From Oxford University Hospitals NHS Foundation Trust (H.-K.L., M.A.M., B.L.A., P.C.M., A.J.B., J.L., R.G., M.R., A.T., B.A., I.B., A.R.B., E.K., T.W., T.H.N.W., L.K.B., A.A., P.B., M.S.) and the Nuffield Departments of Orthopaedics, Rheumatology and Musculoskeletal Science (I.R., R.Z., C.C., A.A.) and Medicine (M.K., C.S., P.C.M., A.J.B., B.A., G.E.T., P.B., M.S.) and the Division of Medical Sciences (B.A.L.), University of Oxford, Oxford, the Division of Infectious Diseases, Imperial College London (H.-K.L., G.C.), Medical Research Council Clinical Trials Unit, University College London (A.S.W.), Royal Free London NHS Foundation Trust (S.W., D.J.F.M., S.H.), Guy's and St. Thomas' NHS Foundation Trust (C.J.H., K.B.), and Public Health England (J.P.), London, University Hospital of Wales, Cardiff (H.C.H.), University Hospital Birmingham NHS Foundation Trust (D.B.) and Heart of England NHS Foundation Trust (N.J., C.E.M., A.F.W., S.S.), Birmingham, Royal National Orthopaedic Hospital NHS Trust, Stanmore (S.W., F.E.F., D.J.F.M.), Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool (J.F., H.E.R.), Cambridge University Hospitals NHS Foundation Trust, Cambridge (E.M., J.M.), Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde (R.A.S., C.V.), and Health Economics and Health Technology Assessment, University of Glasgow (C.G., N.M., A.H.B.), Glasgow, Leeds Teaching Hospital NHS Trust, University of Leeds, Leeds (J.A.T.S.), Ninewells Hospital, NHS Tayside, Dundee (I.A.), Northumbria Healthcare NHS Foundation Trust, Northumberland (S.C.E., D.J.B.), Western General Hospital, NHS Lothian, Edinburgh (R.K.S.), and Hull and East Yorkshire Hospitals NHS Trust, Hull (G.B.) - all in the United Kingdom; University of Bern, Bern, Switzerland (P.S.); Oxford University Clinical Research Unit, Wellcome Trust, Ho Chi Minh City, Vietnam (G.E.T.); and Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya (P.B.). C.F.O. and J.B. are patient representatives and do not have an institutional affiliation.