Ganesh M Mugundu

Affiliations

Clinical Pharmacology and Quantitative Pharmacology, R&D Clinical Pharmacology and Safety Sciences, AstraZeneca, Waltham, MA, USA.

Publications (9)

Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors.

Cancer chemotherapy and pharmacology

Avec: Mats Någård , Mei-Lin Ah-See , James Strauss , Trisha Wise-Draper , Howard P Safran , Laura Nadeau , William J Edenfield , Lionel D Lewis , Lone H Ottesen , Yan Li ,

Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study.

Targeted oncology

Avec: Hidenori Kato , Paul de Souza , Sang-We Kim , Jason D Lickliter , Yoichi Naito , Keunchil Park , Sanjeev Kumar , Yung-Jue Bang

Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T-cell subsets and immunophenotypes in cancer patients.

CPT: pharmacometrics & systems pharmacology

Avec: Ahmed M Salem , Aman P Singh

Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab.

Frontiers in immunology

Avec: Agnish Dey , Matthew Austin , Harriet M Kluger , Nataliya Trunova , Helen Mann , Norah Shire , Claire Morgan , Diansong Zhou ,

Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Kathleen N Moore , Setsuko K Chambers , Erika P Hamilton , Lee-May Chen , Amit M Oza , Sharad A Ghamande , Gottfried E Konecny , Steven C Plaxe , Daniel L Spitz , Jill J J Geenen , Tiffany A Troso-Sandoval , Janiel M Cragun , Esteban Rodrigo Imedio , Sanjeev Kumar , Zhongwu Lai , Juliann Chmielecki , Suzanne F Jones , David R Spigel , Karen A Cadoo

Longitudinal Circulating Tumor DNA Modeling to Predict Disease Progression in First-line Mutant Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer.

Clinical pharmacology and therapeutics

Avec: Martin Johnson , Carlos Serra Traynor , Karthick Vishwanathan , Philip Overend , Ryan Hartmaier , Aleksandra Markovets , Juliann Chmielecki , J Carl Barrett , Helen Tomkinson , Suresh S Ramalingam

A phase Ib study of adavosertib, a selective Wee1 inhibitor, in patients with locally advanced or metastatic solid tumors.

Investigational new drugs

Avec: Gerald S Falchook , Jasgit Sachdev , Esteban Rodrigo Imedio , Sanjeev Kumar , Suzanne Jenkins , Juliann Chmielecki , Suzanne Jones , David R Spigel , Melissa Johnson

Adavosertib (AZD1775) does not prolong the QTc interval in patients with advanced solid tumors: a phase I open-label study.

Cancer chemotherapy and pharmacology

Avec: Mats Någård , Mei-Lin Ah-See , James Strauss , Trisha Wise-Draper , Howard P Safran , Laura Nadeau , William J Edenfield , Lionel D Lewis , Dinko Rekić , Corina Dota , Lone H Ottesen , Yan Li ,

Population Pharmacokinetic Modeling of Adavosertib (AZD1775) in Patients with Solid Tumors.

Journal of clinical pharmacology

Avec: Martin Johnson , Daniel Kaschek , Dana Ghiorghiu , Shankar Lanke , Kowser Miah , Henning Schmidt ,

Réseau de co-auteurs

Sanjeev Kumar 3 collaborations

Juliann Chmielecki 3 collaborations

Mats Någård 2 collaborations

Mei-Lin Ah-See 2 collaborations

James Strauss 2 collaborations

Trisha Wise-Draper 2 collaborations

Howard P Safran 2 collaborations

Laura Nadeau 2 collaborations

William J Edenfield 2 collaborations

Lionel D Lewis 2 collaborations

Lone H Ottesen 2 collaborations

Yan Li 2 collaborations

Esteban Rodrigo Imedio 2 collaborations

David R Spigel 2 collaborations

Martin Johnson 2 collaborations

Hidenori Kato 1 collaboration

Paul de Souza 1 collaboration

Sang-We Kim 1 collaboration

Jason D Lickliter 1 collaboration

Yoichi Naito 1 collaboration

Keunchil Park 1 collaboration

Yung-Jue Bang 1 collaboration

Ahmed M Salem 1 collaboration

Aman P Singh 1 collaboration

Agnish Dey 1 collaboration

Matthew Austin 1 collaboration

Harriet M Kluger 1 collaboration

Nataliya Trunova 1 collaboration

Helen Mann 1 collaboration

Norah Shire 1 collaboration

Claire Morgan 1 collaboration

Diansong Zhou 1 collaboration

Kathleen N Moore 1 collaboration

Setsuko K Chambers 1 collaboration

Erika P Hamilton 1 collaboration

Lee-May Chen 1 collaboration

Amit M Oza 1 collaboration

Sharad A Ghamande 1 collaboration

Gottfried E Konecny 1 collaboration

Steven C Plaxe 1 collaboration

Daniel L Spitz 1 collaboration

Jill J J Geenen 1 collaboration

Tiffany A Troso-Sandoval 1 collaboration

Janiel M Cragun 1 collaboration

Zhongwu Lai 1 collaboration

Suzanne F Jones 1 collaboration

Karen A Cadoo 1 collaboration

Carlos Serra Traynor 1 collaboration

Karthick Vishwanathan 1 collaboration

Philip Overend 1 collaboration

Ryan Hartmaier 1 collaboration

Aleksandra Markovets 1 collaboration

J Carl Barrett 1 collaboration

Helen Tomkinson 1 collaboration

Suresh S Ramalingam 1 collaboration

Gerald S Falchook 1 collaboration

Jasgit Sachdev 1 collaboration

Suzanne Jenkins 1 collaboration

Suzanne Jones 1 collaboration

Melissa Johnson 1 collaboration

Dinko Rekić 1 collaboration

Corina Dota 1 collaboration

Daniel Kaschek 1 collaboration

Dana Ghiorghiu 1 collaboration

Shankar Lanke 1 collaboration

Kowser Miah 1 collaboration

Henning Schmidt 1 collaboration