Hans-Peter Kiem

Affiliations

Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
Pathology, University of Washington School of Medicine, Seattle, Washington, USA.

Publications (36)

Human gene therapy

Avec: Yogendra S Rajawat , Olivier Humbert , Savannah M Cook , Stefan Radtke , Dnyanada Pande , Mark Enstrom , Martin E Wohlfahrt ,

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

Journal of visualized experiments : JoVE

Avec: Stefan Radtke , Anai M Perez , Rasika Venkataraman , Sowmya Reddy , Kevin G Haworth , Olivier Humbert , Christopher W Peterson

MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.

Experimental hematology

Avec: Stefan Radtke , Yan-Yi Chan , Trisha R Sippel , Anthony Rongvaux

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants.

Stem cell reports

Avec: Christopher W Peterson , Jennifer E Adair , Martin E Wohlfahrt , Claire Deleage , Stefan Radtke , Blake Rust , Krystin K Norman , Zachary K Norgaard , Lauren E Schefter , Gabriella M Sghia-Hughes , Andrea Repetto , Audrey Baldessari , Robert D Murnane , Jacob D Estes ,

Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation.

eLife

Avec: E Fabian Cardozo-Ojeda , Elizabeth R Duke , Christopher W Peterson , Daniel B Reeves , Bryan T Mayer , Joshua T Schiffer

Targeting the membrane-proximal C2-set domain of CD33 for improved CD33-directed immunotherapy.

Leukemia

Avec: Colin D Godwin , George S Laszlo , Salvatore Fiorenza , Eliotte E Garling , Tinh-Doan Phi , Olivia M Bates , Colin E Correnti , Benjamin G Hoffstrom , Margaret C Lunn , Olivier Humbert , Cameron J Turtle , Roland B Walter

Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells.

Nature biotechnology

Avec: Khrystyna North , Salima Benbarche , Bo Liu , Joseph Pangallo , Sisi Chen , Maximilian Stahl , Jan Philipp Bewersdorf , Robert F Stanley , Caroline Erickson , Hana Cho , Jose Mario Bello Pineda , James D Thomas , Jacob T Polaski , Andrea E Belleville , Austin M Gabel , Dylan B Udy , Olivier Humbert , Omar Abdel-Wahab , Robert K Bradley

CD90-targeted lentiviral vectors for HSC gene therapy.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: Kurt Berckmueller , Justin Thomas , Eman A Taha , Seunga Choo , Ravishankar Madhu , Greta Kanestrom , Peter B Rupert , Roland Strong , Stefan Radtke

Efficient manufacturing and engraftment of

Molecular therapy. Methods & clinical development

Avec: Jason Murray , Teresa Einhaus , Rasika Venkataraman , Stefan Radtke , Anjie Zhen , Mayra A Carrillo , Scott G Kitchen , Christopher W Peterson ,

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice.

Blood

Avec: Asim Saha , Rahul Palchaudhuri , Leanne Lanieri , Sharon Hyzy , Megan J Riddle , Jamie Panthera , Cindy Eide , Jakub Tolar , Angela Panoskaltsis-Mortari , Lev Gorfinkel , Victor Tkachev , Ulrike Gerdemann , Francesca Alvarez-Calderon , Elisa Rojas Palato , Margaret L MacMillan , John E Wagner , Leslie S Kean , Mark Osborn , David T Scadden , Lisa M Olson , Bruce R Blazar

CAR T-cell therapy for cancer and HIV through novel approaches to HIV-associated haematological malignancies.

The Lancet. Haematology

Avec: Blake J Rust , Thomas S Uldrick

CRISPR/Cas9 for the treatment of haematological diseases: a journey from bacteria to the bedside.

British journal of haematology

Avec: Olivier Humbert , Clare Samuelson ,

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy.

Nature communications

Avec: Alyssa Sheih , Valentin Voillet , Laïla-Aïcha Hanafi , Hannah A DeBerg , Masanao Yajima , Reed Hawkins , Vivian Gersuk , Stanley R Riddell , David G Maloney , Martin E Wohlfahrt , Dnyanada Pande , Mark R Enstrom , Jennifer E Adair , Raphaël Gottardo , Peter S Linsley , Cameron J Turtle

Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.

Science translational medicine

Avec: Olivier Humbert , Stefan Radtke , Clare Samuelson , Ray R Carrillo , Anai M Perez , Sowmya S Reddy , Christopher Lux , Sowmya Pattabhi , Lauren E Schefter , Olivier Negre , Ciaran M Lee , Gang Bao , Jennifer E Adair , Christopher W Peterson , David J Rawlings , Andrew M Scharenberg ,

Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy.

Blood

Avec: Kevin A Hay , Jordan Gauthier , Alexandre V Hirayama , Jenna M Voutsinas , Qian Wu , Daniel Li , Ted A Gooley , Sindhu Cherian , Xueyan Chen , Barbara S Pender , Reed M Hawkins , Aesha Vakil , Rachel N Steinmetz , Gary Schoch , Aude G Chapuis , Brian G Till , Jorge D Ramos , Mazyar Shadman , Ryan D Cassaday , Utkarsh H Acharya , Stanley R Riddell , David G Maloney , Cameron J Turtle

Multiplex CRISPR/Cas9 genome editing in hematopoietic stem cells for fetal hemoglobin reinduction generates chromosomal translocations.

Molecular therapy. Methods & clinical development

Avec: Clare Samuelson , Stefan Radtke , Haiying Zhu , Mallory Llewellyn , Emily Fields , Savannah Cook , Meei-Li W Huang , Keith R Jerome , Olivier Humbert

Bringing gene therapy to where it's needed.

Trends in molecular medicine

Avec: Stefan Radtke ,

Safe and efficient

Molecular therapy. Methods & clinical development

Avec: Chang Li , Hongjie Wang , Sucheol Gil , Audrey Germond , Connie Fountain , Audrey Baldessari , Jiho Kim , Zhinan Liu , Aphrodite Georgakopoulou , Stefan Radtke , Tamás Raskó , Amit Pande , Christina Chiang , Eli Chin , Evangelia Yannaki , Zsuzsanna Izsvák , Thalia Papayannopoulou , André Lieber

Erratum: Safe and efficient

Molecular therapy. Methods & clinical development

In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies.

JCI insight

Avec: Chang Li , Aphrodite Georgakopoulou , Gregory A Newby , Kelcee A Everette , Evangelos Nizamis , Kiriaki Paschoudi , Efthymia Vlachaki , Sucheol Gil , Anna K Anderson , Theodore Koob , Lishan Huang , Hongjie Wang , David R Liu , Evangelia Yannaki , André Lieber

Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.

AIDS (London, England)

Avec: David A Siegel , Cassandra Thanh , Eunice Wan , Rebecca Hoh , Kristen Hobbs , Tony Pan , Erica A Gibson , Deanna L Kroetz , Jeffrey Martin , Frederick Hecht , Christopher Pilcher , Maureen Martin , Mary Carrington , Satish Pillai , Michael P Busch , Mars Stone , Claire N Levy , Meei-Li Huang , Pavitra Roychoudhury , Florian Hladik , Keith R Jerome , Timothy J Henrich , Steven G Deeks , Sulggi A Lee

Stochastic fate decisions of HSCs after transplantation: early contribution, symmetric expansion, and pool formation.

Blood

Avec: Stefan Radtke , Mark Enstrom , Dnyanada Pande , Elizabeth R Duke , E Fabian Cardozo-Ojeda , Ravishankar Madhu , Staci Owen , Greta Kanestrom , Margaret Cui , Anai M Perez , Joshua T Schiffer ,

Efficient

Frontiers in immunology

Avec: Sandra Dross , Rasika Venkataraman , Shabnum Patel , Meei-Li Huang , Catherine M Bollard , Margherita Rosati , George N Pavlakis , Barbara K Felber , Katharine J Bar , George M Shaw , Keith R Jerome , James I Mullins , Deborah Heydenburg Fuller , Christopher W Peterson

Molecular therapy. Methods & clinical development

Avec: Aphrodite Georgakopoulou , Chang Li , André Lieber

Assessment and streamlined preparation of low-cytotoxicity lentiviral vectors for mobilized human hematopoietic stem cell transduction.

Experimental hematology

Avec: Paul T Toran , Martin Wohlfahrt , Julia Foye , Don M Wojchowski

Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes.

Blood

Avec: Stosh Ozog , Nina D Timberlake , Kip Hermann , Olivia Garijo , Kevin G Haworth , Guoli Shi , Christopher M Glinkerman , Lauren E Schefter , Saritha D'Souza , Elizabeth Simpson , Gabriella Sghia-Hughes , Raymond R Carillo , Dale L Boger , Igor Slukvin , Byoung Y Ryu , Brian P Sorrentino , Jennifer E Adair , Scott A Snyder , Alex A Compton , Bruce E Torbett

Mouse models in hematopoietic stem cell gene therapy and genome editing.

Biochemical pharmacology

Avec: Stefan Radtke , Olivier Humbert ,

Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.

Cell stem cell

Avec: Christopher W Peterson ,

Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.

Molecular therapy. Methods & clinical development

Avec: Françoise Haeseleer , Yoshinori Fukazawa , Haesun Park , Benjamin Varco-Merth , Blake J Rust , Jeremy V Smedley , Karsten Eichholz , Christopher W Peterson , Rosemarie Mason , Mario Roederer , Louis J Picker , Afam A Okoye , Lawrence Corey

Safe and Effective

Human gene therapy

Avec: Paula Cannon , Aravind Asokan , Agnieszka Czechowicz , Paula Hammond , Donald B Kohn , Andre Lieber , Punam Malik , Peter Marks , Matthew Porteus , Els Verhoeyen , Drew Weissman , Irving Weissman ,

Now you see me, now you don't: New approaches to sparing nonmalignant cells from CAR T cell therapies.

Med (New York, N.Y.)

Avec: Nicholas E Petty , Justin Thomas , Stefan Radtke ,

Intraosseous delivery of platelet-targeted factor VIII lentiviral vector in humanized NBSGW mice.

Blood advances

Avec: Julia H Joo , Xuefeng Wang , Swati Singh , Chun-Yu Chen , Chong Li , Jennifer E Adair , David J Rawlings , Carol H Miao

In vivo HSC prime editing rescues sickle cell disease in a mouse model.

Blood

Avec: Chang Li , Aphrodite Georgakopoulou , Gregory A Newby , Peter J Chen , Kelcee A Everette , Kiriaki Paschoudi , Efthymia Vlachaki , Sucheol Gil , Anna K Anderson , Theodore Koob , Lishan Huang , Hongjie Wang , David R Liu , Evangelia Yannaki , André Lieber

CD20 CAR T-cells safely and reversibly ablate B-cell follicles in a nonhuman primate model of HIV persistence.

Molecular therapy : the journal of the American Society of Gene Therapy

Avec: John K Bui , Carly E Starke , Nikhita H Poole , Blake J Rust , Keith R Jerome , Christopher W Peterson

A simplified, G-CSF-free procedure allows for in vivo HSC gene therapy of sickle cell disease in a mouse model.

Blood advances

Avec: Chang Li , Anna Kate Anderson , Peter G Ruminski , Michael P Rettig , Darja Karpova , John F DiPersio , André Lieber

Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors.

Human gene therapy

Avec: Daniel Stone , Elizabeth J Kenkel , Michelle A Loprieno , Motoko Tanaka , Harshana S De Silva Feelixge , Arjun J Kumar , Laurence Stensland , Willimark M Obenza , Solomon Wangari , Chul Y Ahrens , Robert D Murnane , Christopher W Peterson , Meei-Li Huang , Martine Aubert , Shiu-Lok Hu , Keith R Jerome

Réseau de co-auteurs

Stefan Radtke 14 collaborations

Christopher W Peterson 10 collaborations

Olivier Humbert 8 collaborations

Chang Li 6 collaborations

André Lieber 6 collaborations

Jennifer E Adair 5 collaborations

Keith R Jerome 5 collaborations

Aphrodite Georgakopoulou 5 collaborations

Hongjie Wang 4 collaborations

Sucheol Gil 4 collaborations

Evangelia Yannaki 4 collaborations

Dnyanada Pande 3 collaborations

Martin E Wohlfahrt 3 collaborations

Anai M Perez 3 collaborations

Rasika Venkataraman 3 collaborations

Lauren E Schefter 3 collaborations

Audrey Baldessari 3 collaborations

Cameron J Turtle 3 collaborations

Blake J Rust 3 collaborations

Clare Samuelson 3 collaborations

Meei-Li Huang 3 collaborations

Mark Enstrom 2 collaborations

Kevin G Haworth 2 collaborations

Robert D Murnane 2 collaborations

E Fabian Cardozo-Ojeda 2 collaborations

Elizabeth R Duke 2 collaborations

Joshua T Schiffer 2 collaborations

Justin Thomas 2 collaborations

Ravishankar Madhu 2 collaborations

Greta Kanestrom 2 collaborations

Stanley R Riddell 2 collaborations

David G Maloney 2 collaborations

David J Rawlings 2 collaborations

Audrey Germond 2 collaborations

Connie Fountain 2 collaborations

Jiho Kim 2 collaborations

Zhinan Liu 2 collaborations

Tamás Raskó 2 collaborations

Amit Pande 2 collaborations

Christina Chiang 2 collaborations

Eli Chin 2 collaborations

Zsuzsanna Izsvák 2 collaborations

Thalia Papayannopoulou 2 collaborations

Gregory A Newby 2 collaborations

Kelcee A Everette 2 collaborations

Kiriaki Paschoudi 2 collaborations

Efthymia Vlachaki 2 collaborations

Anna K Anderson 2 collaborations

Theodore Koob 2 collaborations

Lishan Huang 2 collaborations

David R Liu 2 collaborations

Yogendra S Rajawat 1 collaboration

Savannah M Cook 1 collaboration

Sowmya Reddy 1 collaboration

Yan-Yi Chan 1 collaboration

Trisha R Sippel 1 collaboration

Anthony Rongvaux 1 collaboration

Claire Deleage 1 collaboration

Blake Rust 1 collaboration

Krystin K Norman 1 collaboration

Zachary K Norgaard 1 collaboration

Gabriella M Sghia-Hughes 1 collaboration

Andrea Repetto 1 collaboration

Jacob D Estes 1 collaboration

Daniel B Reeves 1 collaboration

Bryan T Mayer 1 collaboration

Colin D Godwin 1 collaboration

George S Laszlo 1 collaboration

Salvatore Fiorenza 1 collaboration

Eliotte E Garling 1 collaboration

Tinh-Doan Phi 1 collaboration

Olivia M Bates 1 collaboration

Colin E Correnti 1 collaboration

Benjamin G Hoffstrom 1 collaboration

Margaret C Lunn 1 collaboration

Roland B Walter 1 collaboration

Khrystyna North 1 collaboration

Salima Benbarche 1 collaboration

Bo Liu 1 collaboration

Joseph Pangallo 1 collaboration

Sisi Chen 1 collaboration

Maximilian Stahl 1 collaboration

Jan Philipp Bewersdorf 1 collaboration

Robert F Stanley 1 collaboration

Caroline Erickson 1 collaboration

Hana Cho 1 collaboration

Jose Mario Bello Pineda 1 collaboration

James D Thomas 1 collaboration

Jacob T Polaski 1 collaboration

Andrea E Belleville 1 collaboration

Austin M Gabel 1 collaboration

Dylan B Udy 1 collaboration

Omar Abdel-Wahab 1 collaboration

Robert K Bradley 1 collaboration

Kurt Berckmueller 1 collaboration

Eman A Taha 1 collaboration

Seunga Choo 1 collaboration

Peter B Rupert 1 collaboration

Roland Strong 1 collaboration

Jason Murray 1 collaboration

Teresa Einhaus 1 collaboration

Anjie Zhen 1 collaboration

Mayra A Carrillo 1 collaboration

Scott G Kitchen 1 collaboration

Asim Saha 1 collaboration

Rahul Palchaudhuri 1 collaboration

Leanne Lanieri 1 collaboration

Sharon Hyzy 1 collaboration

Megan J Riddle 1 collaboration

Jamie Panthera 1 collaboration

Cindy Eide 1 collaboration

Jakub Tolar 1 collaboration

Angela Panoskaltsis-Mortari 1 collaboration

Lev Gorfinkel 1 collaboration

Victor Tkachev 1 collaboration

Ulrike Gerdemann 1 collaboration

Francesca Alvarez-Calderon 1 collaboration

Elisa Rojas Palato 1 collaboration

Margaret L MacMillan 1 collaboration

John E Wagner 1 collaboration

Leslie S Kean 1 collaboration

Mark Osborn 1 collaboration

David T Scadden 1 collaboration

Lisa M Olson 1 collaboration

Bruce R Blazar 1 collaboration

Thomas S Uldrick 1 collaboration

Alyssa Sheih 1 collaboration

Valentin Voillet 1 collaboration

Laïla-Aïcha Hanafi 1 collaboration

Hannah A DeBerg 1 collaboration

Masanao Yajima 1 collaboration

Reed Hawkins 1 collaboration

Vivian Gersuk 1 collaboration

Mark R Enstrom 1 collaboration

Raphaël Gottardo 1 collaboration

Peter S Linsley 1 collaboration

Ray R Carrillo 1 collaboration

Sowmya S Reddy 1 collaboration

Christopher Lux 1 collaboration

Sowmya Pattabhi 1 collaboration

Olivier Negre 1 collaboration

Ciaran M Lee 1 collaboration

Gang Bao 1 collaboration

Andrew M Scharenberg 1 collaboration

Kevin A Hay 1 collaboration

Jordan Gauthier 1 collaboration

Alexandre V Hirayama 1 collaboration

Jenna M Voutsinas 1 collaboration

Qian Wu 1 collaboration

Daniel Li 1 collaboration

Ted A Gooley 1 collaboration

Sindhu Cherian 1 collaboration

Xueyan Chen 1 collaboration

Barbara S Pender 1 collaboration

Reed M Hawkins 1 collaboration

Aesha Vakil 1 collaboration

Rachel N Steinmetz 1 collaboration

Gary Schoch 1 collaboration

Aude G Chapuis 1 collaboration

Brian G Till 1 collaboration

Jorge D Ramos 1 collaboration

Mazyar Shadman 1 collaboration

Ryan D Cassaday 1 collaboration

Utkarsh H Acharya 1 collaboration

Haiying Zhu 1 collaboration

Mallory Llewellyn 1 collaboration

Emily Fields 1 collaboration

Savannah Cook 1 collaboration

Meei-Li W Huang 1 collaboration

Evangelos Nizamis 1 collaboration

David A Siegel 1 collaboration

Cassandra Thanh 1 collaboration

Eunice Wan 1 collaboration

Rebecca Hoh 1 collaboration

Kristen Hobbs 1 collaboration

Tony Pan 1 collaboration

Erica A Gibson 1 collaboration

Deanna L Kroetz 1 collaboration

Jeffrey Martin 1 collaboration

Frederick Hecht 1 collaboration

Christopher Pilcher 1 collaboration

Maureen Martin 1 collaboration

Mary Carrington 1 collaboration

Satish Pillai 1 collaboration

Michael P Busch 1 collaboration

Mars Stone 1 collaboration

Claire N Levy 1 collaboration

Pavitra Roychoudhury 1 collaboration

Florian Hladik 1 collaboration

Timothy J Henrich 1 collaboration

Steven G Deeks 1 collaboration

Sulggi A Lee 1 collaboration

Staci Owen 1 collaboration

Margaret Cui 1 collaboration

Sandra Dross 1 collaboration

Shabnum Patel 1 collaboration

Catherine M Bollard 1 collaboration

Margherita Rosati 1 collaboration

George N Pavlakis 1 collaboration

Barbara K Felber 1 collaboration

Katharine J Bar 1 collaboration

George M Shaw 1 collaboration

James I Mullins 1 collaboration

Deborah Heydenburg Fuller 1 collaboration

Paul T Toran 1 collaboration

Martin Wohlfahrt 1 collaboration

Julia Foye 1 collaboration

Don M Wojchowski 1 collaboration

Stosh Ozog 1 collaboration

Nina D Timberlake 1 collaboration

Kip Hermann 1 collaboration

Olivia Garijo 1 collaboration

Guoli Shi 1 collaboration

Christopher M Glinkerman 1 collaboration

Saritha D'Souza 1 collaboration

Elizabeth Simpson 1 collaboration

Gabriella Sghia-Hughes 1 collaboration

Raymond R Carillo 1 collaboration

Dale L Boger 1 collaboration

Igor Slukvin 1 collaboration

Byoung Y Ryu 1 collaboration

Brian P Sorrentino 1 collaboration

Scott A Snyder 1 collaboration

Alex A Compton 1 collaboration

Bruce E Torbett 1 collaboration

Françoise Haeseleer 1 collaboration

Yoshinori Fukazawa 1 collaboration

Haesun Park 1 collaboration

Benjamin Varco-Merth 1 collaboration

Jeremy V Smedley 1 collaboration

Karsten Eichholz 1 collaboration

Rosemarie Mason 1 collaboration

Mario Roederer 1 collaboration

Louis J Picker 1 collaboration

Afam A Okoye 1 collaboration

Lawrence Corey 1 collaboration

Paula Cannon 1 collaboration

Aravind Asokan 1 collaboration

Agnieszka Czechowicz 1 collaboration

Paula Hammond 1 collaboration

Donald B Kohn 1 collaboration

Andre Lieber 1 collaboration

Punam Malik 1 collaboration

Peter Marks 1 collaboration

Matthew Porteus 1 collaboration

Els Verhoeyen 1 collaboration

Drew Weissman 1 collaboration

Irving Weissman 1 collaboration

Nicholas E Petty 1 collaboration

Julia H Joo 1 collaboration

Xuefeng Wang 1 collaboration

Swati Singh 1 collaboration

Chun-Yu Chen 1 collaboration

Chong Li 1 collaboration

Carol H Miao 1 collaboration

Peter J Chen 1 collaboration

John K Bui 1 collaboration

Carly E Starke 1 collaboration

Nikhita H Poole 1 collaboration

Anna Kate Anderson 1 collaboration

Peter G Ruminski 1 collaboration

Michael P Rettig 1 collaboration

Darja Karpova 1 collaboration

John F DiPersio 1 collaboration

Daniel Stone 1 collaboration

Elizabeth J Kenkel 1 collaboration

Michelle A Loprieno 1 collaboration

Motoko Tanaka 1 collaboration

Harshana S De Silva Feelixge 1 collaboration

Arjun J Kumar 1 collaboration

Laurence Stensland 1 collaboration

Willimark M Obenza 1 collaboration

Solomon Wangari 1 collaboration

Chul Y Ahrens 1 collaboration

Martine Aubert 1 collaboration

Shiu-Lok Hu 1 collaboration