Hunter Nisonoff

Affiliations

D. E. Shaw Research, New York, New York 10036, United States.

Publications (10)

Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography.

Journal of chemical information and modeling

Avec: Jack B Greisman , Lindsay Willmore , Christine Y Yeh , Fabrizio Giordanetto , Sahar Shahamadtar , Paul Maragakis , David E Shaw

Epistatic Net allows the sparse spectral regularization of deep neural networks for inferring fitness functions.

Nature communications

Avec: Amirali Aghazadeh , Orhan Ocal , David H Brookes , Yijie Huang , O Ozan Koyluoglu , Jennifer Listgarten , Kannan Ramchandran

Learning protein fitness models from evolutionary and assay-labeled data.

Nature biotechnology

Avec: Chloe Hsu , Clara Fannjiang , Jennifer Listgarten

A Deep-Learning View of Chemical Space Designed to Facilitate Drug Discovery.

Journal of chemical information and modeling

Avec: Paul Maragakis , Brian Cole , David E Shaw

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.

Nucleic acids research

Avec: Peter H Yoon , Petr Skopintsev , Honglue Shi , LinXing Chen , Benjamin A Adler , Muntathar Al-Shimary , Rory J Craig , Kenneth J Loi , Evan C DeTurk , Zheng Li , Jasmine Amerasekera , Marena Trinidad , Kai Chen , Arushi Lahiri , Ron Boger , Steve Jacobsen , Jillian F Banfield , Jennifer A Doudna

RNA language models predict mutations that improve RNA function.

bioRxiv : the preprint server for biology

Avec: Yekaterina Shulgina , Marena I Trinidad , Conner J Langeberg , Seyone Chithrananda , Petr Skopintsev , Amos J Nissley , Jaymin Patel , Ron S Boger , Honglue Shi , Peter H Yoon , Erin E Doherty , Tara Pande , Aditya M Iyer , Jennifer A Doudna , Jamie H D Cate

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.

bioRxiv : the preprint server for biology

Avec: Peter H Yoon , Petr Skopintsev , Honglue Shi , Lin-Xing Chen , Benjamin A Adler , Muntathar Al-Shimary , Rory J Craig , Zheng Li , Jasmine Amerasekera , Marena Trinidad , Kai Chen , Arushi Lahiri , Ron Boger , Steve Jacobsen , Jillian F Banfield , Jennifer A Doudna

Coherent Blending of Biophysics-Based Knowledge with Bayesian Neural Networks for Robust Protein Property Prediction.

ACS synthetic biology

Avec: Yixin Wang , Jennifer Listgarten

Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.

Journal of medicinal chemistry

Avec: Alexander M Taylor , Bret R Williams , Fabrizio Giordanetto , Elizabeth H Kelley , André Lescarbeau , Kelley Shortsleeves , Yong Tang , W Patrick Walters , Alfonso Arrazate , Christine Bowman , Erin Brophy , Emily W Chan , Gauri Deshmukh , Jack B Greisman , Thomas L Hunsaker , D Randal Kipp , Pablo Saenz Lopez-Larrocha , Danilo Maddalo , Iain J Martin , Paul Maragakis , Mark Merchant , Mark Murcko , Vi Nguyen , Vy Nguyen , Olivia Orozco , Christopher Owen , Levi Pierce , Molly Schmidt , David E Shaw , Sherri Smith , Eric Therrien , John C Tran , Jim Watters , Nigel J Waters , Jeremy Wilbur , Lindsay Willmore

GENTANGLE: integrated computational design of gene entanglements.

Bioinformatics (Oxford, England)

Avec: Jose Manuel Martí , Chloe Hsu , Charlotte Rochereau , Chenling Xu , Tomasz Blazejewski , Sean P Leonard , Christina S Kang-Yun , Jennifer Chlebek , Dante P Ricci , Dan Park , Harris Wang , Jennifer Listgarten , Yongqin Jiao , Jonathan E Allen

Réseau de co-auteurs

Jennifer Listgarten 4 collaborations

Paul Maragakis 3 collaborations

David E Shaw 3 collaborations

Peter H Yoon 3 collaborations

Petr Skopintsev 3 collaborations

Honglue Shi 3 collaborations

Jennifer A Doudna 3 collaborations

Jack B Greisman 2 collaborations

Lindsay Willmore 2 collaborations

Fabrizio Giordanetto 2 collaborations

Chloe Hsu 2 collaborations

Benjamin A Adler 2 collaborations

Muntathar Al-Shimary 2 collaborations

Rory J Craig 2 collaborations

Zheng Li 2 collaborations

Jasmine Amerasekera 2 collaborations

Marena Trinidad 2 collaborations

Kai Chen 2 collaborations

Arushi Lahiri 2 collaborations

Ron Boger 2 collaborations

Steve Jacobsen 2 collaborations

Jillian F Banfield 2 collaborations

Christine Y Yeh 1 collaboration

Sahar Shahamadtar 1 collaboration

Amirali Aghazadeh 1 collaboration

Orhan Ocal 1 collaboration

David H Brookes 1 collaboration

Yijie Huang 1 collaboration

O Ozan Koyluoglu 1 collaboration

Kannan Ramchandran 1 collaboration

Clara Fannjiang 1 collaboration

Brian Cole 1 collaboration

LinXing Chen 1 collaboration

Kenneth J Loi 1 collaboration

Evan C DeTurk 1 collaboration

Yekaterina Shulgina 1 collaboration

Marena I Trinidad 1 collaboration

Conner J Langeberg 1 collaboration

Seyone Chithrananda 1 collaboration

Amos J Nissley 1 collaboration

Jaymin Patel 1 collaboration

Ron S Boger 1 collaboration

Erin E Doherty 1 collaboration

Tara Pande 1 collaboration

Aditya M Iyer 1 collaboration

Jamie H D Cate 1 collaboration

Lin-Xing Chen 1 collaboration

Yixin Wang 1 collaboration

Alexander M Taylor 1 collaboration

Bret R Williams 1 collaboration

Elizabeth H Kelley 1 collaboration

André Lescarbeau 1 collaboration

Kelley Shortsleeves 1 collaboration

Yong Tang 1 collaboration

W Patrick Walters 1 collaboration

Alfonso Arrazate 1 collaboration

Christine Bowman 1 collaboration

Erin Brophy 1 collaboration

Emily W Chan 1 collaboration

Gauri Deshmukh 1 collaboration

Thomas L Hunsaker 1 collaboration

D Randal Kipp 1 collaboration

Pablo Saenz Lopez-Larrocha 1 collaboration

Danilo Maddalo 1 collaboration

Iain J Martin 1 collaboration

Mark Merchant 1 collaboration

Mark Murcko 1 collaboration

Vi Nguyen 1 collaboration

Vy Nguyen 1 collaboration

Olivia Orozco 1 collaboration

Christopher Owen 1 collaboration

Levi Pierce 1 collaboration

Molly Schmidt 1 collaboration

Sherri Smith 1 collaboration

Eric Therrien 1 collaboration

John C Tran 1 collaboration

Jim Watters 1 collaboration

Nigel J Waters 1 collaboration

Jeremy Wilbur 1 collaboration

Jose Manuel Martí 1 collaboration

Charlotte Rochereau 1 collaboration

Chenling Xu 1 collaboration

Tomasz Blazejewski 1 collaboration

Sean P Leonard 1 collaboration

Christina S Kang-Yun 1 collaboration

Jennifer Chlebek 1 collaboration

Dante P Ricci 1 collaboration

Dan Park 1 collaboration

Harris Wang 1 collaboration

Yongqin Jiao 1 collaboration

Jonathan E Allen 1 collaboration