Jakub Scaber

Affiliations

MRC Computational Genomics Analysis and Training Programme (CGAT), MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, Oxford, OX3 9DS, UK.

ORCID: http://orcid.org/0000-0003-0146-1821

Publications (13)

Embryonic progenitor pools generate diversity in fine-scale excitatory cortical subnetworks.

Nature communications

Avec: Tommas J Ellender , Sophie V Avery , Kashif Mahfooz , Alexander von Klemperer , Sophie L Nixon , Matthew J Buchan , Joram J van Rheede , Aleksandra Gatti , Cameron Waites , Hania J Pavlou , David Sims , Sarah E Newey , Colin J Akerman

Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.

Neurobiology of disease

Avec: David Gordon , Ruxandra Dafinca , Javier Alegre-Abarrategui , Lucy Farrimond , Connor Scott , Daniel Biggs , Louisa Kent , Peter L Oliver , Benjamin Davies , Olaf Ansorge , Richard Wade-Martins , Kevin Talbot

Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair.

Human molecular genetics

Avec: Nidaa A Ababneh , Rowan Flynn , Andrew Douglas , Paola Barbagallo , Ana Candalija , Martin R Turner , David Sims , Ruxandra Dafinca , Sally A Cowley , Kevin Talbot

Advantages of routine next-generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic.

European journal of neurology

Avec: Alexander G Thompson , Lucy Farrimond , Emily Feneberg , Malcolm Proudfoot , Lynn Ossher , Martin R Turner , Kevin Talbot

Two case reports of distal upper limb weakness following influenza-like illness: an emerging pattern of para-infectious myositis in adults.

BMC neurology

Avec: Adam J Molyneux , Camilla Buckley , Alastair J S Webb

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons.

Scientific reports

Avec: Björn F Vahsen , Elizabeth Gray , Ana Candalija , Kaitlyn M L Cramb , Ruxandra Dafinca , Antigoni Katsikoudi , Yinyan Xu , Lucy Farrimond , Richard Wade-Martins , William S James , Martin R Turner , Sally A Cowley , Kevin Talbot

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9.

Nature communications

Avec: Björn F Vahsen , Sumedha Nalluru , Georgia R Morgan , Lucy Farrimond , Emily Carroll , Yinyan Xu , Kaitlyn M L Cramb , Benazir Amein , Antigoni Katsikoudi , Ana Candalija , Mireia Carcolé , Ruxandra Dafinca , Adrian M Isaacs , Richard Wade-Martins , Elizabeth Gray , Martin R Turner , Sally A Cowley , Kevin Talbot

Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons.

Stem cell reports

Avec: Iona Thomas-Wright , Alex J Clark , Yinyan Xu , Björn F Vahsen , Mireia Carcolé , Ruxandra Dafinca , Lucy Farrimond , Adrian M Isaacs , David L Bennett , Kevin Talbot

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD.

Stem cell reports

Avec: Ruxandra Dafinca , Paola Barbagallo , Lucy Farrimond , Ana Candalija , Nida'a A Ababneh , Chaitra Sathyaprakash , Jane Vowles , Sally A Cowley , Kevin Talbot

Genetic testing in motor neurone disease.

Practical neurology

Avec: Thanuja Dharmadasa , Evan Edmond , Rachael Marsden , Alexander Thompson , Kevin Talbot , Martin R Turner

Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain.

Brain communications

Avec: Alexander G Thompson , Elizabeth Gray , Nick Verber , Yoana Bobeva , Vittoria Lombardi , Stephanie R Shepheard , Ozlem Yildiz , Emily Feneberg , Lucy Farrimond , Thanuja Dharmadasa , Pamela Gray , Evan C Edmond , Delia Gagliardi , Janine Kirby , Thomas M Jenkins , Pietro Fratta , Christopher J McDermott , Sanjay G Manohar , Kevin Talbot , Andrea Malaspina , Pamela J Shaw , Martin R Turner

Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation.

Cell stem cell

Avec: Elisa Giacomelli , Björn F Vahsen , Elizabeth L Calder , Yinyan Xu , Elizabeth Gray , Ruxandra Dafinca , Kevin Talbot , Lorenz Studer

Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons.

Brain communications

Avec: Ruxandra Dafinca , Carlota Tosat-Bitrian , Emily Carroll , Björn F Vahsen , Javier Gilbert-Jaramillo , Emily Feneberg , Errin Johnson , Kevin Talbot

Réseau de co-auteurs

Kevin Talbot 11 collaborations

Ruxandra Dafinca 8 collaborations

Lucy Farrimond 7 collaborations

Martin R Turner 6 collaborations

Björn F Vahsen 5 collaborations

Ana Candalija 4 collaborations

Sally A Cowley 4 collaborations

Elizabeth Gray 4 collaborations

Yinyan Xu 4 collaborations

Richard Wade-Martins 3 collaborations

Emily Feneberg 3 collaborations

David Sims 2 collaborations

Paola Barbagallo 2 collaborations

Alexander G Thompson 2 collaborations

Kaitlyn M L Cramb 2 collaborations

Antigoni Katsikoudi 2 collaborations

Emily Carroll 2 collaborations

Mireia Carcolé 2 collaborations

Adrian M Isaacs 2 collaborations

Thanuja Dharmadasa 2 collaborations

Tommas J Ellender 1 collaboration

Sophie V Avery 1 collaboration

Kashif Mahfooz 1 collaboration

Alexander von Klemperer 1 collaboration

Sophie L Nixon 1 collaboration

Matthew J Buchan 1 collaboration

Joram J van Rheede 1 collaboration

Aleksandra Gatti 1 collaboration

Cameron Waites 1 collaboration

Hania J Pavlou 1 collaboration

Sarah E Newey 1 collaboration

Colin J Akerman 1 collaboration

David Gordon 1 collaboration

Javier Alegre-Abarrategui 1 collaboration

Connor Scott 1 collaboration

Daniel Biggs 1 collaboration

Louisa Kent 1 collaboration

Peter L Oliver 1 collaboration

Benjamin Davies 1 collaboration

Olaf Ansorge 1 collaboration

Nidaa A Ababneh 1 collaboration

Rowan Flynn 1 collaboration

Andrew Douglas 1 collaboration

Malcolm Proudfoot 1 collaboration

Lynn Ossher 1 collaboration

Adam J Molyneux 1 collaboration

Camilla Buckley 1 collaboration

Alastair J S Webb 1 collaboration

William S James 1 collaboration

Sumedha Nalluru 1 collaboration

Georgia R Morgan 1 collaboration

Benazir Amein 1 collaboration

Iona Thomas-Wright 1 collaboration

Alex J Clark 1 collaboration

David L Bennett 1 collaboration

Nida'a A Ababneh 1 collaboration

Chaitra Sathyaprakash 1 collaboration

Jane Vowles 1 collaboration

Evan Edmond 1 collaboration

Rachael Marsden 1 collaboration

Alexander Thompson 1 collaboration

Nick Verber 1 collaboration

Yoana Bobeva 1 collaboration

Vittoria Lombardi 1 collaboration

Stephanie R Shepheard 1 collaboration

Ozlem Yildiz 1 collaboration

Pamela Gray 1 collaboration

Evan C Edmond 1 collaboration

Delia Gagliardi 1 collaboration

Janine Kirby 1 collaboration

Thomas M Jenkins 1 collaboration

Pietro Fratta 1 collaboration

Christopher J McDermott 1 collaboration

Sanjay G Manohar 1 collaboration

Andrea Malaspina 1 collaboration

Pamela J Shaw 1 collaboration

Elisa Giacomelli 1 collaboration

Elizabeth L Calder 1 collaboration

Lorenz Studer 1 collaboration

Carlota Tosat-Bitrian 1 collaboration

Javier Gilbert-Jaramillo 1 collaboration

Errin Johnson 1 collaboration