fidelis Cho-Ngwa 1 collaboration

Chelsea Fischer 1 collaboration

Chris Marcellino 1 collaboration

Michelle R Arkin 1 collaboration

James H McKerrow 1 collaboration

Case W McNamara 1 collaboration

Nancy Tricoche 1 collaboration

Shabnam Jawahar 1 collaboration

André Luiz Lourenco 1 collaboration

Nurit Azouz 1 collaboration

Christina Stallings 1 collaboration

Sean P Whelan 1 collaboration

Bin Yang 1 collaboration

Alexander W Hird 1 collaboration

Michael S Bodnarchuk 1 collaboration

Xiaolan Zheng 1 collaboration

Les Dakin 1 collaboration

Qibin Su 1 collaboration

Kevin Daly 1 collaboration

Robert Godin 1 collaboration

Maureen M Hattersley 1 collaboration

Patrick Brassil 1 collaboration

Sean Redmond 1 collaboration

Daniel John Russell 1 collaboration

Allen T Hopper 1 collaboration

Ziping Yang 1 collaboration

Jennifer Barks 1 collaboration

Mary Savari Dhason 1 collaboration

Qiuling Wang 1 collaboration

L David Sibley 1 collaboration

André Luiz Lourenço 1 collaboration

Nurit P Azouz 1 collaboration

Christina L Stallings 1 collaboration

Sean P J Whelan 1 collaboration

Kevin Tamadonfar 1 collaboration

Denise Sanick 1 collaboration

Robert Obermann 1 collaboration

Bereket Yemane 1 collaboration

Cassie Jarvis 1 collaboration

Francisco M Franco 1 collaboration

Yevhenii Kyriukha 1 collaboration

William Nolan 1 collaboration

Beth Gohara 1 collaboration

Andrzej M Krezel 1 collaboration

Liana Beld 1 collaboration

Hyeim Jung 1 collaboration

Peter U Fischer 1 collaboration

Judy A Sakanari 1 collaboration